LOCUS       NC_003888              22793 bp    DNA     linear   CON 03-AUG-2016
DEFINITION  Streptomyces coelicolor A3(2) chromosome, complete genome.
ACCESSION   NC_003888
VERSION     NC_003888.3
KEYWORDS    .
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645882.
            On Jun 22, 2003 this sequence version replaced NC_003888.2.
            RefSeq Category: Reference Genome
            MOD: Model Organism
            UPR: UniProt Genome
            COMPLETENESS: full length.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2023-11-22 14:16:39
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 7409663
            Orig. end    :: 7432456
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..22793
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12793]"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12793
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     cand_cluster    1..22793
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..22793
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="21"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     regulatory      complement(23..27)
                     /note="possible RBS upstream of SC5A7.18c"
                     /regulatory_class="ribosome_binding_site"
     gene            complement(49..843)
                     /db_xref="GeneID:1102108"
                     /gene_synonym="SC5A7.19c"
                     /locus_tag="SCO6669"
     CDS             complement(49..843)
                     /codon_start=1
                     /db_xref="GeneID:1102108"
                     /gene_functions="regulatory (smcogs) SMCOG1195:IclR family
                     transcriptional regulator (Score: 230.7; E-value: 2.4e-70)"
                     /gene_kind="regulatory"
                     /gene_synonym="SC5A7.19c"
                     /locus_tag="SCO6669"
                     /note="SC5A7.19c, probable transcriptional regulator, len:
                     264 aa; similar to members of the iclR family e.g.
                     GYLR_STRCO glycerol operon regulatory protein (254 aa),
                     fasta scores; opt: 277 z-score: 318.0 E(): 1.8e-10, 31.4%
                     identity in 245 aa overlap. Contains probable
                     helix-turn-helix motif from aa 28-49 (Score 1240, +3.41
                     SD)"
                     /product="transcriptional regulator"
                     /protein_id="NP_630744.1"
                     /transl_table=11
                     /translation="MTAPATPTAPDRLLAVLAAFDHAHPALSLTDISRRAGLSLTTAHR
                     LVGALTRWGALERDGAGVYHVGLRSWEIAALAPRGLALRQVAWPYLEDLYEATHENVQL
                     AVRDGGEVVYIEWLAARSSIGVHIRVGARWPLHATGVGLALLAHGEPEFQEAYRTGPLA
                     SFTPYTITDPVRLRRVLAEVRRTGAAVSDRQITDDALSVAAPVHGPDGTVTAAVSVVVP
                     HAGAQVPALVPAVRLAARGISRALGWRPNIPRTGEDGPPYSS"
     PFAM_domain     complement(112..468)
                     /aSDomain="IclR"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF01614.21"
                     /description="Bacterial transcriptional regulator"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6669_0833"
                     /evalue="2.10E-25"
                     /label="SCO6669"
                     /locus_tag="SCO6669"
                     /protein_end="244"
                     /protein_start="125"
                     /score="89.2"
                     /tool="antismash"
                     /translation="VHIRVGARWPLHATGVGLALLAHGEPEFQEAYRTGPLASFTPYTI
                     TDPVRLRRVLAEVRRTGAAVSDRQITDDALSVAAPVHGPDGTVTAAVSVVVPHAGAQVP
                     ALVPAVRLAARGISR"
     PFAM_domain     complement(664..813)
                     /aSDomain="HTH_IclR"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF09339.13"
                     /db_xref="GO:0003677"
                     /db_xref="GO:0006355"
                     /description="IclR helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6669_0832"
                     /evalue="4.60E-14"
                     /gene_ontologies="GO:0003677: DNA binding"
                     /gene_ontologies="GO:0006355: regulation of DNA-templated
                     transcription"
                     /label="SCO6669"
                     /locus_tag="SCO6669"
                     /protein_end="60"
                     /protein_start="10"
                     /score="52.1"
                     /tool="antismash"
                     /translation="DRLLAVLAAFDHAHPALSLTDISRRAGLSLTTAHRLVGALTRWGA
                     LERDG"
     regulatory      972..975
                     /note="possible RBS upstream of SC5A7.20"
                     /regulatory_class="ribosome_binding_site"
     gene            982..2307
                     /db_xref="GeneID:1102109"
                     /gene_synonym="SC5A7.20"
                     /locus_tag="SCO6670"
     CDS             982..2307
                     /codon_start=1
                     /db_xref="GeneID:1102109"
                     /gene_synonym="SC5A7.20"
                     /locus_tag="SCO6670"
                     /note="SC5A7.20, probable glucosidase, len: 441 aa; similar
                     to e.g. CELF_ECOLI 6-phospho-beta-glucosidase (450 aa),
                     fasta scores; opt: 537 z-score: 628.7 E(): 8.8e-28, 31.8%
                     identity in 456 aa overlap"
                     /product="glucosidase"
                     /protein_id="NP_630745.1"
                     /transl_table=11
                     /translation="MLGGGGFRVPLVYGALLGDRGEGRVSDVVLHDLDPARLTAVTRVL
                     AEQAAGVPDAPTVTATTDLDEALRGADFVFSAIRVGGLQGRADDERVALAEGVLGQETV
                     GAGGIAYGLRTVPVAVDIARRVARLAPDAWVINFTNPAGLVTEAMSRHLGDRAIGICDS
                     PVGLGRRVARVLGADPDRAFVDYVGLNHLGWLRGLRVGGRDELPRLLADPALLGSFEEG
                     RLFGAEWLRSLGAVPNEYLHYYYFNRETVRAYQEAGLTRGAFLRDQQARFYDEMRRPDA
                     PALATWDRTRAEREATYMAENRETAGAGEREAEDLSGGYEKVALALMRAVARDERATLI
                     LNVRNRGTLSVLDADAVIEVPCLVDANGAHPMAVDPLPDHATGLVRAVKGVERDVLAAA
                     GTGSRAAAVRAFALHPLVDSVDVARRLVDGYRAVHPGLAYLR"
     PFAM_domain     991..1509
                     /aSDomain="Glyco_hydro_4"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF02056.19"
                     /db_xref="GO:0004553"
                     /db_xref="GO:0005975"
                     /description="Family 4 glycosyl hydrolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6670_0834"
                     /evalue="2.10E-42"
                     /gene_ontologies="GO:0004553: hydrolase activity,
                     hydrolyzing O-glycosyl compounds"
                     /gene_ontologies="GO:0005975: carbohydrate metabolic
                     process"
                     /label="SCO6670"
                     /locus_tag="SCO6670"
                     /protein_end="176"
                     /protein_start="3"
                     /score="144.8"
                     /tool="antismash"
                     /translation="GGGFRVPLVYGALLGDRGEGRVSDVVLHDLDPARLTAVTRVLAEQ
                     AAGVPDAPTVTATTDLDEALRGADFVFSAIRVGGLQGRADDERVALAEGVLGQETVGAG
                     GIAYGLRTVPVAVDIARRVARLAPDAWVINFTNPAGLVTEAMSRHLGDRAIGICDSPVG
                     LGRRVARVLG"
     PFAM_domain     1537..2232
                     /aSDomain="Glyco_hydro_4C"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF11975.11"
                     /db_xref="GO:0004553"
                     /description="Family 4 glycosyl hydrolase C-terminal
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6670_0835"
                     /evalue="5.90E-45"
                     /gene_ontologies="GO:0004553: hydrolase activity,
                     hydrolyzing O-glycosyl compounds"
                     /label="SCO6670"
                     /locus_tag="SCO6670"
                     /protein_end="417"
                     /protein_start="185"
                     /score="154.0"
                     /tool="antismash"
                     /translation="YVGLNHLGWLRGLRVGGRDELPRLLADPALLGSFEEGRLFGAEWL
                     RSLGAVPNEYLHYYYFNRETVRAYQEAGLTRGAFLRDQQARFYDEMRRPDAPALATWDR
                     TRAEREATYMAENRETAGAGEREAEDLSGGYEKVALALMRAVARDERATLILNVRNRGT
                     LSVLDADAVIEVPCLVDANGAHPMAVDPLPDHATGLVRAVKGVERDVLAAAGTGSRAAA
                     VRAFALHPLV"
     gene            complement(2300..3466)
                     /db_xref="GeneID:1102110"
                     /gene_synonym="SC5A7.21c"
                     /locus_tag="SCO6671"
     CDS             complement(2300..3466)
                     /codon_start=1
                     /db_xref="GeneID:1102110"
                     /gene_synonym="SC5A7.21c"
                     /locus_tag="SCO6671"
                     /note="SC5A7.21c, unknown, len: 388 aa; Similar to
                     TR:Q9RSB2 (EMBL:AE002054) conserved hypothetical protein
                     from Deinococcus radiodurans (338 aa) fasta scores; opt:
                     415, Z-score: 392.3, E(): 3.2e-14, 31.333% identity
                     (32.639% ungapped) in 300 aa overlap. Contains nine
                     degenerate PA repeats at C-terminus"
                     /product="hypothetical protein"
                     /protein_id="NP_630746.1"
                     /transl_table=11
                     /translation="MASPVRVWLNRTYAENVFFMDQLRRNPADRAVEIHATHGDPDSPV
                     LAAADTAELEPEGLSPAGYVEYALAQCARRGIDVFVPRLHQSAIVAHRAEFEALGTALL
                     APPPEAVAVFRDKVIAYEAVRAIGVPVPPWWRVRTADELVLAVEELEAGGHRACFKPAS
                     GAGGVGFRMVTRDPFSLTHLNGFPSPSVPLPLVVEALRAAEEPVDWLVMPRLEQPEVSV
                     DCLTGPDNRVRLAVGRTKNGRRRGFTLHDQWLTPARRIAETFGLHHLSNVQFRMYGDRP
                     VLMDVNTRPAGGLHQLALCGVNVPWAAVRLALGDDPGQLEPPFLGQDYAVVSGPRPLRP
                     VTLPHQRADLPAATTPAPAPAPAAAAAPAPAPAERAAAPASSAPVGLT"
     repeat_region   complement(2348..2401)
                     /gene_synonym="SC5A7.21c"
                     /locus_tag="SCO6671"
                     /note="9 x 6 bp repeats"
     PFAM_domain     complement(2471..2848)
                     /aSDomain="ATPgrasp_Ter"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF15632.9"
                     /description="ATP-grasp in the biosynthetic pathway with
                     Ter operon"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6671_0836"
                     /evalue="3.20E-35"
                     /label="SCO6671"
                     /locus_tag="SCO6671"
                     /protein_end="332"
                     /protein_start="206"
                     /score="120.8"
                     /tool="antismash"
                     /translation="VDWLVMPRLEQPEVSVDCLTGPDNRVRLAVGRTKNGRRRGFTLHD
                     QWLTPARRIAETFGLHHLSNVQFRMYGDRPVLMDVNTRPAGGLHQLALCGVNVPWAAVR
                     LALGDDPGQLEPPFLGQDYAVV"
     regulatory      complement(3472..3478)
                     /note="possible RBS upstream of SC5A7.21c"
                     /regulatory_class="ribosome_binding_site"
     misc_feature    3721..3736
                     /note="TFBS match to LexA, Repressor of DNA damage
                     response, confidence: weak, score: 19.96"
                     /tool="antismash"
     regulatory      3737..3740
                     /note="possible RBS upstream of SC5A7.22"
                     /regulatory_class="ribosome_binding_site"
     gene            3749..4636
                     /db_xref="GeneID:1102111"
                     /gene_synonym="SC5A7.22"
                     /locus_tag="SCO6672"
     CDS             3749..4636
                     /codon_start=1
                     /db_xref="GeneID:1102111"
                     /gene_synonym="SC5A7.22"
                     /locus_tag="SCO6672"
                     /note="SC5A7.22, unknown, len: 295 aa; similar to a
                     hypothetical protein from M. tuberculosis TR:O33337
                     (EMBL:AL008967) MTV002.60C (324 aa), fasta scores; opt:
                     1202 z-score: 1507.9 E(): 0, 57.2% identity in 285 aa
                     overlap"
                     /product="hypothetical protein"
                     /protein_id="NP_630747.1"
                     /transl_table=11
                     /translation="MTTRAGAPGKLWAISDLHVGYEENRALVERTRPESDDDWLLVAGD
                     VAETVADIRWALGILADRFRRVVWAPGNHELWTHPKDAVDLRGVARYEHLVEMCRELGV
                     TTPEDPYPVWEGAGGPAVVAPLFLLYDYSFLPAGCATKAEGLEYAQGTGVVCSDEYLLH
                     PDPYPSREDWCRARVAETERRLAAIPADLPTIPVNHYPLHRHPTDVLWYPEFAMWCGTS
                     LTADWHRRFRVETMVYGHLHIPRTTWHEGVRFEEVSVGYPREWRKRPGPPGQLRRILPS
                     TRASAAPSHQEVTR"
     PFAM_domain     3776..4480
                     /aSDomain="Metallophos"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00149.31"
