LOCUS       NC_003888              22181 bp    DNA     linear   CON 03-AUG-2016
DEFINITION  Streptomyces coelicolor A3(2) chromosome, complete genome.
ACCESSION   NC_003888
VERSION     NC_003888.3
KEYWORDS    RefSeq; complete genome.
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces; Streptomyces
            albidoflavus group.
REFERENCE   1  (bases 1 to 8667507)
  AUTHORS   Hsiao,N.H. and Kirby,R.
  TITLE     Comparative genomics of Streptomyces avermitilis, Streptomyces
            cattleya, Streptomyces maritimus and Kitasatospora aureofaciens
            using a Streptomyces coelicolor microarray system
  JOURNAL   Antonie Van Leeuwenhoek 93 (1-2), 1-25 (2008)
   PUBMED   17588127
REFERENCE   2  (bases 1 to 8667507)
  AUTHORS   Bentley,S.D., Chater,K.F., Cerdeno-Tarraga,A.M., Challis,G.L.,
            Thomson,N.R., James,K.D., Harris,D.E., Quail,M.A., Kieser,H.,
            Harper,D., Bateman,A., Brown,S., Chandra,G., Chen,C.W., Collins,M.,
            Cronin,A., Fraser,A., Goble,A., Hidalgo,J., Hornsby,T., Howarth,S.,
            Huang,C.H., Kieser,T., Larke,L., Murphy,L., Oliver,K., O'Neil,S.,
            Rabbinowitsch,E., Rajandream,M.A., Rutherford,K., Rutter,S.,
            Seeger,K., Saunders,D., Sharp,S., Squares,R., Squares,S., Taylor,K.,
            Warren,T., Wietzorrek,A., Woodward,J., Barrell,B.G., Parkhill,J. and
            Hopwood,D.A.
  TITLE     Complete genome sequence of the model actinomycete Streptomyces
            coelicolor A3(2)
  JOURNAL   Nature 417 (6885), 141-147 (2002)
   PUBMED   12000953
REFERENCE   3  (bases 1 to 8667507)
  AUTHORS   Redenbach,M., Kieser,H.M., Denapaite,D., Eichner,A., Cullum,J.,
            Kinashi,H. and Hopwood,D.A.
  TITLE     A set of ordered cosmids and a detailed genetic and physical map for
            the 8 Mb Streptomyces coelicolor A3(2) chromosome
  JOURNAL   Mol. Microbiol. 21 (1), 77-96 (1996)
   PUBMED   8843436
REFERENCE   4  (bases 1 to 8667507)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-MAY-2002) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
  REMARK    Direct Submission
REFERENCE   5  (bases 1 to 8667507)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAY-2002) Sanger Institute, Wellcome Trust Genome
            Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
  REMARK    Direct Submission
COMMENT     ##antiSMASH-Data-START##
            Version     :: 8.0.1
            Run date    :: 2025-05-26 12:13:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start :: 6656218
            Orig. end   :: 6678399
            ##antiSMASH-Data-END##
            REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645882.
            On Jun 22, 2003 this sequence version replaced NC_003888.2.
            RefSeq Category: Reference Genome
            MOD: Model Organism
            UPR: UniProt Genome
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22181
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="19"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22181
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22181
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12181](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12181
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    277..489
                     /gene_synonym="SC9B1.11"
                     /locus_tag="SCO6064"
                     /note="Pfam match to entry PF00528 BPD_transp,
                     Binding-protein-dependent transport systems inner membrane
                     component, score 50.70, E-value 3.3e-11."
     misc_feature    319..332
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.06"
                     /tool="antismash"
     gene            686..1648
                     /db_xref="GeneID:1101506"
                     /gene_synonym="SC9B1.12"
                     /locus_tag="SCO6065"
     CDS             686..1648
                     /codon_start=1
                     /db_xref="GeneID:1101506"
                     /gene_synonym="SC9B1.12"
                     /locus_tag="SCO6065"
                     /note="SC9B1.12, probable substrate-binding protein, len:
                     320aa; similar to many eg. TR:O69725 (EMBL:AL022121)
                     hypothetical protein from Mycobacterium tuberculosis (315
                     aa) fasta scores; opt: 574, z-score: 637.7, E(): 3.4e-28,
                     (35.8% identity in 313 aa overlap) and SW:PROX_BACSU
                     glycine/betaine/L-proline binding protein from Bacillus
                     subtilis (313 aa) fasta scores; opt: 136, z-score: 157.8,
                     E(): 0.18, (25.7% identity in 311 aa overlap). Contains
                     possible N-terminal signal sequence."
                     /product="substrate-binding protein"
                     /protein_id="NP_630174.1"
                     /transl_table=11
                     /translation="MNFTAKSSRSRTRHTGAAAVALTAAAALLAGCSSDSDGTSDNPLA
                     GDKAEAGTVVVGSNNFAESTLLADIYGEALKAKGLKVTYKHNIGSRETTYGMMKNGSVT
                     VLPEYNGSLLAYLDPKARQKSVEAVNEAAKAKLDKKLTLLESSPAENKDSVSVNAETAK
                     KHGLTAESTLADLKDVAPDLVIGGSPEFQTRQQGLKGLESVYGLKFKSFKALDAGGPLT
                     QSALTKNDVQAADVFTTDPTIIKEKFVVLKDPENLFGHANVTPLVTKDGLNEEGVATLN
                     AVSAKLDTETLLDLDAQVQLDKKDPLDVAKEWLKSAGLV"
     PFAM_domain     842..1630
                     /aSDomain="OpuAC"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF04069.15"
                     /db_xref="GO:0022857"
                     /db_xref="GO:0043190"
                     /db_xref="GO:0055085"
                     /description="Substrate binding domain of ABC-type glycine
                     betaine transport system"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6065_0703"
                     /evalue="3.00E-54"
                     /gene_ontologies="GO:0022857: transmembrane transporter
                     activity"
                     /gene_ontologies="GO:0043190: ATP-binding cassette (ABC)
                     transporter complex"
                     /gene_ontologies="GO:0055085: transmembrane transport"
                     /label="SCO6065"
                     /locus_tag="SCO6065"
                     /protein_end="315"
                     /protein_start="52"
                     /score="184.4"
                     /tool="antismash"
                     /translation="TVVVGSNNFAESTLLADIYGEALKAKGLKVTYKHNIGSRETTYGM
                     MKNGSVTVLPEYNGSLLAYLDPKARQKSVEAVNEAAKAKLDKKLTLLESSPAENKDSVS
                     VNAETAKKHGLTAESTLADLKDVAPDLVIGGSPEFQTRQQGLKGLESVYGLKFKSFKAL
                     DAGGPLTQSALTKNDVQAADVFTTDPTIIKEKFVVLKDPENLFGHANVTPLVTKDGLNE
                     EGVATLNAVSAKLDTETLLDLDAQVQLDKKDPLDVAKEWLK"
     gene            complement(1680..2225)
                     /db_xref="GeneID:1101507"
                     /gene_synonym="cvnD6; SC9B1.13c"
                     /locus_tag="SCO6066"
     CDS             complement(1680..2225)
                     /codon_start=1
                     /db_xref="GeneID:1101507"
                     /gene_synonym="cvnD6; SC9B1.13c"
                     /locus_tag="SCO6066"
                     /note="SC9B1.13c, cvnD6, possible ATP/GTP-binding protein,
                     len: 181aa; similar to others egs. TR:O50391
                     (EMBL:AL009198) hypothetical protein from Mycobacterium
                     tuberculosis (193 aa) fasta scores; opt: 689, z-score:
                     849.1, E(): 0, (61.4% identity in 166 aa overlap) and two
                     ATP/GTP-binding proteins from Streptomyces coelicolor:
                     TR:O86519 (EMBL:AL031124) (174 aa) fasta scores; opt: 665,
                     z-score: 820.6, E(): 0, (55.0% identity in 171 aa overlap)
                     and TR:CAA19989 (EMBL:AL031124) (174 aa) fasta scores; opt:
                     662, z-score: 817.0, E(): 0, (55.6% identity in 171 aa
                     overlap). Contains Prosite match to PS00017 ATP/GTP-binding
                     site motif A (P-loop)."
                     /product="ATP/GTP-binding protein"
                     /protein_id="NP_630175.1"
                     /transl_table=11
                     /translation="MKILIAGGFGVGKTTMVGSVSEIAPLRTEEPLTAAGLDVDDLAGI
                     EEKRATTVALDFGRITIGRDVVLYLFGTPGQQRFWFMWNDLAIGALGAVVLVDVRRPES
                     SFAAIDFFERRGIPFVVAVNGFHGRHPYPAAEIREALALPEHVQVLLCDARERTSSRDV
                     LIALIDQLIDAAAGAAAS"
     PFAM_domain     complement(1707..2213)
                     /aSDomain="ATP_bind_1"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF03029.20"
                     /description="Conserved hypothetical ATP binding protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6066_0704"
                     /evalue="4.70E-29"
                     /label="SCO6066"
                     /locus_tag="SCO6066"
                     /protein_end="173"
                     /protein_start="4"
                     /score="102.0"
                     /tool="antismash"
                     /translation="IAGGFGVGKTTMVGSVSEIAPLRTEEPLTAAGLDVDDLAGIEEKR
                     ATTVALDFGRITIGRDVVLYLFGTPGQQRFWFMWNDLAIGALGAVVLVDVRRPESSFAA
                     IDFFERRGIPFVVAVNGFHGRHPYPAAEIREALALPEHVQVLLCDARERTSSRDVLIAL
                     IDQLID"
     misc_feature    complement(2184..2207)
                     /gene_synonym="cvnD6; SC9B1.13c"
                     /locus_tag="SCO6066"
                     /note="PS00017 ATP/GTP-binding site motif A (P-loop)."
     gene            complement(2278..2637)
                     /db_xref="GeneID:1101508"
                     /gene_synonym="cvnC6; SC9B1.14c"
                     /locus_tag="SCO6067"
     CDS             complement(2278..2637)
                     /codon_start=1
                     /db_xref="GeneID:1101508"
                     /gene_synonym="cvnC6; SC9B1.14c"
                     /locus_tag="SCO6067"
                     /note="SC9B1.14c, cvnC6, unknown, len: 119 aa; similar to
                     other hypothetical proteins egs. two from Streptomyces
                     coelicolor: TR:O86520 (EMBL:AL031124) (190 aa) fasta
                     scores; opt: 242, z-score: 321.0, E(): 1.5e-10, (39.8%
                     identity in 118 aa overlap) and TR:O86523 (EMBL:AL031124)
                     (132 aa) fasta scores; opt: 228, z-score: 305.7, E():
                     1e-09, (39.3% identity in 112 aa overlap), and TR:O50392
                     (EMBL:AL009198) from Mycobacterium tuberculosis (122 aa)
                     fasta scores; opt: 188, z-score: 255.2, E(): 6.8e-07,
                     (37.5% identity in 120 aa overlap)."
                     /product="hypothetical protein"
                     /protein_id="NP_630176.1"
                     /transl_table=11
                     /translation="MTGGDAAGRLVRPFTLTGGRTRPSRADFTLITTVTAIDPQPSRAA
                     RPQPEHLRILRLCAEPMAVAELAARLDLPVSVVVILLSDLLEAGRITARPPHPVSRATD
                     DLDLLQKVRDGLGRL"
     PFAM_domain     complement(2281..2622)
                     /aSDomain="DUF742"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF05331.14"
                     /description="Protein of unknown function (DUF742)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6067_0705"
                     /evalue="5.70E-40"
                     /label="SCO6067"
                     /locus_tag="SCO6067"
                     /protein_end="119"
                     /protein_start="5"
                     /score="135.8"
                     /tool="antismash"
                     /translation="AAGRLVRPFTLTGGRTRPSRADFTLITTVTAIDPQPSRAARPQPE
                     HLRILRLCAEPMAVAELAARLDLPVSVVVILLSDLLEAGRITARPPHPVSRATDDLDLL
                     QKVRDGLGRL"
     gene            complement(2639..3058)
                     /db_xref="GeneID:1101509"
                     /gene_synonym="cvnB6; SC9B1.15c"
                     /locus_tag="SCO6068"
     CDS             complement(2639..3058)
                     /codon_start=1
                     /db_xref="GeneID:1101509"
                     /gene_synonym="cvnB6; SC9B1.15c"
                     /locus_tag="SCO6068"
                     /note="SC9B1.15c, cvnB6, unknown, len: 119 aa; similar to
                     other hypothetical proteins egs. two from Streptomyces
                     coelicolor: TR:O86521 (EMBL:AL031124) (140 aa) fasta
                     scores; opt: 331, z-score: 424.2, E(): 2.6e-16, (41.5%
                     identity in 130 aa overlap) and TR:O86524 (EMBL:AL031124)
                     (137 aa) fasta scores; opt: 325, z-score: 416.9, E():
                     6.7e-16, (44.3% identity in 122 aa overlap), and TR:O50393
                     (EMBL:AL009198) from Mycobacterium tuberculosis (130 aa)
                     fasta scores; opt: 282, z-score: 364.1, E(): 5.8e-13,
                     (39.1% identity in 115 aa overlap)."
