LOCUS       NC_003888              21161 bp    DNA     linear   CON 03-AUG-2016
DEFINITION  Streptomyces coelicolor A3(2) chromosome, complete genome.
ACCESSION   NC_003888
VERSION     NC_003888.3
KEYWORDS    RefSeq; complete genome.
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces; Streptomyces
            albidoflavus group.
REFERENCE   1  (bases 1 to 8667507)
  AUTHORS   Hsiao,N.H. and Kirby,R.
  TITLE     Comparative genomics of Streptomyces avermitilis, Streptomyces
            cattleya, Streptomyces maritimus and Kitasatospora aureofaciens
            using a Streptomyces coelicolor microarray system
  JOURNAL   Antonie Van Leeuwenhoek 93 (1-2), 1-25 (2008)
   PUBMED   17588127
REFERENCE   2  (bases 1 to 8667507)
  AUTHORS   Bentley,S.D., Chater,K.F., Cerdeno-Tarraga,A.M., Challis,G.L.,
            Thomson,N.R., James,K.D., Harris,D.E., Quail,M.A., Kieser,H.,
            Harper,D., Bateman,A., Brown,S., Chandra,G., Chen,C.W., Collins,M.,
            Cronin,A., Fraser,A., Goble,A., Hidalgo,J., Hornsby,T., Howarth,S.,
            Huang,C.H., Kieser,T., Larke,L., Murphy,L., Oliver,K., O'Neil,S.,
            Rabbinowitsch,E., Rajandream,M.A., Rutherford,K., Rutter,S.,
            Seeger,K., Saunders,D., Sharp,S., Squares,R., Squares,S., Taylor,K.,
            Warren,T., Wietzorrek,A., Woodward,J., Barrell,B.G., Parkhill,J. and
            Hopwood,D.A.
  TITLE     Complete genome sequence of the model actinomycete Streptomyces
            coelicolor A3(2)
  JOURNAL   Nature 417 (6885), 141-147 (2002)
   PUBMED   12000953
REFERENCE   3  (bases 1 to 8667507)
  AUTHORS   Redenbach,M., Kieser,H.M., Denapaite,D., Eichner,A., Cullum,J.,
            Kinashi,H. and Hopwood,D.A.
  TITLE     A set of ordered cosmids and a detailed genetic and physical map for
            the 8 Mb Streptomyces coelicolor A3(2) chromosome
  JOURNAL   Mol. Microbiol. 21 (1), 77-96 (1996)
   PUBMED   8843436
REFERENCE   4  (bases 1 to 8667507)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-MAY-2002) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
  REMARK    Direct Submission
REFERENCE   5  (bases 1 to 8667507)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAY-2002) Sanger Institute, Wellcome Trust Genome
            Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
  REMARK    Direct Submission
COMMENT     ##antiSMASH-Data-START##
            Version     :: 8.0.1
            Run date    :: 2025-05-26 12:13:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start :: 5701115
            Orig. end   :: 5722276
            ##antiSMASH-Data-END##
            REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645882.
            On Jun 22, 2003 this sequence version replaced NC_003888.2.