                     /db_xref="GO:0016787"
                     /description="Calcineurin-like phosphoesterase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6672_0837"
                     /evalue="1.40E-16"
                     /gene_ontologies="GO:0016787: hydrolase activity"
                     /label="SCO6672"
                     /locus_tag="SCO6672"
                     /protein_end="244"
                     /protein_start="9"
                     /score="61.7"
                     /tool="antismash"
                     /translation="KLWAISDLHVGYEENRALVERTRPESDDDWLLVAGDVAETVADIR
                     WALGILADRFRRVVWAPGNHELWTHPKDAVDLRGVARYEHLVEMCRELGVTTPEDPYPV
                     WEGAGGPAVVAPLFLLYDYSFLPAGCATKAEGLEYAQGTGVVCSDEYLLHPDPYPSRED
                     WCRARVAETERRLAAIPADLPTIPVNHYPLHRHPTDVLWYPEFAMWCGTSLTADWHRRF
                     RVETMVYGHLHIP"
     regulatory      4620..4626
                     /gene_synonym="SC5A7.22"
                     /locus_tag="SCO6672"
                     /note="possible RBS upstream of SC5A7.23"
                     /regulatory_class="ribosome_binding_site"
     gene            4633..5313
                     /db_xref="GeneID:1102112"
                     /gene_synonym="SC5A7.23"
                     /locus_tag="SCO6673"
     CDS             4633..5313
                     /NRPS_PKS="Domain: ACPS (103-167). E-value: 6.4e-22. Score:
                     69.8. Matches aSDomain: nrpspksdomains_SCO6673_ACPS.1"
                     /codon_start=1
                     /db_xref="GeneID:1102112"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1060:4'-phosphopantetheinyl transferase (Score: 244.8;
                     E-value: 1.1e-74)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SC5A7.23"
                     /locus_tag="SCO6673"
                     /note="SC5A7.23, unknown, len: 226 aa; similar to
                     hypothetical proteins from Streptomyces and M. tuberculosis
                     e.g. S. coelicolor TR:O24813 (EMBL:AB007189) (208 aa),
                     fasta scores; opt: 674 z-score: 960.0 E(): 0, 49.1%
                     identity in 214 aa overlap"
                     /product="hypothetical protein"
                     /protein_id="NP_630748.1"
                     /transl_table=11
                     /translation="MIEELLPGTVVAVEAFGQDDAGHLPLYPEEEELVARAVAKRRREF
                     TVVRSCARRAMEKLGVPAQPVLTGERGAPRWPEGIAGSMTHCDGYGAAALVRLTDLASL
                     GIDAEPDGPLPDGVLESIALPAEVALLRRLGGARPGVHWDRLLFSAKESVYKAWYPLTG
                     QWLDFTEADIEIRVDPADPRRGTLHAALLVPGPTVDGRRLSRFDGRWSARDGLVTTAVT
                     VPRT"
     PFAM_domain     4717..4914
                     /aSDomain="4PPT_N"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF17837.4"
                     /description="4'-phosphopantetheinyl transferase N-terminal
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6673_0838"
                     /evalue="1.80E-25"
                     /label="SCO6673"
                     /locus_tag="SCO6673"
                     /protein_end="94"
                     /protein_start="28"
                     /score="89.0"
                     /tool="antismash"
                     /translation="EEEELVARAVAKRRREFTVVRSCARRAMEKLGVPAQPVLTGERGA
                     PRWPEGIAGSMTHCDGYGAAA"
     PFAM_domain     4939..5160
                     /aSDomain="ACPS"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF01648.23"
                     /db_xref="GO:0000287"
                     /db_xref="GO:0008897"
                     /description="4'-phosphopantetheinyl transferase
                     superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6673_0839"
                     /evalue="8.00E-11"
                     /gene_ontologies="GO:0000287: magnesium ion binding"
                     /gene_ontologies="GO:0008897: holo-[acyl-carrier-protein]
                     synthase activity"
                     /label="SCO6673"
                     /locus_tag="SCO6673"
                     /protein_end="176"
                     /protein_start="102"
                     /score="42.2"
                     /tool="antismash"
                     /translation="SLGIDAEPDGPLPDGVLESIALPAEVALLRRLGGARPGVHWDRLL
                     FSAKESVYKAWYPLTGQWLDFTEADIEIR"
     aSDomain        4942..5133
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCO6673_ACPS.1"
                     /evalue="6.40E-22"
                     /label="SCO6673_ACPS.1"
                     /locus_tag="SCO6673"
                     /protein_end="167"
                     /protein_start="103"
                     /score="69.8"
                     /tool="antismash"
                     /translation="LGIDAEPDGPLPDGVLESIALPAEVALLRRLGGARPGVHWDRLLF
                     SAKESVYKAWYPLTGQWLD"
     gene            complement(5332..5568)
                     /db_xref="GeneID:1102113"
                     /gene_synonym="SC5A7.24c"
                     /locus_tag="SCO6674"
     CDS             complement(5332..5568)
                     /codon_start=1
                     /db_xref="GeneID:1102113"
                     /gene_synonym="SC5A7.24c"
                     /locus_tag="SCO6674"
                     /note="SC5A7.24c, unknown, len: 78 aa"
                     /product="hypothetical protein"
                     /protein_id="NP_630749.1"
                     /transl_table=11
                     /translation="MTTAVLTDRERTAVQAYLRLLHTVRAGFDTGTGPGDSPRPPVVPP
                     SVLAEAEQALRAAGLTGNEEAFFRLLRDWCPPT"
     regulatory      complement(5578..5581)
                     /note="possible RBS upstream of SC5A7.24c"
                     /regulatory_class="ribosome_binding_site"
     gene            complement(5664..6320)
                     /db_xref="GeneID:1102114"
                     /gene_synonym="SC5A7.25c"
                     /locus_tag="SCO6675"
     CDS             complement(5664..6320)
                     /codon_start=1
                     /db_xref="GeneID:1102114"
                     /gene_synonym="SC5A7.25c"
                     /locus_tag="SCO6675"
                     /note="SC5A7.25c, possible DNA-binding protein, len: 218
                     aa. Contains probable helix-turn-helix motif from aa 92-113
                     (Score 1665, +4.86 SD)"
                     /product="DNA-binding protein"
                     /protein_id="NP_630750.1"
                     /transl_table=11
                     /translation="MTGGFEGPGAKPTTTLAAVVARVGALADRLDVPHAEVFDVGRLSA
                     ASGVPESVVGALLGGRPTGGADVQTRFVQRLDLLRRTRLKPNGRKYTQQEIADGAGMSR
                     QQAGALINGDRRPTMEHCDAIQRFFRVHAGFLTAEDPEALAGALQRTEQELLQQLADRE
                     RQAAAPADDPLERLLQDHGVRGIAWRAAQLPTDQHRDKVAEWLDMLLESVKRPES"
     PFAM_domain     complement(5916..6059)
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF01381.25"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6675_0840"
                     /evalue="4.40E-09"
                     /label="SCO6675"
                     /locus_tag="SCO6675"
                     /protein_end="135"
                     /protein_start="87"
                     /score="36.4"
                     /tool="antismash"
                     /translation="GRKYTQQEIADGAGMSRQQAGALINGDRRPTMEHCDAIQRFFRVH
                     AGF"
     regulatory      complement(6329..6333)
                     /note="possible RBS upstream of SC5A7.25c"
                     /regulatory_class="ribosome_binding_site"
     gene            6505..7212
                     /db_xref="GeneID:1102115"
                     /gene_synonym="SC5A7.26"
                     /locus_tag="SCO6676"
     CDS             6505..7212
                     /codon_start=1
                     /db_xref="GeneID:1102115"
                     /gene_synonym="SC5A7.26"
                     /locus_tag="SCO6676"
                     /note="SC5A7.26, unknown, len: 235 aa"
                     /product="hypothetical protein"
                     /protein_id="NP_630751.1"
                     /transl_table=11
                     /translation="MRTPREGRIGKRGDLPMAFQAGGQRPAPRPAPATPEAQAYLQDYT
                     ALLEAVPFPSLVVDHRWDVVLANGAFRTLFQGAGPHPTAMPDDNFLRFVLFHPDAATVL
                     GEHESSWCLPMLAHFAATLERYGHDPGLQAVRRDIAQDPIMEAAYRQGLPHWIRAVGAR
                     AVEHDGAVRPLHHPDPRRGTTECRVVVETPASLQELGYTRLTLVLREPRRAAHRAPRAR
                     HTPAHLRVVPAAE"
     PFAM_domain     6640..7083
                     /aSDomain="MLTR_LBD"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF17765.4"
                     /description="MmyB-like transcription regulator ligand
                     binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6676_0841"
                     /evalue="7.60E-14"
                     /label="SCO6676"
                     /locus_tag="SCO6676"
                     /protein_end="193"
                     /protein_start="45"
                     /score="52.4"
                     /tool="antismash"
                     /translation="ALLEAVPFPSLVVDHRWDVVLANGAFRTLFQGAGPHPTAMPDDNF
                     LRFVLFHPDAATVLGEHESSWCLPMLAHFAATLERYGHDPGLQAVRRDIAQDPIMEAAY
                     RQGLPHWIRAVGARAVEHDGAVRPLHHPDPRRGTTECRVVVETP"
     gene            complement(7104..7646)
                     /db_xref="GeneID:1102116"
                     /gene_synonym="SC5A7.27c"
                     /locus_tag="SCO6677"
     CDS             complement(7104..7646)
                     /codon_start=1
                     /db_xref="GeneID:1102116"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 92.6; E-value:
                     5.4e-28)"
                     /gene_kind="transport"
                     /gene_synonym="SC5A7.27c"
                     /locus_tag="SCO6677"
                     /note="SC5A7.27c, probable ABC transporter ATP-binding
                     protein, len: 180 aa; similar to part of many e.g. taurine
                     transport atp-binding protein tauB (255 aa), fasta scores;
                     opt: 309 z-score: 436.0 E(): 4.9e-17, 43.6% identity in 117
                     aa overlap. Contains Pfam match to entry PF00005 ABC_tran,
                     ABC transporters, score 31.20, E-value 1.9e-09. Has large
                     overlap with convergent downstream gene; database
                     similarities do not extend into the overlap. The sequence
                     of the cosmid has been checked, and is correct"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="NP_630752.1"
                     /transl_table=11
                     /translation="MKPQRPISARAWTRAAPRTCRHVELLLKHAALSRERCGELVAEAL
                     APVGLADAAGAHPWQLSGGMQQRVAIARARAYEPEVLLMAEPFTAVDAQTRAGLGDLVR
                     VLWRERGITVLFVTHDIDEAVHLGERVIVLSAAPPPALTTRHSAAGTTLRWAGVWRARG
                     ARWAARRGSLRTSVNRV"
     misc_feature    complement(7236..7637)
                     /gene_synonym="SC5A7.27c"
                     /locus_tag="SCO6677"
                     /note="Pfam match to entry PF00005 ABC_tran, ABC
                     transporters, score 31.20, E-value 1.9e-09"
     PFAM_domain     complement(7383..7526)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00005.30"
                     /db_xref="GO:0005524"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6677_0842"
                     /evalue="1.50E-06"
                     /gene_ontologies="GO:0005524: ATP binding"
                     /label="SCO6677"
                     /locus_tag="SCO6677"
                     /protein_end="88"
                     /protein_start="40"
                     /score="28.9"
                     /tool="antismash"
                     /translation="VAEALAPVGLADAAGAHPWQLSGGMQQRVAIARARAYEPEVLLMA
                     EPF"
     gene            complement(7669..8610)
                     /db_xref="GeneID:1102117"
                     /gene_synonym="SC5A7.28c"
                     /locus_tag="SCO6678"
     CDS             complement(7669..8610)
                     /codon_start=1
                     /db_xref="GeneID:1102117"
                     /gene_functions="other (smcogs) SMCOG1094:ferredoxin
                     (Score: 196.6; E-value: 8.6e-60)"
                     /gene_kind="other"
                     /gene_synonym="SC5A7.28c"
                     /locus_tag="SCO6678"
                     /note="SC5A7.28c, probable iron-sulfur oxidoreductase beta
                     subunit, len: 313 aa; similar to many e.g. POBB_PSEPS
                     phenoxybenzoate dioxygenase beta subunit (Pseudomonas
                     pseudoalcaligenes) (319 aa), fasta scores; opt: 824
                     z-score: 993.1 E(): 0, 45.9% identity in 303 aa overlap.
                     C-terminus is a 2Fe-2S ferredoxin domain similar to e.g.