                     /product="hypothetical protein"
                     /protein_id="NP_630177.1"
                     /transl_table=11
                     /translation="MTRPSPATHTELDQLLTGLVERVADVNQAVVLSEDGLVVSKSTGF
                     LRDDAERLAATASGLMSLSKGVSMDFRGGPVRQALIEMANSYLILTSAGPGAHLVVLTG
                     PNADVGVVAYQMNMLVKKIGEHLSAAPRATAGPGE"
     PFAM_domain     complement(2750..3022)
                     /aSDomain="Robl_LC7"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF03259.20"
                     /description="Roadblock/LC7 domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6068_0706"
                     /evalue="8.30E-25"
                     /label="SCO6068"
                     /locus_tag="SCO6068"
                     /protein_end="103"
                     /protein_start="12"
                     /score="86.5"
                     /tool="antismash"
                     /translation="DQLLTGLVERVADVNQAVVLSEDGLVVSKSTGFLRDDAERLAATA
                     SGLMSLSKGVSMDFRGGPVRQALIEMANSYLILTSAGPGAHLVVLT"
     gene            complement(3055..5688)
                     /db_xref="GeneID:1101510"
                     /gene_synonym="cvnA6; SC9B1.16c"
                     /locus_tag="SCO6069"
     CDS             complement(3055..5688)
                     /codon_start=1
                     /db_xref="GeneID:1101510"
                     /gene_synonym="cvnA6; SC9B1.16c"
                     /locus_tag="SCO6069"
                     /note="SC9B1.16c, cvnA6, possible large hypothetical
                     protein, len: 877aa; similar to two neighbouring
                     hypothetical proteins from Streptomyces coelicolor
                     TR:O86525 (EMBL:AL031124) (1329 aa) fasta scores; opt:
                     1056, z-score: 919.5, E(): 0, (30.4% identity in 891 aa
                     overlap) TR:O86522 (EMBL:AL031124) (1111 aa) fasta scores;
                     opt: 804, z-score: 701.8, E(): 9e-32, (28.4% identity in
                     849 aa overlap). Contains possible N-terminal signal
                     sequence."
                     /product="large hypothetical protein"
                     /protein_id="NP_630178.1"
                     /transl_table=11
                     /translation="MPARKSRKKGARRRLGSIRLSLILLALVPGVTLAAVWGVTTIQMF
                     SEGLRLRAQTQLSRDTGAMGTEATLALQKERSLSAAWLAAPDGDRSELDAQRKKTDAAV
                     AQLVGQSDAIESAPTRVSDRLYSVLGSVGSLEYYRNQVDDPSDITAEQALDQYTSIVDE
                     QIHAFQELSQVDDGDLTSQAGPLVALEHAAELVSQEDARLTLAWPSGRMDEEQWSRFAQ
                     LVHTRRWLVQDQIVPSLTGSAKTQTERILASSEWKSLQDVEDQVLEARSAGRGDRIDLP
                     DARQRWITAFEKISTQYGQLIRQQTDGLLDRSAEEARGLLIKAGVLSAGGLIALLLCIV
                     MSWRITRSLSRRLRGLRLATLSLAEERLPDVVARLERGETVDVESATPPLDYGRDELGQ
                     VAQAFNAAQRTAVHTAVELADTRRGFQKVILGIARQSQNLVNMQLGKLDALEREHTDPE
                     ILKGLYELDSTASQLRRYEENLVIISGEQPRRTWREPVSLVDILRSAVGEVAEYQRVEL
                     HADEEVALAPPAVADVIHLLAELIDNATAYSPAPNPVGVRAALVAKGLAVEIEDRGLGL
                     SEEDYASFNAQLAVAPQFDVVALADDLRLGMFVVARLAHRHGITVTLRPSPYGGTTAIV
                     LIPHDIVVREPAGGADGPGAAANGARAPWVAAPTARDSADPAGPAIDTGSVTGTGTETG
                     QAAPGAAAGRSATASAAAGDPSGAPRPVRPVRSSRPAPAGPAAAGAGSPRGHSGASAHD
                     ASDGRGGLAPLPRRVPQTSLAAELRDEDPGGRRDGSDHAAADAYADFTAERAASSLAGF
                     QRGTLRAHTDDDADEAADPRAAHEADEAAEGVGGADDRATDGHALSSAAHSTPTADRRP
                     PTKDTR"
     PFAM_domain     complement(4459..4659)
                     /aSDomain="HAMP"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00672.28"
                     /db_xref="GO:0007165"
                     /db_xref="GO:0016020"
                     /description="HAMP domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6069_0708"
                     /evalue="1.50E-08"
                     /gene_ontologies="GO:0007165: signal transduction"
                     /gene_ontologies="GO:0016020: membrane"
                     /label="SCO6069"
                     /locus_tag="SCO6069"
                     /protein_end="410"
                     /protein_start="343"
                     /score="35.0"
                     /tool="antismash"
                     /translation="RITRSLSRRLRGLRLATLSLAEERLPDVVARLERGETVDVESATP
                     PLDYGRDELGQVAQAFNAAQRT"
     PFAM_domain     complement(4753..5478)
                     /aSDomain="NIT"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF08376.13"
                     /description="Nitrate and nitrite sensing"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6069_0707"
                     /evalue="1.00E-31"
                     /label="SCO6069"
                     /locus_tag="SCO6069"
                     /protein_end="312"
                     /protein_start="70"
                     /score="111.3"
                     /tool="antismash"
                     /translation="ALQKERSLSAAWLAAPDGDRSELDAQRKKTDAAVAQLVGQSDAIE
                     SAPTRVSDRLYSVLGSVGSLEYYRNQVDDPSDITAEQALDQYTSIVDEQIHAFQELSQV
                     DDGDLTSQAGPLVALEHAAELVSQEDARLTLAWPSGRMDEEQWSRFAQLVHTRRWLVQD
                     QIVPSLTGSAKTQTERILASSEWKSLQDVEDQVLEARSAGRGDRIDLPDARQRWITAFE
                     KISTQYGQLIRQQTDGLLDR"
     gene            complement(5757..6770)
                     /db_xref="GeneID:1101511"
                     /gene_synonym="SC9B1.17c"
                     /locus_tag="SCO6070"
     CDS             complement(5757..6770)
                     /codon_start=1
                     /db_xref="GeneID:1101511"
                     /gene_functions="transport (smcogs) SMCOG1205: ABC
                     transporter, carbohydrate uptake"
                     /gene_kind="transport"
                     /gene_synonym="SC9B1.17c"
                     /locus_tag="SCO6070"
                     /note="SC9B1.17c, possible solute binding protein, len:
                     337aa; similarity to many eg. SW:RBSB_BACSU D-ribose
                     binding protein from Bacillus subtilis (305 aa) fasta
                     scores; opt: 251, z-score: 270.5, E(): 9.6e-08, (26.4%
                     identity in 288 aa overlap). Contains possible N-terminal
                     signal sequence and Prosite match to PS00013 Prokaryotic
                     membrane lipoprotein lipid attachment site."
                     /product="solute binding protein"
                     /protein_id="NP_630179.1"
                     /transl_table=11
                     /translation="MSTAPPPTHSPGPARAAALTAAVCLLVAGCSALGGDEDGSAADAA
                     GGSGGDRMKIVMVTHGGEGDAFWDRVRKGAEAAAAKDGVDLTYAGDADTADQADLVRDA
                     IRDKADGIAVTLAKPQAMKAPVAEAKAAGIPVVGLNSGIDAWRSTGLLEYFGQDESVAG
                     RAVGDKLDDLRAKHALCVIHERGNVALEARCAGVKKTFGGETEMLYVEGTDMKAVGAAV
                     TARLRQDPSIDEVVMNGAAFALTAVEAVDEAGSDAHVATFDLDNDLVAAVKRGDVQFAV
                     DQQPYLQGYLAVDALWLYRTNGNVSGGGVAPVLTGPAFVTRTNADSVAEFAAGGTR"
     PFAM_domain     complement(5874..6605)
                     /aSDomain="Peripla_BP_4"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF13407.9"
                     /description="Periplasmic binding protein domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6070_0709"
                     /evalue="2.10E-37"
                     /label="SCO6070"
                     /locus_tag="SCO6070"
                     /protein_end="299"
                     /protein_start="55"
                     /score="129.3"
                     /tool="antismash"
                     /translation="VMVTHGGEGDAFWDRVRKGAEAAAAKDGVDLTYAGDADTADQADL
                     VRDAIRDKADGIAVTLAKPQAMKAPVAEAKAAGIPVVGLNSGIDAWRSTGLLEYFGQDE
                     SVAGRAVGDKLDDLRAKHALCVIHERGNVALEARCAGVKKTFGGETEMLYVEGTDMKAV
                     GAAVTARLRQDPSIDEVVMNGAAFALTAVEAVDEAGSDAHVATFDLDNDLVAAVKRGDV
                     QFAVDQQPYLQGYLAVDALWLY"
     misc_feature    complement(6681..6713)
                     /gene_synonym="SC9B1.17c"
                     /locus_tag="SCO6070"
                     /note="PS00013 Prokaryotic membrane lipoprotein lipid
                     attachment site."
     misc_feature    complement(6893..6909)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.22"
                     /tool="antismash"
     gene            7126..7773
                     /db_xref="GeneID:1101512"
                     /gene_synonym="cprB; SC9B1.18"
                     /locus_tag="SCO6071"
     CDS             7126..7773
                     /codon_start=1
                     /db_xref="GeneID:1101512"
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /gene_synonym="cprB; SC9B1.18"
                     /locus_tag="SCO6071"
                     /note="SC9B1.18, cprB, A-factor receptor homolog, len: 215
                     aa; previously sequenced therefore identical to TR:O66122
                     (EMBL:AB000385) CprB, A-factor receptor homolog from
                     Streptomyces coelicolor. Also similar to many others from
                     Actinomycetes e.g. TR:Q54189 (EMBL:D49782) A-factor
                     receptor from Streptomyces griseus (276 aa) fasta scores;
                     opt: 315, z-score: 392.1, E(): 1.6e-14, (36.5% identity in
                     219 aa overlap). Contains Pfam match to entry PF00440 tetR,
                     Bacterial regulatory proteins, tetR family."
                     /product="A-factor receptor-like protein"
                     /protein_id="NP_630180.1"
                     /transl_table=11
                     /translation="MARQLRAEQTRATIIGAAADLFDRRGYESTTLSEIVAHAGVTKGA
                     LYFHFAAKEDLAHAILEIQSRTSRRLAKDLDGRGYSSLEALMRLTFGMARLCVQGPVLR
                     AGLRLATAGVPVRPPLPHPFTEWREIATSRLLDAVRQSDVHQDIDVDSVAHTLVCSVVG
                     TRVVGGTLEPAGREPRRLAEMWYILIRGMVPVTRRARYVTLAARLEQETGTA"
     misc_feature    7165..7305
                     /gene_synonym="cprB; SC9B1.18"
                     /locus_tag="SCO6071"
                     /note="Pfam match to entry PF00440 tetR, Bacterial
                     regulatory proteins, tetR family, score 65.00, E-value
                     2.8e-16."
     PFAM_domain     7165..7305
                     /aSDomain="TetR_N"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00440.26"
                     /db_xref="GO:0003677"
                     /description="Bacterial regulatory proteins, tetR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6071_0710"
                     /evalue="3.60E-17"
                     /gene_ontologies="GO:0003677: DNA binding"
                     /label="SCO6071"
                     /locus_tag="SCO6071"
                     /protein_end="60"
                     /protein_start="13"
                     /score="62.0"
                     /tool="antismash"
                     /translation="IIGAAADLFDRRGYESTTLSEIVAHAGVTKGALYFHFAAKEDLAH
                     AI"
     gene            7851..9851
                     /db_xref="GeneID:1101513"
                     /gene_synonym="SC9B1.19"
                     /locus_tag="SCO6072"
     CDS             7851..9851
                     /codon_start=1
                     /db_xref="GeneID:1101513"
                     /gene_synonym="SC9B1.19"
                     /locus_tag="SCO6072"
                     /note="SC9B1.19, unknown, len: 666aa; similar to many
                     hypothetical proteins from eukaryotes eg. TR:O45417
                     (EMBL:Z92832) from Caenorhabditis elegans (450 aa) fasta
                     scores; opt: 395, z-score: 410.1, E(): 1.6e-15, (28.0%
                     identity in 447 aa overlap)."