            RefSeq Category: Reference Genome
            MOD: Model Organism
            UPR: UniProt Genome
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21161
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="14"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21161
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21161
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11161](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11161
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(420..433)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.36"
                     /tool="antismash"
     misc_feature    complement(559..571)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     gene            complement(740..997)
                     /db_xref="GeneID:1100681"
                     /gene_synonym="2SC7G11.02c; wblE"
                     /locus_tag="SCO5240"
     CDS             complement(740..997)
                     /codon_start=1
                     /db_xref="GeneID:1100681"
                     /gene_synonym="2SC7G11.02c; wblE"
                     /locus_tag="SCO5240"
                     /note="2SC7G11.02c, wblE, hypothetical protein, len: 85 aa;
                     identical to previously sequenced TR:Q9X952 (EMBL:AJ239087)
                     Streptomyces coelicolor hypothetical 9.7 kDa protein WblE,
                     85 aa"
                     /product="hypothetical protein"
                     /protein_id="NP_629386.1"
                     /transl_table=11
                     /translation="MDWRHRAVCREEDPELFFPIGNTGPALLQIEEAKAVCRRCPVMEQ
                     CLQWALESGQDSGVWGGLSEDERRAMKRRAARNRARQASA"
     PFAM_domain     complement(785..991)
                     /aSDomain="Whib"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF02467.19"
                     /description="Transcription factor WhiB"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5240_0509"
                     /evalue="9.10E-28"
                     /label="SCO5240"
                     /locus_tag="SCO5240"
                     /protein_end="71"
                     /protein_start="2"
                     /score="96.8"
                     /tool="antismash"
                     /translation="WRHRAVCREEDPELFFPIGNTGPALLQIEEAKAVCRRCPVMEQCL
                     QWALESGQDSGVWGGLSEDERRAM"
     regulatory      complement(1003..1009)
                     /regulatory_class="ribosome_binding_site"
     misc_feature    1042..1057
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     misc_feature    complement(1043..1054)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     misc_feature    1219..1228
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 15.86"
                     /tool="antismash"
     misc_feature    1219..1233
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.74"
                     /tool="antismash"
     gene            complement(1318..2286)
                     /db_xref="GeneID:1100682"
                     /gene_synonym="2SC7G11.03c"
                     /locus_tag="SCO5241"
     CDS             complement(1318..2286)
                     /codon_start=1
                     /db_xref="GeneID:1100682"
                     /gene_synonym="2SC7G11.03c"
                     /locus_tag="SCO5241"
                     /note="2SC7G11.03c, hypothetical protein, len: 322 aa;
                     similar to TR:O05848 (EMBL:Z95120) Mycobacterium
                     tuberculosis hypothetical 34.5 kDa protein MTCY07D11.08c,
                     321 aa; fasta scores: opt: 694 z-score: 788.3 E(): 0; 39.9%
                     identity in 328 aa overlap. Contains Pfam match to entry
                     PF00781 DAGKc, Diacylglycerol kinase catalytic domain
                     (presumed)"
                     /product="hypothetical protein"
                     /protein_id="NP_629387.1"
                     /transl_table=11
                     /translation="MRALLVVNPAATTTSARTRDVLIHALASEMKLEAVTTEYRGHARD
                     LGRQAAQGDDIDLVVALGGDGTVNEVVNGLLHAGPDPDHLPGLAVVPGGSTNVFARALG
                     LPNHAVEATGALLDALREGSERTVGLGLASGTPGSEDEAVPARWFTFNAGLGFDAGVVG
                     RVEQHRERGRKSTHALYVRQVVRQLIGEPHRRSGTITLERAGEDPVTDLVLSIVSNTCP
                     WTFLGNRPIYASPEASFDTALDVFGLSRLSTAAVARYGTQLLTSSPERGPRGRHAVSLH
                     DLTEFTLHSKVPLPLQMDGDHLGLRTSVTFTGVRRALRVIV"
     misc_feature    complement(1888..2283)
                     /gene_synonym="2SC7G11.03c"
                     /locus_tag="SCO5241"
                     /note="Pfam match to entry PF00781 DAGKc, Diacylglycerol
                     kinase catalytic domain (presumed), score 47.80, E-value
                     2.3e-10"
     PFAM_domain     complement(1933..2283)
                     /aSDomain="DAGK_cat"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00781.27"
                     /db_xref="GO:0016301"
                     /description="Diacylglycerol kinase catalytic domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5241_0510"
                     /evalue="7.70E-26"
                     /gene_ontologies="GO:0016301: kinase activity"
                     /label="SCO5241"
                     /locus_tag="SCO5241"
                     /protein_end="118"
                     /protein_start="1"
                     /score="90.3"
                     /tool="antismash"
                     /translation="RALLVVNPAATTTSARTRDVLIHALASEMKLEAVTTEYRGHARDL
                     GRQAAQGDDIDLVVALGGDGTVNEVVNGLLHAGPDPDHLPGLAVVPGGSTNVFARALGL
                     PNHAVEATGALLD"
     misc_feature    complement(2296..5595)
                     /note="previously sequenced DNA fragment. EMBL:AF162936
                     Streptomyces coelicolor A3(2) Na/H antiporter homolog gene,
                     partial cds; and hypothetical protein (ushY), sigma factor
                     SigH anti-sigma factor (ushX), and RNA polymerase
                     alternative sigma factor (sigH) genes, complete cds."
