LOCUS NC_003888 26742 bp DNA linear CON 03-AUG-2016 DEFINITION Streptomyces coelicolor A3(2) chromosome, complete genome. ACCESSION NC_003888 VERSION NC_003888.3 KEYWORDS . SOURCE Streptomyces coelicolor A3(2) ORGANISM Streptomyces coelicolor A3(2) Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group. COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL645882. On Jun 22, 2003 this sequence version replaced NC_003888.2. RefSeq Category: Reference Genome MOD: Model Organism UPR: UniProt Genome COMPLETENESS: full length. ##antiSMASH-Data-START## Version :: 7.1.0 Run date :: 2023-11-22 14:16:39 NOTE: This is a single region extracted from a larger record! Orig. start :: 7506016 Orig. end :: 7532758 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..26742 /aStool="rule-based-clusters" /category="terpene" /contig_edge="False" /core_location="[10000:16742]" /cutoff="20000" /detection_rule="(Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)" /neighbourhood="10000" /product="terpene" /protocluster_number="1" /tool="antismash" proto_core 10001..16742 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)" /neighbourhood="10000" /product="terpene" /protocluster_number="1" cand_cluster 1..26742 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)" /kind="single" /product="terpene" /protoclusters="1" /tool="antismash" region 1..26742 /candidate_cluster_numbers="1" /contig_edge="False" /product="terpene" /region_number="22" /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)" /tool="antismash" gene complement(292..885) /db_xref="GeneID:1102189" /gene_synonym="SC5F2A.33c" /locus_tag="SCO6750" CDS complement(292..885) /EC_number="5.3.3.2" /codon_start=1 /db_xref="GeneID:1102189" /gene_synonym="SC5F2A.33c" /locus_tag="SCO6750" /note="catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate" /product="isopentenyl-diphosphate delta-isomerase" /protein_id="NP_630823.1" /transl_table=11 /translation="MPITPATATPSSSNGTAEAILLELVDENGVTIGTAEKLSAHQPPG RLHRAFSVFLFDERGRLLIQQRALGKYHSPGVWSNTCCGHPYPGEAPFAAAARRTFEEL GVSPSLLAEAGTVRYNHPDPASGLVEQEYNHLFVGLVQAELRPDPEEVAGTAFVSPAEL TERHAQDTFSAWFMTVLDAARPAVRELTGTSAGW" aSDomain complement(349..816) /aSDomain="TIGR02150" /aSTool="tigrfam" /description="IPP_isom_1: isopentenyl-diphosphate delta-isomerase" /detection="hmmscan" /domain_id="TIGRFam_SCO6750_0093" /evalue="1.10E-35" /identifier="TIGR02150" /label="SCO6750" /locus_tag="SCO6750" /protein_end="179" /protein_start="23" /score="120.9" /tool="antismash" /translation="LVDENGVTIGTAEKLSAHQPPGRLHRAFSVFLFDERGRLLIQQRA LGKYHSPGVWSNTCCGHPYPGEAPFAAAARRTFEELGVSPSLLAEAGTVRYNHPDPASG LVEQEYNHLFVGLVQAELRPDPEEVAGTAFVSPAELTERHAQDTFSAWFMTV" PFAM_domain complement(367..747) /aSDomain="NUDIX" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00293.31" /description="NUDIX domain" /detection="hmmscan" /domain_id="clusterhmmer_SCO6750_0854" /evalue="2.00E-25" /label="SCO6750" /locus_tag="SCO6750" /protein_end="173" /protein_start="46" /score="89.4" /tool="antismash" /translation="LHRAFSVFLFDERGRLLIQQRALGKYHSPGVWSNTCCGHPYPGEA PFAAAARRTFEELGVSPSLLAEAGTVRYNHPDPASGLVEQEYNHLFVGLVQAELRPDPE EVAGTAFVSPAELTERHAQDTFS" gene complement(1162..2100) /db_xref="GeneID:1102190" /gene_synonym="SC5F2A.34c" /locus_tag="SCO6751" CDS complement(1162..2100) /codon_start=1 /db_xref="GeneID:1102190" /gene_synonym="SC5F2A.34c" /locus_tag="SCO6751" /note="SC5F2A.34c, possible efflux protein, len: 312aa; similar to many eg. SW:CZCD_ALCSP cation efflux protein from Alcaligenes sp. (316 aa) fasta scores; opt: 834, z-score: 949.4, E(): 0, (47.0% identity in 300 aa overlap). Contains several probable membrane spanning hydrophobic regions." /product="efflux protein" /protein_id="NP_630824.1" /transl_table=11 /translation="MGAGHDHGHAHGGHAGGTATAAYRGRLRVALSITLTVMVVEIVGG LVADSLALIADAAHMATDALGLGMALLAVHFASRPPSDRRTFGYARAEILAALANCLLL LGVGGYVLYEAIDRFVTPADTAAGPTVVFGAIGLVANMVSLSLLMRGQKESLNVRGAFL EVAADALGSLAVIVSALVILATGWQPADPIASLLIGLMIVPRTLRLLRETLDVLLEAAP KGVDIAEVRAHILALDGVEDVHDLHAWTITSGMPVLSAHVVVDGEALSAIGHEKMLHEL QGCLGDHFDVEHCTFQLEPSGHAEHEARLCR" aSDomain complement(1195..2025) /aSDomain="TIGR01297" /aSTool="tigrfam" /description="CDF: cation diffusion facilitator family transporter" /detection="hmmscan" /domain_id="TIGRFam_SCO6751_0094" /evalue="9.00E-93" /identifier="TIGR01297" /label="SCO6751" /locus_tag="SCO6751" /protein_end="302" /protein_start="25" /score="308.6" /tool="antismash" /translation="RLRVALSITLTVMVVEIVGGLVADSLALIADAAHMATDALGLGMA LLAVHFASRPPSDRRTFGYARAEILAALANCLLLLGVGGYVLYEAIDRFVTPADTAAGP TVVFGAIGLVANMVSLSLLMRGQKESLNVRGAFLEVAADALGSLAVIVSALVILATGWQ PADPIASLLIGLMIVPRTLRLLRETLDVLLEAAPKGVDIAEVRAHILALDGVEDVHDLH AWTITSGMPVLSAHVVVDGEALSAIGHEKMLHELQGCLGDHFDVEHCTFQLEPSG" PFAM_domain complement(1447..2022) /aSDomain="Cation_efflux" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01545.24" /db_xref="GO:0006812" /db_xref="GO:0008324" /db_xref="GO:0016020" /db_xref="GO:0055085" /description="Cation efflux family" /detection="hmmscan" /domain_id="clusterhmmer_SCO6751_0855" /evalue="8.50E-49" /gene_ontologies="GO:0006812: monoatomic cation transport" /gene_ontologies="GO:0008324: monoatomic cation transmembrane transporter activity" /gene_ontologies="GO:0016020: membrane" /gene_ontologies="GO:0055085: transmembrane transport" /label="SCO6751" /locus_tag="SCO6751" /protein_end="218" /protein_start="26" /score="166.1" /tool="antismash" /translation="LRVALSITLTVMVVEIVGGLVADSLALIADAAHMATDALGLGMAL LAVHFASRPPSDRRTFGYARAEILAALANCLLLLGVGGYVLYEAIDRFVTPADTAAGPT VVFGAIGLVANMVSLSLLMRGQKESLNVRGAFLEVAADALGSLAVIVSALVILATGWQP ADPIASLLIGLMIVPRTLRLLRETLDVLL" misc_feature 2194..2208 /note="TFBS match to ZuR, Zinc-responsive repressor, confidence: weak, score: 18.72" /tool="antismash" gene 2578..4395 /db_xref="GeneID:1102191" /gene_synonym="SC5F2A.35; SC6A5.01" /locus_tag="SCO6752" CDS 2578..4395 /codon_start=1 /db_xref="GeneID:1102191" /gene_synonym="SC5F2A.35; SC6A5.01" /locus_tag="SCO6752" /note="SC6A5.01, partial CDS, possible integral membrane transferase, len: >490aa; similar to TR:O67379 (EMBL:AE000737) glucose-1-phosphate thymidylyltransferase from Aquifex aeolicus (428 aa) fasta scores; opt: 215, z-score: 245.5, E(): 2.2e-06, (26.2% identity in 210 aa overlap). Contains Prosite match to PS00379 CDP-alcohol phosphatidyltransferases signature and possible membrane spanning hydrophobic regions.; SC5F2A.35, partial CDS, possible transferase, len: >148aa; C-terminal region lies on cosmid 6A5 (EMBL:AL049485). Similar over a defined region to many proposed/hypothetical proteins eg. TR:O67379 (EMBL:AE000737) proposed glucose-1-phosphate thymidylyltransferase from Aquifex aeolicus (428 aa) fasta scores; opt: 215, z-score: 239.5, E(): 5e-06, (26.2% identity in 210 aa overlap). Contains Prosite match to PS00379 CDP-alcohol phosphatidyltransferases signature. Also contains possible membrane spanning hydrophobic regions." /product="integral membrane transferase" /protein_id="NP_733714.1" /transl_table=11 /translation="MPTAILTGQPVPGSSIESELRSLGFDVHVAAGAAETETLLARVPG EERVAVVDARFVGHPHALRLGLTDPRFPLAAIQGAVTAQPAARQMLTRAMARENSTGGG TAVDVDSLADRITAALDADGAGVHRPELGSLVAAVPADPQARNEARQAVAAVDDEAVRL KSAVKARDGFVTTHFISPYSRYIARWCARRGLTPNQVTTASLITALIAAGCAATGTRGG FVAAGVLLIASFVLDCTDGQLARYSLQYSTLGAWLDATFDRAKEYAYYAGLALGAARGG DDVWALALGAMVLQTCRHVVDFSFNEANHDASANTSPTAALSDKLDSVGWTVWLRRMIV LPIGERWAMIAVLTALTTPRITFYALLIGCAFAATYTTAGRVLRSLTRKATRTDRAAKA LADLADSGPLAEAGAKGLRTAARRLPGFATPAVALLGGAAVVATAALTDFGGPWPLVAA LGYVLTSALAVARPLKGALDWLVPPFFRAAEYLTVLFLAAKADVNGALPAAFGLVAAVA YHHYDTVYRIRGDAGAPPQWLVRTVGGHEGRTLVITLLAVLLTAAQFKVALTVLAVVVA LVVLVESIRFWVAAHQVGAPAVHDEGEPA" misc_feature 2922..3021 /gene_synonym="SC5F2A.35; SC6A5.01" /locus_tag="SCO6752" /note="Overlap with cosmid 6A5 (EMBL:AL049485)" PFAM_domain 3160..3585 /aSDomain="CDP-OH_P_transf" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01066.24" /db_xref="GO:0008654" /db_xref="GO:0016020" /db_xref="GO:0016780" /description="CDP-alcohol phosphatidyltransferase" /detection="hmmscan" /domain_id="clusterhmmer_SCO6752_0856" /evalue="5.10E-11" /gene_ontologies="GO:0008654: phospholipid biosynthetic process" /gene_ontologies="GO:0016020: membrane" /gene_ontologies="GO:0016780: phosphotransferase activity, for other substituted phosphate groups" /label="SCO6752" /locus_tag="SCO6752" /protein_end="336" /protein_start="194" /score="43.4" /tool="antismash" /translation="LTPNQVTTASLITALIAAGCAATGTRGGFVAAGVLLIASFVLDCT DGQLARYSLQYSTLGAWLDATFDRAKEYAYYAGLALGAARGGDDVWALALGAMVLQTCR HVVDFSFNEANHDASANTSPTAALSDKLDSVGWTVWLR" misc_feature 3295..3363 /gene_synonym="SC5F2A.35; SC6A5.01" /locus_tag="SCO6752" /note="PS00379 CDP-alcohol phosphatidyltransferases signature." PFAM_domain 3757..4392 /aSDomain="DUF5941" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF19365.2" /description="Family of unknown function (DUF5941)" /detection="hmmscan" /domain_id="clusterhmmer_SCO6752_0857" /evalue="2.60E-95" /label="SCO6752" /locus_tag="SCO6752" /protein_end="605" /protein_start="393" /score="318.4" /tool="antismash" /translation="DRAAKALADLADSGPLAEAGAKGLRTAARRLPGFATPAVALLGGA AVVATAALTDFGGPWPLVAALGYVLTSALAVARPLKGALDWLVPPFFRAAEYLTVLFLA AKADVNGALPAAFGLVAAVAYHHYDTVYRIRGDAGAPPQWLVRTVGGHEGRTLVITLLA VLLTAAQFKVALTVLAVVVALVVLVESIRFWVAAHQVGAPAVHDEGEPA" gene 4392..5144 /db_xref="GeneID:1102192" /gene_synonym="SC6A5.02" /locus_tag="SCO6753" CDS 4392..5144 /codon_start=1 /db_xref="GeneID:1102192" /gene_functions="biosynthetic-additional (rule-based-clusters) NTP_transf_3" /gene_functions="biosynthetic-additional (smcogs) SMCOG1064:glucose-1-phosphate adenylyl/thymidylyltransferase (Score: 78; E-value: 1.1e-23)" /gene_kind="biosynthetic-additional" /gene_synonym="SC6A5.02" /locus_tag="SCO6753" /note="SC6A5.02, probable nucleotide sugar-1-phosphate transferase, len: 250aa; similar to many eg. TR:O05171 (EMBL:Y11985) dNDP-glucose synthase from the avilamycin biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 (355 aa) fasta scores; opt: 192, z-score: 226.4, E(): 2.6e-05. (26.9% identity in 242 aa overlap). Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase." /product="nucleotide sugar-1-phosphate transferase" /protein_id="NP_630825.1" /sec_met_domain="NTP_transf_3 (E-value: 7e-10, bitscore: 38.3, seeds: 297, tool: rule-based-clusters)" /transl_table=11 /translation="MIGLVLAAGAGRRLRPYTDTLPKALVPVGPEGAEDSITVLDLTLA NFAEVGLTEVGIIVGYRKEAVYDRQAELEQKYGVKLTLIDNDKAEEWNNAYSLWCGRDA LKDGVILANGDTVHPVSVEKTLLAARGDGKKIILALDTVKNLADEEMKVVVDPDKGVQR ITKLMDPADATGEYIGVTLIEGEAAAELADALKTTFERDPQLYYEDGYQELVNRGFKVD VAPIGDVKWVEIDNHDDLAKGREIACQY" misc_feature 4395..5141 /gene_synonym="SC6A5.02" /locus_tag="SCO6753" /note="Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase." PFAM_domain 4398..4889 /aSDomain="NTP_transferase" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00483.26" /db_xref="GO:0009058" /description="Nucleotidyl transferase" /detection="hmmscan" /domain_id="clusterhmmer_SCO6753_0858" /evalue="2.30E-11" /gene_ontologies="GO:0009058: biosynthetic process" /label="SCO6753" /locus_tag="SCO6753" /protein_end="166" /protein_start="2" /score="43.9" /tool="antismash" /translation="GLVLAAGAGRRLRPYTDTLPKALVPVGPEGAEDSITVLDLTLANF AEVGLTEVGIIVGYRKEAVYDRQAELEQKYGVKLTLIDNDKAEEWNNAYSLWCGRDALK DGVILANGDTVHPVSVEKTLLAARGDGKKIILALDTVKNLADEEMKVVVDPDKGVQRIT K" gene 5171..6193 /db_xref="GeneID:1102193" /gene_synonym="SC6A5.03" /locus_tag="SCO6754" CDS 5171..6193 /codon_start=1 /db_xref="GeneID:1102193" /gene_functions="biosynthetic-additional (rule-based-clusters) Fe-ADH" /gene_functions="biosynthetic-additional (rule-based-clusters) DHQ_synthase" /gene_functions="biosynthetic-additional (smcogs) SMCOG1181:dehydrogenase (Score: 80; E-value: 2.7e-24)" /gene_kind="biosynthetic-additional" /gene_synonym="SC6A5.03" /locus_tag="SCO6754" /note="SC6A5.03, possible glycerol dehydrogenase, len: 340aa; similar to many eg. SW:GLDA_PSEPU glycerol dehydrogenase, GldA, from Pseudomonas putida (365 aa) fasta scores; opt: 261, z-score: 303.7, E(): 1.3e-09, (27.9% identity in 308 aa overlap)." /product="glycerol dehydrogenase" /protein_id="NP_630826.1" /sec_met_domain="Fe-ADH (E-value: 1.4e-23, bitscore: 82.2, seeds: 218, tool: rule-based-clusters)" /sec_met_domain="DHQ_synthase (E-value: 1.3e-08, bitscore: 33.2, seeds: 76, tool: rule-based-clusters)" /transl_table=11 /translation="MDIRAGALDDLGCVLADERISHSGKLAVAVSGGSGARLRDRVAPS LPGADWFEVGGGTLDDAIKLAGAMKGGHYDAVVGLGGGKIIDCAKFAAARIGLPLVAVP TNLAHDGLCSPVATLDNDAGRGSYGVPNPIAVVIDLDVIRAAPARFVRAGIGDAVSNVS AIADWELANRVKGEKIDGLAAAMARQAGEAVLRHPGGIGDNDFLQVLAEALVLSGIAMS VSGDSRPSSGACHEINHAFDLLFPERAAAHGEQCGLGAAFAMYLRGAHEESANMARVLR RHGLPVLPEEIGFTPEEFFRAVEFAPQTRPGRYTILEHLDLTTDQIKDLYADYVKAIGS " PFAM_domain 5177..5941 /aSDomain="Fe-ADH_2" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF13685.9" /description="Iron-containing alcohol dehydrogenase" /detection="hmmscan" /domain_id="clusterhmmer_SCO6754_0859" /evalue="5.70E-56" /label="SCO6754" /locus_tag="SCO6754" /protein_end="257" /protein_start="2" /score="190.2" /tool="antismash" /translation="IRAGALDDLGCVLADERISHSGKLAVAVSGGSGARLRDRVAPSLP GADWFEVGGGTLDDAIKLAGAMKGGHYDAVVGLGGGKIIDCAKFAAARIGLPLVAVPTN LAHDGLCSPVATLDNDAGRGSYGVPNPIAVVIDLDVIRAAPARFVRAGIGDAVSNVSAI ADWELANRVKGEKIDGLAAAMARQAGEAVLRHPGGIGDNDFLQVLAEALVLSGIAMSVS GDSRPSSGACHEINHAFDLLFPERAAAHGEQCG" gene 6267..6950 /db_xref="GeneID:1102194" /gene_synonym="SC6A5.04" /locus_tag="SCO6755" CDS 6267..6950 /codon_start=1 /db_xref="GeneID:1102194" /gene_synonym="SC6A5.04" /locus_tag="SCO6755" /note="SC6A5.04, possible integral membrane transferase, len: 227aa; similar to many eg. TR:O67379 (EMBL:AE000737) glucose-1-phophate thymidylyltransferase from Aquifex aeolicus (428 aa) fasta scores; opt: 206, z-score: 257.3, E(): 5e-07, (28.1% identity in 199 aa overlap). Contains possible membrane spanning hydrophobic region." /product="transferase" /protein_id="NP_630827.1" /transl_table=11 /translation="MREVSLRIDRYLVNTRITPNQLTYLMTVCGVLAAPALLVPGIWGA VLGVVAVQLYLLLDCVDGEIARWRKQYSLGGVYLDRVGAYLTDAAVLVGLGLRAADIWG TGRIDWLWAFLGTLAALGAILIKAETDLVGVARHQNGMPPVKEAASEIRSSGMALARRA AGALKFHRLILGIEATLLILVLAIVDQARGDLFFTRLGTAVLAGIALLQTLLHLVSILA SSRLK" misc_feature complement(6304..6318) /note="TFBS match to ZuR, Zinc-responsive repressor, confidence: weak, score: 17.34" /tool="antismash" PFAM_domain 6315..6665 /aSDomain="CDP-OH_P_transf" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01066.24" /db_xref="GO:0008654" /db_xref="GO:0016020" /db_xref="GO:0016780" /description="CDP-alcohol phosphatidyltransferase" /detection="hmmscan" /domain_id="clusterhmmer_SCO6755_0860" /evalue="4.50E-09" /gene_ontologies="GO:0008654: phospholipid biosynthetic process" /gene_ontologies="GO:0016020: membrane" /gene_ontologies="GO:0016780: phosphotransferase activity, for other substituted phosphate groups" /label="SCO6755" /locus_tag="SCO6755" /protein_end="133" /protein_start="16" /score="37.1" /tool="antismash" /translation="ITPNQLTYLMTVCGVLAAPALLVPGIWGAVLGVVAVQLYLLLDCV DGEIARWRKQYSLGGVYLDRVGAYLTDAAVLVGLGLRAADIWGTGRIDWLWAFLGTLAA LGAILIKAETDLV" gene 6959..7831 /db_xref="GeneID:1102195" /gene_synonym="SC6A5.05" /locus_tag="SCO6756" CDS 6959..7831 /codon_start=1 /db_xref="GeneID:1102195" /gene_functions="biosynthetic-additional (rule-based-clusters) Glycos_transf_2" /gene_kind="biosynthetic-additional" /gene_synonym="SC6A5.05" /locus_tag="SCO6756" /note="SC6A5.05, possible glycosyltransferase, len: 290aa; similar to many eg. TR:E1388141 (EMBL:AL035478) transferase from Streptomyces coelicolor (344 aa) fasta scores; opt: 202, z-score: 235.1, E(): 8.6e-06, (28.1% identity in 317 aa overlap). Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases. Contains possible membrane spanning hydrophobic regions." /product="glycosyltransferase" /protein_id="NP_630828.1" /sec_met_domain="Glycos_transf_2 (E-value: 1.2e-11, bitscore: 43.6, seeds: 256, tool: rule-based-clusters)" /transl_table=11 /translation="MKVGAVVITMGNRPEELRALLDSVAKQDGDPVQVVVVGNGSPVPE VPEGVRTVELPENLGIPGGRNVGIEAFGPGGSDVDILLFLDDDGLLARTDTAELCREAF AADDELGIISFRIADPDTGETQRRHVPRLRASDPMRSSRVTTFLGGANAVRTRVLTQVG GLPDAFFYAHEETDLAWRALDAGWMIDYRSDMVLNHPTTAPSRHAVYHRMVARNRVWLA RRNLPALLVPVYLGVWMALTLLRRPSRPALKAWFGGFREGWATPCGPRRPMRWRTVWRL TRLGRPPVI" misc_feature 6971..7450 /gene_synonym="SC6A5.05" /locus_tag="SCO6756" /note="Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases." PFAM_domain 6974..7342 /aSDomain="Glycos_transf_2" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00535.29" /description="Glycosyl transferase family 2" /detection="hmmscan" /domain_id="clusterhmmer_SCO6756_0861" /evalue="1.40E-09" /label="SCO6756" /locus_tag="SCO6756" /protein_end="128" /protein_start="5" /score="38.1" /tool="antismash" /translation="VVITMGNRPEELRALLDSVAKQDGDPVQVVVVGNGSPVPEVPEGV RTVELPENLGIPGGRNVGIEAFGPGGSDVDILLFLDDDGLLARTDTAELCREAFAADDE LGIISFRIADPDTGETQRR" gene 7931..8860 /db_xref="GeneID:1102196" /gene_synonym="SC6A5.06" /locus_tag="SCO6757" CDS 7931..8860 /codon_start=1 /db_xref="GeneID:1102196" /gene_synonym="SC6A5.06" /locus_tag="SCO6757" /note="SC6A5.06, probable ABC transporter membrane component, len: 309aa; similar to many eg. TR:O66230 (EMBL:AB010150) ABC transporter membrane component from Escherichia coli (264 aa) fasta scores; opt: 346, z-score: 414.3, E(): 8.9e-16, (27.3% identity in 267 aa overlap). Contains Pfam match to entry PF01061 ABC2_membrane, ABC-2 type transporter, score 109.60, E-value 6.1e-29 and Prosite match to PS00211 ABC transporters family signature. Also contains probable membrane spanning hydrophobic regions." /product="ABC transporter membrane protein" /protein_id="NP_630829.1" /transl_table=11 /translation="MSETTHDGTVAMTKPVSPDEGLTPARLAAKYGLSVSGARPSLKEY VRQLWGRRHFILAFSQAKLTAQYSQAKLGQLWQVATPLLNALVYFLIFGLILDAGRGME KDVYIPFLVTGVFVFTFTQSSAMAGVRAIAGNLGLVRALHFPRASLPVSFALQQLQQLL ASMIVLFLVVVGFGSYPSLSWLLVLPVLVLQFLFNTGLALVVARMGAKTPDLAQLMPFI MRTWMYASGVMFSIPIMLKDKPDWIADVLQWNPAAVYMDLMRFALIDGYGSENLPPHVW AVALGWAVVLAVGGFVYFWKAEERYGRG" misc_feature 8066..8851 /gene_synonym="SC6A5.06" /locus_tag="SCO6757" /note="Pfam match to entry PF01061 ABC2_membrane, ABC-2 type transporter, score 109.60, E-value 6.1e-29." PFAM_domain 8108..8731 /aSDomain="ABC2_membrane" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01061.27" /db_xref="GO:0016020" /db_xref="GO:0140359" /description="ABC-2 type transporter" /detection="hmmscan" /domain_id="clusterhmmer_SCO6757_0862" /evalue="7.90E-18" /gene_ontologies="GO:0016020: membrane" /gene_ontologies="GO:0140359: ABC-type transporter activity" /label="SCO6757" /locus_tag="SCO6757" /protein_end="267" /protein_start="59" /score="64.8" /tool="antismash" /translation="SQAKLTAQYSQAKLGQLWQVATPLLNALVYFLIFGLILDAGRGME KDVYIPFLVTGVFVFTFTQSSAMAGVRAIAGNLGLVRALHFPRASLPVSFALQQLQQLL ASMIVLFLVVVGFGSYPSLSWLLVLPVLVLQFLFNTGLALVVARMGAKTPDLAQLMPFI MRTWMYASGVMFSIPIMLKDKPDWIADVLQWNPAAVYMDLMRFAL" misc_feature 8777..8821 /gene_synonym="SC6A5.06" /locus_tag="SCO6757" /note="PS00211 ABC transporters family signature." gene 8880..9641 /db_xref="GeneID:1102197" /gene_synonym="SC6A5.07" /locus_tag="SCO6758" CDS 8880..9641 /codon_start=1 /db_xref="GeneID:1102197" /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 126.6; E-value: 2.1e-38)" /gene_kind="transport" /gene_synonym="SC6A5.07" /locus_tag="SCO6758" /note="SC6A5.07, probable ABC transporter ATP-binding component, len: 253aa; similar to many eg. SW:TAGH_BACSU TagH, ABC transporter ATP-binding component from Bacillus subtilis (527 aa) fasta scores; opt: 621, z-score: 686.7, E(): 6e-31, (48.5% identity in 202 aa overlap). Contains Pfam match to entry PF00005 ABC_tran, ABC transporter, score 123.70, E-value 3.4e-33 and Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature." /product="ABC transporter ATP-binding protein" /protein_id="NP_630830.1" /transl_table=11 /translation="MPTVIADEVHIVYRVNGAKTGKGSATAALSRILKKGSDDAKRGVR KVHAVRGVSFTAYRGEAIGLIGSNGSGKSTLLRAIAGLLPAERGKVYTDGQPSLLGVNA ALMNDLTGERNVILGGLAMGMSREQIKERYQEIVDFSGINEKGDFITLPMRTYSSGMAA RLRFSIAAAKDHDVLMIDEALATGDRKFQTRSEERIRELKKQAGTIFLVSHNNKSIRDT CNRVLWLERGELRMDGPTDEVLKEYEKFTGK" PFAM_domain 9030..9431 /aSDomain="ABC_tran" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00005.30" /db_xref="GO:0005524" /description="ABC transporter" /detection="hmmscan" /domain_id="clusterhmmer_SCO6758_0863" /evalue="1.90E-16" /gene_ontologies="GO:0005524: ATP binding" /label="SCO6758" /locus_tag="SCO6758" /protein_end="184" /protein_start="50" /score="61.0" /tool="antismash" /translation="RGVSFTAYRGEAIGLIGSNGSGKSTLLRAIAGLLPAERGKVYTDG QPSLLGVNAALMNDLTGERNVILGGLAMGMSREQIKERYQEIVDFSGINEKGDFITLPM RTYSSGMAARLRFSIAAAKDHDVLMIDEAL" misc_feature 9057..9575 /gene_synonym="SC6A5.07" /locus_tag="SCO6758" /note="Pfam match to entry PF00005 ABC_tran, ABC transporter, score 123.70, E-value 3.4e-33." misc_feature 9078..9101 /gene_synonym="SC6A5.07" /locus_tag="SCO6758" /note="PS00017 ATP/GTP-binding site motif A (P-loop)." misc_feature 9348..9392 /gene_synonym="SC6A5.07" /locus_tag="SCO6758" /note="PS00211 ABC transporters family signature." gene 10001..10912 /db_xref="GeneID:1102198" /gene_synonym="SC6A5.08" /locus_tag="SCO6759" CDS 10001..10912 /codon_start=1 /db_xref="GeneID:1102198" /gene_functions="biosynthetic (rule-based-clusters) terpene: phytoene_synt" /gene_kind="biosynthetic" /gene_synonym="SC6A5.08" /locus_tag="SCO6759" /note="SC6A5.08, probable phytoene synthase, len: 303aa; similar to many eg. TR:Q50892 (EMBL:Z21955) phytoene synthase from the light-induced carotenoid biosynthesis cluster of Myxococcus xanthus (336 aa) fasta scores; opt: 322, z-score: 379.7, E(): 7.5e-14, (31.8% identity in 274 aa overlap). Contains Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases, score 34.70, E-value 1.2e-08." /product="phytoene synthase" /protein_id="NP_630831.1" /sec_met_domain="phytoene_synt (E-value: 2.1e-39, bitscore: 134.2, seeds: 8, tool: rule-based-clusters)" /transl_table=11 /translation="MTVTDTAHAVDPERGTLAKAADENFPVAPFFLPRAWRTDLMAVYG FARLVDDIGDGDLAPGGADARLLGVPEDRADDRLLMLDAFEADLRRVFDGSDGAPRHPL LRRLVPTVRRRALTPEPFLGLIAANRQDQLVARYETYDDLLAYCELSANPVGRLVLAVT GTSTPERIRRSDEICTALQIVEHLQDVAEDLGRDRIYLPAEDMKRFHVQEADLAAPSAN ASVRALIAYEAARARDLLNEGAPLVGSVHGRLRLLLAGFVAGGRAALNAIAAADHDVLP GPPKSGKVHLLREAGVVLRGEG" aSDomain 10052..10891 /aSDomain="TIGR03464" /aSTool="tigrfam" /description="HpnC: squalene synthase HpnC" /detection="hmmscan" /domain_id="TIGRFam_SCO6759_0095" /evalue="3.90E-99" /identifier="TIGR03464" /label="SCO6759" /locus_tag="SCO6759" /protein_end="297" /protein_start="17" /score="329.5" /tool="antismash" /translation="AKAADENFPVAPFFLPRAWRTDLMAVYGFARLVDDIGDGDLAPGG ADARLLGVPEDRADDRLLMLDAFEADLRRVFDGSDGAPRHPLLRRLVPTVRRRALTPEP FLGLIAANRQDQLVARYETYDDLLAYCELSANPVGRLVLAVTGTSTPERIRRSDEICTA LQIVEHLQDVAEDLGRDRIYLPAEDMKRFHVQEADLAAPSANASVRALIAYEAARARDL LNEGAPLVGSVHGRLRLLLAGFVAGGRAALNAIAAADHDVLPGPPKSGKVHLLREAGV" PFAM_domain 10055..10852 /aSDomain="SQS_PSY" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00494.22" /db_xref="GO:0009058" /description="Squalene/phytoene synthase" /detection="hmmscan" /domain_id="clusterhmmer_SCO6759_0864" /evalue="9.30E-68" /gene_ontologies="GO:0009058: biosynthetic process" /label="SCO6759" /locus_tag="SCO6759" /protein_end="284" /protein_start="18" /score="228.7" /tool="antismash" /translation="KAADENFPVAPFFLPRAWRTDLMAVYGFARLVDDIGDGDLAPGGA