                     /product="hypothetical protein"
                     /protein_id="NP_630181.1"
                     /transl_table=11
                     /translation="MPGLIVRRGVALGLTVRNGVASRLTVRRGVARGLTVRIGVASGLT
                     VRRGGRVSPDRPARGRAWAVRPDWGRVPLDRPARGCAWADRPEWGRARADRLARGRARA
                     DRPARVVLGLTVRIGVASGLTVRRGGRVSPDRPARGRAWAVRPDWGRVPLDRPARGCAW
                     ADRPEWGRARADRLARGRARADRPARVVLGLTVRIGVASGSTVRRGGRVPPDCPARGRA
                     RPDCPVPGVCSARSPGTGDALGPPPGTGDACGPTGTVTRMADTPSVTAPVILGDEPGSF
                     PHGVLAERHPALVRQVRDAFPFGPERLRALDALLASCADGVVEPLPADADPTGRDRDRW
                     ARWGMDAYAGRSWYDVPWLWAESHFYRRLLDAVGYFGPGAWQGVDPFRPAKLAELDAPE
                     TDEELAALDGLDELPTEERTRALLHGSLWGNRADLGFRLSDRGAGTEGAVEALVADDSD
                     ALWSLLPAPGTGPAERGPATLCLVADNAGRELVPDLLLVSHLLAEGRVDRAVLHVKPYP
                     YYVSDATPTDVLDALRRLVAAGGAAAAHGERLWTALTDGRVTVRAHPFSCAPLPYADMP
                     DDLRADFAAATVTVLKGDLNYRRLVGDRWWPPTTSFARVTAYFPGPVAALRTLKSDVVT
                     GLDAKTEAALDASGERRWRTSGTHALIQVRS"
     repeat_region   7947..8519
                     /gene_synonym="SC9B1.19"
                     /locus_tag="SCO6072"
                     /note="Complex repeat region which appears to translate
                     into two pairs of repeated domains (17071-17163 and
                     17161-17403) in SC9B1.19. Each of these domains appears to
                     contains smaller degenerate repeats."
     PFAM_domain     8706..9782
                     /aSDomain="ARMT1-like_dom"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF01937.22"
                     /description="Damage-control phosphatase ARMT1-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6072_0711"
                     /evalue="1.10E-84"
                     /label="SCO6072"
                     /locus_tag="SCO6072"
                     /protein_end="644"
                     /protein_start="285"
                     /score="284.5"
                     /tool="antismash"
                     /translation="LAERHPALVRQVRDAFPFGPERLRALDALLASCADGVVEPLPADA
                     DPTGRDRDRWARWGMDAYAGRSWYDVPWLWAESHFYRRLLDAVGYFGPGAWQGVDPFRP
                     AKLAELDAPETDEELAALDGLDELPTEERTRALLHGSLWGNRADLGFRLSDRGAGTEGA
                     VEALVADDSDALWSLLPAPGTGPAERGPATLCLVADNAGRELVPDLLLVSHLLAEGRVD
                     RAVLHVKPYPYYVSDATPTDVLDALRRLVAAGGAAAAHGERLWTALTDGRVTVRAHPFS
                     CAPLPYADMPDDLRADFAAATVTVLKGDLNYRRLVGDRWWPPTTSFARVTAYFPGPVAA
                     LRTLKSDVVTGLDAKTEAA"
     gene            10001..12181
                     /db_xref="GeneID:1101514"
                     /gene_synonym="SC9B1.20"
                     /locus_tag="SCO6073"
     CDS             10001..12181
                     /codon_start=1
                     /db_xref="GeneID:1101514"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /gene_synonym="SC9B1.20"
                     /locus_tag="SCO6073"
                     /note="SC9B1.20, possible cyclase, len: 726 aa; C-terminal
                     region similar to SW:PTLS_STRSQ pentalenene synthase from
                     Streptomyces UC5319 (336 aa) fasta scores; opt: 382,
                     z-score: 446.4, E(): 1.5e-17, (28.9% identity in 339 aa
                     overlap)."
                     /product="cyclase"
                     /protein_id="NP_630182.1"
                     /sec_met_domain="T1TS (E-value: 8.8e-76, bitscore: 254.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQQPFQLPHFYLPHPARLNPHLDEARAHSTTWAREMGMLEGSGV
                     WEQSDLEAHDYGLLCAYTHPDCDGPALSLITDWYVWVFFFDDHFLEKYKRSQDRLAGKA
                     HLDRLPLFMPLDDAAGMPEPRNPVEAGLADLWTRTVPAMSADWRRRFAVATEHLLNESM
                     WELSNINEGRVANPVEYIEMRRKVGGAPWSAGLVEYATAEVPAAVAGTRPLRVLMETFS
                     DAVHLRNDLFSYQREVEDEGELSNGVLVLETFFGCTTQEAADLVNDVLTSRLHQFEHTA
                     FTEVPAVALEKGLTPLEVAAVGAYTKGLQDWQSGGHEWHMRSSRYMNKGERPLAGWQAL
                     TGPGTSAADVGALLADAVAQRARSYTYVPFQKVGPSVIPDIRMPYPLELSPALDGARRH
                     LSEWCREMGILSEGVWDEDKLESCDLPLCAAGLDPDATQDQLDLASGWLAFGTYGDDYY
                     PLVYGHRRDLAAARLTTTRLSDCMPLDGEPVPPPGNAMERSLIDLWVRTTAGMTPEERR
                     PLKKAVDDMTEAWLWELSNQIQNRVPDPVDYLEMRRATFGSDLTLGLCRAGHGPAVPPE
                     VYRSGPVRSLENAAIDYACLLNDVFSYQKEIEYEGEIHNAVLVVQNFFGVDYPAALGVV
                     QDLMNQRMRQFEHVVAHELPVVYDDFQLSEEARTVMRGYVTDLQNWMAGILNWHRNVPR
                     YKAEYLAGRTHGFLPDRIPAPPVPRSSPALTH"
     PFAM_domain     10229..10822
                     /aSDomain="Terpene_syn_C_2"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF19086.3"
                     /description="Terpene synthase family 2, C-terminal metal
                     binding"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6073_0712"
                     /evalue="2.30E-37"
                     /label="SCO6073"
                     /locus_tag="SCO6073"
                     /protein_end="274"
                     /protein_start="76"
                     /score="128.9"
                     /tool="antismash"
                     /translation="DWYVWVFFFDDHFLEKYKRSQDRLAGKAHLDRLPLFMPLDDAAGM
                     PEPRNPVEAGLADLWTRTVPAMSADWRRRFAVATEHLLNESMWELSNINEGRVANPVEY
                     IEMRRKVGGAPWSAGLVEYATAEVPAAVAGTRPLRVLMETFSDAVHLRNDLFSYQREVE
                     DEGELSNGVLVLETFFGCTTQEAADLVNDVLTSRL"
     PFAM_domain     11339..11935
                     /aSDomain="Terpene_syn_C_2"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF19086.3"
                     /description="Terpene synthase family 2, C-terminal metal
                     binding"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6073_0713"
                     /evalue="4.70E-46"
                     /label="SCO6073"
                     /locus_tag="SCO6073"
                     /protein_end="645"
                     /protein_start="446"
                     /score="157.3"
                     /tool="antismash"
                     /translation="WLAFGTYGDDYYPLVYGHRRDLAAARLTTTRLSDCMPLDGEPVPP
                     PGNAMERSLIDLWVRTTAGMTPEERRPLKKAVDDMTEAWLWELSNQIQNRVPDPVDYLE
                     MRRATFGSDLTLGLCRAGHGPAVPPEVYRSGPVRSLENAAIDYACLLNDVFSYQKEIEY
                     EGEIHNAVLVVQNFFGVDYPAALGVVQDLMNQRMRQ"
     gene            12295..12906
                     /db_xref="GeneID:1101515"
                     /gene_synonym="SC9B1.21"
                     /locus_tag="SCO6074"
     CDS             12295..12906
                     /codon_start=1
                     /db_xref="GeneID:1101515"
                     /gene_synonym="SC9B1.21"
                     /locus_tag="SCO6074"
                     /note="SC9B1.21, possible integral membrane protein, len:
                     203aa; some similarity to eukaryotic hypothetical proteins
                     eg. TR:Q22260 (EMBL:Z70756) (290 aa) fasta scores; opt:
                     185, z-score: 170.7, E(): 0.035, (34.4% identity in 157 aa
                     overlap). Also similar to TR:CAA22418 (EMBL:AL034447)
                     transmembrane protein from Streptomyces coelicolor (396 aa)
                     fasta scores; opt: 186, z-score: 169.8, E(): 0.039, (33.1%
                     identity in 166 aa overlap)."
                     /product="hypothetical protein"
                     /protein_id="NP_630183.1"
                     /transl_table=11
                     /translation="MPGRDPGPGTEPDGARHPHTGRRRRRRLTTLLLGVLAAAVLLLTG
                     VGLGTVGATVIGMSKLAELRQRAAAQGPGGAGGAGGAGEQGATGTATGTRGAPAHPSAG
                     PSAGRSPSPAPAGATLGVEAVDDEKPGARVVGVHVPGPGYAAGLVRGDVLLAVGTTRVD
                     SATDLAHAVARAGPGKEVKLTVRHRSGGYQQLTAVPGVVT"
     PFAM_domain     12649..12858
                     /aSDomain="PDZ_2"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF13180.9"
                     /db_xref="GO:0005515"
                     /description="PDZ domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6074_0714"
                     /evalue="7.30E-11"
                     /gene_ontologies="GO:0005515: protein binding"
                     /label="SCO6074"
                     /locus_tag="SCO6074"
                     /protein_end="188"
                     /protein_start="118"
                     /score="42.4"
                     /tool="antismash"
                     /translation="TLGVEAVDDEKPGARVVGVHVPGPGYAAGLVRGDVLLAVGTTRVD
                     SATDLAHAVARAGPGKEVKLTVRHR"
     gene            complement(12899..13720)
                     /db_xref="GeneID:1101516"
                     /gene_synonym="SC9B1.22c"
                     /locus_tag="SCO6075"
     CDS             complement(12899..13720)
                     /codon_start=1
                     /db_xref="GeneID:1101516"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SC9B1.22c"
                     /locus_tag="SCO6075"
                     /note="SC9B1.22c, unknown, len: 273aa; similar to many
                     hypothetical proteins eg. TR:O06629 (EMBL:Z95618) from
                     Mycobacterium tuberculosis (318 aa) fasta scores; opt: 353,
                     z-score: 408.1, E(): 2.1e-15, (32.5% identity in 252 aa
                     overlap)."
                     /product="hypothetical protein"
                     /protein_id="NP_630184.1"
                     /sec_met_domain="Metallophos_2 (E-value: 8.4e-08, bitscore:
                     31.3, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYVTQALTSGVSRSGRPEEADTVLVLAHISDLHLDGSPRATERAE
                     RVRERLWRLPGRVDALLVTGDIADHGTEAEYEEAARVLGLRDGSAPFPVLTCPGNHDSR
                     APYRKALLGRPAADGPANEVHVFDGGAVLMCDSSIPGSDEGELDGETYDWIEASLDGLD
                     DGLPALLAFHHPPTPVHHPLPDSYRLRHPERLAALLERRPGIAGLITGHAHSPAATVFA
                     GRPLVVGPGVTWTLRLPWEGEQVADRDAPVGLAFHVLDDAGRLTSHFRTVT"
     PFAM_domain     complement(13076..13645)
                     /aSDomain="Metallophos"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00149.31"
                     /db_xref="GO:0016787"
                     /description="Calcineurin-like phosphoesterase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6075_0715"
                     /evalue="1.30E-15"
                     /gene_ontologies="GO:0016787: hydrolase activity"
                     /label="SCO6075"
                     /locus_tag="SCO6075"
                     /protein_end="215"
                     /protein_start="25"
                     /score="58.6"
                     /tool="antismash"
                     /translation="LAHISDLHLDGSPRATERAERVRERLWRLPGRVDALLVTGDIADH
                     GTEAEYEEAARVLGLRDGSAPFPVLTCPGNHDSRAPYRKALLGRPAADGPANEVHVFDG
                     GAVLMCDSSIPGSDEGELDGETYDWIEASLDGLDDGLPALLAFHHPPTPVHHPLPDSYR
                     LRHPERLAALLERRPGIAGLITGHAHS"
     misc_feature    complement(13699..13716)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.61"
                     /tool="antismash"
     misc_feature    complement(13700..13702)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13839..14969
                     /db_xref="GeneID:1101517"
                     /gene_synonym="SC9B1.23"
                     /locus_tag="SCO6076"
     CDS             13839..14969
                     /codon_start=1
                     /db_xref="GeneID:1101517"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SC9B1.23"
                     /locus_tag="SCO6076"
                     /note="SC9B1.23, probable dipeptidase, len: 376aa; similar
                     to many eg. SW:PEPQ_LACDL proline dipeptidase from
                     Lactobacillus delbrueckii subsp. lactis DSM7290 (368 aa)
                     fasta scores; opt: 681, z-score: 740.0, E(): 0, (34.6%
                     identity in 353 aa overlap)."