     gene            2414..2872
                     /db_xref="GeneID:1100683"
                     /gene_synonym="2SC7G11.04"
                     /locus_tag="SCO5242"
     CDS             2414..2872
                     /codon_start=1
                     /db_xref="GeneID:1100683"
                     /gene_synonym="2SC7G11.04"
                     /locus_tag="SCO5242"
                     /note="2SC7G11.04, possible integral membrane protein, len:
                     152 aa; similar to TR:O05849 (EMBL:Z95120) Mycobacterium
                     tuberculosis hypothetical 14.3 kDa protein MTCY07D11.09,
                     143 aa; fasta scores: opt: 177 z-score: 215.5 E(): 0.00015;
                     33.8% identity in 136 aa overlap"
                     /product="hypothetical protein"
                     /protein_id="NP_629388.1"
                     /transl_table=11
                     /translation="MSSEQTPTPASATAEETTPRPGRLTAAAAIAALEGLALVVGGGWM
                     LVEGLTGHPDDRTSAVTGGVTLIVLALLPLLAARGLIARRGWSRGPAVITQIMALPVAY
                     NMVRADSLAVPAGIVLGVVAVTALVLLVNPTTTQALGIRGPGNAGKQP"
     gene            complement(2892..3977)
                     /db_xref="GeneID:1100684"
                     /gene_synonym="2SC7G11.05c; sig1"
                     /locus_tag="SCO5243"
     CDS             complement(2892..3977)
                     /codon_start=1
                     /db_xref="GeneID:1100684"
                     /gene_synonym="2SC7G11.05c; sig1"
                     /locus_tag="SCO5243"
                     /note="2SC7G11.05c, sig1, RNA polymerase sigma factor, len:
                     361 aa; identical to previously sequenced TR:Q9RIT0
                     (EMBL:AJ249450) Streptomyces coelicolor A3(2) Sig1 protein,
                     361 aa and similar TR:CAB93744 (EMBL:AL357613) Streptomyces
                     coelicolor regulatory protein SC5F8.16c, 83 aa; fasta
                     scores: opt: 414 z-score: 534.4 E(): 3.9e-24; 72.0%
                     identity in 82 aa overlap. Contains Pfam match to entry
                     PF00140 sigma70, Sigma-70 factor and possible
                     helix-turn-helix motif at residues 326..347 (+7.10 SD)"
                     /product="RNA polymerase sigma factor"
                     /protein_id="NP_629389.1"
                     /transl_table=11
                     /translation="MRDGDGPVRDEERGTRELPAEGTRSPNEARRTADGIDGIPEQARP
                     HPEDETSPGAAVPGEGQRTGETPVRPVRAEARARERATGGTMSEHERHADGHAPGARGT
                     QGTRHDPQDRSGARLLFAELRTLEKDSPEYAELRNRLVRMHLPLVEHLARRFRNRGEPL
                     DDLTQVATIGLIKSVDRFDPDRGVEFSTYATPTVVGEIKRHFRDKGWAVRVPRRLQELR
                     LALTTATAELSQLHGRSPTVHELAEKLSISEEEVLEGLESANAYSTLSLDVPDTDDESP
                     AVADTLGAEDEALEGVEYRESLKPLLEDLPPREKRILLLRFFGNMTQSQIAQEVGISQM
                     HVSRLLARTLAQLREKLLVEE"
     aSDomain        complement(2907..3569)
                     /aSDomain="TIGR02937"
                     /aSTool="tigrfam"
                     /description="sigma70-ECF: RNA polymerase sigma factor,
                     sigma-70 family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO5243_0067"
                     /evalue="6.10E-38"
                     /identifier="TIGR02937"
                     /label="SCO5243"
                     /locus_tag="SCO5243"
                     /protein_end="357"
                     /protein_start="136"
                     /score="128.0"
                     /tool="antismash"