DARLLGVPEDRADDRLLMLDAFEADLRRVFDGSDGAPRHPLLRRLVPTVRRRALTPEPF LGLIAANRQDQLVARYETYDDLLAYCELSANPVGRLVLAVTGTSTPERIRRSDEICTAL QIVEHLQDVAEDLGRDRIYLPAEDMKRFHVQEADLAAPSANASVRALIAYEAARARDLL NEGAPLVGSVHGRLRLLLAGFVAGGRAALNAIAAADHDVLPGPP" misc_feature 10094..10717 /gene_synonym="SC6A5.08" /locus_tag="SCO6759" /note="Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases, score 34.70, E-value 1.2e-08." gene 10921..11859 /db_xref="GeneID:1102199" /gene_synonym="SC6A5.09" /locus_tag="SCO6760" CDS 10921..11859 /codon_start=1 /db_xref="GeneID:1102199" /gene_functions="biosynthetic (rule-based-clusters) terpene: phytoene_synt" /gene_kind="biosynthetic" /gene_synonym="SC6A5.09" /locus_tag="SCO6760" /note="SC6A5.09, probable phytoene synthase, len: 312aa; similar to many egs. SW:CRTB_MYCTU probable phytoene synthase from Mycobacterium tuberculosis (302 aa) fasta scores; opt: 791, z-score: 925.6, E(): 0, (48.3% identity in 286 aa overlap) and SW:PSY_ARATH phytoene synthase precusor from Arabidopsis thaliana (mouse ear cress) (423 aa) fasta scores; opt: 493, z-score: 577.3, E(): 7.4e-25, (34.4% identity in 282 aa overlap). Contains Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases, score 168.70, E-value 9.4e-47 and Prosite matches to PS01044 Squalene and phytoene synthases signature 1 and PS01045 Squalene and phytoene synthases signature 2." /product="phytoene synthase" /protein_id="NP_630832.1" /sec_met_domain="phytoene_synt (E-value: 2.7e-56, bitscore: 189.6, seeds: 8, tool: rule-based-clusters)" /transl_table=11 /translation="MESSANMPAPVLAAYSYCEAVTGQQARNFAHGIRLLPTPKRRAMS ALYAFSRRVDDIGDGVLADDVKVTRLDETRAVLARIQDGAVEEDDTDPVAVALADAARR FPIPLGGLDELIDGVQMDLRGETYETWDDLKVYCRCVAGAIGRLSLGVFGTEPGARGAE RAPEYADTLGLALQLTNILRDVREDAEGGRTYLPADDLAKFGCAAGFNGPTPPEGSDFA GLVHFEVRRARALFAEGYRLLPMLDRRSGACVAAMAGIYRRLLDRIERDPEAVLRGRVS LPGREKAYVAVRGLSGLDARHVTRRTVRRRA" aSDomain 10984..11802 /aSDomain="TIGR03465" /aSTool="tigrfam" /description="HpnD: squalene synthase HpnD" /detection="hmmscan" /domain_id="TIGRFam_SCO6760_0096" /evalue="5.60E-98" /identifier="TIGR03465" /label="SCO6760" /locus_tag="SCO6760" /protein_end="294" /protein_start="21" /score="325.2" /tool="antismash" /translation="TGQQARNFAHGIRLLPTPKRRAMSALYAFSRRVDDIGDGVLADDV KVTRLDETRAVLARIQDGAVEEDDTDPVAVALADAARRFPIPLGGLDELIDGVQMDLRG ETYETWDDLKVYCRCVAGAIGRLSLGVFGTEPGARGAERAPEYADTLGLALQLTNILRD VREDAEGGRTYLPADDLAKFGCAAGFNGPTPPEGSDFAGLVHFEVRRARALFAEGYRLL PMLDRRSGACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGREKAYVAVRG" misc_feature 10984..11820 /gene_synonym="SC6A5.09" /locus_tag="SCO6760" /note="Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases, score 168.70, E-value 9.4e-47." PFAM_domain 10990..11775 /aSDomain="SQS_PSY" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00494.22" /db_xref="GO:0009058" /description="Squalene/phytoene synthase" /detection="hmmscan" /domain_id="clusterhmmer_SCO6760_0865" /evalue="3.90E-71" /gene_ontologies="GO:0009058: biosynthetic process" /label="SCO6760" /locus_tag="SCO6760" /protein_end="285" /protein_start="23" /score="239.8" /tool="antismash" /translation="QQARNFAHGIRLLPTPKRRAMSALYAFSRRVDDIGDGVLADDVKV TRLDETRAVLARIQDGAVEEDDTDPVAVALADAARRFPIPLGGLDELIDGVQMDLRGET YETWDDLKVYCRCVAGAIGRLSLGVFGTEPGARGAERAPEYADTLGLALQLTNILRDVR EDAEGGRTYLPADDLAKFGCAAGFNGPTPPEGSDFAGLVHFEVRRARALFAEGYRLLPM LDRRSGACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGR" misc_feature 11329..11376 /gene_synonym="SC6A5.09" /locus_tag="SCO6760" /note="PS01044 Squalene and phytoene synthases signature 1." misc_feature 11434..11511 /gene_synonym="SC6A5.09" /locus_tag="SCO6760" /note="PS01045 Squalene and phytoene synthases signature 2." PFAM_domain 11859..12014 /aSDomain="DUF6380" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF19907.2" /description="Family of unknown function (DUF6380)" /detection="hmmscan" /domain_id="clusterhmmer_SCO6761_0866" /evalue="6.80E-20" /label="SCO6761" /locus_tag="SCO6761" /protein_end="52" /protein_start="0" /score="71.0" /tool="antismash" /translation="MDTPGTLDTRDPYKTGGGQWRATLRWRSASLTETVSRTPFKHRGG RTGKGAP" gene 11859..12017 /db_xref="GeneID:1102200" /gene_synonym="SC6A5.10" /locus_tag="SCO6761" CDS 11859..12017 /codon_start=1 /db_xref="GeneID:1102200" /gene_synonym="SC6A5.10" /locus_tag="SCO6761" /note="SC6A5.10, unknown, len: 52 aa; designated based upon Hidden-Markov Model and probable ribosome binding site." /product="hypothetical protein" /protein_id="NP_630833.1" /transl_table=11 /translation="MDTPGTLDTRDPYKTGGGQWRATLRWRSASLTETVSRTPFKHRGG RTGKGAP" gene 12014..13450 /db_xref="GeneID:1102201" /gene_synonym="SC6A5.11" /locus_tag="SCO6762" CDS 12014..13450 /codon_start=1 /db_xref="GeneID:1102201" /gene_functions="biosynthetic-additional (rule-based-clusters) DAO" /gene_functions="biosynthetic-additional (smcogs) SMCOG1222:dehydrogenase (Score: 58; E-value: 1.5e-17)" /gene_kind="biosynthetic-additional" /gene_synonym="SC6A5.11" /locus_tag="SCO6762" /note="SC6A5.11, possible phytoene dehydrogenase, len: 478aa; similar to many from eukaryotes eg. SW:CRTI_CAPAN phytoene dehydrogenase precursor from Capsicum annuum (bell pepper) (582 aa) fasta scores; opt: 276, z-score: 302.1, E(): 1.6e-09, (24.0% identity in 459 aa overlap). Also similar to prokaryotes eg. TR:P72449 (EMBL:X95596) proposed dehydrogenase from a cryptic carotenoid biosynthesis cluster in Streptomyces griseus (517 aa) fasta scores; opt: 206, z-score: 226.8, E(): 2.5e-05, (29.7% identity in 512 aa overlap)" /product="phytoene dehydrogenase" /protein_id="NP_630834.1" /sec_met_domain="DAO (E-value: 4.2e-07, bitscore: 28.7, seeds: 521, tool: rule-based-clusters)" /transl_table=11 /translation="MTQGKGTREGGVLADVSALGPGGHAVVVGGGLAGVTTALALADAG VRVTLLEGRPRLGGLAFSFQRGDLTVDNGQHVYLRCCTAYRWFLDRIGGAALAPVQERL DVPVVDLARTEGNRLGRLRRDALPVPLHLGRSLATYPHLSLAERASVGRAALALKGLDL ADPSLDTQDFGSWLTAHGQSARAVEALWDLVGVATLNAVAGDASLGLAAMVFKTGLLSD PGAADIGWARVPLGELHDRLARKALDSAGVRTEVRTRVTSVSVNENGGWSVQVPGETLE ADAVVLAVPQREAHDLLPDGALDAPENLLRIGTAPILNIHVIYDRKVLGTPFLTALGTP VQWVFDRTEASGLKEGQYLALSQSTAQNDIDEPVAVLRERYLPELERLLPRTRGAEVKD FFVTRERTATFAPAPGVGRLRPGARTKAPGLYLAGAWTATGWPATMESAVRSGVGAAAA ALGALGRSRGLLPDFFEEAA" aSDomain 12089..13393 /aSDomain="TIGR03467" /aSTool="tigrfam" /description="HpnE: squalene-associated FAD-dependent desaturase" /detection="hmmscan" /domain_id="TIGRFam_SCO6762_0097" /evalue="1.80E-139" /identifier="TIGR03467" /label="SCO6762" /locus_tag="SCO6762" /protein_end="460" /protein_start="25" /score="463.7" /tool="antismash" /translation="VVVGGGLAGVTTALALADAGVRVTLLEGRPRLGGLAFSFQRGDLT VDNGQHVYLRCCTAYRWFLDRIGGAALAPVQERLDVPVVDLARTEGNRLGRLRRDALPV PLHLGRSLATYPHLSLAERASVGRAALALKGLDLADPSLDTQDFGSWLTAHGQSARAVE ALWDLVGVATLNAVAGDASLGLAAMVFKTGLLSDPGAADIGWARVPLGELHDRLARKAL DSAGVRTEVRTRVTSVSVNENGGWSVQVPGETLEADAVVLAVPQREAHDLLPDGALDAP ENLLRIGTAPILNIHVIYDRKVLGTPFLTALGTPVQWVFDRTEASGLKEGQYLALSQST AQNDIDEPVAVLRERYLPELERLLPRTRGAEVKDFFVTRERTATFAPAPGVGRLRPGAR TKAPGLYLAGAWTATGWPATMESAVRSGVGAAAAAL" PFAM_domain 12107..13390 /aSDomain="Amino_oxidase" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01593.27" /db_xref="GO:0016491" /description="Flavin containing amine oxidoreductase" /detection="hmmscan" /domain_id="clusterhmmer_SCO6762_0867" /evalue="3.80E-49" /gene_ontologies="GO:0016491: oxidoreductase activity" /label="SCO6762" /locus_tag="SCO6762" /protein_end="459" /protein_start="31" /score="168.3" /tool="antismash" /translation="LAGVTTALALADAGVRVTLLEGRPRLGGLAFSFQRGDLTVDNGQH VYLRCCTAYRWFLDRIGGAALAPVQERLDVPVVDLARTEGNRLGRLRRDALPVPLHLGR SLATYPHLSLAERASVGRAALALKGLDLADPSLDTQDFGSWLTAHGQSARAVEALWDLV GVATLNAVAGDASLGLAAMVFKTGLLSDPGAADIGWARVPLGELHDRLARKALDSAGVR TEVRTRVTSVSVNENGGWSVQVPGETLEADAVVLAVPQREAHDLLPDGALDAPENLLRI GTAPILNIHVIYDRKVLGTPFLTALGTPVQWVFDRTEASGLKEGQYLALSQSTAQNDID EPVAVLRERYLPELERLLPRTRGAEVKDFFVTRERTATFAPAPGVGRLRPGARTKAPGL YLAGAWTATGWPATMESAVRSGVGAAAAA" gene 13447..14583 /db_xref="GeneID:1102202" /gene_synonym="SC6A5.12" /locus_tag="SCO6763" CDS 13447..14583 /codon_start=1 /db_xref="GeneID:1102202" /gene_functions="biosynthetic-additional (smcogs) SMCOG1182:Polyprenyl synthetase (Score: 274.6; E-value: 1.5e-83)" /gene_kind="biosynthetic-additional" /gene_synonym="SC6A5.12" /locus_tag="SCO6763" /note="SC6A5.12, probable polyprenyl synthatase, len: 378aa; similar to many eg. SW:GGPP_MYCTU probable geranylgeranyl pyrophosphate synthatase from Mycobacterium tuberculosis (359 aa) fasta scores; opt: 1103, z-score: 1231.0, E(): 0, (49.3% identity in 355 aa overlap) and SW:IDSA_METTM short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrophicum (324 aa) fasta scores; opt: 547, z-score: 614.0, E(): 6.7e-27, (38.2% identity in 293 aa overlap). Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases, score 176.70, E-value 3.9e-49 and Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop), PS00723 Polyprenyl synthetases signature 1 and PS00606 Beta-ketoacyl synthases active site." /product="polyprenyl synthatase" /protein_id="NP_630835.1" /transl_table=11 /translation="MKADPRGTGSRTPGTATGGKTVPTVPPAPTADRRTTVDVTALLER GRTLATPVLRAAVDRLAPPMDTVAAYHFGWIDAQGNPADGDGGKAVRPALAVLSAEVTG AAPEVGVPGAVAVELVHNFSLLHDDLMDGDEQRRHRDTVWKVHGPAQAILVGDALFALA NEVLLELGTVEAGRATRRLTKASRSLIDGQAQDISYEHRDRVSVEECLEMEGNKTGALL ACASSIGAVLGGADERTADTLEKYGYHLGLAFQAVDDLLGIWGDPDATGKQTWSDLRQR KKSLPVVAALAAGGAASERLGEILTADAKASDFANFSEEEFAARAALIEEAGGREWTAD EARRQHTIAIEALDAVDMPDRVRDRFTALADFVVVRKR" misc_feature 13486..13509 /gene_synonym="SC6A5.12" /locus_tag="SCO6763" /note="PS00017 ATP/GTP-binding site motif A (P-loop)." misc_feature 13669..14436 /gene_synonym="SC6A5.12" /locus_tag="SCO6763" /note="Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases, score 176.70, E-value 3.9e-49." PFAM_domain 13702..14379 /aSDomain="polyprenyl_synt" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00348.20" /db_xref="GO:0008299" /description="Polyprenyl synthetase" /detection="hmmscan" /domain_id="clusterhmmer_SCO6763_0868" /evalue="1.30E-50" /gene_ontologies="GO:0008299: isoprenoid biosynthetic process" /label="SCO6763" /locus_tag="SCO6763" /protein_end="311" /protein_start="85" /score="172.0" /tool="antismash" /translation="DGGKAVRPALAVLSAEVTGAAPEVGVPGAVAVELVHNFSLLHDDL MDGDEQRRHRDTVWKVHGPAQAILVGDALFALANEVLLELGTVEAGRATRRLTKASRSL IDGQAQDISYEHRDRVSVEECLEMEGNKTGALLACASSIGAVLGGADERTADTLEKYGY HLGLAFQAVDDLLGIWGDPDATGKQTWSDLRQRKKSLPVVAALAAGGAASERLGEILTA DAKA" misc_feature 13819..13863 /gene_synonym="SC6A5.12" /locus_tag="SCO6763" /note="PS00723 Polyprenyl synthetases signature 1." misc_feature 14089..14139 /gene_synonym="SC6A5.12" /locus_tag="SCO6763" /note="PS00606 Beta-ketoacyl synthases active site." gene 14700..16742 /db_xref="GeneID:1102203" /gene_synonym="SC6A5.13" /locus_tag="SCO6764" CDS 14700..16742 /codon_start=1 /db_xref="GeneID:1102203" /gene_functions="biosynthetic (rule-based-clusters) terpene: terpene_cyclase" /gene_kind="biosynthetic" /gene_synonym="SC6A5.13" /locus_tag="SCO6764" /note="SC6A5.13, probable squalene-hopene cyclase, len: 680 aa; similar to many e.g. SW:SQHC_ALIAC squalene-hopene cyclase A key enzyme in triterpenoid metabolism in Bacillus acidocaldarius (630 aa) fasta scores; opt: 2153, z-score: 2386.3, E(): 0, (51.8% identity in 620 aa overlap). Contains two Pfam matches to entry PF00432 prenyltrans, Prenyltransferase and squalene oxidase repeats and a Prosite match to PS01074 Terpene synthases signature." /product="squalene-hopene cyclase" /protein_id="NP_630836.1" /sec_met_domain="terpene_cyclase (E-value: 5.2e-21, bitscore: 74.1, seeds: 14, tool: rule-based-clusters)" /transl_table=11 /translation="MTATTDGSTGASLRPLAASASDTDITIPAAAAGVPEAAARATRRA TDFLLAKQDAEGWWKGDLETNVTMDAEDLLLRQFLGIQDEETTRAAALFIRGEQREDGT