                     /product="dipeptidase"
                     /protein_id="NP_630185.1"
                     /transl_table=11
                     /translation="MTGSSPAASFTADDYRARMERAARAAADAGLAGLLVAPGPDLVWL
                     TGYAPTADTERLTLLVLAPDRDPVLVVPTLEAPDAAKAAGAPALTLRDWTDGKDPYAAT
                     AALLDGSGRFGISDNAWAMHLLALQRTLPDTSYASLTEALPMLRAVKDAAELELLAAAG
                     AAADAAFEEIRRVRFGGRRESEVAADLADLLRRFGHSQVDFTIVASGPNGANPHHEVGD
                     RVIEDGDMIVLDFGGLKDGYGSDTSRTVHVGAPTDEERRVHDLVREAQEAGFCAVRPGA
                     ACQDVDRAARAVIAGAGYGEYFIHRTGHGIGVTTHEPPYMIEGEEQPLVPGMCFSVEPG
                     VYLPGRFGVRIEDIVTVTEDGGRRLNDTTREMVLVE"
     PFAM_domain     13890..14288
                     /aSDomain="Creatinase_N"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF01321.21"
                     /description="Creatinase/Prolidase N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6076_0716"
                     /evalue="1.80E-13"
                     /label="SCO6076"
                     /locus_tag="SCO6076"
                     /protein_end="150"
                     /protein_start="17"
                     /score="51.4"
                     /tool="antismash"
                     /translation="RMERAARAAADAGLAGLLVAPGPDLVWLTGYAPTADTERLTLLVL
                     APDRDPVLVVPTLEAPDAAKAAGAPALTLRDWTDGKDPYAATAALLDGSGRFGISDNAW
                     AMHLLALQRTLPDTSYASLTEALPMLRAV"
     misc_feature    14283..14966
                     /gene_synonym="SC9B1.23"
                     /locus_tag="SCO6076"
                     /note="Pfam match to entry PF00557 pep_M24,
                     metallopeptidase family M24, score 192.90, E-value
                     5.2e-54."
     PFAM_domain     14310..14915
                     /aSDomain="Peptidase_M24"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00557.27"
                     /description="Metallopeptidase family M24"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6076_0717"
                     /evalue="3.20E-56"
                     /label="SCO6076"
                     /locus_tag="SCO6076"
                     /protein_end="359"
                     /protein_start="157"
                     /score="190.5"
                     /tool="antismash"
                     /translation="LLAAAGAAADAAFEEIRRVRFGGRRESEVAADLADLLRRFGHSQV
                     DFTIVASGPNGANPHHEVGDRVIEDGDMIVLDFGGLKDGYGSDTSRTVHVGAPTDEERR
                     VHDLVREAQEAGFCAVRPGAACQDVDRAARAVIAGAGYGEYFIHRTGHGIGVTTHEPPY
                     MIEGEEQPLVPGMCFSVEPGVYLPGRFGVRIEDIVTVTE"
     gene            14966..15970
                     /db_xref="GeneID:1101518"
                     /gene_synonym="SC9B1.24; SCBAC1A6.01"
                     /locus_tag="SCO6077"
     CDS             14966..15970
                     /codon_start=1
                     /db_xref="GeneID:1101518"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SC9B1.24; SCBAC1A6.01"
                     /locus_tag="SCO6077"
                     /note="SCBAC1A6.01, unknown (fragment), len: >60 aa;
                     SC9B1.24, partial CDS, possible transferase, len: >317aa;
                     similarity to many antibiotic resistance
                     phosphotransferases eg. TR:Q47396 (EMBL:D16251) macrolide
                     2'-phosphotransferase I from Escherichia coli (301 aa)
                     fasta scores; opt: 197, z-score: 224.6, E(): 3.4e-05,
                     (26.9% identity in 201 aa overlap) and SW:VPH_STRVI
                     viomycin phosphotransferase from Streptomyces vinaceus (287
                     aa) fasta scores; opt: 194, z-score: 221.6, E(): 5e-05,
                     (28.8% identity in 257 aa overlap)."
                     /product="transferase"
                     /protein_id="NP_733686.1"
                     /sec_met_domain="APH (E-value: 6e-18, bitscore: 64.5,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGDGPTPNAPADPSGRRRDMTQAPTPTADTVRRLVRSLLGGSTE
                     PDVRPVAGGVAPDTWWVGTRHVLRLAPDRETAVRGRRELRLRELVRPYLPVALPASVAH
                     GEWAPGLAYTLDAKVAGGSGEDHDVSALGEADLAALLTGLREVPVRQAETLGVPRAAPR
                     SLEALRQSAERAVRRLAAADEFDTARPERLTREAAAQLGVQPGAAVLVHHGLTGGHLVV
                     SADGRVRGVLGWSDAVLGDPAEDIAGLALSVGSPAAVRAATLAGYGARPCLRGLWLARC
                     DAVIHLAEALDGHGGGPLPATVPLLRTRLRRAWEPILLERVTELRDDGRDDTA"
     PFAM_domain     15104..15778
                     /aSDomain="APH"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF01636.26"
                     /description="Phosphotransferase enzyme family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6077_0718"
                     /evalue="8.10E-18"
                     /label="SCO6077"
                     /locus_tag="SCO6077"
                     /protein_end="271"
                     /protein_start="46"
                     /score="65.3"
                     /tool="antismash"
                     /translation="DVRPVAGGVAPDTWWVGTRHVLRLAPDRETAVRGRRELRLRELVR
                     PYLPVALPASVAHGEWAPGLAYTLDAKVAGGSGEDHDVSALGEADLAALLTGLREVPVR
                     QAETLGVPRAAPRSLEALRQSAERAVRRLAAADEFDTARPERLTREAAAQLGVQPGAAV
                     LVHHGLTGGHLVVSADGRVRGVLGWSDAVLGDPAEDIAGLALSVGSPAAVRAATLAGYG
                     ARP"
     gene            complement(15981..17726)
                     /db_xref="GeneID:1101519"
                     /gene_synonym="SCBAC1A6.02c"
                     /locus_tag="SCO6078"
     CDS             complement(15981..17726)
                     /codon_start=1
                     /db_xref="GeneID:1101519"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CBM_48"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCBAC1A6.02c"
                     /locus_tag="SCO6078"
                     /note="SCBAC1A6.02c, probable alpha amylase, len: 581 aa;
                     highly similar to TR:Q44316 (EMBL:D63343) Arthrobacter sp.
                     maltooligosyl trehalose trehalohydrolase TreZ, 598 aa;
                     fasta scores: opt: 2063 z-score: 2298.1 E(): 0; 53.3%
                     identity in 583 aa overlap. Contains Pfam match to entry
                     PF00128 alpha-amylase, Alpha amylase"
                     /product="alpha amylase"
                     /protein_id="NP_630186.1"
                     /sec_met_domain="CBM_48 (E-value: 0.00017, bitscore: 20.6,
                     seeds: 59, tool: rule-based-clusters)"
                     /sec_met_domain="Alpha-amylase (E-value: 3.7e-11, bitscore:
                     42.0, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFEVWAPQAGRVTLRCDGATRALERDPERPGWWCGEAPARDGSR
                     YGFAVDDGPVLPDPRSRRQPDGPDGLSAVVDHGRYAWRTPWAGRPLPGGVLYELHVGTY
                     TPEGTLDAAADRLEHLVRLGVTHVELMPLCPFPGRHGWGYEGVSLWAVHEPYGGPEALK
                     RFVDRAHDLGLGVVLDVVHNHLGPSGNHLPAFGPYFTDTHHTPWGVAVNLDAPGSDEVR
                     AYLVDSALAWLRDYRLDGLRLDAVHALADTRACHFLEQLSTAVDGLAADLERPLFLIAE
                     SDLNDPRIITPRAEGGLGVHAQWNDDFHHALHAALTGESQGYYADFARDPLAALAKTLI
                     RGYFHDGTYSSFRGRSHGRALDRGRVAAHRLTGYSQTHDQVGNRAQGDRLASLVSPGLA
                     ACAATLTLTAPFTPMLFMGEEWAAGTPWQFFTDHTDPQLAQAVRQGRRREFAAHGWREE
                     DVPDPQDPATRERSCLDWSEPEREPHARVLDWYRRLIALRAEQPDLTDPDLADTRVAYD
                     GTGRWLAFRRGDIRVAVNLGTEPAAIPLGNRPARVLAAWEPVEGPGANGILRVPGESSV
                     VLVQE"
     PFAM_domain     complement(15996..16259)
                     /aSDomain="DUF3459"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF11941.11"
                     /description="Domain of unknown function (DUF3459)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6078_0720"
                     /evalue="1.50E-18"
                     /label="SCO6078"
                     /locus_tag="SCO6078"
                     /protein_end="577"
                     /protein_start="489"
                     /score="67.0"
                     /tool="antismash"
                     /translation="WYRRLIALRAEQPDLTDPDLADTRVAYDGTGRWLAFRRGDIRVAV
                     NLGTEPAAIPLGNRPARVLAAWEPVEGPGANGILRVPGESSVV"
     misc_feature    complement(16059..17444)
                     /gene_synonym="SCBAC1A6.02c"
                     /locus_tag="SCO6078"
                     /note="Pfam match to entry PF00128 alpha-amylase, Alpha
                     amylase, score -23.30, E-value 2.5e-05"
     aSDomain        complement(16098..17723)
                     /aSDomain="TIGR02402"
                     /aSTool="tigrfam"
                     /description="trehalose_TreZ: malto-oligosyltrehalose
                     trehalohydrolase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO6078_0090"
                     /evalue="1.20E-232"
                     /identifier="TIGR02402"
                     /label="SCO6078"