                     FERV_ANAVA ferredoxin, vegetative (Anabaena variabilis) (98
                     aa), fasta scores; opt: 187 z-score: 222.4 E(): 3.8e-05,
                     38.2% identity in 68 aa overlap. Contains PS00197 2Fe-2S
                     ferredoxins, iron-sulfur binding region signature and Pfam
                     match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster
                     binding domains, score 35.50, E-value 1.2e-06"
                     /product="iron-sulfur oxidoreductase subunit beta"
                     /protein_id="NP_630753.1"
                     /transl_table=11
                     /translation="MTRYEAELVVGRRETAADGVLVLTLRHPRDEPLPVWEPGAHVDVV
                     LGPGLERQYSLCGDPGDRAVWRVAVLREKAGRGGSAYVHEELRAGDKVRVRGPRNNFRL
                     ERAPRYRFVAGGIGITPVLPMLAAAEEAGAEWSLLYGGRTRAGMAFTKELERYGDRVRI
                     VPEDESGLLDLASVLDDVAPGTLVYCCGPGGLLDAVEARCPAGSLRVERFRPKEAAVQA
                     PAGPEFEVVLARSGRTVAVPPGTSVLDAVRETGVEVLYSCTEGTCGTCETEVVEGEPDH
                     RDSVLTEEERAAGETMLICVSRCRGRRLVLDL"
     misc_feature    complement(7678..7932)
                     /gene_synonym="SC5A7.28c"
                     /locus_tag="SCO6678"
                     /note="Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur
                     cluster binding domains, score 35.50, E-value 1.2e-06"
     PFAM_domain     complement(7702..7911)
                     /aSDomain="Fer2"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00111.30"
                     /db_xref="GO:0051536"
                     /description="2Fe-2S iron-sulfur cluster binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6678_0844"
                     /evalue="4.40E-14"
                     /gene_ontologies="GO:0051536: iron-sulfur cluster binding"
                     /label="SCO6678"
                     /locus_tag="SCO6678"
                     /protein_end="303"
                     /protein_start="233"
                     /score="52.3"
                     /tool="antismash"
                     /translation="RSGRTVAVPPGTSVLDAVRETGVEVLYSCTEGTCGTCETEVVEGE
                     PDHRDSVLTEEERAAGETMLICVSR"
     misc_feature    complement(7801..7827)
                     /gene_synonym="SC5A7.28c"
                     /locus_tag="SCO6678"
                     /note="PS00197 2Fe-2S ferredoxins, iron-sulfur binding
                     region signature"
     PFAM_domain     complement(8014..8277)
                     /aSDomain="NAD_binding_1"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00175.24"
                     /db_xref="GO:0016491"
                     /description="Oxidoreductase NAD-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6678_0843"
                     /evalue="1.10E-05"
                     /gene_ontologies="GO:0016491: oxidoreductase activity"
                     /label="SCO6678"
                     /locus_tag="SCO6678"
                     /protein_end="199"
                     /protein_start="111"
                     /score="26.2"
                     /tool="antismash"
                     /translation="FVAGGIGITPVLPMLAAAEEAGAEWSLLYGGRTRAGMAFTKELER
                     YGDRVRIVPEDESGLLDLASVLDDVAPGTLVYCCGPGGLLDAV"
     gene            complement(8607..8777)
                     /db_xref="GeneID:1102118"
                     /gene_synonym="SC5A7.29c"
                     /locus_tag="SCO6679"
     CDS             complement(8607..8777)
                     /codon_start=1
                     /db_xref="GeneID:1102118"
                     /gene_synonym="SC5A7.29c"
                     /locus_tag="SCO6679"
                     /note="SC5A7.29c, unknown, len: 56 aa"
                     /product="hypothetical protein"
                     /protein_id="NP_630754.1"
                     /transl_table=11
                     /translation="MSGRTGEIYRIAWLPGTDVLHGTCHCGAEHTAEDPVAMWDWMLAH
                     PRGHDLPGDGS"
     gene            complement(8774..9853)
                     /db_xref="GeneID:1102119"
                     /gene_synonym="SC5A7.30c"
                     /locus_tag="SCO6680"
     CDS             complement(8774..9853)
                     /codon_start=1
                     /db_xref="GeneID:1102119"
                     /gene_synonym="SC5A7.30c"
                     /locus_tag="SCO6680"
                     /note="SC5A7.30c, probable oxidoreductase alpha subunit,
                     len: 359 aa; similar to many e.g. VANA_PSES9 vanillate
                     demethylase (monooxygenase) (329 aa), fasta scores; opt:
                     636 z-score: 695.7 E(): 1.7e-31, 34.6% identity in 338 aa
                     overlap"
                     /product="oxidoreductase subunit alpha"
                     /protein_id="NP_630755.1"
                     /transl_table=11
                     /translation="MPHMTAFARNQWYVAAYSHEVGRELLGRTVLGEPLVLYRAEEDGG
                     PVVLHDRCVHRRYPLSEAPTRLDGDRIVCGYHGFTYDTTGTCVYVPGQKRVPRTARVAS
                     YPVAERDSLVWVWIGDPALADPEAVPRARHLDAPGWVTVRGMEPIDADYGLLVDNLLDL
                     SHETYLHGGHIGTPEVAETPITTEVDEGAGIVRVSRHMDDAECPPFYARSTGIVGRIDR
                     WQDIEYHAPCLYVLHSRVAPTGTVPAPDGGDPEGFHTEITYAITPSGDGKVYDFWAVSR
                     DWATDDAEVTEFLYKSNRTVVMQDVDALNLLQRTLGGERAGYQELSINIDTGGLAARRI
                     LARLVEEGEGAGTGPRVAR"
     regulatory      complement(8782..8786)
                     /gene_synonym="SC5A7.30c"
                     /locus_tag="SCO6680"
                     /note="possible RBS upstream of SC5A7.29c"
                     /regulatory_class="ribosome_binding_site"
     PFAM_domain     complement(8813..9409)
                     /aSDomain="VanA_C"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF19112.3"
                     /db_xref="GO:0016491"
                     /description="Vanillate O-demethylase oxygenase C-terminal
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6680_0846"
                     /evalue="8.40E-41"
                     /gene_ontologies="GO:0016491: oxidoreductase activity"
                     /label="SCO6680"
                     /locus_tag="SCO6680"
                     /protein_end="347"
                     /protein_start="148"
                     /score="140.3"
                     /tool="antismash"
                     /translation="IDADYGLLVDNLLDLSHETYLHGGHIGTPEVAETPITTEVDEGAG
                     IVRVSRHMDDAECPPFYARSTGIVGRIDRWQDIEYHAPCLYVLHSRVAPTGTVPAPDGG
                     DPEGFHTEITYAITPSGDGKVYDFWAVSRDWATDDAEVTEFLYKSNRTVVMQDVDALNL
                     LQRTLGGERAGYQELSINIDTGGLAARRILARLVEE"
     PFAM_domain     complement(9563..9823)
                     /aSDomain="Rieske"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00355.29"
                     /db_xref="GO:0051537"
                     /description="Rieske [2Fe-2S] domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6680_0845"
                     /evalue="9.60E-16"
                     /gene_ontologies="GO:0051537: 2 iron, 2 sulfur cluster
                     binding"
                     /label="SCO6680"
                     /locus_tag="SCO6680"
                     /protein_end="97"
                     /protein_start="10"
                     /score="57.6"
                     /tool="antismash"
                     /translation="QWYVAAYSHEVGRELLGRTVLGEPLVLYRAEEDGGPVVLHDRCVH
                     RRYPLSEAPTRLDGDRIVCGYHGFTYDTTGTCVYVPGQKRVP"
     regulatory      complement(9860..9863)
                     /note="possible RBS upstream of SC5A7.30c"
                     /regulatory_class="ribosome_binding_site"
     regulatory      9995..9998
                     /note="possible RBS upstream of SC5A7.31"
                     /regulatory_class="ribosome_binding_site"
     gene            10001..12793
                     /db_xref="GeneID:1102120"
                     /gene_synonym="SC5A7.31"
                     /locus_tag="SCO6681"
     CDS             10001..12793
                     /codon_start=1
                     /db_xref="GeneID:1102120"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 78.9;
                     E-value: 7.6e-24)"
                     /gene_kind="biosynthetic"
                     /gene_synonym="SC5A7.31"
                     /locus_tag="SCO6681"
                     /note="SC5A7.31, unknown, len 930 aa; some similarity to
                     several e.g. PKN2_MYXXA serine-threonine-protein kinase
                     Pkn2 (Myxococcus xanthus) (830 aa), Smith-Waterman scores;
                     E: 1.5e-06, 23% identity in 829 bp overlap. Also has short
                     segment of similarity to the active site regions of several
                     Serine-Threonine protein kinases e.g. PKAA_STRCO P54739
                     serine-threonine protein kinase pkaA (533 aa), blastp
                     scores; Expect= 3.7e-05, 39% identity in 27 aa overlap.
                     Contains possible transmembrane anchor and six degenerate
                     repeats of the sequence VDETTR"
                     /product="Ser/Thr protein kinase"
                     /protein_id="NP_630756.1"
                     /sec_met_domain="micKC (E-value: 5.2e-235, bitscore: 781.1,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.9e-09, bitscore: 36.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 0.00013, bitscore:
                     19.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAATVRGGTPRDSVVSVSNRWEGAGVNKGYAVYCDADPYFYDAP
                     HRTADRTGAARSRYAAASSPVPEGWQRHESGDWLALRPADADLPAQGWKIHVSACLDNA
                     ESVLDRVWRHCVDGGTAFKFVPSRYLLHQRNAKYADRAGSGKFVTVYPADEAEFERLVG
                     ELSELLAGEPGPHILSDLRIGDGPVHVRYGGFTRRDCYDADGELRPAVSGPDGVLVPDL
                     RGPVFRIPEWVDPPAFLRPHLDARSAVTVTGMPYTVESALHFSNGGGVYLARDTRTGAR
                     VVLKEARPHAGLAADGADAVTRLHRERRALERLSGLACTPEVLDHRTVGEHHFLVLEHI
                     DGKPLNTFFARRHPLIEADPGERRLAEYTDWALDVHARVERAVAEVHARGVVFNDLHLF
                     NIMVRDDDSVALLDFEAAHHVDEAGRQIVANPGFVAPPDRRGVAVDRYALACLRIVLFL
                     PLTSLLAVDRHKAAHLAEVVAEQFPVDRAFLDAAVEEITRVDGSTRVDGSTRADETTRA
                     DETTRLDVTTRVHGAPDAARRPAGPVAPVRPDDWPRSRDSMAAAIRASATPSRTDRLFP
                     GDIAQFATAGGGLAFAHGAAGVLYALAESGAGRDEDGEQWLLERTKRPPSGMPLGFHDG
                     LAGLAWTLERLGHRDRALDLAELLLDQPLDHLGPDLHGGTAGLGLALESLAATTGQAAL
                     HSAALHCAELAADGLPGGSVPADRVSRGRARAGLLYGGAGRALLFLRLFERTRDSALLD
                     LARDALRQDLARCVRGAGGALQVDEGWRTMPYLGAGSVGIGMVLDDYLAHRADEEFARA
                     ANEIVAAAQAMFYAQPGLYRGVAGMVLHLGRTTATAPGTGPRAVRRQLDALSWHAMSYR
                     DRLAFPGEQMMRLSMDLSTGTAGCLLAVASVLGDAPAGLPFLPPPRRSGGPLTRPHQEP
                     "
     PFAM_domain     10799..11371
                     /aSDomain="Pkinase"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00069.28"
                     /db_xref="GO:0004672"
                     /db_xref="GO:0005524"
                     /db_xref="GO:0006468"
                     /description="Protein kinase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6681_0847"
                     /evalue="8.40E-10"
                     /gene_ontologies="GO:0004672: protein kinase activity"
                     /gene_ontologies="GO:0005524: ATP binding"
                     /gene_ontologies="GO:0006468: protein phosphorylation"
                     /label="SCO6681"
                     /locus_tag="SCO6681"
                     /protein_end="457"
                     /protein_start="266"
                     /score="38.6"
                     /tool="antismash"
                     /translation="GGGVYLARDTRTGARVVLKEARPHAGLAADGADAVTRLHRERRAL
                     ERLSGLACTPEVLDHRTVGEHHFLVLEHIDGKPLNTFFARRHPLIEADPGERRLAEYTD
                     WALDVHARVERAVAEVHARGVVFNDLHLFNIMVRDDDSVALLDFEAAHHVDEAGRQIVA
                     NPGFVAPPDRRGVAVDRYALACLRIVLF"
     repeat_region   11477..11584
                     /gene_synonym="SC5A7.31"
                     /locus_tag="SCO6681"
                     /note="6x 18 bp repeats"
     misc_feature    11880..16859
                     /note="99.98% identical (1 conflict) to SC03771 U03771
                     Streptomyces coelicolor A3(2) aerial mycelium formation
                     gene cluster (ramA, ramB, and ramR) genes from 1 to 4980"
     regulatory      12819..12823
                     /note="possible RBS upstream of SC5A7.32"
                     /regulatory_class="ribosome_binding_site"
     PFAM_domain     12831..12956
                     /aSDomain="RamS"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF19402.2"
                     /description="Lanthionine-containing peptide SapB precursor
                     RamS"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6682_0848"
                     /evalue="5.70E-17"
                     /label="SCO6682"
                     /locus_tag="SCO6682"
                     /protein_end="42"
                     /protein_start="0"
                     /score="62.0"
                     /tool="antismash"
                     /translation="MNLFDLQSMETPKEEAMGDVETGSRASLLLCGDSSLSITTCN"
     gene            12831..12959
                     /db_xref="GeneID:1102121"
                     /gene_synonym="SC5A7.32"
                     /locus_tag="SCO6682"
     CDS             12831..12959
                     /codon_start=1
                     /db_xref="GeneID:1102121"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SC5A7.32"
                     /locus_tag="SCO6682"
                     /note="SC5A7.32, unknown, len: 42 aa; similar to CDS
                     upstream of S. griseus RamA TR:Q07642 (EMBL:D13614) (43
                     aa), fasta scores; opt: 154 z-score: 293.0 E(): 4.4e-09,
                     53.7% identity in 41 aa overlap"
                     /product="hypothetical protein"
                     /protein_id="NP_630757.1"
                     /transl_table=11
                     /translation="MNLFDLQSMETPKEEAMGDVETGSRASLLLCGDSSLSITTCN"
     CDS_motif       12831..12893
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MNLFDLQSMETPKEEAMGDVE"
                     /locus_tag="SCO6682_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12894..12959
                     /prepeptide="core"
                     /locus_tag="SCO6682_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="32.20"
                     /molecular_weight="1955.2"
                     /monoisotopic_mass="1954.0"
                     /core_sequence="TGSRASLLLCGDSSLSITTCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNLFDLQSMETPKEEAMGDVE"
                     /leader_location="[12830:12893](+)"
                     /alternative_weights="1973.2"
                     /alternative_weights="1991.2"
                     /alternative_weights="2009.2"
                     /alternative_weights="2027.3"
                     /alternative_weights="2045.3"
                     /alternative_weights="2063.3"
     gene            12995..14905
                     /db_xref="GeneID:1102122"
                     /gene_synonym="ramA"
                     /locus_tag="SCO6683"
     CDS             12995..14905
                     /codon_start=1
                     /db_xref="GeneID:1102122"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 258.4; E-value:
                     2.3e-78)"
                     /gene_kind="transport"
                     /gene_synonym="ramA"
                     /locus_tag="SCO6683"
                     /note="SC5A7.33, ramA, probable ABC transporter, len: 636
                     aa; N-terminus contains transmembrane domain, C-terminus
                     contains ATP-binding domain. Almost identical to TR:Q53818
                     (EMBL:U03771) potential ATP-binding membrane transport
                     protein RamA (636 aa)(99.8% identity in 636 aa
                     overlap)Y08A_MYCTU hypothetical ABC transporter ATP-binding
                     protein MTCY50.10 (631 aa), fasta scores; opt: 556 z-score:
                     414.6 E(): 7.4e-16, 28.1% identity in 626 aa overlap.
                     Contains sixteen degenerate GA repeats at C-terminus,
                     PS00017 ATP /GTP-binding match to entry PF00005 ABC_tran,
                     ABC transporters, score 139.50, E-value 6e-38. Some
                     similarity to RamB (E(): 3.7e-05, 32.7% identity in 627 aa
                     overlap)"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="NP_630758.1"
                     /transl_table=11
                     /translation="MSPAAGAPGSGPGRRRLPALDVRRFSPVRKSRPVPPRAPGRALEV
                     LVLLCSVAAAVAAVAQPLALGRTLDLLLRDGDAGWWLPLSAALLLGELLLDSATSLFTG
                     RCNATWTASVRTRALRGLLRTAPEHARPYPPGDIGTRLTLNAADAGGAPAARAALAASL
                     ITPLGALVALALVDVWVALCVLTGLPALALLLRSFARDTGATVAAYQRTQSLIASRLLE
                     ALEGADTIGAAGTGERERARVLAPLAELAAQGRHMWALHGRALGRSGVLVPLLTLAATA
                     VGGLRLAAGELSVGDLLAVGRYAQLTAGVGAAASLLGAIVRAREARRRTRELERMTATV
                     YGTRRLPPNGPGELRLCGVRVLRGGREVLRADGVRVPGGSTVAVVGRSGAGKSVLAAVA
                     GRLIDPDEGYVLLDGVRLDRLTHEALRTEVAYAFERPVLGEGTIAEAVADGARRSSRER
                     VRQAARAAGADGFVRRLPHGYDTPLPRAPLSGGEHQRLGLARAFAHAGRLLVLDDATSS
                     LDTATEHEVDLALRRSVRPGTRLVVAHRPSVADRADLVLWLEDGQVRAVGTHRELWHTA
                     GYREVFGAGAGAGAGAGAGAGADAGAGADAGPGPDSGAATAVGGSGPGPVRRPEPEEAR
                     P"
     PFAM_domain     13130..13894
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00664.26"
                     /db_xref="GO:0005524"
                     /db_xref="GO:0016020"
                     /db_xref="GO:0055085"
                     /db_xref="GO:0140359"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6683_0849"
                     /evalue="1.90E-17"
                     /gene_ontologies="GO:0005524: ATP binding"
                     /gene_ontologies="GO:0016020: membrane"
                     /gene_ontologies="GO:0055085: transmembrane transport"
                     /gene_ontologies="GO:0140359: ABC-type transporter
                     activity"
                     /label="SCO6683"
                     /locus_tag="SCO6683"
                     /protein_end="300"
                     /protein_start="45"
                     /score="63.9"
                     /tool="antismash"
                     /translation="LVLLCSVAAAVAAVAQPLALGRTLDLLLRDGDAGWWLPLSAALLL
                     GELLLDSATSLFTGRCNATWTASVRTRALRGLLRTAPEHARPYPPGDIGTRLTLNAADA
                     GGAPAARAALAASLITPLGALVALALVDVWVALCVLTGLPALALLLRSFARDTGATVAA
                     YQRTQSLIASRLLEALEGADTIGAAGTGERERARVLAPLAELAAQGRHMWALHGRALGR
                     SGVLVPLLTLAATAVGGLRLAAGELSVGDLLAV"
     PFAM_domain     14117..14542
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00005.30"
                     /db_xref="GO:0005524"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6683_0850"
                     /evalue="9.60E-21"
                     /gene_ontologies="GO:0005524: ATP binding"
                     /label="SCO6683"
                     /locus_tag="SCO6683"
                     /protein_end="516"
                     /protein_start="374"
                     /score="74.9"
                     /tool="antismash"
                     /translation="RVPGGSTVAVVGRSGAGKSVLAAVAGRLIDPDEGYVLLDGVRLDR
                     LTHEALRTEVAYAFERPVLGEGTIAEAVADGARRSSRERVRQAARAAGADGFVRRLPHG
                     YDTPLPRAPLSGGEHQRLGLARAFAHAGRLLVLDDATS"
     misc_feature    14129..14677
                     /gene_synonym="ramA"
                     /locus_tag="SCO6683"
                     /note="Pfam match to entry PF00005 ABC_tran, ABC
                     transporters, score 139.50, E-value 6e-38"
     misc_feature    14150..14173
                     /gene_synonym="ramA"
                     /locus_tag="SCO6683"
                     /note="PS00017 ATP /GTP-binding site motif A (P-loop)"
     repeat_region   14741..14836
                     /gene_synonym="ramA"
                     /locus_tag="SCO6683"
                     /note="16 x 6 bp degenerate repeats"
     regulatory      14891..14894
                     /gene_synonym="ramA"
                     /locus_tag="SCO6683"
                     /note="possible RBS upstream of ramB"
                     /regulatory_class="ribosome_binding_site"
     gene            14902..16728
                     /db_xref="GeneID:1102123"
                     /gene_synonym="ramB"
                     /locus_tag="SCO6684"
     CDS             14902..16728
                     /codon_start=1
                     /db_xref="GeneID:1102123"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 163.9; E-value:
                     9.7e-50)"
                     /gene_kind="transport"
                     /gene_synonym="ramB"
                     /locus_tag="SCO6684"
                     /note="SC5A7.34, ramB, probable ABC transporter, len: 608
                     aa; N-terminus contains transmembrane domain, C-terminus
                     contains ATP-binding domain. IdenticalTR:Q53819
                     (EMBL:U03771) potential ATP-binding membrane protein RamB
                     (608 aa) and similar tyo many e.g. Y07D_MYCTU hypothetical
                     ABC transporter ATP-binding protein MTCY02B10.13 (579 aa),
                     fasta scores; opt: 456 z-score: 443.0 E(): 1.9e-17, 31.8%
                     identity in 614 aa overlap. Contains sixteen degenerate PE
                     repeats between the N- andC-terminal domains. Also contains
                     PS00017 ATP /GTP-binding site motif A (P-loop), PS00211 ABC
                     transporters family signature and Pfam match to entry
                     PF00005 ABC_tran, ABC transporters, score 157.10, E-value
                     3e-43. Some similarity to RamA (E(): 2.7e-05, 33.4%
                     identity in 628 aa overlap)"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="NP_630759.1"
                     /transl_table=11
                     /translation="MTSTEAGALRRLAPPARRFLAHRKGVLVRLALWSLAESGQAFLVG
                     HAVARSVDEGFLAGDPRRGLLWLGVALVAVLSGARVVRGVFAQLAGVTEPLRDGLVRHA
                     VDRSMARAAPGGPGGTDRAAVSRLTNQVEIARDSFAGLVLTLRSFVFTAAGALLGLLSL
                     HPALLVVVLPPLAAGLALFLVTLRPMAAAQRRALAADEALGEHAASARAALRDLTACGT
                     GPGAERHGADLVADAAAAARTLAGWAAVRTAALGVAGHLPVLALLVAVEWLRGHGVSVG
                     ALLGAFTYLVQSLLPALHTLMTALGAAGSRLLVVLDRILGPEPEPEPEPEPEPEPELGS
                     GLEPEPEPASEPESGPSTASASAAAFAVHTAAAPAVELRSVTLSYGVRAEPVLDALDLR
                     VAPGEHLAVVGPSGIGKSTLTRLVAGTLAPSRGEVRVAGRVVTGRPAAELAALRVLVPQ
                     DAYVFSGTVGDNLAYLRTDPSPAELDAAVEAFGLAPLVERLGGLDATVRPAELSPGERQ
                     LVALVRAYLSPAPLLLLDEATCHLDPASEARAEKALAGRSGTLVVVAHRLSSAVRADRT
                     LVLDGIRAQSGTHAELLGRSPLYRDLTGHWNS"
     repeat_region   15865..15960
                     /gene_synonym="ramB"
                     /locus_tag="SCO6684"
                     /note="16 x 6 bp degenerate repeats"
     PFAM_domain     16078..16515
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00005.30"
                     /db_xref="GO:0005524"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6684_0851"
                     /evalue="1.90E-22"
                     /gene_ontologies="GO:0005524: ATP binding"
                     /label="SCO6684"
                     /locus_tag="SCO6684"
                     /protein_end="538"
                     /protein_start="392"
                     /score="80.4"
                     /tool="antismash"
                     /translation="LDALDLRVAPGEHLAVVGPSGIGKSTLTRLVAGTLAPSRGEVRVA
                     GRVVTGRPAAELAALRVLVPQDAYVFSGTVGDNLAYLRTDPSPAELDAAVEAFGLAPLV
                     ERLGGLDATVRPAELSPGERQLVALVRAYLSPAPLLLLDEAT"
     misc_feature    16108..16644
                     /gene_synonym="ramB"
                     /locus_tag="SCO6684"
                     /note="Pfam match to entry PF00005 ABC_tran, ABC
                     transporters, score 157.10, E-value 3e-43"
     misc_feature    16129..16152
                     /gene_synonym="ramB"
                     /locus_tag="SCO6684"
                     /note="PS00017 ATP /GTP-binding site motif A (P-loop)"
     misc_feature    16432..16476
                     /gene_synonym="ramB"
                     /locus_tag="SCO6684"
                     /note="PS00211 ABC transporters family signature"
     gene            complement(16733..17341)
                     /db_xref="GeneID:1102124"
                     /gene_synonym="ramR; SC6G3.01c"
                     /locus_tag="SCO6685"
     CDS             complement(16733..17341)
                     /codon_start=1
                     /db_xref="GeneID:1102124"
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 80; E-value:
                     2.4e-24)"
                     /gene_kind="regulatory"
                     /gene_synonym="ramR; SC6G3.01c"
                     /locus_tag="SCO6685"
                     /note="SC5A7.35c, ramR, two-component system response
                     regulator, len: >41 aa. Identical to TR:Q53820
                     (EMBL:U03771) potential response regulator for aerial
                     mycelium production RamR (202 aa), and similar to many e.g.