                     /translation="LRNRLVRMHLPLVEHLARRFRNRGEPLDDLTQVATIGLIKSVDRF
                     DPDRGVEFSTYATPTVVGEIKRHFRDKGWAVRVPRRLQELRLALTTATAELSQLHGRSP
                     TVHELAEKLSISEEEVLEGLESANAYSTLSLDVPDTDDESPAVADTLGAEDEALEGVEY
                     RESLKPLLEDLPPREKRILLLRFFGNMTQSQIAQEVGISQMHVSRLLARTLAQLREKL"
     aSDomain        complement(2907..3575)
                     /aSDomain="TIGR02980"
                     /aSTool="tigrfam"
                     /description="SigBFG: RNA polymerase sigma-70 factor,
                     sigma-B/F/G subfamily"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO5243_0066"
                     /evalue="1.50E-95"
                     /identifier="TIGR02980"
                     /label="SCO5243"
                     /locus_tag="SCO5243"
                     /protein_end="357"
                     /protein_start="134"
                     /score="317.2"
                     /tool="antismash"
                     /translation="AELRNRLVRMHLPLVEHLARRFRNRGEPLDDLTQVATIGLIKSVD
                     RFDPDRGVEFSTYATPTVVGEIKRHFRDKGWAVRVPRRLQELRLALTTATAELSQLHGR
                     SPTVHELAEKLSISEEEVLEGLESANAYSTLSLDVPDTDDESPAVADTLGAEDEALEGV
                     EYRESLKPLLEDLPPREKRILLLRFFGNMTQSQIAQEVGISQMHVSRLLARTLAQLREK
                     L"
     PFAM_domain     complement(2913..3062)
                     /aSDomain="Sigma70_r4"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF04545.19"
                     /db_xref="GO:0003700"
                     /db_xref="GO:0006352"
                     /db_xref="GO:0006355"
                     /description="Sigma-70, region 4"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5243_0513"
                     /evalue="2.30E-16"
                     /gene_ontologies="GO:0003700: DNA-binding transcription
                     factor activity"
                     /gene_ontologies="GO:0006352: DNA-templated transcription
                     initiation"
                     /gene_ontologies="GO:0006355: regulation of DNA-templated
                     transcription"
                     /label="SCO5243"
                     /locus_tag="SCO5243"
                     /protein_end="355"
                     /protein_start="305"
                     /score="59.2"
                     /tool="antismash"
                     /translation="LLEDLPPREKRILLLRFFGNMTQSQIAQEVGISQMHVSRLLARTL
                     AQLRE"
     misc_feature    complement(2913..3575)
                     /gene_synonym="2SC7G11.05c; sig1"
                     /locus_tag="SCO5243"
                     /note="Pfam match to entry PF00140 sigma70, Sigma-70
                     factor, score 266.90, E-value 2.7e-76"
     PFAM_domain     complement(3135..3314)
                     /aSDomain="Sigma70_r3"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF04539.19"
                     /db_xref="GO:0003700"
                     /db_xref="GO:0006352"
                     /db_xref="GO:0006355"
                     /description="Sigma-70 region 3"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5243_0512"
                     /evalue="1.00E-14"
                     /gene_ontologies="GO:0003700: DNA-binding transcription
                     factor activity"
                     /gene_ontologies="GO:0006352: DNA-templated transcription
                     initiation"
                     /gene_ontologies="GO:0006355: regulation of DNA-templated
                     transcription"
                     /label="SCO5243"