                     /locus_tag="SCO6078"
                     /protein_end="543"
                     /protein_start="1"
                     /score="771.0"
                     /tool="antismash"
                     /translation="QFEVWAPQAGRVTLRCDGATRALERDPERPGWWCGEAPARDGSRY
                     GFAVDDGPVLPDPRSRRQPDGPDGLSAVVDHGRYAWRTPWAGRPLPGGVLYELHVGTYT
                     PEGTLDAAADRLEHLVRLGVTHVELMPLCPFPGRHGWGYEGVSLWAVHEPYGGPEALKR
                     FVDRAHDLGLGVVLDVVHNHLGPSGNHLPAFGPYFTDTHHTPWGVAVNLDAPGSDEVRA
                     YLVDSALAWLRDYRLDGLRLDAVHALADTRACHFLEQLSTAVDGLAADLERPLFLIAES
                     DLNDPRIITPRAEGGLGVHAQWNDDFHHALHAALTGESQGYYADFARDPLAALAKTLIR
                     GYFHDGTYSSFRGRSHGRALDRGRVAAHRLTGYSQTHDQVGNRAQGDRLASLVSPGLAA
                     CAATLTLTAPFTPMLFMGEEWAAGTPWQFFTDHTDPQLAQAVRQGRRREFAAHGWREED
                     VPDPQDPATRERSCLDWSEPEREPHARVLDWYRRLIALRAEQPDLTDPDLADTRVAYDG
                     TGRWLAFRRGDIRVAVNLGTEPAAI"
     PFAM_domain     complement(17157..17405)
                     /aSDomain="Alpha-amylase"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00128.27"
                     /db_xref="GO:0005975"
                     /description="Alpha amylase, catalytic domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6078_0719"
                     /evalue="1.00E-09"
                     /gene_ontologies="GO:0005975: carbohydrate metabolic
                     process"
                     /label="SCO6078"
                     /locus_tag="SCO6078"
                     /protein_end="190"
                     /protein_start="107"
                     /score="38.6"
                     /tool="antismash"
                     /translation="GTLDAAADRLEHLVRLGVTHVELMPLCPFPGRHGWGYEGVSLWAV
                     HEPYGGPEALKRFVDRAHDLGLGVVLDVVHNHLGPSGN"
     misc_feature    17857..17872
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.79"
                     /tool="antismash"
     misc_feature    complement(17861..17875)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.42"
                     /tool="antismash"
     gene            17904..18455
                     /db_xref="GeneID:1101520"
                     /gene_synonym="SCBAC1A6.03"
                     /locus_tag="SCO6079"
     CDS             17904..18455
                     /codon_start=1
                     /db_xref="GeneID:1101520"
                     /gene_synonym="SCBAC1A6.03"
                     /locus_tag="SCO6079"
                     /note="SCBAC1A6.03, conserved hypothetical protein, len:
                     183 aa; similar to TR:Q9RP36 (EMBL:AF173844) Mycobacterium
                     smegmatis signal transduction protein GarA, 158 aa; fasta
                     scores: opt: 185 z-score: 231.8 E(): 2.5e-05; 36.4%
                     identity in 143 aa overlap. Contains Pfam match to entry
                     PF00498 FHA, FHA domain"
                     /product="hypothetical protein"
                     /protein_id="NP_630187.1"
                     /transl_table=11
                     /translation="MTSSFEFPTYPARLSDAERDKALSVLRDGVAMGRLSHDTFIRRME
                     LALAARRLEELAVLTADLPTENRLSRLVFGTVEAVSGFGVRLGRAWRAERLPKLLLPHP
                     GAGHPLRIGRDPASGLRLSHETVSRVHAELSRQGGMWVLRDLGSTNGTTVNGRRVIGAA
                     VVHEGDQIGFGGMSFRLAAN"
     PFAM_domain     17940..18095
                     /aSDomain="DUF1707"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF08044.14"
                     /description="Domain of unknown function (DUF1707)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6079_0721"
                     /evalue="2.90E-16"
                     /label="SCO6079"
                     /locus_tag="SCO6079"
                     /protein_end="64"
                     /protein_start="12"
                     /score="59.4"
                     /tool="antismash"
                     /translation="RLSDAERDKALSVLRDGVAMGRLSHDTFIRRMELALAARRLEELA
                     VLTADLP"
     misc_feature    18231..18425
                     /gene_synonym="SCBAC1A6.03"
                     /locus_tag="SCO6079"
                     /note="Pfam match to entry PF00498 FHA, FHA domain, score
                     74.90, E-value 1.7e-18"
     PFAM_domain     18234..18425
                     /aSDomain="FHA"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00498.29"
                     /db_xref="GO:0005515"
                     /description="FHA domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO6079_0722"
                     /evalue="5.70E-18"
                     /gene_ontologies="GO:0005515: protein binding"
                     /label="SCO6079"
                     /locus_tag="SCO6079"
                     /protein_end="174"
                     /protein_start="110"
                     /score="65.1"
                     /tool="antismash"
                     /translation="RIGRDPASGLRLSHETVSRVHAELSRQGGMWVLRDLGSTNGTTVN
                     GRRVIGAAVVHEGDQIGFG"
     misc_feature    18546..18557
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.28"
                     /tool="antismash"
     gene            18849..20006
                     /db_xref="GeneID:1101521"
                     /gene_synonym="SCBAC1A6.04"
                     /locus_tag="SCO6080"
     CDS             18849..20006
                     /codon_start=1
                     /db_xref="GeneID:1101521"
                     /gene_synonym="SCBAC1A6.04"
                     /locus_tag="SCO6080"
                     /note="SCBAC1A6.04, possible dehydrogenase, len: 385 aa;
                     similar to TR:Q53924 (EMBL:X62373) Streptomyces coelicolor
                     hydroxylacyl-CoA dehydrogenase ORFB, 394 aa; fasta scores:
                     opt: 835 z-score: 981.3 E(): 0; 42.0% identity in 381 aa
                     overlap"
                     /product="dehydrogenase"
                     /protein_id="NP_630188.1"
                     /transl_table=11
                     /translation="MGGATALRLAERAVADPRLTEGADATWNLLLCVDPDGLRRNEGWL
                     TGPYTLGRYARNFFRPGFLEQPEWLPDGPDRATLPETRTLLALQDELRPFLQCSLHGVD
                     VGGGFVELTHELPGLAQRISHTAARLGIPRELGAYDTLYWPDLGPAVYRIPPPRRGDLT
                     AAITEAAVDSTWCHPRRHGTVTAVVEAPMWGVAAVADDSPPVDRDGVLRTVSRTLRHDT
                     RRLRRVLARLRPHLAAVPEAAHLLAPVDDYLLVCPRLADEWDPDTDDRTDRSLPPMNTS
                     HLVALRLAGRRLSLRTAGLLHQLVTRTGGDPAGVLAELDRLVDEGCADYRDGCGAHWIP
                     VGRQVEYQTRVVLAAFELAGRRAAAGARSGEPGRGSEAAVPMHRD"
     misc_feature    20240..20258
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.14"
                     /tool="antismash"
     misc_feature    20241..20257
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.22"
                     /tool="antismash"
     misc_feature    complement(20969..20983)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.84"
                     /tool="antismash"
     misc_feature    complement(21003..21017)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.83"
                     /tool="antismash"
     misc_feature    complement(22128..22142)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.15"
                     /tool="antismash"
ORIGIN
        1 ggatacgacg gcatccccac gcgcctgctg gaacacgtcc agtacaccct gatggccctc
       61 ggactcgccg ccgccatcgg gctgcccgtc gggctgctga ccgggcacac cggacgcggc
      121 ggcaacgccg tcgccttcgt cgccaccgcc gcccgcgccc tgcccagctt cggtctgctg
      181 gtgctgatcg ccgtcgtcgt cggcatcggc ctgctgcccg tgatggtccc gctcgtcgtg
      241 ctcgcggtcc cgcccatcct cgtgaccacc tacgaggcgg tccgctccgt cgacccctcg
      301 ccggtggacg ccgcccgggg catgggcatg cacgagtcgg gcatcctctt ccgggtcgaa
      361 ctcccggtcg ccctcccgct ggtcctcagc gggctgcgct cggccgccat ccaggtcgtg
      421 tcgacggcga ccatcgccgc ctacgtcagc ctcggcggca tcggccgcta catcatcgac
      481 gggctctacc agcgcgacta cgagaaggtc gtcggcggcg ccacgctggt ggccgtcctg
      541 gccctggtca ccctcgcgct cttctgggcg gcgggacggt tcgcggtctc gccgggggtg
      601 cgcaggcgct gagcgcccgg gccgcggaga aaccgtaacc aggccgtact tgactcaccg
      661 gcaagcggat cgtttggatc gacggatgaa tttcaccgcg aagagcagca ggtccaggac
      721 caggcacacc ggcgcggcgg ccgtcgcgct caccgccgcg gcggcgctgc tcgcgggctg
      781 ttcctccgac tccgacggca cctccgacaa cccgctcgcg ggtgacaagg cggaggccgg
      841 caccgtcgtc gtcggctcga acaacttcgc cgagagcacc ctgctcgccg acatctacgg
      901 ggaggcgctc aaggccaagg gcctcaaggt cacctacaag cacaacatag gcagccggga
      961 gacgacctac ggcatgatga agaacggctc cgtcacggtg ctgccggagt acaacggctc
     1021 gctgctcgcc tacctcgacc cgaaggcccg gcagaagtcc gtggaggcgg tgaacgaggc
     1081 ggcgaaggcc aagctcgaca agaagctgac gctgctggag tcgtcaccgg ccgagaacaa
     1141 ggactcggtg agcgtcaacg ccgagaccgc gaagaagcac ggcctcaccg ccgagtcgac
     1201 cctcgccgac ctcaaggacg tcgcaccgga cctggtgatc ggaggctcgc ccgagttcca