WATFYGGPGELSTTIEAYVALRLAGDSPEAPHMARAAEWIRSRGGIASARVFTRIWLAL FGWWKWDDLPELPPELIYFPTWVPLNIYDFGCWARQTIVPLTIVSAKRPVRPAPFPLDE LHTDPARPNPPRPLAPVASWDGAFQRIDKALHAYRKVAPRRLRRAAMNSAARWIIERQE NDGCWGGIQPPAVYSVIALYLLGYDLEHPVMRAGLESLDRFAVWREDGARMIEACQSPV WDTCLATIALADAGVPEDHPQLVKASDWMLGEQIVRPGDWSVKRPGLPPGGWAFEFHND NYPDIDDTAEVVLALRRVRHHDPERVEKAIGRGVRWNLGMQSKNGAWGAFDVDNTSAFP NRLPFCDFGEVIDPPSADVTAHVVEMLAVEGLAHDPRTRRGIQWLLDAQETDGSWFGRW GVNYVYGTGSVIPALTAAGLPTSHPAIRRAVRWLESVQNEDGGWGEDLRSYRYVREWSG RGASTASQTGWALMALLAAGERDSKAVERGVAWLAATQREDGSWDEPYFTGTGFPWDFS INYNLYRQVFPLTALGRYVHGEPFAKKPRAADAPAEAAPAEVKGS" aSDomain 14805..16664 /aSDomain="TIGR01507" /aSTool="tigrfam" /description="hopene_cyclase: squalene-hopene cyclase" /detection="hmmscan" /domain_id="TIGRFam_SCO6764_0098" /evalue="2.70E-238" /identifier="TIGR01507" /label="SCO6764" /locus_tag="SCO6764" /protein_end="655" /protein_start="35" /score="790.5" /tool="antismash" /translation="EAAARATRRATDFLLAKQDAEGWWKGDLETNVTMDAEDLLLRQFL GIQDEETTRAAALFIRGEQREDGTWATFYGGPGELSTTIEAYVALRLAGDSPEAPHMAR AAEWIRSRGGIASARVFTRIWLALFGWWKWDDLPELPPELIYFPTWVPLNIYDFGCWAR QTIVPLTIVSAKRPVRPAPFPLDELHTDPARPNPPRPLAPVASWDGAFQRIDKALHAYR KVAPRRLRRAAMNSAARWIIERQENDGCWGGIQPPAVYSVIALYLLGYDLEHPVMRAGL ESLDRFAVWREDGARMIEACQSPVWDTCLATIALADAGVPEDHPQLVKASDWMLGEQIV RPGDWSVKRPGLPPGGWAFEFHNDNYPDIDDTAEVVLALRRVRHHDPERVEKAIGRGVR WNLGMQSKNGAWGAFDVDNTSAFPNRLPFCDFGEVIDPPSADVTAHVVEMLAVEGLAHD PRTRRGIQWLLDAQETDGSWFGRWGVNYVYGTGSVIPALTAAGLPTSHPAIRRAVRWLE SVQNEDGGWGEDLRSYRYVREWSGRGASTASQTGWALMALLAAGERDSKAVERGVAWLA ATQREDGSWDEPYFTGTGFPWDFSINYNLYRQVFPLTALGRYVH" aSDomain 14823..16658 /aSDomain="TIGR01787" /aSTool="tigrfam" /description="squalene_cyclas: squalene/oxidosqualene cyclases" /detection="hmmscan" /domain_id="TIGRFam_SCO6764_0099" /evalue="6.10E-185" /identifier="TIGR01787" /label="SCO6764" /locus_tag="SCO6764" /protein_end="653" /protein_start="41" /score="614.4" /tool="antismash" /translation="TRRATDFLLAKQDAEGWWKGDLETNVTMDAEDLLLRQFLGIQDEE TTRAAALFIRGEQREDGTWATFYGGPGELSTTIEAYVALRLAGDSPEAPHMARAAEWIR SRGGIASARVFTRIWLALFGWWKWDDLPELPPELIYFPTWVPLNIYDFGCWARQTIVPL TIVSAKRPVRPAPFPLDELHTDPARPNPPRPLAPVASWDGAFQRIDKALHAYRKVAPRR LRRAAMNSAARWIIERQENDGCWGGIQPPAVYSVIALYLLGYDLEHPVMRAGLESLDRF AVWREDGARMIEACQSPVWDTCLATIALADAGVPEDHPQLVKASDWMLGEQIVRPGDWS VKRPGLPPGGWAFEFHNDNYPDIDDTAEVVLALRRVRHHDPERVEKAIGRGVRWNLGMQ SKNGAWGAFDVDNTSAFPNRLPFCDFGEVIDPPSADVTAHVVEMLAVEGLAHDPRTRRG IQWLLDAQETDGSWFGRWGVNYVYGTGSVIPALTAAGLPTSHPAIRRAVRWLESVQNED GGWGEDLRSYRYVREWSGRGASTASQTGWALMALLAAGERDSKAVERGVAWLAATQRED GSWDEPYFTGTGFPWDFSINYNLYRQVFPLTALGRY" PFAM_domain 14826..15683 /aSDomain="SQHop_cyclase_N" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF13249.9" /description="Squalene-hopene cyclase N-terminal domain" /detection="hmmscan" /domain_id="clusterhmmer_SCO6764_0869" /evalue="3.40E-121" /label="SCO6764" /locus_tag="SCO6764" /protein_end="328" /protein_start="42" /score="404.0" /tool="antismash" /translation="RRATDFLLAKQDAEGWWKGDLETNVTMDAEDLLLRQFLGIQDEET TRAAALFIRGEQREDGTWATFYGGPGELSTTIEAYVALRLAGDSPEAPHMARAAEWIRS RGGIASARVFTRIWLALFGWWKWDDLPELPPELIYFPTWVPLNIYDFGCWARQTIVPLT IVSAKRPVRPAPFPLDELHTDPARPNPPRPLAPVASWDGAFQRIDKALHAYRKVAPRRL RRAAMNSAARWIIERQENDGCWGGIQPPAVYSVIALYLLGYDLEHPVMRAGLESLDRFA VWRED" PFAM_domain 15711..16661 /aSDomain="SQHop_cyclase_C" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF13243.9" /description="Squalene-hopene cyclase C-terminal domain" /detection="hmmscan" /domain_id="clusterhmmer_SCO6764_0870" /evalue="6.10E-140" /label="SCO6764" /locus_tag="SCO6764" /protein_end="654" /protein_start="337" /score="465.9" /tool="antismash" /translation="SPVWDTCLATIALADAGVPEDHPQLVKASDWMLGEQIVRPGDWSV KRPGLPPGGWAFEFHNDNYPDIDDTAEVVLALRRVRHHDPERVEKAIGRGVRWNLGMQS KNGAWGAFDVDNTSAFPNRLPFCDFGEVIDPPSADVTAHVVEMLAVEGLAHDPRTRRGI QWLLDAQETDGSWFGRWGVNYVYGTGSVIPALTAAGLPTSHPAIRRAVRWLESVQNEDG GWGEDLRSYRYVREWSGRGASTASQTGWALMALLAAGERDSKAVERGVAWLAATQREDG SWDEPYFTGTGFPWDFSINYNLYRQVFPLTALGRYV" misc_feature 16179..16307 /gene_synonym="SC6A5.13" /locus_tag="SCO6764" /note="Pfam match to entry PF00432 prenyltrans, Prenyltransferase and squalene oxidase repeats, score 29.90, E-value 5.7e-05." misc_feature 16227..16271 /gene_synonym="SC6A5.13" /locus_tag="SCO6764" /note="PS01074 Terpene synthases signature." misc_feature 16323..16487 /gene_synonym="SC6A5.13" /locus_tag="SCO6764" /note="Pfam match to entry PF00432 prenyltrans, Prenyltransferase and squalene oxidase repeats, score 35.30, E-value 1.4e-06." gene 16742..17383 /db_xref="GeneID:1102204" /gene_synonym="SC6A5.14" /locus_tag="SCO6765" CDS 16742..17383 /codon_start=1 /db_xref="GeneID:1102204" /gene_synonym="SC6A5.14" /locus_tag="SCO6765" /note="SC6A5.14, possible lipoprotein, len: 213 aa; similar to SW:TYRT_STRLN proposed tyrosinase co-factor from the melanin biosynthesis in Streptomyces lincolnensis (140 aa) fasta scores; opt: 115, z-score: 142.8, E(): 1.2, (29.2% identity in 120 aa overlap). Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site." /product="lipoprotein" /protein_id="NP_630837.1" /transl_table=11 /translation="MTPQTGPSPLLIACALGIEHLALRTGDRAGAGGPVTVLRTGMGPR AAERSVTRVLADPALEGAAVLATGFCAGLSPGMHPGDLVVAEETRDPRSTVPCVATDRL VKELARAVPGRTVHTGPLTGSDHVVRGPERADLLATGAIAVDMESAATLLSAVRTGPRP VAAVRVVVDAPEHELVRIGTVRGGISAFRVLRSVLPAFFEWHRSLLLPRR" misc_feature 16751..16783 /gene_synonym="SC6A5.14" /locus_tag="SCO6765" /note="PS00013 Prokaryotic membrane lipoprotein lipid attachment site." PFAM_domain 16832..17260 /aSDomain="PNP_UDP_1" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01048.23" /db_xref="GO:0003824" /db_xref="GO:0009116" /description="Phosphorylase superfamily" /detection="hmmscan" /domain_id="clusterhmmer_SCO6765_0871" /evalue="3.20E-15" /gene_ontologies="GO:0003824: catalytic activity" /gene_ontologies="GO:0009116: nucleoside metabolic process" /label="SCO6765" /locus_tag="SCO6765" /protein_end="173" /protein_start="30" /score="56.2" /tool="antismash" /translation="AGGPVTVLRTGMGPRAAERSVTRVLADPALEGAAVLATGFCAGLS PGMHPGDLVVAEETRDPRSTVPCVATDRLVKELARAVPGRTVHTGPLTGSDHVVRGPER ADLLATGAIAVDMESAATLLSAVRTGPRPVAAVRVVVDA" aSDomain 17390..18343 /aSDomain="TIGR03470" /aSTool="tigrfam" /description="HpnH: hopanoid biosynthesis associated radical SAM protein HpnH" /detection="hmmscan" /domain_id="TIGRFam_SCO6766_0100" /evalue="1.70E-161" /identifier="TIGR03470" /label="SCO6766" /locus_tag="SCO6766" /protein_end="318" /protein_start="0" /score="534.5" /tool="antismash" /translation="MAMPLRQSIKVATYLAEQKIRRRDKFPLIVELEPLFACNLACEGC GKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIVRQLVAKRKYVF LCTNAMLMRKKMDKFKPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVEAIKEAKRRGF RVTTNSTFFNTDTPQTIVEVLNFLNDDLKVDEMMISPAYAYEKAPDQEHFLGVEQTREL FKKAFSGGNRARWRLNHSPLFLDFLEGKVDFPCTAWAIPNYSLFGWQRPCYLMSDGYVP TYRELIEKTDWDKYGRGKDPRCDNCMAHCGYEPTAVL" gene 17390..18412 /db_xref="GeneID:1102205" /gene_synonym="SC6A5.15" /locus_tag="SCO6766" CDS 17390..18412 /codon_start=1 /db_xref="GeneID:1102205" /gene_functions="biosynthetic-additional (rule-based-clusters) PF04055" /gene_kind="biosynthetic-additional" /gene_synonym="SC6A5.15" /locus_tag="SCO6766" /note="SC6A5.15, unknown, len: 340 aa; similar to many of undefined function e.g. TR:P95416 (EMBL:D84475) NirJ, from a locus for heme D1 biosynthesis in Pseudomonas aeruginosa (387 aa) fasta scores; opt: 222, z-score: 264.2, E(): 2.1e-07, (24.2% identity in 207 aa overlap)." /product="hypothetical protein" /protein_id="NP_630838.1" /sec_met_domain="PF04055 (E-value: 5.6e-18, bitscore: 64.7, seeds: 518, tool: rule-based-clusters)" /transl_table=11 /translation="MAMPLRQSIKVATYLAEQKIRRRDKFPLIVELEPLFACNLACEGC GKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIVRQLVAKRKYVF LCTNAMLMRKKMDKFKPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVEAIKEAKRRGF RVTTNSTFFNTDTPQTIVEVLNFLNDDLKVDEMMISPAYAYEKAPDQEHFLGVEQTREL FKKAFSGGNRARWRLNHSPLFLDFLEGKVDFPCTAWAIPNYSLFGWQRPCYLMSDGYVP TYRELIEKTDWDKYGRGKDPRCDNCMAHCGYEPTAVLATMGSLKESLRAMRETVSGNRE " PFAM_domain 17489..17950 /aSDomain="Radical_SAM" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF04055.24" /db_xref="GO:0003824" /db_xref="GO:0051536" /description="Radical SAM superfamily" /detection="hmmscan" /domain_id="clusterhmmer_SCO6766_0872" /evalue="7.60E-18" /gene_ontologies="GO:0003824: catalytic activity" /gene_ontologies="GO:0051536: iron-sulfur cluster binding" /label="SCO6766" /locus_tag="SCO6766" /protein_end="187" /protein_start="33" /score="65.6" /tool="antismash" /translation="PLFACNLACEGCGKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSI AGGEPLMHPQIDEIVRQLVAKRKYVFLCTNAMLMRKKMDKFKPSPYFAFAVHIDGLRER HDESVAKEGVFDEAVEAIKEAKRRGFRVTTNSTFFNTDTPQTIVEVLNFL" PFAM_domain 17975..18373 /aSDomain="DUF3463" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF11946.11" /description="Domain of unknown function (DUF3463)" /detection="hmmscan" /domain_id="clusterhmmer_SCO6766_0873" /evalue="1.20E-55" /label="SCO6766" /locus_tag="SCO6766" /protein_end="328" /protein_start="195" /score="187.1" /tool="antismash" /translation="MMISPAYAYEKAPDQEHFLGVEQTRELFKKAFSGGNRARWRLNHS PLFLDFLEGKVDFPCTAWAIPNYSLFGWQRPCYLMSDGYVPTYRELIEKTDWDKYGRGK DPRCDNCMAHCGYEPTAVLATMGSLKESL" gene 18417..19571 /db_xref="GeneID:1102206" /gene="ispG" /gene_synonym="gcpE" /locus_tag="SCO6767" CDS 18417..19571 /EC_number="1.17.7.1" /codon_start=1 /db_xref="GeneID:1102206" /gene="ispG" /gene_synonym="gcpE" /locus_tag="SCO6767" /note="catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis" /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase" /protein_id="NP_630839.1" /transl_table=11 /translation="MTAIPLGLPGVPVRPIAERRVSRRIQVGPVAVGGGAPVSVQSMTT TRTSDIGATLQQIAELTASGCQIVRVACPTQDDADALPVIARKSQIPVIADIHFQPKYV FAAIEAGCAAVRVNPGNIKQFDDKVKEIAKAAKDHGTPIRIGVNAGSLDRRLLQKYGRA TPEALAESALWEASLFEEHDFRDIKISVKHNDPVVMVEAYRQLAAQCDYPLHLGVTEAG PAFQGTIKSAVAFGALLSQGIGDTIRVSLSTPPVEEIKVGIQILESLNLRQRGLEIVSC PSCGRAQVDVYKLAEEVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQI FVKGEVVKTVPESKIVETLIEEAMRIAEQMEKDGASGAPAVTVS" aSDomain 18471..19499 /aSDomain="TIGR00612" /aSTool="tigrfam" /description="ispG_gcpE: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase" /detection="hmmscan" /domain_id="TIGRFam_SCO6767_0101" /evalue="2.20E-128" /identifier="TIGR00612" /label="SCO6767" /locus_tag="SCO6767" /protein_end="361" /protein_start="18" /score="426.4" /tool="antismash" /translation="RRVSRRIQVGPVAVGGGAPVSVQSMTTTRTSDIGATLQQIAELTA SGCQIVRVACPTQDDADALPVIARKSQIPVIADIHFQPKYVFAAIEAGCAAVRVNPGNI KQFDDKVKEIAKAAKDHGTPIRIGVNAGSLDRRLLQKYGRATPEALAESALWEASLFEE HDFRDIKISVKHNDPVVMVEAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLS QGIGDTIRVSLSTPPVEEIKVGIQILESLNLRQRGLEIVSCPSCGRAQVDVYKLAEEVT AGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVVKTVPESKIVET LIE" PFAM_domain 18483..19502 /aSDomain="GcpE" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF04551.17" /db_xref="GO:0016114" /db_xref="GO:0046429" /description="GcpE protein" /detection="hmmscan" /domain_id="clusterhmmer_SCO6767_0874" /evalue="4.10E-135" /gene_ontologies="GO:0016114: terpenoid biosynthetic process" /gene_ontologies="GO:0046429: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity" /label="SCO6767" /locus_tag="SCO6767" /protein_end="362" /protein_start="22" /score="450.6" /tool="antismash" /translation="RRIQVGPVAVGGGAPVSVQSMTTTRTSDIGATLQQIAELTASGCQ IVRVACPTQDDADALPVIARKSQIPVIADIHFQPKYVFAAIEAGCAAVRVNPGNIKQFD DKVKEIAKAAKDHGTPIRIGVNAGSLDRRLLQKYGRATPEALAESALWEASLFEEHDFR DIKISVKHNDPVVMVEAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSQGIG DTIRVSLSTPPVEEIKVGIQILESLNLRQRGLEIVSCPSCGRAQVDVYKLAEEVTAGLE GMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVVKTVPESKIVETLIEE " gene 19597..21567 /db_xref="GeneID:1102207" /gene_synonym="SC6A5.17" /locus_tag="SCO6768" CDS 19597..21567 /EC_number="2.2.1.7" /codon_start=1 /db_xref="GeneID:1102207" /gene_functions="biosynthetic-additional (rule-based-clusters) DXP_synthase_N" /gene_functions="biosynthetic-additional (rule-based-clusters) TPP_enzyme_C" /gene_functions="biosynthetic-additional (smcogs) SMCOG1110:1-deoxy-D-xylulose-5-phosphate synthase (Score: 252.3; E-value: 8e-77)" /gene_kind="biosynthetic-additional" /gene_synonym="SC6A5.17" /locus_tag="SCO6768" /note="catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate" /product="1-deoxy-D-xylulose-5-phosphate synthase" /protein_id="NP_630840.1" /sec_met_domain="DXP_synthase_N (E-value: 4.2e-111, bitscore: 369.3, seeds: 174, tool: rule-based-clusters)" /sec_met_domain="TPP_enzyme_C (E-value: 3.4e-05, bitscore: 22.5, seeds: 323, tool: rule-based-clusters)" /transl_table=11 /translation="MTILENIRGPRDLKALSEAELGELSDEIRDFLVHAVARTGGHLGP NLGVVELTVALHRVFESPDDRILWDTGHQSYVHKLLTGRQDFSKLRSKGGLSGYPSREE SAHDVIENSHASTVLGWADGLAKARQVQGERSHVVAVIGDGALTGGMAWEALNNIAAAR DRPLIIVVNDNERSYAPTIGGLANHLATLRTTDGYERALAWGKDVLQRTPVVGHTVYEA LHGAKKGFKDAFAPQGLFEDLGLKYLGPIDGHDIGAVESALRRAKRFHGPVLVHCLTEK GRGYEPALRDEEDHFHTVGVMDPLTCEPLGPAGGPSWTSVFGEEIVRIGEERADVVAIT AAMLHPVGLAPFAERFPDRVWDVGIAEQHAAVSAAGLATGGLHPVVAVYATFLNRAFDQ LLMDVALHRCGVTFVLDRAGVTGVDGASHNGMWDMSVLQVVPGLRIAAPRDADQLRTQL REAVAVDDAPTLLRFPKESVGPAVPAVDRIGGLDVLHTADRSEVLLVAVGVMAPVCLGA AELLEARGIGCTVVDPRWVKPVDPALAPLAARHRLVAVVEDNSRAAGVGSAVALALGDA EVDVPVRRFGIPEQFLAHAKRAEVLADIGLTPVDVAGRIAASLALAEPAGDRAGGPAVE QPGDGRMSGDGRIVMPAQGEN" PFAM_domain 19606..20433 /aSDomain="DXP_synthase_N" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF13292.9" /db_xref="GO:0008661" /db_xref="GO:0016114" /description="1-deoxy-D-xylulose-5-phosphate synthase" /detection="hmmscan" /domain_id="clusterhmmer_SCO6768_0875" /evalue="1.70E-110" /gene_ontologies="GO:0008661: 1-deoxy-D-xylulose-5-phosphate synthase activity" /gene_ontologies="GO:0016114: terpenoid biosynthetic process" /label="SCO6768" /locus_tag="SCO6768" /protein_end="279" /protein_start="3" /score="368.7" /tool="antismash" /translation="LENIRGPRDLKALSEAELGELSDEIRDFLVHAVARTGGHLGPNLG VVELTVALHRVFESPDDRILWDTGHQSYVHKLLTGRQDFSKLRSKGGLSGYPSREESAH DVIENSHASTVLGWADGLAKARQVQGERSHVVAVIGDGALTGGMAWEALNNIAAARDRP LIIVVNDNERSYAPTIGGLANHLATLRTTDGYERALAWGKDVLQRTPVVGHTVYEALHG AKKGFKDAFAPQGLFEDLGLKYLGPIDGHDIGAVESALRRAKRFHGPVLVHCLT" aSDomain 19612..21453 /aSDomain="TIGR00204" /aSTool="tigrfam" /description="dxs: 1-deoxy-D-xylulose-5-phosphate synthase" /detection="hmmscan" /domain_id="TIGRFam_SCO6768_0102" /evalue="2.00E-183" /identifier="TIGR00204" /label="SCO6768" /locus_tag="SCO6768" /protein_end="619" /protein_start="5" /score="609.2" /tool="antismash" /translation="NIRGPRDLKALSEAELGELSDEIRDFLVHAVARTGGHLGPNLGVV ELTVALHRVFESPDDRILWDTGHQSYVHKLLTGRQDFSKLRSKGGLSGYPSREESAHDV IENSHASTVLGWADGLAKARQVQGERSHVVAVIGDGALTGGMAWEALNNIAAARDRPLI IVVNDNERSYAPTIGGLANHLATLRTTDGYERALAWGKDVLQRTPVVGHTVYEALHGAK KGFKDAFAPQGLFEDLGLKYLGPIDGHDIGAVESALRRAKRFHGPVLVHCLTEKGRGYE PALRDEEDHFHTVGVMDPLTCEPLGPAGGPSWTSVFGEEIVRIGEERADVVAITAAMLH PVGLAPFAERFPDRVWDVGIAEQHAAVSAAGLATGGLHPVVAVYATFLNRAFDQLLMDV ALHRCGVTFVLDRAGVTGVDGASHNGMWDMSVLQVVPGLRIAAPRDADQLRTQLREAVA VDDAPTLLRFPKESVGPAVPAVDRIGGLDVLHTADRSEVLLVAVGVMAPVCLGAAELLE ARGIGCTVVDPRWVKPVDPALAPLAARHRLVAVVEDNSRAAGVGSAVALALGDAEVDVP VRRFGIPEQFLAHAKRAEVLADIGLTPVDVAGRIAASL" misc_feature 19681..19740 /gene_synonym="SC6A5.17" /locus_tag="SCO6768" /note="PS00801 Transketolase signature 1." PFAM_domain 20542..21030 /aSDomain="Transket_pyr" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF02779.27" /description="Transketolase, pyrimidine binding domain" /detection="hmmscan" /domain_id="clusterhmmer_SCO6768_0876" /evalue="4.30E-34" /label="SCO6768" /locus_tag="SCO6768" /protein_end="478" /protein_start="315" /score="117.9" /tool="antismash" /translation="PSWTSVFGEEIVRIGEERADVVAITAAMLHPVGLAPFAERFPDRV WDVGIAEQHAAVSAAGLATGGLHPVVAVYATFLNRAFDQLLMDVALHRCGVTFVLDRAG VTGVDGASHNGMWDMSVLQVVPGLRIAAPRDADQLRTQLREAVAVDDAPTLLRFPKESV " PFAM_domain 21085..21426 /aSDomain="Transketolase_C" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF02780.23" /description="Transketolase, C-terminal domain" /detection="hmmscan" /domain_id="clusterhmmer_SCO6768_0877" /evalue="1.30E-28" /label="SCO6768" /locus_tag="SCO6768" /protein_end="610" /protein_start="496" /score="99.5" /tool="antismash" /translation="ADRSEVLLVAVGVMAPVCLGAAELLEARGIGCTVVDPRWVKPVDP ALAPLAARHRLVAVVEDNSRAAGVGSAVALALGDAEVDVPVRRFGIPEQFLAHAKRAEV LADIGLTPVD" gene 21568..22953 /db_xref="GeneID:1102208" /gene_synonym="SC6A5.18" /locus_tag="SCO6769" CDS 21568..22953 /NRPS_PKS="Domain: Aminotran_3 (41-363). E-value: 2.7e-91. Score: 297.9. Matches aSDomain: nrpspksdomains_SCO6769_Aminotran_3.1" /codon_start=1 /db_xref="GeneID:1102208" /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_3" /gene_functions="biosynthetic-additional (smcogs) SMCOG1013:aminotransferase class-III (Score: 373.2; E-value: 2.7e-113)" /gene_kind="biosynthetic-additional" /gene_synonym="SC6A5.18" /locus_tag="SCO6769" /note="SC6A5.18, probable aminotransferase, len: 461 aa; similar to many e.g. SW:ARGD_BACSU acetylornithine aminotransferase from Bacillus subtilis (385 aa) fasta scores; opt: 663, z-score: 757.6, E(): 0, (37.8% identity in 341 aa overlap). Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and Prosite match to PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site." /product="aminotransferase" /protein_id="NP_630841.1" /sec_met_domain="Aminotran_3 (E-value: 2.2e-89, bitscore: 298.8, seeds: 13, tool: rule-based-clusters)" /transl_table=11 /translation="MTKEFDLAALLAERGAERYELHARHLNHQLPRMLHTIGFDKVYER AEGAHFWDADGNDYLDMLAGFAVMGLGRHHPVVRKALHDVLDASLADLTRFDCPPLPGL LAEKLLSYSPHLDRVFFGNSGTEAVETALKFARYATGRQRILYCPHAFHGLTAGSLSVN GEDGFRKGFAPLLPDTAVPLGDLDALARELKKGDVAALIVEPVQGKGVHEAPPGYLLAA QELLHRHKALLIADEVQTGLGRTGKFYAYQHSDGVEPDLVCVAKALSGGYVPVGATLGK DWIFQKVYSSMDRVQVHSASFGSNAQAMAAGLAVLSVMENEEIVANAAAVGERLKSRLA ELVDRYELLADVRGRGLMIGIEFGRPRSLKLRSRWTMLQAARKGLFAQMVVVPLLQRHR ILTQVSGDHLEVIKLIPPLIVDTDDADRFVDAFTEVMEDAHHGGGLMWDFGKTLVKQAV ANR" aSDomain 21691..22656 /aSDomain="Aminotran_3" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_SCO6769_Aminotran_3.1" /evalue="2.70E-91" /label="SCO6769_Aminotran_3.1" /locus_tag="SCO6769" /protein_end="363" /protein_start="41" /score="297.9" /tool="antismash" /translation="VYERAEGAHFWDADGNDYLDMLAGFAVMGLGRHHPVVRKALHDVL DASLADLTRFDCPPLPGLLAEKLLSYSPHLDRVFFGNSGTEAVETALKFARYATGRQRI LYCPHAFHGLTAGSLSVNGEDGFRKGFAPLLPDTAVPLGDLDALARELKKGDVAALIVE PVQGKGVHEAPPGYLLAAQELLHRHKALLIADEVQTGLGRTGKFYAYQHSDGVEPDLVC VAKALSGGYVPVGATLGKDWIFQKVYSSMDRVQVHSASFGSNAQAMAAGLAVLSVMENE EIVANAAAVGERLKSRLAELVDRYELLADVRGRGLMIGIEF" PFAM_domain 21691..22872 /aSDomain="Aminotran_3" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00202.24" /db_xref="GO:0008483" /db_xref="GO:0030170" /description="Aminotransferase class-III" /detection="hmmscan" /domain_id="clusterhmmer_SCO6769_0878" /evalue="5.60E-89" /gene_ontologies="GO:0008483: transaminase activity" /gene_ontologies="GO:0030170: pyridoxal phosphate binding" /label="SCO6769" /locus_tag="SCO6769" /protein_end="435" /protein_start="41" /score="298.8" /tool="antismash" /translation="VYERAEGAHFWDADGNDYLDMLAGFAVMGLGRHHPVVRKALHDVL DASLADLTRFDCPPLPGLLAEKLLSYSPHLDRVFFGNSGTEAVETALKFARYATGRQRI LYCPHAFHGLTAGSLSVNGEDGFRKGFAPLLPDTAVPLGDLDALARELKKGDVAALIVE PVQGKGVHEAPPGYLLAAQELLHRHKALLIADEVQTGLGRTGKFYAYQHSDGVEPDLVC VAKALSGGYVPVGATLGKDWIFQKVYSSMDRVQVHSASFGSNAQAMAAGLAVLSVMENE EIVANAAAVGERLKSRLAELVDRYELLADVRGRGLMIGIEFGRPRSLKLRSRWTMLQAA RKGLFAQMVVVPLLQRHRILTQVSGDHLEVIKLIPPLIVDTDDADRFVDAFTEV" misc_feature 21709..22749 /gene_synonym="SC6A5.18" /locus_tag="SCO6769" /note="Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate, score 343.70, E-value 5.1e-119." misc_feature 22264..22380 /gene_synonym="SC6A5.18" /locus_tag="SCO6769" /note="PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site." gene 23027..23641 /db_xref="GeneID:1102209" /gene_synonym="SC6A5.19" /locus_tag="SCO6770" CDS 23027..23641 /codon_start=1 /db_xref="GeneID:1102209" /gene_functions="other (smcogs) SMCOG1148:hypothetical protein (Score: 113.9; E-value: 1.7e-34)" /gene_kind="other" /gene_synonym="SC6A5.19" /locus_tag="SCO6770" /note="SC6A5.19, probable DNA-binding protein, len: 204 aa; similar to several of undefined function eg. TR:O86784 (EMBL:AL031317) hypothetical protein from Streptomyces coelicolor (201 aa) fasta scores; opt: 297, z-score: 356.2, E(): 1.5e-12, (34.9% identity in 212 aa overlap). Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix." /product="DNA-binding protein" /protein_id="NP_630842.1" /transl_table=11 /translation="MSSSETGPAEGAVAAVAPQLRELRRRAALTLEAAARAAGLSPAHL SRLETGQRQPSLPMLLSLARVYGTTVAELLGESAADRDAVVRAADMEPTAAGGWTYWRA GAPGRGMQALRVQVPYGSQGDVVRVHPGEEWLHVLRGRLRLRLGDTEHRLTAGDSAHFD SMTPHRIAAQDPDGVELLFVHTLLQSPTAALCLGPTPGETP" misc_feature 23084..23248 /gene_synonym="SC6A5.19" /locus_tag="SCO6770" /note="Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 52.80, E-value 7.6e-12." PFAM_domain 23084..23248 /aSDomain="HTH_3" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01381.25" /description="Helix-turn-helix" /detection="hmmscan" /domain_id="clusterhmmer_SCO6770_0879" /evalue="1.20E-13" /label="SCO6770" /locus_tag="SCO6770" /protein_end="74" /protein_start="19" /score="51.0" /tool="antismash" /translation="LRELRRRAALTLEAAARAAGLSPAHLSRLETGQRQPSLPMLLSLA RVYGTTVAEL" PFAM_domain 23372..23575 /aSDomain="Cupin_2" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF07883.14" /description="Cupin domain" /detection="hmmscan" /domain_id="clusterhmmer_SCO6770_0880" /evalue="1.60E-13" /label="SCO6770" /locus_tag="SCO6770" /protein_end="183" /protein_start="115" /score="50.3" /tool="antismash" /translation="VQVPYGSQGDVVRVHPGEEWLHVLRGRLRLRLGDTEHRLTAGDSA HFDSMTPHRIAAQDPDGVELLFV" gene 23638..23757 /db_xref="GeneID:1102210" /gene_synonym="SC6A5.20" /locus_tag="SCO6771" CDS 23638..23757 /codon_start=1 /db_xref="GeneID:1102210" /gene_synonym="SC6A5.20" /locus_tag="SCO6771" /note="SC6A5.20, possible small hydrophobic hypothetical protein, len: 39 aa; contains possible N-terminal signal sequence." /product="small hydrophobic hypothetical protein" /protein_id="NP_630843.1" /transl_table=11 /translation="MSTMQEKFPRALWVRLIVYIALGHVFGGFLYLLFEVGAK" PFAM_domain 23641..23754 /aSDomain="DUF6126" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF19621.2" /description="Family of unknown function (DUF6126)" /detection="hmmscan" /domain_id="clusterhmmer_SCO6771_0881" /evalue="1.40E-18" /label="SCO6771" /locus_tag="SCO6771" /protein_end="39" /protein_start="1" /score="66.1" /tool="antismash" /translation="STMQEKFPRALWVRLIVYIALGHVFGGFLYLLFEVGAK" gene complement(23779..24642) /db_xref="GeneID:1102211" /gene_synonym="SC6A5.21c" /locus_tag="SCO6772" CDS complement(23779..24642) /codon_start=1 /db_xref="GeneID:1102211" /gene_synonym="SC6A5.21c" /locus_tag="SCO6772" /note="SC6A5.21c, unknown, len: 287aa; similar to TR:P96830 (EMBL:Z92770) hypothetical protein from Mycobacterium tuberculosis (276 aa) fasta scores; opt: 189, z-score: 220.4, E(): 5.6e-05, (32.3% identity in 279 aa overlap)." /product="hypothetical protein" /protein_id="NP_630844.1" /transl_table=11 /translation="MPYRRVEPAGEQRRRGGVGGAPVTQQVPSTEPELTGVRNFRDVGG LPTVDGRRVRQGVLFRSGHLAHATGEDAAFLASLGLHTIFDFRNAADQKLEGPDVDLPG VRNVNLPLSDPADGAEFWKMVRDGDLDQLREILADGKAADRMIGSYRAIVTERTAEHSR ILHALAEDSVPALMHCAAGKDRAGLSIAVTLLALGVEREAVVEDYLKSNAAHRRYKVRR SGSAASAYSPEVMELLSPLFDARAEYLAAAFETVEETWGGVDAYLEQGLRLTPATRERL RERMLD" PFAM_domain