                     /locus_tag="SCO5243"
                     /protein_end="281"
                     /protein_start="221"
                     /score="54.5"
                     /tool="antismash"
                     /translation="RLALTTATAELSQLHGRSPTVHELAEKLSISEEEVLEGLESANAY
                     STLSLDVPDTDDESP"
     PFAM_domain     complement(3348..3557)
                     /aSDomain="Sigma70_r2"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF04542.17"
                     /db_xref="GO:0003700"
                     /db_xref="GO:0006352"
                     /db_xref="GO:0006355"
                     /description="Sigma-70 region 2"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5243_0511"
                     /evalue="7.90E-21"
                     /gene_ontologies="GO:0003700: DNA-binding transcription
                     factor activity"
                     /gene_ontologies="GO:0006352: DNA-templated transcription
                     initiation"
                     /gene_ontologies="GO:0006355: regulation of DNA-templated
                     transcription"
                     /label="SCO5243"
                     /locus_tag="SCO5243"
                     /protein_end="210"
                     /protein_start="140"
                     /score="73.8"
                     /tool="antismash"
                     /translation="LVRMHLPLVEHLARRFRNRGEPLDDLTQVATIGLIKSVDRFDPDR
                     GVEFSTYATPTVVGEIKRHFRDKGW"
     gene            complement(3974..4387)
                     /db_xref="GeneID:1100685"
                     /gene_synonym="2SC7G11.06c; prs"
                     /locus_tag="SCO5244"
     CDS             complement(3974..4387)
                     /codon_start=1
                     /db_xref="GeneID:1100685"
                     /gene_synonym="2SC7G11.06c; prs"
                     /locus_tag="SCO5244"
                     /note="2SC7G11.06c, prs1, anti-sigma factor, len: 137 aa;
                     identical to previously sequenced TR:Q9R3X8 (EMBL:AJ249450)
                     Streptomyces coelicolor A3(2) regulator of Sig1, Prs1
                     protein or UshX, 137 aa"
                     /product="anti-sigma factor"
                     /protein_id="NP_629390.1"
                     /transl_table=11
                     /translation="MSQIAGEPATQDFVEVRLPAAGAYLSVLRTATAGLAARLDFTLDE
                     IEDLRIAVDEACAILLQQAVPGSVLSCVFRLVDDSLEVTVSAPTTDGHAPSRDTFAWTV
                     LSALAGKVSSAVDEDKTVSISLYKQRGAGPGPT"
     regulatory      complement(4390..4397)
                     /regulatory_class="ribosome_binding_site"
     misc_feature    4516..4529
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.89"
                     /tool="antismash"
     gene            complement(4638..4898)
                     /db_xref="GeneID:1100686"
                     /gene_synonym="2SC7G11.07c"
                     /locus_tag="SCO5245"
     CDS             complement(4638..4898)
                     /codon_start=1
                     /db_xref="GeneID:1100686"
                     /gene_synonym="2SC7G11.07c"
                     /locus_tag="SCO5245"
                     /note="2SC7G11.07c, hypothetical protein, len: 86 aa;
                     identical to previously sequenced TR:Q9R3I9 (EMBL:AJ249450)
                     Streptomyces coelicolor A3(2) hypothetical 9.6 kDa protein
                     UshY, 86 aa. Contains Pfam match to entry PF02148 zf-UBP,
                     Zn-finger in ubiquitin-hydrolases and other proteins"