     1261 gacgcggcag caggggctca agggcctgga gtcggtgtac ggactgaagt tcaagtcctt
     1321 caaggcgctc gacgcgggcg gtccgctgac ccagtcggcg ctgaccaaga acgacgtgca
     1381 ggcggcggac gtcttcacca ccgacccgac catcatcaag gagaagttcg tcgtcctgaa
     1441 ggacccggag aacctcttcg gccacgcgaa cgtgaccccg ctggtcacca aggacgggct
     1501 gaacgaggag ggcgtggcca cgctcaacgc ggtctccgcc aagctcgaca ccgagacgct
     1561 cctggacctg gacgcccagg tccagctgga caagaaggac ccgctggacg tggccaagga
     1621 gtggctgaag tccgcgggtc tcgtctgacg gaagccctga gacgcctcgc cgcgacccgc
     1681 taggacgccg cggccccggc cgcggcgtcg atcagctggt cgatcagggc gatgaggacg
     1741 tcccggctgg aggtccgctc ccgcgcgtcg cacagcagca cctgcacgtg ctccggcagc
     1801 gcgagggcct cgcggatctc cgccgccggg tacgggtgcc ggccgtggaa gccgttcacg
     1861 gcgacgacga acggaatgcc ccgccgctcg aagaagtcga tcgcggcgaa gctcgactcg
     1921 ggcctgcgga cgtcgaccag gaccaccgcg ccgagcgccc cgatcgccag gtcgttccac
     1981 atgaaccaga accgctgctg gccgggcgta ccgaagaggt acagcaccac gtcccggccg
     2041 atggtgatcc ggccgaagtc cagcgccacc gtcgtggccc gcttctcctc gatgccggcg
     2101 aggtcgtcga cgtccaggcc cgccgcggtc agcggttcct cggtgcgcag cggggcgatc
     2161 tcgctgaccg accccaccat ggtggtcttg ccgacgccga aaccgcccgc gatcaggatc
     2221 ttcaccgcct cgggcgcggt ggagcgtgcg gatgccgtgg gcgtctcggc gacgcgctca
     2281 gagccggcca aggccgtccc tcactttctg cagcaggtcc aggtcgtcgg tggcgcggga
     2341 gaccgggtgc ggcggccggg cggtgatgcg gccggcctcc agcaggtccg agagcaggat
     2401 gacgaccacg ctcaccggca ggtcgagacg ggccgccagc tccgccacgg ccatcggctc
     2461 ggcgcacagc cgcaggatcc gcaggtgctc gggctgcggc cgcgccgccc gggagggctg
     2521 cgggtcgatc gcggtcaccg tcgtgatgag ggtgaagtcg gcgcggctgg gcctggtccg
     2581 gccgccggtc agggtgaacg gccgcacgag ccggcccgca gcgtcgcctc cggtcacgtc
     2641 actcgccggg gccggcggtg gcccgcggtg ccgcgctcag gtgctcgccg atcttcttca
     2701 ccagcatgtt catctggtac gccaccacgc cgacgtcggc gttcggcccg gtgagcacga
     2761 ccaggtgcgc gccggggccc gcggaggtga gtatcaggta gctgttggcc atctcgatga
     2821 gcgcctgacg caccgggccg ccccggaagt ccatgctgac gcccttgctg aggctcatca
     2881 gccccgacgc ggtcgccgcc agccgctcgg cgtcgtcccg caggaacccg gtggacttgc
     2941 tgacgaccag gccgtcctcg gagagcacca cggcctggtt cacgtcggcg acccgctcca
     3001 cgagtccggt gagcaactgg tccagctcgg tgtgcgtggc gggggagggt cgggtcatcg
     3061 cgtgtccttc gtgggcggtc ggcggtcggc ggtcggggtc gagtgggcgg cggaggagag
     3121 cgcgtgcccg tcggtggcgc ggtcgtccgc gccaccgacg ccttcggccg cctcgtctgc
     3181 ttcgtgtgct gcgcgcgggt cggctgcttc gtccgcgtcg tcatcggtgt gggcccgcag
     3241 cgtgccgcgc tggaaaccgg cgagggacga cgcggcgcgc tcggccgtga agtcggcgta
     3301 ggcgtcggcg gccgcgtggt ccgagccgtc ccggcggccg cccggatcct cgtcgcgcag
     3361 ttcggcggcg aggctggtct gcggtacccg gcggggcagc ggcgccagtc cgccgcgccc
     3421 gtcggaggcg tcgtgcgcgg aggcgccgga gtggccgcgg ggggaacccg ccccggctgc
     3481 ggccgggccc gcgggcgccg gccgggacga ccgtacgggg cgcaccggcc ggggggcgcc
     3541 ggacgggtcc cccgccgccg ccgaggccgt ggcggaccgc ccggccgcgg cgcccggggc
     3601 tgcctggccg gtctcggtgc cggtgccggt gacgctgccg gtgtcgatgg ccgggcccgc
     3661 cgggtcggcc gagtcgcgcg cggtgggcgc ggcgacccag ggggcccgcg cgccgttcgc
     3721 cgcggcaccc gggccgtccg ccccgccggc cggctcccgc accacgatgt cgtgcgggat
     3781 cagcacgatc gccgtggtcc cgccgtacgg cgagggccgc agcgtgacgg tgatgccgtg
     3841 ccggtgcgcg aggcgggcca cgacgaacat gccgagccgc aggtcgtcgg cgagcgccac
     3901 cacgtcgaac tgcggggcca ccgccagctg ggcgttgaac gacgcgtagt cctcctccga
     3961 caggccgagc ccgcggtcct cgatctccac ggccaggccc ttggccacca gcgccgcccg
     4021 cacgccgacc gggttgggcg cgggggagta cgcggtcgcg ttgtcgatca gctcggccag
     4081 gaggtggatc acgtcggcca ccgcgggcgg ggcgagggcc acctcctcgt cggcgtgcag
     4141 ctccacccgc tggtactcgg cgacctcgcc gacggcgctg cgcaggatgt cgaccagcga
     4201 cacgggctcg cgccaggtgc gccggggctg ctcgccgctg atgatgacga ggttctcctc
     4261 gtagcgccgc agctgactgg ccgtggagtc cagctcgtac aggcccttga ggatctcggg
     4321 gtccgtgtgc tcccgctcca gggcgtccag tttgccgagc tgcatgttga cgaggttctg
     4381 gctctgccgc gcgatgccca ggatgacctt ctggaagccg cgccgggtgt cggcgagttc
     4441 gacggcggtg tgcacggcgg tgcgctgcgc cgcgttgaac gcctgcgcga cctggccgag
     4501 ttcgtcgcgc ccgtagtcca gcggcggggt cgccgactcc acgtcgaccg tctcgccccg
     4561 ttcgaggcgg gccaccacgt cgggcagccg ctcctcggcc aggctcaggg tggccagccg
     4621 cagcccgcgc agccgccggg acagcgagcg ggtgatgcgc caggacatca cgatgcagag
     4681 cagcagggcg atcaggccgc ccgcgctgag gacaccggcc ttgatcagca ggccgcgggc
     4741 ctcctcggcg ctgcggtcga ggagcccgtc cgtctgctgc cggatgagct gcccgtactg
     4801 ggtggagatc ttctcgaagg cggtgatcca gcgctgccgt gcgtccggca ggtcgatccg
     4861 gtcgccccgg cccgccgaac gggcctcgag cacctggtcc tcgacgtcct gcagggactt
     4921 ccactcggag ctggcgagga tccgctcggt ctgggtcttc gcactgccgg tcagagaggg
     4981 gacgatctgg tcctgcacca gccagcggcg ggtgtgcacc agctgggcga accgggacca
     5041 ctgctcctcg tccatccggc cggacggcca ggccagggtg agccgggcgt cctcctggga
     5101 gaccagctcg gcggcgtgct ccagggcgac cagcgggccc gcctgggagg tgaggtcgcc
     5161 gtcgtcgacc tgggagagct cctggaaggc gtggatctgc tcgtcgacga tcgaggtgta
     5221 ctggtcgagc gcctgctcgg cggtgatgtc gctggggtcg tccacctggt tgcggtagta
     5281 ctccaggctg cccaccgagc cgagcaccga gtacagccgg tccgagaccc gggtgggcgc
     5341 gctctcgatc gcgtcggact ggccgaccaa ctgcgcgacc gccgcgtccg tcttcttccg
     5401 ctgcgcgtcc agttcgctcc ggtcgccgtc cggtgcggcc agccaggcgg ccgacaggct
     5461 gcgctccttc tgcagggcca gggtggcctc ggtgcccatg gcgccggtgt cgcggctcag
     5521 ctgcgtctgc gcgcgcagcc gcaggccctc cgagaacatc tggatcgtcg tgacgcccca
     5581 cacggccgcg agggtgacgc cggggaccag ggccaggagg atcagggaga gacgtatgga
     5641 gccgaggcgg cgccgggcac ccttcttccg tgacttccgt gcaggcatcg tcgtcctagg
     5701 cgatcagtgg ggcggggtgg cgggggtgcg gaggtgccgg cggccgcggg gcccggtcac
     5761 cgggtgccgc ccgcggcgaa ctcggcgacc gagtcggcgt tggtccgggt cacgaacgcg
     5821 gggccggtca gcacgggggc cacgccgccg ccgctgacgt tgccgttggt gcggtagagc
     5881 cagagcgcgt ccaccgcgag atagccctgc agatacggct gctggtccac ggcgaactgg
     5941 acgtccccgc gtttgacggc ggccaccagg tcgttgtcga ggtcgaaggt ggcgacgtgg
     6001 gcgtcgctgc ccgcctcgtc gaccgcctcg accgcggtga gggcgaacgc cgcgccgttc
     6061 atgacgactt cgtcgatgct ggggtcctgc cgcagccggg ccgtgacggc cgcgccgacc
     6121 gccttcatgt cggtgccctc gacgtagagc atctcggtct cgccgccgaa ggtcttcttc
     6181 acaccggcgc agcgcgcctc cagggcgacg ttgccgcgct cgtggatgac gcacagggcg
     6241 tgcttcgccc ggaggtcgtc cagcttgtcg ccgacggcgc ggcccgcgac gctctcgtcc
     6301 tgcccgaagt actccaggag cccggtggac cgccaggcgt cgatgccgga gttgaggccg
     6361 accaccggga tcccggccgc cttcgcctcg gcgaccggtg ccttcatcgc ctgcggtttg
     6421 gccagggtca cggcgatgcc gtcggccttg tcacggatgg cgtcccgcac gaggtcggcc
     6481 tggtcggcgg tgtcggcgtc cccggcgtag gtcaggtcga cgccgtcctt ggcggccgcc
     6541 gcctccgcgc ccttgcgcac ccggtcccag aaggcgtcgc cctcaccgcc gtgggtgacc
     6601 atgacgatct tcatccggtc gccgccggac ccgcccgcgg cgtccgccgc cgagccgtcc
     6661 tcgtccccgc cgagggcgga gcagccggcc accagcaggc agacggccgc ggtgagggcc
     6721 gcggcgcgcg cgggtccggg ggagtgggtg ggcgggggag ctgtactcat gggggcgggg
     6781 gcacctcgct gtgcggccga gcaggaggaa cgggacgggc cggcccggag ccgcgggtca
     6841 gtgcgccaac cgggtgaaac tcgcctggcc ggagcaaacc gtgtgtgacc gctggtagtc
     6901 aagtgaccag cgaactgctc tgagttgtcg gtgccgcatc gtgatgaacg ggggtggcga
     6961 aagcgggccg aagcggaatg ccgggcggta tgcccggcgg cgtccgtggg cgcccggggc
     7021 gccgggaagc tgatctgacg gacagttagc cggtgggtta tcgtgtgccg ggggtaaagg
     7081 caggcggcac ggtctgttga gttccagccc gggagaatcc agccgatggc gaggcagcta
     7141 cgcgccgagc agacccgcgc gacgatcatc ggtgcggcgg ccgacctgtt cgaccgccgc
     7201 ggctacgagt cgacgaccct gagcgagata gtcgcccacg ccggggtcac caagggcgcc
     7261 ctgtacttcc acttcgcggc gaaggaagac ctcgcgcacg ccatcctgga gatacagtcc
     7321 cgcacctccc gccggctggc gaaggacctg gacgggcgcg gctactcctc gctggaggcg
     7381 ctgatgcgcc tcaccttcgg catggcccgg ctctgcgtac agggaccggt gctgcgggcc
     7441 gggctgcggc tcgccaccgc gggcgtaccg gtacggccgc ccctgccgca ccccttcacc
     7501 gagtggcggg agatcgccac gtcccggctg ctggacgcgg tgcggcagtc cgacgtgcac
     7561 caggacatcg acgtcgactc cgtcgcccac accctcgtct gctccgtcgt cggcacccgc
     7621 gtcgtgggcg gcaccctcga accggccggg cgcgagcccc gccgcctcgc ggagatgtgg
     7681 tacatcctga tccggggcat ggtcccggtg acccggcgcg cccgctacgt caccctcgcg
     7741 gcccgcctgg aacaggagac gggcacggcc tgaccgtccg gcgcggggtc gcgcccgggc
     7801 cgaccgcccg gaatggggtc gcgctcggcc cgatcacctg gcgcggggtc gtgcccgggc
     7861 tgatcgtccg gcgcggggtc gcgcttgggc tgaccgtccg gaatggggtc gcgtcccgct
     7921 tgaccgtccg gcgcggggtc gcgcgtgggc tgaccgtccg gattggggtc gcgtccggct
     7981 tgaccgtccg gcgcgggggt cgcgtctcgc ctgaccgtcc ggcgcggggt cgcgcttggg
     8041 ctgtccgtcc ggattggggt cgtgtcccgc ttgaccgtcc ggcgcggggt tgcgcctggg
     8101 ccgaccgccc ggaatggggt cgtgctcggg ccgatcgcct ggcgcggggt cgtgcccggg
     8161 ctgatcgtcc ggcgcgggtc gtgcttgggc tgaccgtccg gattggggtc gcgtccggct