complement(23785..24546) /aSDomain="Y_phosphatase3" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF13350.9" /db_xref="GO:0004721" /description="Tyrosine phosphatase family" /detection="hmmscan" /domain_id="clusterhmmer_SCO6772_0882" /evalue="5.40E-64" /gene_ontologies="GO:0004721: phosphoprotein phosphatase activity" /label="SCO6772" /locus_tag="SCO6772" /protein_end="286" /protein_start="32" /score="216.5" /tool="antismash" /translation="ELTGVRNFRDVGGLPTVDGRRVRQGVLFRSGHLAHATGEDAAFLA SLGLHTIFDFRNAADQKLEGPDVDLPGVRNVNLPLSDPADGAEFWKMVRDGDLDQLREI LADGKAADRMIGSYRAIVTERTAEHSRILHALAEDSVPALMHCAAGKDRAGLSIAVTLL ALGVEREAVVEDYLKSNAAHRRYKVRRSGSAASAYSPEVMELLSPLFDARAEYLAAAFE TVEETWGGVDAYLEQGLRLTPATRERLRERML" misc_feature 24789..24803 /note="TFBS match to ZuR, Zinc-responsive repressor, confidence: weak, score: 18.85" /tool="antismash" gene 25163..26101 /db_xref="GeneID:1102212" /gene_synonym="SC6A5.22" /locus_tag="SCO6773" CDS 25163..26101 /codon_start=1 /db_xref="GeneID:1102212" /gene_synonym="SC6A5.22" /locus_tag="SCO6773" /note="SC6A5.22, possible peptidase, len: 312aa; TR:E1355668 (EMBL:AL034355) peptidase from Streptomyces coelicolor (349 aa) fasta scores; opt: 452, z-score: 416.6, E(): 6.6e-16, (34.5% identity in 319 aa overlap) and SW:ALE1_STACP glycylglycine endopeptidase from Staphylococcus capitis (362 aa) fasta scores; opt: 332, z-score: 309.4, E(): 6.2e-10, (35.2% identity in 196 aa overlap). Contains probable N-terminal signal sequence." /product="peptidase" /protein_id="NP_630845.1" /transl_table=11 /translation="MPAKGKHRRTRAMRLTRTIAVAGTGGAALALPLMGAAAANAAPAH SVSEQAVQSVPASAKKAAAEKNSDSRTYTVKSGDYLSKIADEQDVDGGWKKLYADNREA VGSDPSLIHPGLKLSIDGQAAKPSAPSSAQSQKPAQKSAEKPAEKTAAKPAQKSTDAEK ASSSDTGSQSTGTTSGYTSPVAGGTVGTPYHQSGSMWSSGYHTGTDFVVPTGTSLKAVG AGTVVSAGWGGAYGNQVVIQLADGHYAQYAHLSSLSVSAGQSVTAGQQVGLSGATGNVT GPHLHFEIRTTPDYGSDIDPLAFLRSHGVSV" PFAM_domain 25379..25522 /aSDomain="LysM" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01476.23" /description="LysM domain" /detection="hmmscan" /domain_id="clusterhmmer_SCO6773_0883" /evalue="5.10E-08" /label="SCO6773" /locus_tag="SCO6773" /protein_end="120" /protein_start="72" /score="33.0" /tool="antismash" /translation="YTVKSGDYLSKIADEQDVDGGWKKLYADNREAVGSDPSLIHPGLK LSI" PFAM_domain 25772..26065 /aSDomain="Peptidase_M23" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01551.25" /description="Peptidase family M23" /detection="hmmscan" /domain_id="clusterhmmer_SCO6773_0884" /evalue="3.80E-29" /label="SCO6773" /locus_tag="SCO6773" /protein_end="301" /protein_start="203" /score="100.9" /tool="antismash" /translation="YHTGTDFVVPTGTSLKAVGAGTVVSAGWGGAYGNQVVIQLADGHY AQYAHLSSLSVSAGQSVTAGQQVGLSGATGNVTGPHLHFEIRTTPDYGSDIDP" misc_feature complement(26282..26292) /note="TFBS match to HypR, L-hydroxyproline utilization repressor, confidence: weak, score: 16.96" /tool="antismash" ORIGIN 1 gtggaggtcg ccgtcgggcc cgagtgggtg cgggtggccg tggaggacga ccacccctac 61 cgcccgaccg ccctggagac cgaccacggc cgcaccggtg ggcgcggcct gctcctggtc 121 cgcgagacga cccgcgaggc gggcggggcc tgcgacgtgg cccacaccgc gagcggcggc 181 aaggtgatct gggcggccct gccgctcaag cacgccccgc gctagacgcg gcgggtccgg 241 cagcaccccc gggcccggca gcaggcggcg ggcccggcgc cgggacgtcc ctcaccagcc 301 cgcggacgtg cccgtcagtt cgcggacggc cggccgggcc gcgtccagca ccgtcatgaa 361 ccacgccgag aaggtgtcct gcgcgtgccg ctcggtcagc tcggccgggg acacgaaggc 421 agtccccgcc acttcctccg ggtccgggcg cagctcggcc tgcaccagac cgacgaagag 481 gtggttgtac tcctgctcga ccagcccgga ggccgggtcg ggatggttgt agcgcaccgt 541 gccggcctcg gcgagcaggg agggcgacac ccccagctcc tcgaacgtcc gccgggccgc 601 cgccgcgaac ggcgcctcgc cggggtaggg gtgaccgcag caggtgttgg accacacgcc 661 gggggagtgg tacttgccca gcgcccgctg ctggatcagc agccgccccc gctcgtcgaa 721 gaggaacacg gagaaggcgc ggtgcagccg ccccggcggc tggtgcgcgg agagcttctc 781 cgcggtgccg atcgtcacgc cgttctcgtc gaccagttcc agcaaaatgg cttctgcggt 841 gccgttcgac gagctgggcg tcgcggtggc aggagtgatc ggcataccca tccttcacat 901 cggtcctcgc gccccaagtg tgccgtacga atccggcact ctcggcactt cccggcacac 961 ccgcatgtcc cgcctgcccg tgcgggcacc gggggcggcc ggtcggacac cgagcagggg 1021 tccgaggggg caccgttccc gagggcgcgc cccgggaatc gtccggtccg cgtctcctcc 1081 agtggtgcgg cggcggaacg gagcgttcag cggcgcgttc cggtgcgtgc gcgcccccgg 1141 gccgtccgcc gcgtcacggg ctcagcggca cagtcgcgcc tcgtgctccg cgtgaccgct 1201 gggctccagc tggaacgtgc agtgctccac gtcgaagtgg tcgcccagac agccctgcaa 1261 ctcgtggagc atcttctcgt ggccgatcgc gctcagcgct tcgccgtcca ccaccacgtg 1321 cgccgacagc acgggcatgc cggaggtgat ggtccaggcg tgcaggtcgt gcacgtcctc 1381 gaccccgtcg agggccagta tgtgggcgcg cacctccgcg atgtccacgc ccttgggagc 1441 cgcctcgagc agcacgtcca gggtctcgcg cagcaaccgc aaggttcgcg gcacgatcat 1501 cagaccgatc agcagcgacg cgatcgggtc ggcgggctgc cagccggtgg ccaggatcac 1561 cagcgccgag acgatcaccg ccagggagcc cagcgcgtcg gccgccacct ccaggaaggc 1621 gccccgcacg ttcaggctct ccttctggcc gcgcatcagc agcgacagcg acaccatgtt 1681 cgccaccaga ccgatcgcgc cgaagacgac ggtcgggccg gccgcggtgt cggccggcgt 1741 gacgaaccgg tcgatcgcct cgtacaggac gtaaccgccg accccgagca gcagcaggca 1801 gttggccagg gcggcgagga tctcggcgcg ggcgtagccg aaggtgcgcc ggtcgctcgg 1861 cggtcggctc gcgaagtgca cggccagcag ggccatgccg aggcccaggg catcggtcgc 1921 catgtgcgcg gcgtcggcga tcagggcgag ggagtcggcg accagaccgc cgacgatctc 1981 gacgaccatg acggtgaggg tgatcgacag cgccacgcgc agcctgcccc ggtacgcggc 2041 ggtcgccgtc ccgccggcgt gccccccgtg cgcgtgcccg tgatcgtgcc cagcccccat 2101 gagaaagccg cctcctcgtg tgtaccggcg tccggcgacc cggcgcccgg atgccagtca 2161 actacgggta gggggtatcg ggcaacgcgg cactgaacac cgttgtcatg tgccttgacc 2221 tgcggaaacg tttcgcaggt cagagtgttg cgaggatgcg gagggtgcgg cttccgccgt 2281 cagggggacc ggtccgacgg ggctcgtcct gaccctgtgc gaacaacggc ggacactgtg 2341 cgatgtccgc gatgcccggt ctgggggcgc ggtttgtcgg gcgggccccg aatccacgat 2401 gatgatcgcg gcaaaggcgg gagcaagtgg cgtcgaccga ccgtcaaacg ggcggtgaac 2461 acggcgttcc cggcatccga taccctctgc cgacatgccg cccgggtgcc ccaggcacgg 2521 gcgtcccacc atgcacaggc ccggcgtcca ggcgccggca ccagggagtg agttcggttg 2581 ccgaccgcca tcctcaccgg tcagccggtc ccgggttcgt cgatcgagag cgagctgcgg 2641 tccctgggct tcgacgtgca cgtcgcggcc ggggccgcgg agaccgagac cctcctcgcc 2701 cgggtccccg gcgaggagcg ggtcgccgtc gtcgacgccc gtttcgtggg ccacccgcac 2761 gcgctgcgcc tcggcctcac cgacccccgc ttcccgctcg ccgcgatcca gggcgcggtg 2821 accgcccagc cggccgcccg ccagatgctg acccgcgcga tggcccgcga gaattccacg 2881 ggcggcggca ccgctgtgga cgtcgacagc ctcgccgacc ggatcaccgc cgccctcgac 2941 gccgacggcg ccggcgtgca ccggcccgaa ctcggcagcc tcgtggccgc cgttcccgcc 3001 gacccgcagg cccgcaacga ggcgcggcag gccgtcgccg ccgtcgacga cgaggccgta 3061 cgcctgaagt cggcggtcaa ggcccgcgac ggcttcgtca ccacccactt catcagcccc 3121 tactcccgct acatcgcccg ctggtgcgcg cgccgcggcc tgacccccaa ccaggtcacc 3181 accgcctcgc tgatcaccgc gctcatagcg gccggctgcg cggccaccgg cacccgcggc 3241 ggcttcgtcg ccgccggcgt cctgctcatc gcctccttcg tcctcgactg caccgacgga 3301 cagctcgccc ggtactccct ccagtactcc acgctcggtg cctggctcga cgccaccttc 3361 gaccgggcca aggagtacgc ctactacgcg ggcctcgccc tcggagcggc ccgcggcggc 3421 gacgacgtgt gggccctggc cctcggcgcg atggtgctcc agacctgccg gcacgtcgtc 3481 gacttctcct tcaacgaggc caatcacgac gcctcggcca acaccagccc caccgccgcc 3541 ctctccgaca agctcgacag cgtcggctgg acggtgtggc tgcgccgcat gatcgtgctg 3601 cccatcggcg aacgctgggc catgatcgcc gtcctgaccg cgctcaccac gccccggatc 3661 accttctacg cgctgctgat cggctgcgcg ttcgccgcga cgtacaccac cgcgggccgt 3721 gtcctgcgct cgctgacccg caaggccacc cgcaccgacc gggccgcgaa ggcgctggcc 3781 gacctggccg actccggtcc gctcgccgag gccggcgcca agggcctgcg caccgccgcc 3841 cgccggctgc ccggcttcgc cacccccgcc gtcgccctcc tcggcggtgc cgccgtcgtc 3901 gccaccgccg cgctcaccga cttcggcggt ccctggccgc tcgtcgccgc gctcgggtac 3961 gtgctgacct ccgcgctcgc cgtcgcccgc cccctcaagg gcgccctcga ctggctggtc 4021 cccccgttct tccgggccgc cgagtacctc accgtcctgt tcctggccgc gaaggccgac 4081 gtgaacgggg cccttccggc ggctttcggg ctggtggccg cggtcgccta ccatcactac 4141 gacacggtct accgcatccg tggcgacgcg ggcgcaccgc cgcagtggct ggtgcggacg 4201 gtcggggggc acgagggccg cacgctggtg atcaccctgc tggccgtgct cctcaccgcc 4261 gcacagttca aggtcgcgct cacggtcctc gccgtggttg tggcactcgt ggtgctcgtc 4321 gagagcatcc gcttctgggt cgccgcccac caggtcggcg cacccgccgt acacgacgaa 4381 ggagaacccg catgatcggc ctcgtgctgg cggccggcgc cggacgccgt ctgcgcccct 4441 acaccgacac cctgcccaag gcactggtcc cggtcggccc cgagggcgcg gaggacagca 4501 tcacggtcct cgacctgacg ctggcgaact tcgccgaggt cggtctgacg gaggtcggga 4561 tcatcgtcgg ctaccgcaag gaggccgtgt acgaccgtca ggcggagctg gagcagaagt 4621 acggcgtcaa gctcaccctc atcgacaacg acaaggccga ggagtggaac aacgcctact 4681 ccctgtggtg cggccgtgac gccctcaagg acggcgtgat cctcgccaac ggcgacaccg 4741 tgcacccggt ctccgtcgag aagaccctgc tcgccgcccg tggcgacggc aagaagatca 4801 tcctcgccct cgacacggtg aagaacctcg ccgacgagga gatgaaggtc gtcgtcgacc 4861 ccgacaaggg cgtgcagcgc atcaccaagc tgatggaccc ggccgacgcg accggcgagt 4921 acatcggcgt caccctcatc gagggcgagg ccgccgcgga gctggccgac gcgctgaaga 4981 ccaccttcga gcgcgacccg cagctctact acgaggacgg ctaccaggag ctggtcaacc 5041 gcggcttcaa ggtcgacgtg gcgccgatcg gcgacgtcaa gtgggtcgag atcgacaacc 5101 acgacgacct cgccaagggc agggagatcg cgtgccagta ctgacgaggc tcatcccgtc 5161 gccggtcgtc gtggacatcc gcgcgggtgc cctcgacgac ctgggatgcg tactcgccga 5221 cgagcgcatc tcccactcgg gcaagctcgc cgtcgccgtc agcggcggct ccggcgcccg 5281 gctgcgcgac cgcgtcgccc cgtccctgcc cggcgccgac tggttcgagg tcggcggcgg 5341 caccctggac gacgcgatca agctggccgg cgccatgaag ggcggccact acgacgcggt 5401 cgtcggcctc ggcggcggca agatcatcga ctgcgccaag ttcgcggccg cgcgcatcgg 5461 ccttccgctg gtcgccgtgc ccaccaacct cgcgcacgac gggctgtgct ccccggtcgc 5521 caccctcgac aacgacgcgg gccgcggctc ctacggtgtg ccgaacccga tcgccgtcgt 5581 catcgacctg gacgtcatcc gcgcggcacc ggcccgcttc gtacgcgccg gcatcggcga 5641 cgccgtctcc aacgtctccg cgatcgcgga ctgggagctg gccaaccggg tcaagggcga 5701 gaagatcgac ggcctggccg ccgcgatggc ccgccaggcc ggcgaggccg tcctgcgcca 5761 ccccggcggc atcggcgaca acgacttcct ccaggtgctg gccgaggcgc tggtgctcag 5821 cggcatcgcc atgtcggtct ccggcgactc gcggccctcc tcgggcgcct gccacgagat 5881 caaccacgcc ttcgacctcc tcttccccga gcgcgcggcc gcccacggcg agcagtgcgg 5941 cctgggcgcg gccttcgcga tgtacctgcg cggggcccac gaggagtccg ccaacatggc 6001 ccgggtcctg cggcggcacg ggctgccggt gctgcccgag gagatcgggt tcactcccga 6061 ggagttcttc cgggccgtgg agttcgcacc ccagacgcgg cccggccgct acacgatcct 6121 cgagcacctc gacctcacca ccgaccagat caaggacctg tacgccgact atgtcaaggc 6181 catcggtagc tgaactacgc ccggtcgtcc atcccgcggg agtcaaggac cggcgcagcg 6241 gtgagcactg ggcgggacgc ctctacatgc gcgaggtctc gctgcggatc gaccgctatc 6301 tggtgaacac caggatcacg cccaaccagc tcacgtacct gatgaccgtc tgcggcgtgc 6361 tggcggcccc ggcgctgctc gtgccgggca tctggggcgc cgtgctcggc gtggtcgcgg 6421 tccagctgta cctgctcctc gactgcgtgg acggcgagat cgcgcgctgg cgcaagcagt 6481 actcgctcgg cggggtctac ctggaccgcg tcggcgccta cctgaccgac gccgcggtcc 6541 tggtcggcct cggcctgcgc gccgccgaca tctggggcac cggccggatc gactggctgt 6601 gggccttcct cggcaccctg gccgcgctcg gcgcgatcct gatcaaggcg gagacggacc 6661 tggtgggcgt cgcccggcac cagaacggga tgccgccggt caaggaggcc gcctccgaga 6721 tccgctcctc cggcatggcg ctggcccgcc gggccgccgg tgcgctcaag ttccaccggc 6781 tgatcctcgg catcgaggcg accttgctga tcctggtcct cgcgatcgtc gaccaggcgc 6841 gcggcgacct gttcttcacc cgcctcggca ccgccgtgct cgccggcatc gcgctgctgc 6901 agaccctgct gcacctggtg tccatcctcg cctccagcag gctgaagtga gcgcgcccgt 6961 gaaggtcggc gccgtcgtca tcacgatggg caaccgcccc gaggagctgc gcgccctgct 7021 cgactcggtc gcgaagcagg acggcgaccc ggtccaggtg gtcgtggtcg gcaacggctc 7081 gcccgtcccg gaggtgcccg aaggcgtgcg caccgtcgag ctgcccgaga acctgggcat 7141 ccccggcggc cgcaacgtcg gcatcgaggc cttcggcccc ggcggcagcg acgtcgacat 7201 cctgctcttc ctcgacgacg acggactgct cgcccgcacc gacaccgccg agctgtgccg 7261 cgaggcgttc gcggccgacg acgagctggg catcatcagc ttccgcatcg ccgacccgga 7321 caccggcgag acccagcgcc ggcacgtccc gcggctgcgc gcctccgacc cgatgcgctc 7381 ctcccgggtc accaccttcc