                     /product="hypothetical protein"
                     /protein_id="NP_629391.1"
                     /transl_table=11
                     /translation="MKQCTHADALPHPEPEPCGETCPECLAEGTDPVQLRLCLVCGHVG
                     CCDSSPNRHATAHYKESGHPLMRTFEPGESWRWCFVDHVLV"
     PFAM_domain     complement(4653..4835)
                     /aSDomain="zf-UBP"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF02148.22"
                     /db_xref="GO:0008270"
                     /description="Zn-finger in ubiquitin-hydrolases and other
                     protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5245_0514"
                     /evalue="3.80E-11"
                     /gene_ontologies="GO:0008270: zinc ion binding"
                     /label="SCO5245"
                     /locus_tag="SCO5245"
                     /protein_end="82"
                     /protein_start="21"
                     /score="43.3"
                     /tool="antismash"
                     /translation="CPECLAEGTDPVQLRLCLVCGHVGCCDSSPNRHATAHYKESGHPL
                     MRTFEPGESWRWCFVD"
     misc_feature    complement(4659..4826)
                     /gene_synonym="2SC7G11.07c"
                     /locus_tag="SCO5245"
                     /note="Pfam match to entry PF02148 zf-UBP, Zn-finger in
                     ubiquitin-hydrolases and other proteins, score 28.50,
                     E-value 1.4e-06"
     regulatory      4953..4956
                     /regulatory_class="ribosome_binding_site"
     gene            4960..6552
                     /db_xref="GeneID:1100687"
                     /gene_synonym="2SC7G11.08"
                     /locus_tag="SCO5246"
     CDS             4960..6552
                     /codon_start=1
                     /db_xref="GeneID:1100687"
                     /gene_synonym="2SC7G11.08"
                     /locus_tag="SCO5246"
                     /note="2SC7G11.08, possible Na+/H+ antiporter, len: 530 aa;
                     identical to C-terminal region of previously sequenced
                     TR:Q9RPC9 (EMBL:AF162936) Streptomyces coelicolor A3(2)
                     Na/H antiporter homolog (fragment), 212 aa and similar to
                     SW:YJCE_ECOLI: (EMBL:U00006) Escherichia coli Na(+)/H(+)
                     exchanger YjcE, 549 aa; fasta scores: opt: 516 z-score:
                     557.0 E(): 1.5e-23; 30.1% identity in 552 aa overlap.
                     Contains Pfam match to entry PF00999 Na_H_Exchanger,
                     Sodium/hydrogen exchanger family and possible hydrophobic
                     membrane spanning regions"
                     /product="Na+/H+ antiporter"
                     /protein_id="NP_629392.1"
                     /transl_table=11
                     /translation="MDVMPLLLLVAGSAAVAAAGRRVPVPVPLLLVAAGLAVSYVPGVP
                     DYTLDPHIVLPLLLPPLLYTAATDSSYLDLRAQARPVALLSVGYVLFATFVVGCAAYLI
                     VPGLPLTAALVLGAVVAPPDAVAATAVARRVGLPSRITTILQGESLVNDATAITAFKVA
                     LAAAVGEGATWAGGIGEFLIAAVGGVGVGLVLMVPLHWLRTHLTEALLQNTLSLLIPFV
                     AYAVAEQVQASGVLAVVVVALYLGHRAWEVDFATRLQEEAVWKMVAFVLESAVFALIGL
                     QLPVVLKGLGEYEGADAAWYALAVFLVVAVARFVWVYPATYLPRLSARVRAREGELSWK
                     GPFVIGWAGMRGVVSLAIAFSIPLTVHGGEPFPERNLILFLTFTTVIGTLVVQGVSLPP
                     LIRLLKFPAHDVQAETLAEANAQAQASRVAELRLDDLLADERNALPAPLADRLRMVLER
                     RRNAVWERLGQVNPVTGETVDDTYRRLSREMISAEREVFVRLRDGRYIDDEMLRTLLRR