     8221 tgaccgtccg gcgcgggggt cgcgtctcgc ctgaccgtcc ggcgcggggt cgcgcttggg
     8281 ctgtccgtcc ggattggggt cgtgtcccgc ttgaccgtcc ggcgcggggt tgcgcctggg
     8341 ccgaccgccc ggaatggggt cgtgctcggg ccgatcgcct ggcgcggggt cgtgcccggg
     8401 ctgatcgtcc ggcgcgggtc gtgcttgggc tgaccgtccg gattggggtc gcgtccggct
     8461 cgaccgtccg gcgcgggggt cgcgtcccgc ccgattgccc ggcgcggggt cgtgctcggc
     8521 ccgattgccc ggtgccgggc gtgtgctcgg cccgatcgcc cggaaccggg gacgcgctcg
     8581 gcccaccgcc cggaacaggg gacgcgtgcg gtccgaccgg tacggtgacg cgcatggccg
     8641 acaccccgtc cgtgaccgcc cccgtcatcc tcggcgacga gcccggctcc ttcccgcacg
     8701 gcgtgctcgc cgagcggcac cccgccctcg tgcggcaggt gcgggacgcc ttccccttcg
     8761 gccccgaacg gctgcgcgcg ctcgacgcgt tgctcgcgag ctgcgccgac ggcgtggtcg
     8821 agccgctgcc cgccgacgcc gaccccaccg gccgcgaccg ggaccgctgg gcgcggtggg
     8881 gcatggacgc gtacgcgggc cgctcctggt acgacgtgcc ctggctgtgg gccgagagcc
     8941 acttctaccg ccggctcctc gacgccgtcg gctacttcgg ccccggcgcc tggcagggcg
     9001 tcgacccctt ccggcccgcc aaactggccg aactcgacgc gccggagacg gacgaggagc
     9061 tcgccgcgct cgacggtctc gacgagttgc ccaccgagga gcggacccgg gcgctgctgc
     9121 acggctcgct gtggggcaac cgcgccgacc tgggcttccg cctctccgac cggggcgccg
     9181 gcaccgaggg cgcggtggag gcactcgtcg ccgacgacag cgacgccctc tggtccctgc
     9241 tcccggcccc cggcacgggc cccgcggagc ggggtccggc cacgctgtgc ctcgtcgccg
     9301 acaacgcggg ccgcgaactc gtccccgatc tgctcctcgt ctcgcacctc ctcgccgagg
     9361 gccgcgtcga ccgggccgtc ctgcacgtca agccgtaccc gtactacgtc tccgacgcca
     9421 cacccaccga cgtgctcgac gccctgcggc ggctggtcgc ggcgggcggc gcggccgcgg
     9481 cccacggcga gcggctctgg accgcgctga ccgacggccg cgtcaccgtc cgcgcccacc
     9541 ccttctcctg cgccccgctg ccctacgcgg acatgcccga cgacctgcgc gcggacttcg
     9601 ccgcggccac cgtcaccgtc ctcaagggcg acctgaacta ccggcgcctg gtgggcgacc
     9661 ggtggtggcc gccgaccacc tccttcgcgc gggtcaccgc gtacttcccc ggcccggtcg
     9721 cggcgctgcg caccctgaag tccgacgtgg tcaccgggct cgacgcgaag accgaggccg
     9781 cgttggacgc gagcggcgag cggcgctggc ggacgagcgg cacgcacgcc ctgatccagg
     9841 tcaggagctg agaaggagcc gcgagggagc cgagaaggag cggcgggcag ccgagtgaga
     9901 acggcgggag aagttcccgc attccgggct gattcacgcg atggtgtgat catgtgcggc
     9961 ccggcggatg cggtcgaaga gccctgggta gggccgggcc atgacgcaac agcccttcca
    10021 actcccgcac ttctacctgc cgcaccccgc acggctcaac ccgcatctcg acgaggcccg
    10081 cgcccactcg acgacgtggg cgcgcgagat gggcatgctg gagggctccg gggtctggga
    10141 gcagtccgac ctcgaagccc acgactacgg cctgctctgc gcctacaccc accccgactg
    10201 cgacgggccg gcgctctccc tcatcaccga ctggtacgtg tgggtcttct tcttcgacga
    10261 ccacttcctg gagaagtaca aacgcagcca ggaccgcctc gccggcaagg cccacctgga
    10321 ccggctcccg ctgttcatgc cgctcgacga cgccgccggg atgcccgagc cgcggaaccc
    10381 ggtggaggcc ggactcgccg acctgtggac ccgcacggtg cccgcgatgt cggccgactg
    10441 gcgccgccgc ttcgccgtcg ccaccgagca cctcctcaac gagtccatgt gggagctgtc
    10501 caacatcaac gaggggcggg tcgccaaccc ggtcgagtac atcgagatgc gccgcaaggt
    10561 cggcggcgcc ccgtggtcgg ccgggctcgt ggagtacgcg accgccgagg tgcccgccgc
    10621 cgtcgccggg accaggccgc tcagggtgct gatggagacg ttctccgacg ccgtgcacct
    10681 gcgcaacgac ctcttctcct accagcgcga ggtcgaggac gagggcgagc tgagcaacgg
    10741 ggtgctggtg ttggagacct tcttcggctg caccacccag gaggccgccg acctggtcaa
    10801 cgacgtcctc acctcgcggc tgcaccagtt cgagcacacc gcgttcaccg aggtgcccgc
    10861 cgtcgccctg gagaagggcc tgaccccgtt ggaggtcgcc gccgtcggcg cgtacacgaa
    10921 gggcctccag gactggcagt ccggcggcca cgagtggcac atgcgttcca gccgctacat
    10981 gaacaagggg gagcggcccc tggccggctg gcaggcgctg accgggcccg gcacctccgc
    11041 ggcggacgtg ggagcactgc tcgccgacgc ggtcgcccaa cgggcccgct cctacacgta
    11101 cgtgcccttc cagaaggtcg gcccgtccgt catccccgac atccgcatgc cctacccgct
    11161 ggagctgagc cccgccctgg acggtgcccg gcggcacctg tccgagtggt gccgggagat
    11221 gggcatcctc agcgagggcg tctgggacga ggacaagctg gagagctgcg accttccgct
    11281 gtgcgccgcc ggactcgacc cggacgccac ccaggaccag ctcgacctcg cctccggctg
    11341 gctggccttc ggcacgtacg gcgacgacta ctacccgctg gtctacggcc accgccggga
    11401 cctcgccgcg gcccggctga ccaccacccg cctgtcggac tgcatgccgc tcgacggcga
    11461 gcccgtccca ccgcccggca acgcgatgga acgctccctg atcgacctgt gggtgcgcac
    11521 gacggccggt atgacgcccg aggagcggcg cccgctgaag aaggccgtcg acgacatgac
    11581 cgaggcctgg ctgtgggagc tgtccaacca gatccagaac cgtgtccccg atcccgtgga
    11641 ctacctggag atgcggcgcg ccaccttcgg atccgacctc accctgggcc tgtgccgcgc
    11701 cggacacggc ccggcggtgc cgcccgaggt ctaccgcagc ggccccgtcc gctccctgga
    11761 gaacgcggcg atcgactacg cgtgcctgct caacgacgtc ttctcctacc agaaggagat
    11821 cgagtacgag ggcgagatcc acaacgcggt cctcgtcgtg cagaacttct tcggcgtcga
    11881 ctatccggcc gccctgggcg tcgtgcagga cctgatgaac cagcgcatgc gccagttcga
    11941 gcacgtcgtc gcgcacgaac tccccgtcgt ctacgacgac ttccagctct ccgaggaggc
    12001 gcggaccgtc atgcgcggct acgtcaccga cctgcagaac tggatggccg gcatcctcaa
    12061 ctggcaccgg aacgtccccc gttacaaggc cgagtacctg gcgggacgca cccacggctt
    12121 cctgccggac cggatcccgg ccccgcccgt gccgaggagc agtcccgcac tgacgcactg
    12181 acgcgctgac ggacgttcag tctcactctt tcgtggctcg tcacgggccg gtgcgccggg
    12241 tagagcacct gccggaggcg atccatggaa cagacagcgt tgcgtcccaa gccgatgccc
    12301 ggccgggatc cggggcccgg caccgaaccc gacggtgccc ggcaccccca caccggccgt
    12361 cggcgccgcc ggcggctcac caccctgctg ctcggggtgc tcgccgcggc cgtcctgctc
    12421 ctcacgggcg tgggactcgg cacggtgggc gccacggtga tcggcatgag caagctcgcc
    12481 gaactgcggc agcgggccgc ggcgcagggc ccgggcgggg ccggaggggc cggaggagcg
    12541 ggagagcagg gggccaccgg gacggcgacg ggcacccggg gcgccccggc gcacccgtcg
    12601 gccggtccgt ccgccgggcg gtccccctcc ccggcaccgg ccggcgcgac cctcggggtc
    12661 gaagccgtgg acgacgagaa gcccggggcc cgggtcgtgg gcgtccacgt gccgggcccc
    12721 gggtacgcgg cgggcctggt gcggggcgac gtactgctcg ccgtcggcac gacccgcgtc
    12781 gactcggcga ccgacctggc gcacgccgtg gcccgcgccg ggccgggcaa ggaggtcaag
    12841 ctcaccgtgc gccaccgcag cggcggctac cagcagctga cggccgtacc gggcgtcgtc
    12901 acgtgaccgt gcggaagtgg ctcgtgagcc gtccggcgtc gtccagcacg tggaaggcga
    12961 gcccgaccgg cgcgtcccgg tccgcgacct gctcgccctc ccagggcagc cgcagcgtcc
    13021 acgtcacccc gggtcccacc accagcggcc gcccggcgaa cacggtggcc gcgggcgagt
    13081 gcgcgtgccc cgtgatcagc ccggcgatcc cgggcctgcg ctccagcagc gcggccaggc
    13141 gctcggggtg gcgcagccgg taggagtcgg gcaggggatg gtgcacgggc gtgggcgggt
    13201 ggtggaaggc gagcagggcc ggaaggccgt cgtcgagacc gtcgagcgag gcctcgatcc
    13261 agtcgtacgt ctccccgtcc agctccccct cgtcgctgcc cgggatgctg gagtcgcaca
    13321 tcaggacggc gccgccgtcg aagacgtgca cctcgttggc ggggccgtcg gcggcggggc
    13381 ggccgagcag ggccttgcgg tagggggcgc ggctgtcgtg gttgcccggg caggtcagta
    13441 cggggaacgg cgcggagccg tcccgcaggc ccaggacgcg ggcggcctcc tcgtactccg
    13501 cctccgtgcc gtggtccgcg atgtccccgg tgaccagcag cgcgtccacc cgcccaggca
    13561 gccgccacag cctctcgcgc acccgctcgg cgcgctccgt cgcccgcggg cttccgtcca
    13621 ggtgcagatc gctgatgtgc gcgagtacga gcacggtgtc ggcctcctcc gggcgcccgg
    13681 accgcgacac ccccgatgtt aatgcttgag tgacatacaa ccattagtcg tcagggtcga
    13741 tcaatcccaa tcggctcgcg tcgcccccgt cctgcgggca ggatgctgcc cgtggtccct
    13801 tcactcctcc gcccactctt ccgccccggg aggcccggat gaccggcagc agccccgccg
    13861 cttccttcac cgccgacgac taccgggccc gtatggagcg cgccgcccgg gctgccgccg
    13921 acgccggcct cgccgggctg ctggtggccc cgggcccgga cctggtgtgg ctcaccggct
    13981 acgcgcccac ggcggacacc gaacggctca cgctgctcgt cctcgccccg gaccgcgacc
    14041 ccgtgctcgt cgtcccgacg ctcgaggccc ccgacgcggc gaaggcggcc ggcgcccccg
    14101 ccctgaccct gcgcgactgg accgacggca aggaccccta cgcggccacc gccgccctcc
    14161 tcgacggatc cggacgcttc ggcatcagcg acaacgcctg ggccatgcac ctgctggcgc
    14221 tccagcgcac cctgcccgac acctcgtacg cctccctcac cgaggcgctg ccgatgctcc
    14281 gtgccgtcaa ggacgcggcg gagctggagc tgctggcggc ggcgggcgcg gccgcggacg
    14341 ccgccttcga ggagatccgg cgggtccgct tcggcgggcg ccgggagtcc gaggtcgccg
    14401 ccgacctcgc cgacctgctg cgccggttcg ggcactccca ggtcgacttc accatcgtcg
    14461 cctccggacc caacggcgcc aacccgcacc acgaggtcgg cgaccgcgtc atcgaggacg
    14521 gcgacatgat cgtcctcgac ttcggcggcc tcaaggacgg ctacggctcg gacacctccc
    14581 gcaccgtcca cgtgggcgca cccaccgacg aggagcgccg ggtgcacgac ctggtccgcg
    14641 aggcgcagga ggccggcttt tgcgcggtgc gccccggcgc cgcctgccag gacgtcgacc
    14701 gggccgcccg cgcggtcatc gccggcgccg ggtacggcga gtacttcatc caccgcaccg
    14761 ggcacggcat cggcgtcacc acgcacgaac cgccgtacat gatcgagggc gaggagcagc
    14821 ccctggtgcc cggcatgtgc ttctccgtcg agcccggcgt ctatctgccc ggccggttcg
    14881 gggtacgcat cgaggacatc gtcaccgtca ccgaggacgg cggcaggcgg ctcaacgaca
    14941 ccacccggga gatggtcctc gtcgagtgac cggtgacgga ccgaccccga acgccccggc
    15001 agacccttca ggacgacggc gcgacatgac ccaggcaccg acacccaccg cggacaccgt
    15061 ccgccgactg gtccgctccc tgctgggcgg gagcacggaa cccgacgtcc ggccggtcgc
    15121 cggaggcgtc gcacccgaca cctggtgggt cggcacccgg cacgtactgc ggctggcccc
    15181 cgaccgggag accgcggtgc gcggccgccg cgaactgcgc ctgcgcgaac tggtccggcc