tcggcggcgc caacgcggtg cgcacccgcg tcctcaccca 7441 ggtcggcggg ctgccggacg ccttcttcta cgcccacgag gagaccgacc tggcctggcg 7501 ggccctcgac gcgggctgga tgatcgacta ccggtccgac atggtgctga accaccccac 7561 gaccgcgccg tcccggcacg cggtctacca ccgcatggtc gcccgcaacc gcgtctggct 7621 cgcccgccgc aacctccccg cgctgctggt cccggtctac ctcggcgtct ggatggccct 7681 cacgctgctg cgccggccgt cgcgacccgc gctgaaggcg tggttcggcg gcttccgcga 7741 gggctgggcc accccgtgcg gtccccgtcg gcccatgcgg tggcgtacgg tgtggcgcct 7801 gacccggctg ggccggcccc cggtgatctg acaagctcgt acccgagagt gttccggccc 7861 cgaaacgggg ccaccaggtc catgccaggc ccgcgaggcc gagcattttc gaagacgaaa 7921 gtttccacca gtgagtgaga caacgcacga cggcacggtc gccatgacca agcccgtgtc 7981 gcccgacgag ggcctcacac cggcccggct cgccgccaag tacgggctgt ccgtgagcgg 8041 cgcccgaccg agcctcaagg agtacgtccg ccagctctgg gggcggcggc acttcatcct 8101 cgccttctcc caggcgaagc tgaccgccca gtacagccag gccaagctcg gccagctgtg 8161 gcaggtggcc acgccgctgc tgaacgcgct cgtctacttc ctgatcttcg gcctgatcct 8221 cgacgcgggc cggggcatgg agaaggacgt ctacatcccg ttcctggtga ccggtgtgtt 8281 cgtcttcacc ttcacccagt cctcggcgat ggcgggcgtg cgcgccatcg ccggcaacct 8341 cgggctggtg cgggcgctgc acttcccgcg ggcctcgctg cccgtctcct tcgccctcca 8401 gcagctccag caactgctgg cctcgatgat cgtgctgttc ctggtggtcg tcggcttcgg 8461 cagctacccc tcgctgtcct ggctgctggt cctcccggtg ctggtcctgc agttcctgtt 8521 caacacgggt ctcgcgctgg tcgtcgcccg gatgggggcc aagacgccgg acctggccca 8581 gctgatgccg ttcatcatgc gcacctggat gtacgcctcg ggcgtgatgt tctccatccc 8641 gatcatgctg aaggacaagc cggactggat cgccgacgtg ctccagtgga acccggccgc 8701 cgtctacatg gacctgatgc gcttcgcgct gatcgacggg tacggctccg agaacctgcc 8761 gccgcacgtg tgggcggtcg cactcggctg ggccgtggtc ctcgccgtgg gcggcttcgt 8821 gtacttctgg aaggcggagg agaggtacgg ccgtggctga acagcagcag gaccagcggg 8881 tgccgacggt catcgcggac gaggtgcaca tcgtctaccg cgtcaacggc gccaagaccg 8941 gcaagggcag cgcgacagcc gccctgagcc gcatactcaa gaagggctcc gacgacgcga 9001 agcggggcgt gcgcaaggtg cacgccgtac gcggcgtctc cttcaccgcc taccggggcg 9061 aggccatcgg cctgatcggc tccaacggct ccgggaagtc gaccctgctg cgcgccatcg 9121 ccgggctgct gcccgccgag cgcggcaagg tctacacgga cgggcagccc tccctgctcg 9181 gcgtgaacgc ggccctgatg aacgacctga ccggcgagcg gaacgtcatc ctcggcggcc 9241 tggccatggg catgtcccgc gagcagatca aggagcgcta ccaggagatc gtcgacttct 9301 ccgggatcaa cgagaagggc gacttcatca ccctgccgat gcgcacgtac tcctccggca 9361 tggccgcccg gctgcggttc tccatcgccg ccgccaagga ccacgacgtc ctgatgatcg 9421 acgaggcgct ggccaccggc gaccgcaagt tccagacccg ctccgaggag cgcatccggg 9481 agctgaagaa gcaggccggc accatcttcc tggtcagcca caacaacaag tccatccgtg 9541 acacctgcaa ccgggtcctg tggctggagc gcggcgagct gcgcatggac ggcccgaccg 9601 acgaggtgct caaggagtac gagaagttca cgggcaagta gcccgacacg ccagggcctc 9661 gccggaactg ttccggcgag gccccgcgtc tgcaaaggaa gcgtcaactc ctggcgttct 9721 caggaatctt gaagtcaatc ggtgtgttgt tgtgatgcgc tgtgcacccc gacgcacgcc 9781 cgtgagttgt acaacgtaag ctgtaccggt cccgaaacgc ggcacatggg gcgataatgc 9841 ccgacaccct ggagcgggcc tgccgcgcgg gtggcggggc ggcgtgtccg aaatagtgtg 9901 tattgggtcg gcagtgtaga acgggagatg tgacggcaat ggcgacggaa actccccagc 9961 tccgcgaagc gtgcgccgtc cccgcccagg gcagcccgcg atgacggtca ccgacacggc 10021 gcacgccgtc gacccggagc gcggcaccct cgccaaggcc gccgacgaga acttccccgt 10081 cgcccccttc ttcctgcccc gcgcctggcg caccgacctc atggccgtct acggcttcgc 10141 ccgtctcgtc gacgacatcg gcgacggcga cctcgccccg ggcggagcgg acgcccgcct 10201 gctcggcgtc cccgaggacc gcgccgacga ccgactgctg atgctggacg ccttcgaggc 10261 ggacctgcgt cgtgtcttcg acggctccga cggtgcgccc cgccacccgc tgctgcgccg 10321 tctggtgccc accgtgcgcc gccgcgcgct gacccccgag cccttcctcg gcctgatcgc 10381 cgccaaccgg caggaccagc tggtcgcacg gtacgagacc tacgacgacc tcctcgccta 10441 ctgcgagctg tccgccaacc ccgtcggccg tctcgtcctc gccgtcaccg gcacctcgac 10501 ccccgaacgg atccgccgct ccgacgagat ctgcaccgcc ctgcagatcg tcgagcacct 10561 ccaggacgtc gccgaggacc tcggacggga ccggatctac ctgcccgccg aggacatgaa 10621 gcgcttccac gtccaggagg cggacctcgc cgcgcccagc gcgaacgcct ccgtgcgcgc 10681 gctgatcgcc tacgaggccg cccgcgcccg cgacctgctg aatgaaggcg cccccctggt 10741 gggtagcgtc cacggcaggc tgcgactgct cctggcgggc ttcgtggcgg gtggcagggc 10801 ggcgctgaac gcgatcgccg cggcggatca cgacgtactt cccggcccgc ccaagtcagg 10861 caaggtccac ttgctgcgcg aggcgggcgt ggtcctgcga ggagaggggt gatcgggtcc 10921 gtggagtcgt cagcgaacat gccggcaccg gtgctcgccg cctacagcta ctgcgaggcc 10981 gtcaccggtc agcaggcacg caacttcgcc cacggcatcc ggctgctgcc cacgcccaag 11041 cggcgggcga tgtccgcgct gtacgcgttc tcgcgccggg tcgacgacat cggcgacgga 11101 gtgctggcgg acgacgtcaa ggtcacccgg ctggacgaga cccgggccgt gctcgcccgg 11161 atccaggacg gcgcggtcga ggaggacgac accgacccgg tcgccgtcgc cctcgccgac 11221 gcggcccggc ggtttcccat cccgctcggc ggcctcgacg agctgatcga cggcgtccag 11281 atggacctgc gcggcgagac ctacgagacc tgggacgacc tgaaggtcta ctgccgctgc 11341 gtggcgggcg ccatcggacg cctctcgctc ggcgtcttcg gcaccgaacc gggggcgcgc 11401 ggcgccgagc gcgcgcccga gtacgccgac acgctcgggc tcgcgctgca gctcaccaac 11461 atcctgcgcg acgtccggga ggacgccgag ggcgggcgca cctacctgcc cgccgacgac 11521 ctcgccaagt tcggctgcgc ggccggattc aacggcccga caccacccga gggctccgac 11581 ttcgcgggcc tcgtgcactt cgaagtgcgt cgggcccgcg cccttttcgc cgagggctac 11641 cggctgctgc ccatgctcga ccggcgcagc ggcgcctgcg tggccgccat ggccggcatc 11701 taccgccgtc tcctggaccg catcgagcgc gaccccgagg ccgtactgcg cggccgggtc 11761 tccctgccgg gacgcgagaa ggcgtacgtc gccgtgcgcg gcctgtccgg cctcgacgcc 11821 cggcacgtca cccggcggac cgtcaggagg cgcgcctgat ggacacaccg ggcacactcg 11881 acacccggga cccgtacaaa accggcggcg ggcagtggcg ggcaaccctg cggtggcggt 11941 cggcgtccct gactgagacg gtcagccgta cgccgttcaa acaccgcggc ggccggacag 12001 ggaagggcgc accatgacgc agggcaaggg cacgcgcgag ggcggagtgc tcgcggacgt 12061 ctcggccctc ggccccggcg ggcatgccgt cgtggtcggc ggcggactcg cgggggtcac 12121 caccgcgctg gcactggcgg acgccggtgt gcgcgtcacc ctgctcgaag gacgcccccg 12181 gctcggcggg ctcgccttct ccttccagcg cggcgacctc accgtcgaca acggccagca 12241 cgtgtacctg cgctgctgca ccgcctaccg gtggttcctc gaccggatcg gcggagccgc 12301 gctcgcaccg gtgcaggaac gtctcgacgt gcccgtggtc gacctggcga ggaccgaggg 12361 caaccggctc ggcagactgc ggcgcgacgc gctgcccgtc cccctgcatc tggggcgcag 12421 cctcgcgacc tacccgcacc tctccctcgc cgaacgcgcc tcggtgggac gcgccgcgct 12481 cgcgctcaag gggctcgacc tcgccgatcc gagcctggac acccaggact tcggcagctg 12541 gctgaccgcg cacggtcagt cggcgcgtgc cgtcgaggcc ctgtgggacc tggtcggggt 12601 cgccaccctc aacgcggtcg cgggcgacgc ctcgctgggg ctcgccgcga tggtgttcaa 12661 gaccggtctg ctgtccgacc cgggagcggc cgacatcggg tgggcccgtg tcccgctggg 12721 cgaactgcac gaccggctgg cccgcaaggc gctcgactcc gcgggcgtcc gtaccgaggt 12781 ccgtacacgc gtcacctccg tctccgtaaa cgagaacggc ggctggagcg ttcaggttcc 12841 cggcgagacg ctcgaagcgg acgccgtcgt cctcgccgta ccccagcgcg aggcccacga 12901 cctgctgccg gacggtgcgc tggacgcccc ggaaaatctt ctgcggatcg gcaccgcgcc 12961 gatcctcaac atccacgtga tctacgaccg caaggtgctc ggcacgccgt tcctcacggc 13021 cctcggcacc ccggtccagt gggtgttcga ccgcaccgag gcctccgggc tgaaggaggg 13081 tcagtacctg gcgctgtccc agtcgaccgc gcagaacgac atcgacgagc ccgtggccgt 13141 gctgcgcgag cggtacctgc ccgaactgga gcggctgctg ccgcgcaccc ggggtgccga 13201 ggtgaaggac ttcttcgtga ccagggagcg caccgccacg ttcgcccccg cccccggcgt 13261 cgggcgcctc aggcccggcg cccgcaccaa ggcacccggc ctctacctgg ccggagcgtg 13321 gaccgccacc gggtggcccg cgaccatgga gagtgcggtt cgcagcggtg tcggggcggc 13381 ggccgccgcg ctcggcgccc tgggccggtc ccgcggcctc cttcccgatt tcttcgagga 13441 ggcggcgtga aagccgatcc gcgcgggacc ggctcccgca ctcccggcac cgcaactgga 13501 ggaaagactg tgcccactgt gcccccggcc ccgacggccg atcgacggac cacggtggac 13561 gtgaccgcgc ttctggagcg cggccggacc ctggccacgc cggtcctgcg ggcggccgtc 13621 gaccgcctgg cccctcccat ggacaccgtc gccgcctacc acttcggctg gatcgacgcc 13681 cagggcaacc ccgcggacgg cgacggtggc aaggccgtcc gccccgcgct cgccgtgctc 13741 tccgccgagg tcaccggcgc cgcccccgag gtcggcgtgc ccggcgcggt ggccgtggaa 13801 ctggtgcaca acttctccct cctgcacgac gacctgatgg acggcgacga gcagcgccgc 13861 caccgcgaca ccgtctggaa ggtgcacggc cccgcccagg ccatcctggt cggcgacgcc 13921 ctgttcgccc tcgccaacga ggtgctgctc gaactgggca ccgtcgaggc cgggcgggcc 13981 acccgccgcc tgaccaaggc cagccgctcc ctgatcgacg gtcaggccca ggacatctcc 14041 tacgagcacc gcgaccgcgt cagcgtcgag gagtgcctgg agatggaggg caacaagacc 14101 ggcgccctgc tcgcctgcgc cagctccatc ggcgcggtgc tcggcggcgc cgacgaacgc 14161 accgccgaca ccctggagaa gtacggctac cacctcggtc tcgccttcca ggccgtcgac 14221 gacctgctcg gcatctgggg cgacccggac gccaccggca agcagacctg gagcgacctg 14281 cgccagcgca agaagtcgct gccggtcgtc gccgccctcg cggccggcgg ggccgcttcc 14341 gagcggctcg gcgagatcct cacggccgac gccaaggcca gcgacttcgc gaacttctcc 14401 gaggaggagt tcgcggcccg cgccgccctc atcgaggaag cgggcgggcg ggagtggacc 14461 gccgacgagg cgcgtcgcca gcacaccatc gccatcgaag ccctcgacgc cgtcgacatg 14521 cccgaccggg tgcgggaccg gttcacggcc ctcgcggact tcgtcgtcgt acgaaagaga 14581 tgatcattat cggtcgaata gccctcgcgt agtcgccggc cggtgtcgtg gagacacgag 14641 caccggccga cggcggaccc agcagacgca ccacatgcac actgcacgaa ggggaagcca 14701 tgacagcgac gaccgacgga agcaccggag cctccctgcg gcccctggca gcctcggcca 14761 gcgacaccga catcacgatc cccgccgcgg cggccggggt acccgaagcc gccgcccgcg 14821 ccacccggcg tgccaccgac ttcctgctcg ccaagcagga cgccgagggc tggtggaagg 14881 gcgacctcga gacgaacgtc acgatggacg ccgaggacct gctcctgcgt cagttcctgg 14941 gcatccagga cgaggagacc acccgcgccg ccgcgctgtt catccgcggc gagcagcgcg 15001 aggacggcac ctgggccacc ttctacggcg gccccggcga actgtccacg accatcgagg 15061 cctacgtcgc cctccgcctg gccggcgact cacccgaggc gccccacatg gcgcgggccg 15121 cggagtggat caggtcccgc ggcggcatcg cctccgcccg ggtcttcacc cggatctggc 15181 tggccctgtt cggctggtgg aagtgggacg acctgcccga actcccgccg gagctgatct 15241 acttccccac ctgggtcccg ctcaacatct acgacttcgg ctgctgggcc cggcagacca 15301 tcgtgccgct caccatcgtc tccgcgaagc ggccggtgcg tcccgcgccg ttcccgctgg 15361 acgaactgca caccgacccg gcccgcccca acccgccacg ccccctggca cccgtggcca 15421 gctgggacgg cgccttccag cgcatcgaca aggccctgca cgcctaccgc aaggtcgccc 15481 cgcgccggct gcgccgggcc gcgatgaaca gcgccgcccg ctggatcatc gagcggcagg 15541 agaacgacgg ctgctggggc ggcatccagc cgcctgcggt ctactcggtc atcgccctct 15601 acctgctcgg ctacgacctc gaacaccccg tgatgcgcgc gggactggag tcgctggacc 15661 gtttcgccgt ctggcgcgag gacggcgccc ggatgatcga ggcctgccag tccccggtgt 15721 gggacacctg cctggccacc atcgcgctgg ccgacgcggg cgtgcccgag gaccacccgc 15781 agctggtgaa ggcctcggac tggatgctcg gcgaacagat cgtgcgcccc ggcgactggt 15841 cggtgaagcg ccccggactc ccgcccggcg gctgggcgtt cgagttccac aacgacaact 15901 accccgacat cgacgacacc gccgaggtgg tcctcgccct gcgccgggtc aggcaccacg 15961 acccggaacg ggtggagaag gcgatcgggc gcggggtgcg ctggaacctc ggcatgcagt 16021 cgaagaacgg cgcctggggc gccttcgacg tcgacaacac cagcgccttc cccaaccggc 16081 tgccgttctg cgacttcggc gaggtcatcg acccgccgtc cgcggacgtc accgcgcacg 16141 tcgtcgagat gctcgccgtc gagggcctcg cccacgaccc gcgcacccgc cgcggcatcc 16201 agtggctgct cgacgcccag gagacggacg gttcgtggtt cggccgctgg ggcgtcaact 16261 acgtctacgg caccggttcc gtgatccccg cgctgaccgc ggccggactg cccacctcgc 16321 acccggccat ccgccgggcg gtgcgctggc tggagtccgt ccagaacgag gacggcggct 16381 ggggcgagga cctgcgctcc taccgctacg tccgggagtg gagcggccgg ggcgcctcga 16441 ccgcctcgca gaccggctgg gcgctgatgg ccctgctggc ggcaggggag cgggactcca 16501 aagccgtgga gcgcggcgtc gcatggctcg cggccaccca gcgggaggac ggctcctggg 16561 acgagcccta cttcacgggc accggcttcc cgtgggactt ctccatcaac tacaacctct 16621 accgccaggt cttcccgctc accgctctcg gccggtacgt ccacggggag cccttcgcca 16681 agaagccccg cgcggccgac gcccccgccg aagccgcccc ggccgaggtg aagggcagct 16741 gatgaccccg cagaccggcc cgtccccgct gctgatcgcc tgcgcgctcg gcatcgagca 16801 cctcgccctg cgcaccggcg accgcgccgg cgccggcggg ccggtcaccg tcctgcgcac 16861 cggcatgggt cccagggcgg ccgaacgctc ggtcacccgg gtcctcgccg acccggcgct 16921 cgagggcgcc gccgtgctcg ccacgggctt ctgcgccgga ctctcgcccg gcatgcaccc 16981 cggtgacctg gtcgtcgccg aggagacccg ggacccgcgc tccaccgtcc cctgcgtcgc 17041 gaccgaccgg ctcgtcaagg aactcgcgcg agccgtcccc gggcgcaccg