                     Streptomyces peucetius TR:Q54821 (EMBL:L37338) daunorubicin
                     biosynthesis regulatory protein dnrN (202 aa), fasta
                     scores; opt: 173 z-score: 382.4 E(): 4.6e-14, 65.0%
                     identity in 40 aa overlap; SC6G3.01c, ramR, probable
                     two-component system response regulator, partial CDS, len:
                     >201 aa; previously sequenced as TR:Q53820 (EMBL:U03771),
                     RamR, potential response regulator for aerial mycelium
                     production. Similar to many two-component system
                     transcriptional regulators e.g. TR:Q07640 (EMBL:AB006206),
                     AfmR, Streptomyces griseus transcriptional regulator
                     involved in aerial mycelium formation (210 aa), fasta
                     scores; opt: 466 z-score: 545.2 E(): 4.9e-23, 42.6%
                     identity in 202 aa overlap. An alternative start codon is
                     present at codon 4. Contains probable helix-turn-helix
                     motif at aa 158-179 (Score 1876, +5.58 SD). Contains Pfam
                     match to PF00196 GerE, Bacterial regulatory proteins, luxR
                     family"
                     /product="two-component system response regulator"
                     /protein_id="NP_733711.1"
                     /transl_table=11
                     /translation="MGEMVRIAVVHDEKLLRSALVQLLRSDDTLDVSSHCLDADGPELS
                     AALPADVCVVDGECLTGPEDAGAGRLRARYGDRLVVLATAKRPGVLRRAFDGGALGLVD
                     KNAPAHRLITAVHTVARGERFLDETLTVALLKGAEMPLTTRELGVLTLASQGAPIAEIA
                     ARLHLSRGTVRNYMATAVRKVGARNRVDAIRIVQSAGWT"
     misc_feature    16737..16859
                     /note="overlap with Streptomyces coelicolor cosmid 5A7
                     (EMBL:AL031107) from 40215 to 40337."
     misc_feature    16737..18508
                     /note="sequence equivalent to EMBL:U03771 from 4858 to
                     6629"
     misc_feature    complement(16739..16927)
                     /gene_synonym="ramR; SC6G3.01c"
                     /locus_tag="SCO6685"
                     /note="Match to PF00196 GerE, Bacterial regulatory
                     proteins, luxR family Score 52.54"
     PFAM_domain     complement(16757..16924)
                     /aSDomain="GerE"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00196.22"
                     /db_xref="GO:0006355"
                     /description="Bacterial regulatory proteins, luxR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6685_0852"
                     /evalue="7.10E-14"
                     /gene_ontologies="GO:0006355: regulation of DNA-templated
                     transcription"
                     /label="SCO6685"
                     /locus_tag="SCO6685"
                     /protein_end="195"
                     /protein_start="139"
                     /score="51.3"
                     /tool="antismash"
                     /translation="MPLTTRELGVLTLASQGAPIAEIAARLHLSRGTVRNYMATAVRKV
                     GARNRVDAIRI"
     gene            17870..18748
                     /db_xref="GeneID:1102125"
                     /gene_synonym="SC6G3.02"
                     /locus_tag="SCO6686"
     CDS             17870..18748
                     /codon_start=1
                     /db_xref="GeneID:1102125"
                     /gene_synonym="SC6G3.02"
                     /locus_tag="SCO6686"
                     /note="SC6G3.02, hypothetical protein, len: 292 aa; unknown
                     function, probable CDS suggested by GC frameplot,
                     positional base preference and amino acid composition.
                     Similar to TR:Q9RJY9 (EMBL:AL133210) Streptomyces
                     coelicolor hypothetical protein SCF37.12, 284 aa; fasta
                     scores: opt: 864 Z-score: 995.3 E(): 8.3e-48; 47.902%
                     identity in 286 aa overlap"
                     /product="hypothetical protein"
                     /protein_id="NP_630760.1"
                     /transl_table=11
                     /translation="MGWLAAGDTYEVALVEGRVVARSASAKSPAEGRRERTLPAEIRER
                     PEVVELQRFAEWLDRHAAECVAQVDNWMVSSLPVPTALLAQVWPDEAWQTALRDIVVVG
                     EGPDEVGFLRDADESQGLRVVNLDGETVRLTSRTVTMPHPVLLPDLEELRTFAAESGVV
                     QGVEQIHRATWPAPGDSDGGDTDVVTEFAGAEYRSWFHLSARATSLGYRISGSRVVDRI
                     RDAGRVFTASVGMSDPYTEEKAWTGGLSWSHGDGYRSLPLHEVGPVAYSEGMRMAAALH
                     AGRTVPTDGAE"
     PFAM_domain     17963..18502
                     /aSDomain="DUF4132"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF13569.9"
                     /description="Domain of unknown function (DUF4132)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6686_0853"
                     /evalue="2.50E-25"
                     /label="SCO6686"
                     /locus_tag="SCO6686"
                     /protein_end="211"
                     /protein_start="31"
                     /score="89.5"
                     /tool="antismash"
                     /translation="GRRERTLPAEIRERPEVVELQRFAEWLDRHAAECVAQVDNWMVSS
                     LPVPTALLAQVWPDEAWQTALRDIVVVGEGPDEVGFLRDADESQGLRVVNLDGETVRLT
                     SRTVTMPHPVLLPDLEELRTFAAESGVVQGVEQIHRATWPAPGDSDGGDTDVVTEFAGA
                     EYRSWFHLSARATSLGY"
ORIGIN
        1 ggggaccggg cggacatggc ggctcctggg gcacgggccg tcccagtatc aggaggagta
       61 cgggggcccg tcctcaccgg tgcgagggat attcgggcgc cagcccaggg cccgggagat
      121 gccgcgggcc gccagccgga ccgccgggac cagcgccggc acctgcgcgc cggcgtgcgg
      181 cacgacgacc gacacggcag cggtcacggt gccgtccggg ccgtgcaccg gggcggccac
      241 cgagagggcg tcgtcggtga tctgccggtc gctcaccgcc gctccggtgc gccgcacctc
      301 ggccagcacc cggcgcaggc gtaccgggtc ggtgatcgtg tacggggtga aggaggcgag
      361 cggaccggtg cggtacgcct cctggaactc cggttcgccg tgcgcgagca gggcgagccc
      421 gaccccggtg gcgtgcagcg gccagcgggc accgacgcgg atgtgcacgc cgatggacga
      481 ccgcgccgcc agccactcga tgtagacgac ctcgccgccg tcccgcaccg ccagctgcac
      541 gttctcgtgg gtcgcctcgt acaggtcctc cagatacggc cacgccacct gccgcagcgc
      601 gagaccgcgc ggggcgagcg cggcgatctc ccacgaccgc aggcccacgt ggtagacgcc
      661 cgcaccgtcc cgctccagcg caccccaccg ggtcagggcg cccaccagcc ggtgtgccgt
      721 ggtcaggctc agcccggccc ggcggctgat gtccgtcagg gacagggccg ggtgcgcgtg
      781 gtcgaacgcg gcgagcacgg cgagcagccg gtcgggggcg gtgggggtgg caggggcggt
      841 caccgggccg agggtagggg cccgcccgcc ccctggacag aggaaagggg aggtgcacgc
      901 gcggaggcac cggccgtgcc atgatcggcg ccgggcggaa gtgcggccgg gcgacggaag
      961 ggtgccaacg tgaggctgac gatgctgggc ggcggcgggt tccgcgtacc gctcgtgtac
     1021 ggggcgctcc tcggagaccg cggcgaggga cgcgtgagcg acgtcgtcct gcacgacctg
     1081 gacccggccc ggctgacggc ggtgacccgg gtactggccg aacaggcggc cggggtgccc
     1141 gacgcgccga cggtgaccgc gacgaccgac ctcgacgagg cgctgcgcgg cgccgacttc
     1201 gtgttctccg cgatccgcgt aggcggcctc cagggacgcg ccgacgacga acgggtggcg
     1261 ctcgcggagg gcgtcctcgg ccaggagacg gtcggcgcgg gcggcatcgc ctacgggctg
     1321 cggaccgtcc cggtcgccgt cgacatcgcc cgccgggtgg cccggctggc accggacgcc
     1381 tgggtcatca acttcaccaa cccggcgggc ctggtcaccg aggccatgtc ccggcacctc
     1441 ggcgaccggg ccatcggcat ctgcgactcg ccggtcggcc tcggccgccg cgtcgcccgc
     1501 gtgctgggcg ccgacccgga ccgcgccttc gtcgactacg tcggcctcaa ccacctcggc
     1561 tggctgcgcg gcctgcgcgt cggtggacgc gacgagctgc cgcggctgct ggccgacccg
     1621 gcgctgctcg gttccttcga ggagggccgg ctcttcggcg ccgagtggct gcgctccctc
     1681 ggcgccgtcc ccaacgagta cctgcactac tactacttca accgggagac cgtccgcgcc
     1741 taccaggagg ccggcctcac ccggggcgcg ttcctgcgcg accagcaggc ccgcttctac
     1801 gacgagatgc gccgccccga cgccccggcc ctcgccacct gggaccgcac ccgcgccgaa
     1861 cgcgaggcca cgtacatggc cgagaaccgc gagacggcgg gcgcgggcga acgcgaggcc
     1921 gaggacctgt ccggcggcta cgagaaggtg gcgctggcgc tgatgcgcgc cgtcgcccgt
     1981 gacgaacgcg ccaccctgat cctcaacgtc cgcaaccgcg gcacgctctc cgtcctcgac
     2041 gccgacgcgg tgatcgaggt cccctgcctg gtcgacgcga acggcgccca cccgatggcg
     2101 gtcgatccgc tgccggacca cgccaccggc ctggtccgcg cggtcaaggg cgtcgagcgc
     2161 gacgtcctgg ccgcggccgg gaccggctcc cgcgcggccg cggtccgtgc cttcgccctg
     2221 caccccctcg tcgactcggt cgacgtcgcc cgccgcctcg tcgacggcta ccgggcggtg
     2281 cacccgggac tggcctacct caggtgagcc ccacgggggc ggacgacgcc ggtgccgccg
     2341 ccctctctgc cggtgccggt gccggtgccg ctgccgctgc cggtgcgggg gccggtgccg
     2401 gtgtcgtcgc ggccgggagg tccgcgcgct ggtgcggcaa ggtcaccggg cgcagcggac
     2461 gcggtcccga caccaccgcg tagtcctgac ccaggaacgg cggctccagc tggcccgggt