    15241 gtacctgccg gtcgcgctgc cggccagcgt ggcgcacggg gagtgggcgc cgggactcgc
    15301 gtacaccctg gacgccaagg tggccggcgg gtcgggcgag gaccacgacg tgtccgccct
    15361 gggcgaggcg gacctcgcgg cgctgctcac cggcctgcgc gaggtgccgg tccggcaggc
    15421 cgagacgctc ggcgtaccgc gggcggcccc gcgctccctg gaggctctgc gccagtccgc
    15481 cgagcgtgcc gtccgccgcc tcgccgcggc cgacgagttc gacaccgcgc ggccggaacg
    15541 gctcacccgg gaggcggcgg cccagctcgg cgtccagccg ggcgcggcgg tcctggtcca
    15601 ccacgggctg accggggggc acctcgtggt cagcgccgac ggccgggtgc gcggcgtcct
    15661 cggctggagc gacgcggtcc tcggcgaccc ggccgaggac atcgccgggc tggccctctc
    15721 cgtgggttca cccgccgccg tccgcgcggc caccctcgcc ggctacggcg cccggccctg
    15781 cctgcgcggc ctgtggctgg cccgctgcga cgcggtaatc cacctcgcgg aggcactcga
    15841 cggccacggc ggcgggccgc tgcctgcgac cgtgccgctg ctcaggaccc ggctgcgacg
    15901 cgcctgggaa ccgatcctcc tggaacgcgt gaccgagctg cgcgacgacg gccgggacga
    15961 caccgcctga gcgcccctgc tcactcctgg accagcacca cgctcgactc gcccggcacc
    16021 cgcagtattc cgttcgcgcc cggcccctcc accggttccc acgccgcgag cacgcgcgcg
    16081 ggccggttgc ccagagggat cgccgccggc tcggtgccca ggttgacggc cacccggatg
    16141 tcgccgcgcc ggaaggcgag ccagcgcccc gtgccgtcgt aggccaccct ggtgtcggcc
    16201 aggtccgggt cggtcaggtc cggctgctcg gcgcgcaggg cgatcagccg ccggtaccag
    16261 tccagtacgc gcgcgtgcgg ctcgcgctcc ggctccgacc agtcgaggca ggagcgctca
    16321 cgcgtcgcag ggtcctgcgg gtcgggcacg tcctcctccc gccagccgtg cgcggcgaac
    16381 tcccgccgtc tgccctgccg taccgcctgg gcgagctggg ggtcggtgtg gtcggtgaag
    16441 aactgccacg gggtgcccgc cgcccactcc tcgcccatga acagcatcgg cgtgaacggc
    16501 gcggtcaggg tcagggtggc cgcgcaggcg gcgaggcccg gggagaccag ggaggccaga
    16561 cggtcgccct gggcgcggtt gccgacctgg tcgtgggtct ggctgtagcc ggtcagccgg
    16621 tgcgcggcga cccggccccg gtccagcgca cggccgtgcg aacggccccg gaaactggag
    16681 taggtgccgt cgtggaagta gccccggatc agggtcttgg cgagcgccgc cagcggatcg
    16741 cgcgcgaagt cggcgtagta gccctgcgac tccccggtca gggcggcgtg cagcgcgtgg
    16801 tggaagtcgt cgttccactg cgcgtgcacg cccaggccgc cctccgcgcg cggggtgatg
    16861 atccgcgggt cgttcaggtc ggactcggcg atcaggaaga gcggccgctc caggtcggcc
    16921 gccaggccgt ccacagcggt cgacaactgc tccaggaagt ggcacgcgcg cgtgtcggcc
    16981 agcgcgtgca ccgcgtccag gcgcagcccg tcgagccggt agtcccgcag ccacgccagc
    17041 gcgctgtcca ccaggtacgc ccgcacctcg tccgagccgg gcgcgtccag gttcacggcg
    17101 acgccccagg gcgtgtggtg ggtgtcggtg aagtacgggc cgaaggcggg caggtggttg
    17161 ccggacgggc ccaggtggtt gtgcaccacg tccaggacca cgccgagccc gaggtcgtgc
    17221 gcccggtcga cgaaccgttt cagcgcctcg ggcccgccgt acggctcgtg caccgcccac
    17281 agcgagaccc cctcgtaccc ccagccgtgc cgaccgggga aggggcacag cggcatcagc
    17341 tcgacgtggg tgacgcccag tcgcaccagg tgttcgaggc ggtcggcggc ggcgtcgagg
    17401 gtgccctcgg gcgtgtacgt ccccacgtgc agctcgtaga ggactccgcc gggcagcgga
    17461 cgcccggccc acggggtccg ccacgcgtac cgcccgtggt cgaccaccgc gctcagcccg
    17521 tcggggccgt ccggctggcg gcgcgagcgc gggtccggca gcaccggacc gtcgtccacc
    17581 gcgaagccgt agcgcgaacc gtcccgcgcc ggagcctcac cgcaccacca ccccggccgc
    17641 tccggatcgc gctccagcgc gcgcgtggcg ccgtcgcacc gcaacgtcac tcggccggcc
    17701 tgtggtgccc acacctcgaa ctgcacggac ggttcccctt cgtctgctca ccgtgatgta
    17761 gcgcgtccat gttccagcac gaggggatca ttccgctggg gattgccctc gcgcgcggcg
    17821 ggtgtcgtga cgctcgcgcg gggggcgctc gcccttttcc cgttttctgg acactccggc
    17881 tccgctgacc gacaatcagc tgcgtgacgt cgtccttcga gttccccacg tatcccgcgc
    17941 ggctgtccga cgcggagcgc gacaaggcgc tgagcgtgct ccgggacggc gtcgccatgg
    18001 ggcgcctgtc gcacgacacg ttcatccgcc ggatggagct ggcgctcgcc gcccgccgtc
    18061 tggaggagct ggccgtgctc accgccgacc tgcccaccga gaaccggctg tcccggctgg
    18121 tgttcggcac cgtcgaggcg gtgtccggat tcggcgtacg gctcggccgg gcgtggcggg
    18181 ccgagcggct gcccaagctg ctgctgcccc accccggcgc cggacatccg ctgcgcatag
    18241 ggcgcgatcc cgccagtgga ctgcggctga gccacgagac ggtctcccgg gtgcacgcgg
    18301 aactcagccg gcagggcggc atgtgggtac tgcgcgacct gggttccacc aacggcacca
    18361 cggtcaacgg gcggcgggtc atcggcgcgg ccgtcgtcca tgagggcgat cagatcggct
    18421 tcggcgggat gtccttccgc ctggcggcga actgacgcga cccggcgacc cggcgacccg
    18481 gcgggagccc tccgggtgga tccatggccc gcgcttcact aggagtcgtg gccgtctccg
    18541 tggctgaaac cgctttgctt ttcgtggtgt tgacgtaccc cgcaagtcgt gactgactgt
    18601 gcgtacaccg cacacaccag gtgaatcgac ggcccgcttc gtggaggtgt gccctgccgc
    18661 ccctcctgcg ctacccgacc gtggacgagc tgggcgcccg ggccgccgca ctcgtcgccc
    18721 ggtaccccag acacgcccgg ctgcggcgtg tcggcacgtc ccgcgcgggc agcccgctgc
    18781 tgctgctctc cgtcggccac ggcagccgcc aggtcctcgt cgtcggcggc ccgcacgcga
    18841 acgagcccgt gggcggcgcc accgccctgc ggctggccga gcgggccgtg gccgaccccc
    18901 ggctcaccga gggcgccgac gccacctgga acctgctgct ctgcgtcgac cccgacggcc
    18961 tgcgccgcaa cgagggctgg ctcaccggcc cctacaccct cggccgctac gcccgtaact
    19021 tcttccggcc cggcttcctg gagcagcccg agtggctgcc cgacggcccg gaccgcgcca
    19081 cgctgcccga gacccgcacc ctgctcgcgc tccaggacga actgcggccc ttccttcagt
    19141 gctccctgca cggcgtggac gtcggcggcg gcttcgtcga gctgacccac gagctgccgg
    19201 gcctggccca gcgcatctcc cacaccgcgg cgcggctcgg cataccccgc gaactcggcg
    19261 cctacgacac cctgtactgg cccgacctcg gacccgccgt ctaccgcatc ccgccgcccc
    19321 gccgcggcga cctgaccgcc gccatcaccg aggccgccgt cgactcgacc tggtgccacc
    19381 cgcggcgcca cggcaccgtc accgcggtcg tcgaggctcc catgtggggc gttgcggccg
    19441 tggcggacga ctcgcccccc gtcgaccgcg acggcgtcct gcgcaccgtg agccgcaccc
    19501 tgcgccacga cacccgccgg ctgcgccgcg tcctcgcccg gctcaggccc cacctcgccg
    19561 ccgtgccgga ggcggcgcac ctgctcgcac cggtcgacga ctacctgctg gtctgccccc
    19621 ggctcgccga cgagtgggac cccgacaccg acgaccggac cgaccgctca ctgccgccga
    19681 tgaacacctc ccacctcgtg gcactgcggc tggccgggcg ccgcctgtcg ctgcgtaccg
    19741 cggggctgct gcaccagctg gtcacccgta ccgggggcga tccggcgggc gtcctggccg
    19801 agctggaccg gctcgtcgac gagggctgcg ccgactaccg cgacggctgc ggggcgcact
    19861 ggataccggt cgggcgccag gtggagtacc agacccgggt cgtgctcgcc gccttcgaac
    19921 tggccggacg gcgtgccgcc gcgggcgccc gctcgggcga gccgggccgg ggttccgagg
    19981 ccgcggtgcc gatgcaccgc gactgacccg cgatcagccg ccgttccacc gtgtgcccgc
    20041 ctcctccacc cgctccagga gcgccaccgg cgtgtccgcg aaaaggtccg ccacgcgcgc
    20101 gtcgcccgcg aactcccgcc cgggcgccag cgcgtcggcc catctgccgg gcggcagcgg
    20161 cagcgtcgtg ccgcgccagc cgcccgcctc ggccagccgc agcgacagcc gggtcacggc
    20221 ggtcacggtc cgccccgacc tggcgaacgc cacgcagtgt gccgccgccg ggccctcggc
    20281 gggcagcggc tcgtaggtcc ccgtgtcgcc gaagacgccg ggccgccggg cccgcagtgc
    20341 cagcgccgcc cgcgtcaccg ccgccttcgc tccggggccc caggcccagc cctcgtcccc
    20401 ggccgcgggg aagtccaccg cgcggcggtt gtccgggtcc accagggcca ggtactcgtg
    20461 ctcggtgccc tggtagaggt ccggtacgcc cggcatcgtc aggtggacca gggccgtgcc
    20521 gaggacgttg gcccggatgt gcggcgccag cgcctcgcgc agggcggtca cccgcgcgcc
    20581 cggcgcgccg cccggccccg ccgccacgaa ccgggccacc gcctcctcgt acgaggggtc
    20641 ctgctccgtc caggtggtgt gcgtccccgc ctcgcgcacg tgcttgagca gcgcctcccg
    20701 cacccgttcc cggtccgccg ggcccagacc gaacaccgtc tgccaggccg cccacgccag
    20761 ctgcccgtcc ggcggaccct cgtccgtgcc ggtggccccg gcggcctcgg tcaggacgtc
    20821 cgcccaccgc gcggggcact gggtgagcac cgccagcgcg gcgcggacgt cggcgctgcg
    20881 cttggtgtca tgggtcgaca cgaccgtgcc cgtggcgggc cagtcgcgct gcacgcgcgc
    20941 gcagtaggcg tggaactcct gcggcgacac ggccggacgg cccggatccc cgcccacctc
    21001 ggtggccgac agcaacggta cgtagcggta gaaggccgtg tcctcgacgg acttggcgcg
    21061 cagcgccgac gcggtctgcg cgaaccgcgt ccggaactcc acgtgatccg gtccgtcccc
    21121 gtaccgcccc agcaccaggc cccgtacgac gtccaccgcg ccggcctcct cgggcaccgt
    21181 gaaggcgtgc cgcgccccgg cggccgcctc ctcggtgacg accgccgccg cgtccaccga
    21241 ggtgtacggc cggtacacct ccagccgcac cagcagctcc accagcgccg tgcgcaacgc
    21301 ccagggcgcc cggtcgcgca gcgccgggtc cggcgcggcg gcgcacaggc ggtgcgccac
    21361 ccgggtcagc cggtccagct cggtggccag ctcgtgcgtg agcacctcgt acgccgcgcg
    21421 ccgcaccgtc gccgcccagt ccccgcccag gtccgcctgc ggggcggcga accgtcggta
    21481 ccggtcgagc agttgtccgt agccggcggg gtccgtgaac agcccgtcga cgtgccgcag
    21541 ggcgtcgtag ccggtcgtgc ccgcgacggg ccaggcggcg ggcagccgct ccccgtccgc
    21601 gaggatcttc tccaccaccg tccaccgtcc gccgctcgcc cggtgcagcc gttccaggta
    21661 cgcgtcgggg tcggcgaggc cgtcgggatg gtcgacgcgc agtccgtcga tcacgccctc
    21721 gtgcagcagc cgcaggacgg tgccgtgcgt cgcctcgaac acctccgggt cctccacgcg
    21781 cacgccgatc agctccgaga tgctgaagaa gcgccggtag ttcagctcgg tgcgggccag
    21841 ccgccaccac accgggcggt accactgcgc gtccagcagc cgtggcagcg gcaggtccgc
    21901 ggtgccgtcc cgcagcggga aggcgtgctc gtggtagcgc agcacgtcgc cgtcgacccg
    21961 gaggtcgtcc agcacctcgc cgagcggggc gcccagcacc ggcagcagca gccggccgtc
    22021 ctgcgcctgc cagtcgatgt cgaaccaccg cgcgtagggc gatgagggcc cctcgcgcag
    22081 cacctcccac agggcgtggt tgtgacgcgg cgacatcgcc atgtggttgg gcacgatgtc
    22141 caccaccagg cccaggccgt gctcccgcgc ggtgcgcgac a
//