tccacaccgg 17101 gccgctgacc ggctcggacc acgtcgtccg cggccccgaa cgcgccgacc tgctcgcgac 17161 cggcgcgatc gccgtggaca tggagtccgc ggccacgctc ctgagcgccg tccgcacggg 17221 tccgcgcccg gttgcggccg tccgagtggt cgtggacgct ccagaacacg aactcgtccg 17281 gatcggcacc gtgcgcggtg gaatatcggc cttccgtgtt cttcgatccg ttcttcccgc 17341 atttttcgaa tggcaccgtt ctttgttgct tccccggagg tgagcccaga tggccatgcc 17401 gctgcgccag tccatcaagg tcgctacata cctggccgaa cagaagattc gccgacggga 17461 caagttcccg ctcatcgtgg agctggaacc gctcttcgcc tgcaacctgg cgtgcgaggg 17521 atgcggcaag atccagcacc ccgccggtgt gctcaagcag cgcatgccgg tcgcacaggc 17581 cgtcggggcg gtgctggaat cgggcgcgcc gatggtctcc atcgccggcg gcgagcccct 17641 gatgcacccg cagatcgacg agatcgtgcg gcagttggtg gccaagcgga agtacgtctt 17701 cctctgcacc aacgccatgc tcatgcgcaa gaagatggac aagttcaagc cctcgccgta 17761 cttcgccttc gcggtgcaca tcgacggact gcgcgagcgg cacgacgagt ccgtggcgaa 17821 ggagggcgtg ttcgacgagg ccgtggaggc catcaaggag gccaagcggc gcggcttccg 17881 ggtgaccacc aactcgacct tcttcaacac cgacaccccg cagaccatcg tcgaggtgct 17941 caacttcctc aacgacgacc tcaaggtcga cgagatgatg atctcgcccg cctacgccta 18001 cgagaaggca cccgaccagg agcacttcct gggcgtggag cagacccgcg agctgttcaa 18061 gaaggccttc tcgggcggca accgggcccg ctggcggctc aaccactccc cgctgttcct 18121 cgacttcctc gagggcaagg tcgacttccc gtgcaccgcg tgggcgatcc cgaactactc 18181 cctcttcggc tggcagcgcc cctgctacct gatgagcgac ggctacgtcc cgacgtaccg 18241 ggagctgatc gagaagaccg actgggacaa gtacggccgc ggcaaggacc cgcgctgcga 18301 caactgcatg gcgcactgcg gctacgagcc caccgccgtc ctggccacca tgggctcgct 18361 caaggagtcc ctgcgcgcca tgcgggagac ggtctccggg aaccgggagt gacgtcgtga 18421 ccgccatccc cttggggctc cccggggtac cggtccggcc gatcgccgag cggcgcgtgt 18481 cgcggcggat ccaggtcggg ccggtggcgg tcgggggcgg ggctccggtg tcggtgcagt 18541 cgatgacgac cacccgtacg tccgacatcg gggccacgct ccagcagatc gccgagctga 18601 cggcgtcggg ctgccagatc gtccgggtgg cctgtcccac ccaggacgac gccgacgcgc 18661 tgcccgtcat cgcgaggaag tcgcagatcc cggtgatcgc ggacatccac ttccagccca 18721 agtacgtctt cgccgcgatc gaggccggct gcgcggcggt ccgggtgaac ccgggcaaca 18781 tcaagcagtt cgacgacaag gtcaaggaga tcgccaaggc ggcgaaggac cacggcacgc 18841 ccatccgcat cggtgtgaac gccggctccc tcgaccgccg cctgctccag aagtacggca 18901 gggcgacccc cgaggccctc gccgagtccg ccctctggga ggcgtcgctc ttcgaggagc 18961 acgacttccg cgacatcaag atctcggtca agcacaacga cccggtcgtc atggtcgagg 19021 cctaccggca actcgccgcc cagtgcgact acccgctgca cctgggggtg acggaggccg 19081 ggcccgcgtt ccagggcacc atcaagtccg ccgtcgcctt cggcgcgctg ctctcgcagg 19141 gcatcggcga caccatccgg gtgtcgctca gcaccccgcc ggtcgaggag atcaaggtcg 19201 gcatccagat cctggagtcg ctgaacctgc gccagcgcgg cctggagatc gtctcctgcc 19261 cgtcctgcgg ccgcgcccag gtcgacgtct acaagctggc cgaggaggtc accgccgggc 19321 tggagggcat ggaggtgccg ctgcgcgtgg ccgtcatggg ctgcgtcgtc aacggccccg 19381 gtgaggcccg cgaggcggac ctcggcgtcg cctccggcaa cggcaagggg cagatcttcg 19441 tcaagggcga ggtcgtcaag accgtgcccg agtcgaagat cgtggagacc ctcatcgagg 19501 aggcgatgag gatcgcggag cagatggaga aggacggcgc ctcgggggcg ccggccgtca 19561 ccgtgagctg aaacgcggac cgaagggggc ccgagcgtga cgattctgga gaacatccgg 19621 ggaccacgcg acctgaaggc gctgtccgag gcggaactcg gtgaactgtc cgacgagata 19681 cgtgacttcc tggtgcacgc ggtcgcccgc accggcggtc acctcggacc caacctcggc 19741 gtggtggaac tcaccgtcgc cctgcaccgg gtcttcgagt cgccggacga ccgcatcctg 19801 tgggacaccg gccatcagag ctatgtgcac aaactcctga ccggacgtca ggacttctcc 19861 aagctgcgga gcaagggcgg cctttccggc tacccctcgc gcgaggagtc cgcgcacgac 19921 gtcatcgaga acagccacgc ctccaccgtc ctcggctggg ccgacggcct cgccaaggcc 19981 cgccaggtgc agggggagcg cagccacgtc gtcgccgtca tcggtgacgg cgcgctcacc 20041 ggcggcatgg cctgggaggc gctgaacaac atcgcggcgg ccagggaccg gccgctgatc 20101 atcgtcgtca acgacaacga acgctcgtac gcgccgacca tcggcggcct cgccaaccac 20161 ctggcgaccc tgcgcaccac cgacggctac gagcgggccc tggcctgggg caaggacgtg 20221 ctccagcgca cgcccgtggt gggccacacc gtctacgagg ccctgcacgg cgccaagaag 20281 ggcttcaagg acgccttcgc cccgcagggg ctcttcgagg acctgggact gaagtacctc 20341 ggtccgatcg acgggcacga catcggcgcc gtcgagtcgg cgctccgccg cgcgaagcgc 20401 ttccacggcc cggtgctcgt gcactgcctc accgagaagg gccgcggcta cgagcccgcc 20461 ctgcgcgacg aggaggacca cttccacacg gtcggcgtga tggacccgct cacctgcgag 20521 ccgctcggcc cggcgggcgg gccgtcctgg acctccgtgt tcggtgagga gatcgtccgg 20581 atcggcgagg agcgcgcgga cgtggtggcg atcaccgcgg ccatgctgca cccggtcggt 20641 ctcgcccctt tcgccgaacg gttccccgac cgcgtctggg acgtcggcat cgccgagcag 20701 cacgccgccg tctccgccgc cggcctcgcc accggcggac tgcacccggt cgtcgccgtc 20761 tacgccacct tcctcaaccg cgccttcgac cagctcctga tggacgtggc cctgcaccgc 20821 tgcggcgtca ccttcgtcct ggaccgggcc ggcgtcaccg gcgtcgacgg cgcctcgcac 20881 aacggcatgt gggacatgtc cgtcctccag gtcgtccccg gactgcggat cgccgccccg 20941 cgcgacgccg accagctgcg cacccagctg cgcgaggcgg tcgccgtgga cgacgcgccg 21001 acgctgctgc gcttcccgaa ggagtccgtc ggccccgccg tgcccgccgt cgaccggatc 21061 ggcggcctgg acgtcctgca caccgccgac cggtccgagg tgctgctcgt ggcggtgggc 21121 gtgatggcac ccgtctgcct cggggccgcc gaactcctcg aggcccgcgg catcggctgc 21181 accgtcgtcg acccgcgctg ggtcaagccg gtcgacccgg cgctcgcacc gctcgcggcc 21241 cggcaccggc tggtcgccgt ggtcgaggac aacagccggg ccgccggggt cggttccgcg 21301 gtggcgctgg cgctcggcga cgccgaggtc gacgtccccg tgcgccgctt cggcatcccc 21361 gagcagttcc tcgcgcacgc caagcgcgcc gaggtgctcg cggacatcgg cctcaccccg 21421 gtcgacgtcg ccgggcggat cgccgcgagt ctggccctcg ccgagccggc cggggaccgg 21481 gcgggtggac cggcagtgga acagcccggc gacggacgga tgtccggcga cggacggatc 21541 gtcatgccag cgcaaggaga gaactgaatg accaaggagt tcgacctcgc cgcgctcttg 21601 gccgagcgcg gggccgagcg gtacgagctg cacgccaggc acctcaacca ccagctgccg 21661 cgcatgctgc acaccatcgg cttcgacaag gtctacgagc gggccgaggg cgcgcacttc 21721 tgggacgcgg acggcaacga ctacctggac atgctcgccg ggttcgcggt gatgggcctg 21781 ggccgccacc acccggtcgt ccgcaaggcg ctgcacgacg tgctcgacgc ctcgctcgcc 21841 gacctgaccc gcttcgactg cccgccgctg ccgggcctgc tggccgagaa gctgctctcc 21901 tacagcccgc acctggaccg cgtcttcttc ggcaacagcg gcaccgaggc cgtcgagacc 21961 gcgctgaagt tcgcccggta cgcgaccggc agacagcgga tcctgtactg cccgcacgcc 22021 ttccacggac tgacggccgg ctccctctcc gtcaacggag aggacggctt ccgcaaaggc 22081 ttcgcaccgc tgctgcccga caccgccgtc ccgctcggcg acctcgacgc cctggcgcgg 22141 gagctgaaga agggcgacgt ggccgccctg atcgtggagc cggtccaggg caagggcgtg 22201 cacgaggccc cgcccggcta cctgctcgcc gcgcaggagc tgctgcaccg gcacaaggcg 22261 ctgctgatcg ccgacgaggt gcagacgggc ctcggccgga ccggcaagtt ctacgcctac 22321 cagcactcgg acggggtgga gcccgacctg gtctgcgtgg ccaaggcgct gtccggcgga 22381 tacgtcccgg tgggtgccac cctgggcaag gactggatct tccagaaggt gtactcctcg 22441 atggaccgcg tgcaggtcca ctcggcgagc ttcgggtcca acgcacaggc catggccgcc 22501 gggctcgcgg tgctgtcggt gatggagaac gaggagatcg tcgcgaacgc cgccgcggtg 22561 ggggagcggc tgaagtcccg gcttgcggag ctggtggacc gctacgagct gctcgccgac 22621 gtccggggcc gcggactgat gatcggcatc gagttcggcc ggcccaggtc cctgaagctg 22681 cgcagccgct ggacgatgct gcaggcggcg cggaagggac tgttcgcgca gatggtggtc 22741 gtgccgctgc tgcaacggca ccggatcctg acccaggtgt ccggcgacca cctggaggtg 22801 atcaagctga tcccgccgct gatcgtcgac accgacgacg ccgaccggtt cgtcgacgcc 22861 ttcacggagg tgatggagga cgcgcaccat ggcggtggcc tgatgtggga cttcgggaag 22921 accctggtca agcaggcggt ggccaaccgc tgagcgcacc ctccaggtct tttgcctctg 22981 aggcaaggaa tttgcctggc gggcaagatt cgggctgaat ggaggcatga gctcctccga 23041 gaccggcccc gccgaggggg cggtcgccgc cgtcgcgccc cagctgcgtg agctgcggcg 23101 gcgggccgcc ctcaccctgg aggccgccgc ccgcgccgca gggctctcgc ccgcccacct 23161 ctcccgcctg gagaccgggc agcgccagcc ctcgctgccg atgctgctct ccctcgcccg 23221 ggtctacggt acgaccgtcg ccgagctgct gggcgagtcg gccgcggacc gggacgccgt 23281 cgtgcgcgcc gccgacatgg aacccaccgc cgcgggcggc tggacgtact ggcgggccgg 23341 agcgccgggc cgcggcatgc aggccctgcg cgtccaggtt ccgtacggct cccagggcga 23401 cgtcgtgcgg gtgcaccccg gcgaggagtg gctgcacgtc ctgcggggcc ggctgcgact 23461 gcgcctcggg gacaccgagc accggctcac cgcgggggac agcgcccact tcgactcgat 23521 gaccccgcac cggatcgccg cgcaggaccc cgacggggtc gagctgctgt tcgtccacac 23581 cctgctgcag agcccgacgg ccgccctgtg cctcggcccg acccctggag agacgccatg 23641 agcaccatgc aggagaagtt cccgcgcgcc ctgtgggtgc ggctgatcgt ctacatcgcc 23701 ctggggcacg tcttcggcgg cttcctctac ctgctgttcg aggtgggcgc caagtagcgc 23761 cgggcgcggg cgggtgggtc agtccagcat ccgctcgcgc agccgctccc gggtcgcggg 23821 agtgaggcgc aggccctgct ccagataggc gtcgacgccg ccccacgtct cctcgacggt 23881 ctcgaaggcc gccgccaggt actcggcgcg cgcgtcgaac agagggctga gcagctccat 23941 gacctcgggg gagtaggccg aggccgcgga accgctgcgg cgcaccttgt agcggcggtg 24001 cgcggcgttc gacttcaggt agtcctcgac gacggcctcg cgctcgacac ccagggcgag 24061 cagcgtgacg gcgatcgaca ggcccgcgcg gtcctttccg gcggcgcagt gcatcagggc 24121 cgggacgctg tcctcggcga gcgcgtgcag gatgcgggag tgctccgcgg tgcgctccgt 24181 gacgatcgcg cggtaggagc cgatcatccg gtccgcggcc ttgccgtcgg ccaggatctc 24241 gcgcagctgg tcgaggtcgc cgtcacggac catcttccag aactcggcgc cgtcggccgg 24301 gtcgctcagc ggcaggttca cattgcgcac gcccggcagg tcgacgtccg ggccctcgag 24361 cttctggtcg gccgcgttgc ggaagtcgaa gatcgtgtgc aggcccagcg aggccaggaa 24421 cgcggcgtcc tccccggtgg cgtgagccag gtgaccgctg cggaacagca ccccctgccg 24481 cacccgccgc ccgtccacgg tcggcagtcc gcccacgtcc cggaagttgc gcacgccggt 24541 cagctcgggt tcggtcgacg ggacctgctg cgtcacgggg gctcctccca ctccgccccg 24601 ccgccgctgc tcgccggcgg gctccacccg acgatacggc atcacccggg cgcgaaatgg 24661 agccccgagg gatattccgg gccgattaga gccttctgtc cgaattggtg gcttaataac 24721 aactggccct gaaatggcgg agggtgaagg tgaggcgcgt gagcagcgtc atatccgtga 24781 ccgtgcgttg cccgtcatgt tcacgtaatt caactgtttc tcaaggggct ttaagcaaaa 24841 gcgcgcgacg gaaatcgacg cagggttacc ggatattccc gtaaaggatc aatcggaaca 24901 cctgccgggg gaacccttcg cttgtccctg tgcgtcttgg tcccttacgt tcaccaccga 24961 tccggacgga cgcctaatcc tgccgccgac cggagcccgc actcatcgac cacccgtaca 25021 cggcaggagc gggggaccca caggtagaac tgcctgttcc ggttcccgga acggcttggg 25081 gtaaagccgc gctccggcgc ggccgggcat ctccagcccg cacccgacag ctcacctcgc 25141 aggcgccgga gaggaattca ccatgcccgc gaagggtaag caccgccgta ccagggccat 25201 gcgcctgacc cgcaccatcg ccgtcgccgg gaccggtggc gccgcgctcg cgctcccgct 25261 gatgggtgcc gccgccgcca acgccgctcc cgcgcactcc gtttccgagc aggccgtgca 25321 gtccgttccg gcgtccgcca agaaggccgc cgccgagaag aactccgact cgcgcaccta 25381 caccgtgaag agcggcgact acctctcgaa gatcgccgac gagcaggacg tcgacggcgg 25441 ctggaagaag ctctacgcgg acaaccgcga ggccgtcggt tccgacccgt cgctgatcca 25501 ccccggtctc aagctctcga tcgacggcca ggccgccaag ccgtcggcgc cgtcctccgc 25561 gcagtcgcag aagcccgcgc agaagtccgc cgagaagcct gcggagaaga ccgccgcgaa 25621 gccggcccag aagtcgacgg acgccgagaa ggcctcctcc tcggacaccg gcagccagtc 25681 cacgggcacc accagcggct acacctcccc cgtcgcgggc ggcaccgtcg gcaccccgta 25741 ccaccagtcc ggcagcatgt ggtccagcgg ctaccacacc ggcaccgact tcgtcgtccc 25801 gaccggcacc tccctcaagg ccgtcggcgc gggcaccgtc gtctccgccg gctggggcgg 25861 cgcgtacggc aaccaggtcg tcatccagct cgccgacggc cactacgccc agtacgccca 25921 cctctcctcg ctctccgtct ccgccggtca gtcggtgacg gcgggtcagc aggtcggcct 25981 ctcgggtgcc accggcaacg tgaccggccc gcacctgcac ttcgagatcc gcaccacgcc 26041 ggactacggc tcggacatcg acccgctggc gttcctgcgc tcgcacggcg tctccgtctg 26101 acgaccggtt ccgcgcggcc cccgcgcacc gaaggccgga ccccgatccc cgggtccggc 26161 cttcggcgtg tccggacccg gtgcgcgcgc cgtacaggcc cctcgccgta ttccggaatt 26221 gacgaatact ttaggcgtgg cctttctcac cgcccgtcaa tcccttccta cggtcgcgta 26281 ggtcacattc caaggtgaat catgggccga tgtggcagac gattcgaaga gtgacagcag 26341 agcagtgatc gggtcgtacg tggcggtggg ggacagcttc accgagggcg tcggcgaccc 26401 cggccccgac ggggcgttcg tcggctgggc cgaccggctc gccgtactgc tcgcggaccg 26461 gcgccccgag ggcgacttca cgtacacgaa cctcgccgtg cgcggcaggc tcctcgacca 26521 gatcgtggcg gaacaggtcc cgcgggtcgt cggactcgcg cccgacctcg tctcgttcgc 26581 ggcgggcggc aacgacatca tccggcccgg caccgatccc gacgaggtcg ccgagcggtt 26641 cgagctggcg gtggccgcgc tgaccgccgc ggccggaacc gtcctggtga ccaccgggtt 26701 cgacacccgg ggggtgcccg tcctcaagca cctgcgcggc aa //