     2521 cgtcgccgag ggccagccgg accgccgccc acggcacgtt gaccccgcac agcgccaact
     2581 ggtgcagtcc gcccgccggg cgggtgttga cgtccatcag gacgggccgg tcgccgtaca
     2641 tccggaactg cacgttggac aggtggtgca gcccgaacgt ctcggcgatc cgccgtgccg
     2701 gtgtcagcca ctggtcgtgc agggtgaacc cgcggcggcg gccgttcttg gtgcggccca
     2761 cggcgaggcg gacccggttg tccggcccgg tgaggcagtc caccgagacc tccggctgct
     2821 ccaggcgcgg catcaccagc cagtccacgg gctcctcggc cgcccgcagc gcctcgacga
     2881 ccaggggcag cggcacggac gggctcggga agccgttgag gtgggtcagg gagaaggggt
     2941 cccgggtgac catccggaag cccacgccgc ccgcgccgga ggccggcttg aagcacgccc
     3001 ggtggccgcc cgcctccagt tcctccaccg cgaggaccag ttcgtcggcc gtgcgcaccc
     3061 gccaccacgg cggcaccggc acgccgatcg cgcggaccgc ctcgtaggcg atcaccttgt
     3121 cccggaagac ggccaccgcc tcgggcggcg gcgcgagcag cgccgtaccc agcgcctcga
     3181 actcggcgcg gtgggccacg atcgcggact ggtgcagccg gggcacgaac acgtcgatgc
     3241 cgcgccgcgc gcactgggcc agggcgtact cgacgtaacc ggccggggag agcccctcgg
     3301 gctccagttc cgcggtgtcc gcggcggcca gcacggggga gtccgggtca ccgtgcgtgg
     3361 catggatctc gacggcccgg tcggcgggat ttctccgcag ctgatccatg aagaagacgt
     3421 tctccgcgta cgtgcggttg agccagacgc gtacgggaga agccatgcaa gccgccttcc
     3481 agggttcgcg ggcagggcga agcgggccgt gcccggccag gggtttggag ggacaccgag
     3541 ccgctctgcg cgaaaggaga gtcgtggcgg ggtgttgggg cgatcatagg ggtacgcgcg
     3601 gcccccagcg caacgagcgt cacacggatg ccccggcccg gccatgcggc ggcccccggg
     3661 acagtcgcac ggccgggccg ggtcgccttg tgacccgccc ggggatgtga tctcgtggcg
     3721 tcgaacgtgt gtctggaagg ggtgggggat gacgacgagg gccggggctc cggggaagct
     3781 gtgggccatc agcgatctgc acgtcggata cgaggagaac cgggccctgg tcgagcggac
     3841 gcgccccgag tccgacgacg actggctgct ggtggccggc gacgtggcgg agaccgtcgc
     3901 cgatatccgc tgggccctcg gcatcctcgc ggaccgcttc cgccgggtcg tctgggcccc
     3961 cggcaaccac gaactgtgga cacatcccaa ggacgcggtc gacctgcgcg gcgtcgcccg
     4021 ctacgagcac ctcgtcgaga tgtgccggga actgggcgtg accacccccg aggacccgta
     4081 cccggtgtgg gagggcgcgg gcggcccggc ggtcgtcgcg ccgctcttcc tgctctacga
     4141 ctactcgttc ctgcccgcgg ggtgtgcgac caaggccgag ggactggagt acgcccaggg
     4201 caccggcgtc gtgtgcagcg acgagtacct gctgcacccc gacccctatc ccagccgcga
     4261 ggactggtgc cgggcgcggg tcgccgagac cgagcgccgg ctcgccgcga tccccgcgga
     4321 cctgcccacg atcccggtca accactaccc gctgcaccgg caccccaccg acgtcctgtg
     4381 gtacccggag ttcgccatgt ggtgcggcac ctcgctgacc gccgactggc accgcaggtt
     4441 ccgggtggag accatggtct acgggcatct gcacatcccg cgcaccacct ggcacgaggg
     4501 ggtccgcttc gaggaggtct cggtgggcta tccccgcgag tggcgcaagc ggcccgggcc
     4561 gccggggcaa ctgcgccgca tcctgccgtc gacgcgggcg tccgcggcac cgtcgcacca
     4621 ggaggtgacc cgttgatcga ggaactgctg cccggcacgg tcgtcgccgt ggaggccttc
     4681 ggccaggacg acgccggtca cctgcccctg tatccggagg aggaggaact cgtcgcgcgg
     4741 gcggtcgcca agcggcgccg tgagttcacc gtggtgcggt cctgcgcccg ccgggccatg
     4801 gagaagctcg gcgtgccggc acagcccgtg ctgaccggcg agcgcggggc tccgcgctgg
     4861 cccgagggga tcgccggcag catgacccac tgcgacggct acggcgccgc cgccctggtc
     4921 cgcctgaccg acctggcctc gctgggcatc gacgccgaac ccgacgggcc gctcccggac
     4981 ggcgtcctgg agagcatcgc cctgcccgcc gaggtggccc tgctgcggcg gctgggcggc
     5041 gcgcggcccg gcgtccactg ggaccggttg ctgttcagcg ccaaggagtc ggtctacaag
     5101 gcgtggtacc ccctcaccgg gcagtggctg gacttcaccg aggcggacat cgagatccgc
     5161 gtggacccgg ccgacccgcg ccgcggcacc ctgcacgccg ccctcctggt gccgggaccg
     5221 accgtggacg gcaggcgcct gagccgcttc gacggccgct ggagcgcccg ggacggcctg
     5281 gtcaccacgg cggtcacggt cccgcgcacc tgaactgcgc ccgcccgccg gtcaggtggg
     5341 cgggcaccag tcccgcagca gccggaagaa cgcctcctcg ttccccgtca gtcccgcggc
     5401 ccgcagcgcc tgctccgcct cggccagcac ggagggcggg acgacgggcg ggcggggaga
     5461 gtcgccgggg cccgtcccgg tgtcgaaacc ggcccgcacg gtgtgcagga gccgcagata
     5521 ggcctggacg gcggtgcgtt cgcggtcggt cagtacggcg gtggtcatcg gtcggctctc
     5581 cccacaacga cgtcagcggt cacgcgcccc cgcacggcgg cggcaccctc ccagcttgcc
     5641 gtccaccact gacaatcccg gcctcacgac tcgggccgct tgacgctttc caggagcatg
     5701 tccagccact cggcgacctt gtcgcggtgc tggtcggtgg gcagttgcgc ggcccgccag
     5761 gcgatgccgc gcacgccgtg gtcctggagc agccgctcca acgggtcgtc ggcgggggcc
     5821 gccgcctgcc gctcccggtc ggcgagctgc tggagcagct cctgctcggt gcgctggagg
     5881 gcgcccgcga gcgcctcggg gtcctcggcg gtgaggaagc cggcgtgcac ccggaagaag
     5941 cgctggatgg cgtcgcagtg ctccatggtg gggcgccggt cgccgttgat gagcgcaccg
     6001 gcctgctgcc gcgacatccc ggcgccgtcg gctatctcct gctgggtgta cttgcggccg
     6061 ttcggcttca gccgggtgcg gcgcagcagg tccaggcgct gcacgaacct ggtctgcacg
     6121 tcggccccgc ccgtcggccg gcccccgagc agggccccga cgacggactc ggggacgccg
     6181 gaggcggcgg acagccggcc cacgtcgaag acctcggcgt gcggtacgtc gagccggtcc
     6241 gcgagggcgc cgacccgggc gacgacggcg gccagcgtgg tggtcggctt ggcgcccgga
     6301 ccttcgaagc cacccgtcac cgacagctct cctacgtctc tcacaggcct cacaggcttc
     6361 tcacaagcgg ttgccgtgaa cttcccggag agtagcctgc cgctcgaact cacatccagg
     6421 catcgccaca actgtggcct atttcagccg tcaacaggca cgaaatgcca cgatagttga
     6481 cacgcctcgc gtcggggcga caggatgcgg acgccgcgag aaggccgcat aggcaagagg
     6541 ggtgacctcc cgatggcatt tcaggcaggt gggcagcggc cggcgccgcg gcccgccccc
     6601 gcgacccccg aggcccaggc ctatctccag gactacaccg ccctcctgga ggccgtcccc
     6661 ttcccctctc tcgtcgtcga ccaccgctgg gacgtggtgc tggccaacgg cgccttccgg
     6721 acactcttcc agggcgccgg accgcacccg acggccatgc cggacgacaa cttcctccgg
     6781 ttcgtcctct tccacccgga cgccgccacg gtcctcggcg agcacgagtc gagctggtgc
     6841 ctgcccatgc tggcgcactt cgccgccacc ctggagcggt acggccacga ccccggactc
     6901 caggccgtcc gccgggacat cgcccaggac ccgatcatgg aggctgccta ccgccagggc
     6961 ctgccgcact ggatccgcgc cgtcggagcg cgggccgtcg aacacgacgg tgccgtgcgg
     7021 ccgctgcacc acccggaccc gcgccgcggc accaccgagt gccgggtcgt ggtcgaaacg
     7081 cccgcgtcgc tccaggagct gggctacacg cggttgacgc tggtcctcag ggagccgcgc
     7141 cgcgccgccc accgggcgcc acgtgcccgc cacacacccg cccacctgag agtcgtcccc
     7201 gccgccgagt gacgggtggt cagtgcgggg ggtggggcgg cggacagtac gatcacccgt
     7261 tcgcccaggt ggacggcctc gtcgatgtca tgggtgacga acaggaccgt gatgccccgc
     7321 tcccgccaca gcacccggac caggtccccg aggccggcgc gggtctgcgc gtcgaccgcc
     7381 gtgaagggtt cggccatcag cagcacctcg ggttcgtacg cccgcgcccg cgcgatggcc
     7441 acccgctgct gcatgccccc ggacaactgc cacgggtggg ccccggcggc gtccgcgagc
     7501 ccgaccggcg cgagcgcctc cgcgaccagc tccccgcacc gctccctgct caacgccgcg
     7561 tgcttcagca gaagttcgac gtgccggcag gtccggggcg cggccctggt ccacgcccgt
     7621 gccgagatgg gccgttgagg tttcaaccga gcaggtgccg ccgtcgagtc acaggtccag
     7681 cacgagccgt cggccccggc accgtgacac gcagatgagc atggtctccc cggcggcccg
     7741 ctcctcctcg gtgagcaccg agtcccggtg gtccggctcg ccctcgacga cctccgtctc
     7801 acaggtcccg caggtcccct ccgtgcagga gtagagcacc tcgacgcccg tctcgcggac
     7861 cgcgtccagg accgatgtgc cgggcgggac ggcgaccgta cggccactgc gcgcgaggac
     7921 gacctcgaac tccggccccg ccggggcctg cacggcagcc tccttcgggc ggaaccgctc
     7981 cacacgcagg ctcccggccg ggcagcgcgc ctcgaccgcg tccagcagcc cgccgggccc
     8041 gcagcagtag acaagggtgc ccggggccac gtcgtccagc acggacgcga ggtcgagcag
     8101 ccccgactcg tcctccggga cgatcctcac ccggtcgccg taccgctcca gctccttcgt
     8161 gaacgccatc ccggcccggg tccgcccgcc gtacagcagg ctccactcgg cgcccgcctc
     8221 ctcggcggcg gccagcatcg gcaggaccgg ggtgatgccg ataccgccgg cgacgaagcg
     8281 gtagcggggt gcccgctcca gccggaagtt gttgcgcggg ccgcgcaccc ggaccttgtc
     8341 cccggcccgc aactcttcgt ggacgtaggc cgagccgccc cgcccggcct tctcgcgcag
     8401 taccgcgacc cgccacaccg cccggtcgcc cgggtcgccg cacagcgagt actgacgctc
     8461 cagaccgggg ccgaggacga cgtcgacgtg ggcgccgggc tcccagaccg ggagcggttc
     8521 gtcccgcgga tggcgcaggg tgagcaccag cacgccgtcg gccgcggtct cccggcggcc
     8581 gacgacgagt tcggcttcgt agcgggtcat gaaccgtccc cgggcaggtc gtgtcctcgc
     8641 gggtgcgcga gcatccagtc ccacatcgcg accgggtcct cggcggtgtg ctcggcgccg
     8701 cagtggcagg tgccgtgcag cacgtcggtg ccggggagcc aggcgatgcg gtagatctcg
     8761 ccggtacgcc cgctcaccgg gccacccgcg gcccggtccc ggcgccctcg ccctcctcga
     8821 ccaggcgggc caggatgcgg cgggcggcca ggcccccggt gtcgatgttg atgctcagct
     8881 cctggtagcc ggcgcgctcg ccgccgagcg tacgctggag caggttgagc gcgtcgacgt
     8941 cctgcatgac gaccgtgcgg ttgctcttgt acaggaactc ggtgacctcg gcgtcgtccg
     9001 tcgcccagtc ccgggagacc gcccagaagt cgtacacctt cccgtcgccg gacggcgtga
     9061 tggcgtaggt gatctcggtg tggaagccct ccggatcacc gccgtcgggc gcgggcacgg
     9121 tcccggtcgg cgcgaccctg ctgtgcagca cgtacaggca gggcgcgtgg tactcgatgt
     9181 cctgccagcg gtcgatgcgc ccgacgatgc ccgtcgacct ggcgtagaac ggcgggcatt
     9241 cggcgtcgtc catgtgccgg ctcacccgga cgatgcccgc gccctcgtcg acctcggtgg
     9301 tgatcggcgt ctcggcgacc tcgggcgtgc cgatgtgacc gccgtgcaga taggtctcgt
     9361 gggagaggtc gagcaggttg tcgaccagca gcccgtagtc cgcgtcgatc ggctccatgc
     9421 cccggaccgt gacccagccc ggcgcgtcca ggtgccgggc ccgcggcacc gcctcggggt
     9481 cggccagcgc cgggtcgccg atccacaccc acaccaggga gtcccgctcg gccaccgggt
     9541 aggaggcgac gcgggcggtg cgcgggacgc gcttctggcc cggcacgtac acgcaggtgc
     9601 cggtcgtgtc gtaggtgaac ccgtggtacc cgcacacgat ccggtccccg tccagccggg
     9661 tgggcgcctc cgagagcgga tagcggcggt gcacacagcg gtcgtgcagg accaccgggc
     9721 cgccgtcctc ctcggcgcgg tagagcacga gcggttcgcc gaggaccgtg cgccccagca
     9781 actcgcgccc cacctcgtga ctgtaggcgg cgacgtacca ctggttcctg gcgaaggcgg
     9841 tcatgtgcgg catgcgcggc tcccgtcgtc ctcgacgtcg tgtggtcaca ccatcgccac
     9901 gccgttccgc cccggcaaca gcccttccgc cacgcggaat tctcccgctc cgggagtccc
     9961 gccgccgcga agttacttgt gcgttccgca cctcggagtg gtgacagccg caactgtccg
    10021 aggcggtacg ccgcgtgaca gcgtcgtctc cgtcagcaac cggtgggagg gagcaggcgt
    10081 gaacaagggc tacgccgtgt actgcgacgc ggacccgtac ttctacgacg ccccgcaccg
    10141 cacggccgac cggaccgggg ccgcgcgctc ccggtacgcc gccgcctcct cgccggtacc
    10201 ggaggggtgg cagcgccacg agagcgggga ctggctcgcg ctgcgtccgg ccgacgccga
    10261 cctgcccgcc caggggtgga agatccatgt ctccgcctgc ctcgacaacg cggagtccgt
    10321 gctcgaccgg gtgtggcggc actgcgtcga cggcggtacg gccttcaagt tcgtgcccag
    10381 ccgctacctg ctgcaccagc gcaacgccaa gtacgcggac cgggccggca gcggcaagtt
    10441 cgtcaccgtg tacccggcgg acgaggcgga gttcgaacgg ctcgtgggag agctgtcgga
    10501 actgctggcc ggcgagcccg gaccgcacat cctgagcgac ctgcggatcg gcgacgggcc
    10561 cgtgcacgtc cgctacggcg gcttcacccg gcgcgactgc tacgacgcgg acggggaact
    10621 gcggccggcc gtgtcaggac ccgacggtgt gctggtgccc gacctgcgcg gtccggtctt
    10681 ccgcatcccg gagtgggtcg acccgcccgc cttcctgcgc ccgcacctcg acgcccgctc
    10741 cgcggtgacc gtgaccggca tgccgtacac cgtcgagtcg gcgctgcact tctccaacgg
    10801 cggcggcgtc tacctcgccc gcgacacccg caccggtgcg cgggtcgtcc tcaaggaggc
    10861 ccgtccgcac gccgggctgg cggccgacgg cgccgacgcc gtgacccggc tgcaccgtga
    10921 acgccgggcg ctggagcggc tgtcggggct cgcctgcacg ccggaggtgc tcgaccaccg
    10981 cacggtcggg gagcaccact tcctcgtcct ggagcacatc gacggcaagc cgctcaacac
    11041 gttcttcgcc cgccggcacc cgctcatcga ggccgacccg ggcgagcgga gactggccga
    11101 gtacaccgac tgggccctcg acgtccacgc gcgggtggaa cgcgccgtcg cggaggtcca
    11161 cgcccggggt gtggtcttca acgacctgca cctgttcaac atcatggtcc gggacgacga
    11221 cagcgtcgcc ctgctggact tcgaggccgc ccaccacgtc gacgaggcgg gacggcagat
    11281 cgtggcgaac ccggggttcg tggcgcctcc cgaccggcgc ggggtggccg tggaccggta
    11341 cgcgctggcg tgtctgcgga tcgtgctgtt cctcccgctc accagtctgc tggccgtcga
    11401 ccggcacaag gcggcacacc tcgcggaggt ggtggcggag cagttcccgg tggaccgggc
    11461 gttcctggac gcggcggtcg aggagatcac gcgcgtcgac gggagcaccc gcgtcgacgg
    11521 gagcacgcgc gccgacgaga ccacgcgcgc cgacgagacc acgcgcctcg acgtgaccac
    11581 gcgcgtccat ggggccccgg acgcggcgcg gcggcccgcc ggtccggtgg cgcccgtccg
    11641 gccggacgac tggccgcgca gccgggactc catggcggcg gcgatccgcg cctccgcgac
    11701 gccctcccgc acggaccgcc tcttccccgg tgacatcgcg cagttcgcca cggcgggcgg
    11761 cgggctggcc ttcgcccacg gtgcggcggg ggtgctgtac gccctggccg agagcggggc
    11821 cggacgggac gaggacggcg agcagtggct gctggagcgg accaagcgac cgccgtcggg
    11881 catgccgctc ggtttccacg acgggctcgc cggactcgcc tggaccctgg agcgcctcgg
    11941 ccaccgcgac cgcgccctcg acctcgccga actcctcctc gaccagccgc tcgaccacct
    12001 gggcccggac ctgcacggcg gcaccgccgg tctcggcctg gccctggagt cgctggccgc
    12061 caccaccggt caggccgcgc tccactcggc ggcgctgcac tgcgccgaac tggccgccga
    12121 cgggttgccg ggcgggagcg tgccggccga ccgcgtcagc cgcggccgcg cccgagccgg
    12181 gctgctgtac ggcggcgcgg ggcgggccct gctcttcctc cggctcttcg aacgcacccg
    12241 ggactccgcc ctcctcgacc tcgcccgcga cgcgctgcgc caggacctcg cccgctgcgt
    12301 ccgcggcgcg ggcggcgcgc tgcaggtcga cgagggctgg cgcaccatgc cctacctggg
    12361 tgccggcagt gtgggcatcg gcatggtgct ggacgactac ctggcgcacc gggcggacga
    12421 ggagttcgca cgggccgcga acgagatcgt ggccgcggcc caggcgatgt tctacgccca
    12481 gcccgggctc taccggggcg tggccggaat ggtcctgcac ctgggccgca ccacggccac
    12541 ggcgcccggt acgggaccgc gggccgtacg gcgccaactg gacgccctgt cctggcacgc
    12601 catgtcctac cgcgaccggc tcgccttccc cggcgagcag atgatgcgcc tgtccatgga
    12661 cctctccacc ggaacggccg gatgcctgct cgccgtcgcc tccgtcctcg gcgacgcgcc
    12721 cgccggactg ccgttcctgc cgccgccgcg ccgaagcggc ggccccctga ctcggcccca
    12781 ccaggagccg tgagaaaagc acaccccttg ccgaacgaaa ggaatgcgtc atgaacctgt
    12841 tcgacctgca gtcgatggag acccccaagg aagaggccat gggggacgtc gagaccggca
    12901 gccgcgcgag cctcctgctc tgcggcgaca gcagcctgag catcaccacc tgtaactgac
    12961 acaggggttg acggccacgg cgacgtggtg agtcatgtcg ccggccgcgg gcgccccggg
    13021 ttccggcccg gggcgccgac gcctgccggc gctcgacgta cggaggttct cgccggtgcg
    13081 aaagagcagg cccgtgccgc cgcgggcgcc ggggcgcgcc ctggaagtcc tggtcctgct
    13141 gtgctcggtc gcggcggccg tggcggcggt ggcccagccc ctggccctcg gccgcaccct
    13201 ggatctgctc ctgcgcgacg gcgacgccgg atggtggctc ccgctgagcg ccgcactgct
    13261 cctgggtgaa ctgctgctgg acagcgcgac ctcgctgttc accggccgct gcaacgccac
    13321 ctggacggcg tccgtccgca cccgcgccct gcgtggactg ctgcgcaccg cccccgagca
    13381 cgcgcggccg tacccgccgg gcgacatcgg gacccgcctg accctcaacg ccgccgacgc
    13441 gggcggcgct ccggcggccc gcgcggcgct ggccgcctca ctgatcaccc cgctgggcgc
    13501 cctggtggcg ctggcgctcg tcgacgtgtg ggtggcgctc tgcgtgctga ccggtctgcc
    13561 cgccctggcg ctgctgctgc gctccttcgc ccgcgacacc ggcgccacgg tcgccgccta
    13621 ccagcgcacc cagtccctga tcgcctcccg gctgctggaa gccctggagg gagcggacac
    13681 gatcggtgcc gcgggaaccg gcgaacggga gcgggcccgt gtcctggcac cgctggcgga
    13741 actggccgcc cagggccggc acatgtgggc gctgcacgga cgggcgctcg gccggagcgg
    13801 tgtcctggtc ccgctgctga cgctggccgc caccgccgtc ggcgggctgc ggctggcggc
    13861 cggcgaactg agcgtggggg acctgctcgc cgtcggccgg tacgcgcagc tcacggccgg
    13921 cgtcggcgcg gcggcgtccc tcctcggggc gatcgtccgg gcccgcgagg cacggcgccg
    13981 gacccgggag ctggaacgga tgaccgcgac ggtgtacggc acgcggcggc tgcctccaaa
    14041 cggtccggga gagctgcgac tgtgcggggt gcgcgtgctg cgcggcggca gggaggtgct
    14101 gcgcgccgac ggcgtgcggg taccgggcgg cagcacggtc gcggtggtcg gccgcagtgg
    14161 ggcgggcaag tccgtcctgg cggccgtcgc gggacggctg atcgaccccg acgaggggta
    14221 cgtcctgctg gacggcgtcc ggctcgaccg cttgacgcac gaggcgctgc gcaccgaggt
    14281 ggcatacgcc ttcgaacggc ccgtactggg ggagggcacg atcgcggagg cggtcgccga
    14341 cggggcacgg cggtcgtcgc gtgagcgggt acgccaagcc gcccgggcgg cgggcgccga
    14401 cggcttcgta cgccggttgc cgcacggcta cgacaccccg ctgccgcggg caccactgtc
    14461 gggcggggag caccagcggc tcggactggc gcgggccttc gcgcacgccg ggcggctgct
    14521 ggtgctggac gacgccacgt ccagtctgga caccgccacg gagcacgagg tggacctggc
    14581 gctgcgtcgc tcggtgcggc cggggaccag gctcgtggtg gcgcaccgcc cgtcggtcgc
    14641 ggaccgggcc gacctggtgc tctggctgga ggacgggcag gtgcgcgccg tcggaaccca
    14701 tcgcgagctg tggcacacgg cggggtaccg ggaggtcttc ggcgcaggag caggagcagg
    14761 agcaggagcc ggagcaggag ccggagcgga tgccggtgcc ggtgctgatg ccggtcccgg
    14821 tcccgattcc ggtgccgcca ccgccgtcgg cggcagtggc ccggggcccg tacgccgtcc
    14881 ggagcccgaa gaggcgcgcc cgtgacgtcc acggaggccg gggcgctgcg ccgcctcgca
    14941 ccgccggccc gccgcttcct cgcccaccgc aagggggtgc tggtacggct cgcgctctgg
    15001 tcgctggccg agtcggggca ggccttcctg gtcggccacg cggtcgcgcg ctccgtcgac
    15061 gaggggttcc tcgccggtga tccgcgccgg ggactgctgt ggctcggggt cgcgctggtc
    15121 gccgtactgt ccggcgcccg ggtcgtccgg ggcgtgttcg cgcagctcgc cggggtgacg
    15181 gagccgctgc gcgacggcct ggtgcggcat gcggtcgacc ggtccatggc ccgggcggca
    15241 ccgggcggcc ccggcgggac ggaccgcgcg gccgtctcgc ggctgacgaa ccaggtggag
    15301 atcgcccggg acagcttcgc cggtctcgtc ctcaccctgc ggtccttcgt cttcaccgcc
    15361 gccggcgcac tgctcggcct gctgtccctg cacccggccc tgctcgtggt ggtgctgccc
    15421 ccgctggcgg ccgggctcgc gctgttcctg gtcacgctgc ggcccatggc ggccgcccag
    15481 cgccgggccc tggcggccga cgaggcgttg ggcgagcacg cggcgagcgc gcgtgcggcg
    15541 ttgcgggacc tcaccgcctg cgggaccggg cccggggcgg agcggcacgg cgcggacctg
    15601 gtcgccgacg ccgccgcggc ggcccggacg ctggccggat gggcggcggt gcgcacggcg
    15661 gcgctcggcg tcgcgggcca cctgcccgtg ctcgcgctgc tggtggcggt ggagtggctg
    15721 cgcgggcacg gggtgagcgt gggggcgctg ctgggcgcgt tcacctacct cgtccagtcc
    15781 ctgctgcccg ccctgcacac cctgatgacc gcactgggcg cggccgggtc ccggctgctg
    15841 gtcgtcctcg accggatcct cggcccggag ccggagccgg agccggagcc ggagccggag
    15901 ccggagccgg agttggggtc ggggctggag ccagagccag agccagcgtc agagccagag
    15961 tcggggccga gcaccgcgag cgcatcggcg gcggcattcg cggtgcacac cgccgcggcc
    16021 ccggcggtgg agctgcggtc cgtcaccctg tcctacggcg tccgggccga gcccgtgctc
    16081 gacgcgctcg acctgcgcgt cgcgccgggt gaacacctcg ccgtcgtggg accgagcggc
    16141 atcgggaagt ccaccctcac ccgcctcgtc gcgggaacgc tcgcgccgag ccgtggcgag
    16201 gtacgcgtgg ccggccgcgt ggtgacgggg cgccccgccg ccgagctcgc cgcactccgg
    16261 gtgctggtcc cgcaggacgc ctatgtgttc tccggcaccg tcggcgacaa cctcgcctac
    16321 ctgcggacgg acccgagccc ggccgaactc gacgccgcgg tcgaggcgtt cggtctcgca
    16381 cctctggtcg agcggctggg cgggctggac gccacggtgc gccccgccga gctctcgccg
    16441 ggggagcggc aactggtcgc gctggtccgc gcgtacctgt cgcccgcccc cctgctgctg
    16501 ctcgacgagg ccacctgcca tctcgatccg gcctccgagg cccgcgcgga gaaggccctc
    16561 gccgggcggt ccgggaccct ggtcgtggtg gcgcaccggc tgtcctcggc cgtccgtgcg
    16621 gaccggaccc tggtgctgga cggcatacgg gcgcagagcg gaacgcacgc cgaactgctg
    16681 ggccgttcgc ctctctaccg ggacctgacg ggacactgga actcgtgacg ggtcaggtcc
    16741 agccggcgct ctgcacgatg cggatcgcgt cgacgcggtt gcgggcaccc accttccgga
    16801 ccgccgtggc catgtagttg cggaccgtcc cccgggacag gtgcaggcgc gccgcgatct
    16861 cggcgatcgg cgccccctgg gaagccaggg tcagcacgcc cagttccctc gtggtcagcg
    16921 gcatctccgc acccttcagc agggccacgg tgagcgtctc gtccaggaag cgttcgcccc
    16981 gggcgaccgt gtgcacggcg gtgatcagcc ggtgggccgg ggcgttcttg tcgaccagcc
    17041 cgagggcgcc cccgtcgaac gcccggcgca gcactcccgg ccgcttggcg gtcgcgagga
    17101 ccacgagccg gtccccgtac cgggcccgca ggcgtccggc tcccgcgtct tccggccccg
    17161 tcaggcactc tccgtccacg acacagacgt cggcgggcaa tgccgcactc agctccggac
    17221 cgtcggcgtc gaggcagtgc gaggacacgt ccagcgtgtc gtcggatctg agcagttgca
    17281 ccagtgccga ccgcagcagc ttctcgtcgt gcaccacggc aatacgaacc atctccccca
    17341 ccccttgtca gcggcggccc cgttcgggcc accgggctcc gcgcgccccc gcgccctcgg
    17401 gccatgtgcc cccatccggg acggcggaac acgacacgta cgcacgtgcg aaccgcatcg
    17461 gaggcaattc gccgtcgtca gggccttgtc gggggacggc cgagacgggt gcggcagcga
    17521 agaagggcgg ataacacacc aatccgcgga cggcttcggc ccgtgcgtga accgacggga
    17581 gtccgccgtc ttcgcgtcgc ggcccctggc gtcctggcca gggcgggttc cgctgcccgg
    17641 ggccggccgc gcccgccgcc cgggcccgac cggccggcgg tccgggcgac accgggcccg
    17701 gccgaaaagc gccgctgtcc aatgtggcgc gaaaggcacc gcgcgatcgg ctcccgtggc
    17761 tgtcggtggg tgcccctagt ctttggccaa cgccacagcg gagcgtgccg gttcaggggc
    17821 cccgtgtgct gtgccgtgtg ttcctagtag tgggagaggc gaagagctga tgggttggct
    17881 ggcagcgggc gacacgtacg aagtcgccct ggtggagggc cgggtggtgg cgcggtccgc
    17941 gtccgcgaag tccccggcgg agggcaggcg ggaacgaacg ctgcccgcgg agatacggga
    18001 gcgccccgag gtggtcgaac tccagcgctt cgccgagtgg ctggaccggc acgccgccga
    18061 atgcgtggcg caggtcgaca actggatggt gtcctcgctc ccggtgccca ccgcgctgct
    18121 cgcgcaggtc tggcccgacg aggcgtggca gacggccctg cgggacatcg tcgtggtcgg
    18181 cgagggcccc gacgaggtcg gcttcctgcg cgacgcggac gagtcgcagg gactgcgggt
    18241 ggtgaacctg gacggggaga ccgtccgcct gacctcccgc acggtgacca tgccgcaccc
    18301 ggtcctcctc cccgacctgg aggaactgcg taccttcgcc gccgagtcgg gcgtggtgca
    18361 gggcgtggag cagatccacc gggccacctg gccggcgccc ggggactccg acggcggcga
    18421 caccgacgtg gtcaccgagt tcgcgggtgc cgagtaccgc tcgtggttcc acctgtccgc
    18481 ccgcgccacg tccctcggtt accggatctc cgggagccgc gtcgtcgacc gcatccggga
    18541 cgccggtcgc gtcttcaccg cctccgtcgg catgagcgac ccctatacgg aggagaaggc
    18601 ctggaccggc ggcctgagct ggagccacgg ggacgggtac cggtctcttc cgctgcacga
    18661 ggtcggcccc gtcgcctatt ccgagggcat gcgcatggcg gcggccctgc acgccggccg
    18721 caccgtgccc acggacggcg ccgagtgaac gccaccgcga tacgcacacc cacgaaaggc
    18781 acgcgatcat gagcgacggc acgacacggc acggggcggc ggaagaggtg gcggagctgc
    18841 tgcgctccgg agccgtgttg ccgcccggca ccaccggggg cggcgaccgc gccgtgcccg
    18901 tgttcacccg ggcctaccgg catccggggc tggacgaccg gatcgtcgta cgtctgacgc
    18961 ccgccgaccc gtccggcacg gaacccgccg cgggagaccc ggcgggcggg gacggtggcg
    19021 ggttcctcgg gctgctgccc gtgggcgagc cggtcgaggt cggcgtcgga cagcaccggg
    19081 ccatgggctt tcccgagtgg gtgctggtcc gccaccccac cgacggccac ctcgcgatgt
    19141 ccctggtcga ggagatgaac aaggtcgcca ggacggtgcg ctcccgggcg aagagggccc
    19201 gcgccaccta cgagtcgatc ggcgcccgcc tcgcgggttc cgtgccgcac ttcctgccca
    19261 ccttctacga ggaggccggc cgggtgttcc tggccgccgg cgagaaggcc tacgcctcgc
    19321 agatgttcgt caacgcgcgc aaggccgaga cggcccatgc cctgccgttc gacgaggccc
    19381 gcatggacgc ggtgttcctg gagttcgccc tcgccgacgc catgccgacc aaggtgctct
    19441 ccagttacgc caagggactc tcgtcccggg tgccggccgc caccgcctac cggcacctgc
    19501 gcgggctctt cgtccggctc gccgcgcacg gcgtggcccc gtcgagcccc ggcgcgggtg
    19561 acctgcgaaa gctggcgaag gccgtcgcgg gcaggaacgc tctcgccgag gagatggcgt
    19621 acctgcgcga ggtgctgccg ctgcccggca cccgcaaggc accacccggc tggtggaagg
    19681 cccaccgggc cgccctgctg gaactgagcc ggcgcgaacc cgccgcccgc ggcaccctgc
    19741 tcggactgct cccctcggag tgggagcacg aggagctggg gcagtggctc gacctgctgg
    19801 acaagaccgg cgccaccgag ggactgtgcg acgccacgct gcccgccgag gcccggtcac
    19861 ccgacggcac cgccggctgg acccgcaggt tcctcgccct gtgccgcacc cacgagcggt
    19921 acctcgcgcc gtccgagctg taccccctcg tggaccgcat ggccggtgcc ctgcgcgccg
    19981 aactgaacga cgagaacgct acgttgcggc ccccggtcgg cgacgtcgac cttctcgacc
    20041 agctcctcgc cctggacgtc ccggtcggcg accccgaggc ccgcccgtgg ctcaacctcc
    20101 aggactgggc ggcccgcgac ggacggcgcg acctcctcgc cctggcggcc gacacccgct
    20161 tccgagaagt cttccggagc ggctgcccca cctacgagcg cgagggcatc gacaagcgca
    20221 ccgtggcccg gctggccgag tcgccgggcg gccgcccgat gctcgccgag tgggtggccg
    20281 gggtcagccg cggctacctc atctgcggac tgggcgactt caccctcaac agcggcccgt
    20341 tccagacgct gaactggctg ccgggcgaga tcctggcgac cgccgagcag gaggtgcggg
    20401 acgcgctggg caccggcatg gcgcccgtgc tgggccgcgc cctgcggaac ggcctgctcg
    20461 acgaactggg ctggcccgcc tgggacgagg cgatcggctc gtccgcgtcc ccggagcagg
    20521 cccgggcgac acaggtggcg gaggcctggc cgcacctcgt cgtccttcag ggcacgcacg
    20581 cccgggtgct cggcgcgcag ggcacggtcc tcagccacca gctccgcctc ccggacgagc
    20641 ggggcccggg cagccccgac gtccggtacg tggacggcgc actgctcgtc tcttggtacg
    20701 tgtccgccac atccacctcg tacggctact ggtaccaccc cgacacgggc gtctcgccga
    20761 ccacggaact caccggcgac gtccgttcct gctacgcctg ccacgcggac ggcagcggcg
    20821 ggacgaacgg catgccgccc gcctcactcc cgctccccgg gggcggcagg accaccggcc
    20881 acggcgtgct gcgacccggg gacacccacg ttccgtggcg gcgccgggtg atcggcgacg
    20941 gcacctcgca ctgggtctgg atcgacgact ggtcccgcga gaagaacagc acctggcacg
    21001 cctacgagcc ggccgacgac acggcggggg agcgcggggg cccggactgg ttcgccgaag
    21061 ggctgcgcgc cgcaccggag ggcagcactc tcggcgcctg ctggctgctg cccgccccgt
    21121 ccgccgaacc gggcccggtg tgcgccccgg tggacgggct gctcggctgg cgggtgatca
    21181 tcgggcccga cggctcgcgg cacggacagg acctggccgg ccactcggtc gtcgtaccgc
    21241 ggcgcgtggg cgggagcccg gagaacgcgc tggtcttccc aggcaccgac cgggccgtca
    21301 ccgtgatgcg atggtcgagc gacctccaac tgcgggactc cgaccaggcg gtgctcgccc
    21361 acttcaagcg tgatcagaca gccggtccct tctccgcggg cacccccctg ctgccgcccc
    21421 tgcgctactg gcacctgctc cggccccgcg acccgcaggg ctccgcggcg ctccgccggg
    21481 tcggcgacga cgtcgcggcg gagctgctgg cggcggccgt cgccgagacg accggagacg
    21541 gggcggcgga ccgggacgcg gtgctcggcc ccgtccgcac gctcttcccg gaggtcggcg
    21601 acgaggcgct gctccggggc atcaccggcg tggcgcgcta cgccgccgag cagcagcgcg
    21661 tcctggacgg gctgctcgcc cggctggact cggcggtccg gggcgtcgtc ccggaggaac
    21721 agcggcccgc actcggcgac cgcctgctcg cctccgcgct gaacggcgtc ggcctgaccg
    21781 aacgcgacgc acgctggtac tacgacttcc agcacagcct cttcgagctt ccgcagctcc
    21841 tcgcccggtc gatgaagggc ctggccgaac cggctcccgc gggcatcttt cacctgtcgc
    21901 tcgccaagca ggagccgttg gagcacctca acgggctggc cctgcccgag ttgcccgccg
    21961 tactggccct ccgggcggcc tcggaagcca ccgaggagga acaccggcag gccctggaca
    22021 ccttcctcgg cgaactggac gcgcacgggc tgacggaact ggaccccggc cactggcgcc
    22081 gggtgcacct ggccttcgac cccgacacct tcgacggacc gggcgacacg cacggctaca
    22141 ggagagggac cgtgctcaac ctggagggcg gcgcgttcct cgtcttcccc gacgactggt
    22201 accagttcgt ccgcgagtac ggaccccacg aggtcaaggg caagcactac ggggcggcct
    22261 accacgaccc gtccggccgc ttcgagacgc cggcccccta cacgccggtg tccgaggagc
    22321 cgttcgtccc ggagccgacc cgggcgcccg gctgggtcgc cgccttccgt gccgaactgg
    22381 ccgagcgcgg ccccgtgccc tggcgccccg aggccgccga ggagttcgcc cggctcaccg
    22441 gcgtcacccc gaccacggcc cggctggtgc tcgccggcat gccgcagacc gacgacaaac
    22501 gcgcgaacgt gccctccgcg accctgaagg tcatcggggt gaagtcggcc gacgcccgtg
    22561 tgtccaagga cgaactgaga tcgctcgaca gcgccgccct gcgggccgtg gtggcggcac
    22621 tgctgcccac cgaaccgtcc cggctctgga cgcacggccc cgacaccgcc cgcgcggccg
    22681 aggtctggaa cgagcggctg ggcagacgca ccccgctgcc cgaagacgtg ctgcacgacg
    22741 ccgtccgcac cgtcgaaccc gtcggctggg cacccgccga cgccctgcgg ggc
//