                     LDLEEAAAYREAT"
     misc_feature    4969..6183
                     /gene_synonym="2SC7G11.08"
                     /locus_tag="SCO5246"
                     /note="Pfam match to entry PF00999 Na_H_Exchanger,
                     Sodium/hydrogen exchanger family, score 230.10, E-value
                     3.2e-65"
     aSDomain        4978..6528
                     /aSDomain="TIGR00831"
                     /aSTool="tigrfam"
                     /description="a_cpa1: Na+/H+ antiporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO5246_0068"
                     /evalue="9.70E-104"
                     /identifier="TIGR00831"
                     /label="SCO5246"
                     /locus_tag="SCO5246"
                     /protein_end="523"
                     /protein_start="6"
                     /score="345.7"
                     /tool="antismash"
                     /translation="LLLVAGSAAVAAAGRRVPVPVPLLLVAAGLAVSYVPGVPDYTLDP
                     HIVLPLLLPPLLYTAATDSSYLDLRAQARPVALLSVGYVLFATFVVGCAAYLIVPGLPL
                     TAALVLGAVVAPPDAVAATAVARRVGLPSRITTILQGESLVNDATAITAFKVALAAAVG
                     EGATWAGGIGEFLIAAVGGVGVGLVLMVPLHWLRTHLTEALLQNTLSLLIPFVAYAVAE
                     QVQASGVLAVVVVALYLGHRAWEVDFATRLQEEAVWKMVAFVLESAVFALIGLQLPVVL
                     KGLGEYEGADAAWYALAVFLVVAVARFVWVYPATYLPRLSARVRAREGELSWKGPFVIG
                     WAGMRGVVSLAIAFSIPLTVHGGEPFPERNLILFLTFTTVIGTLVVQGVSLPPLIRLLK
                     FPAHDVQAETLAEANAQAQASRVAELRLDDLLADERNALPAPLADRLRMVLERRRNAVW
                     ERLGQVNPVTGETVDDTYRRLSREMISAEREVFVRLRDGRYIDDEMLRTLLRRLDLEEA
                     "
     PFAM_domain     4981..6162
                     /aSDomain="Na_H_Exchanger"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00999.24"
                     /db_xref="GO:0006812"
                     /db_xref="GO:0015297"
                     /db_xref="GO:0016020"
                     /db_xref="GO:0055085"
                     /db_xref="GO:1902600"
                     /description="Sodium/hydrogen exchanger family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5246_0515"
                     /evalue="1.70E-60"
                     /gene_ontologies="GO:0006812: monoatomic cation transport"
                     /gene_ontologies="GO:0015297: antiporter activity"
                     /gene_ontologies="GO:0016020: membrane"
                     /gene_ontologies="GO:0055085: transmembrane transport"
                     /gene_ontologies="GO:1902600: proton transmembrane
                     transport"
                     /label="SCO5246"
                     /locus_tag="SCO5246"
                     /protein_end="401"
                     /protein_start="7"
                     /score="205.0"
                     /tool="antismash"
                     /translation="LLVAGSAAVAAAGRRVPVPVPLLLVAAGLAVSYVPGVPDYTLDPH
                     IVLPLLLPPLLYTAATDSSYLDLRAQARPVALLSVGYVLFATFVVGCAAYLIVPGLPLT
                     AALVLGAVVAPPDAVAATAVARRVGLPSRITTILQGESLVNDATAITAFKVALAAAVGE
                     GATWAGGIGEFLIAAVGGVGVGLVLMVPLHWLRTHLTEALLQNTLSLLIPFVAYAVAEQ
                     VQASGVLAVVVVALYLGHRAWEVDFATRLQEEAVWKMVAFVLESAVFALIGLQLPVVLK
                     GLGEYEGADAAWYALAVFLVVAVARFVWVYPATYLPRLSARVRAREGELSWKGPFVIGW
                     AGMRGVVSLAIAFSIPLTVHGGEPFPERNLILFLTFTTVIGTLVVQGVSLPPLI"
     gene            complement(6601..7509)
                     /db_xref="GeneID:1100688"
                     /gene_synonym="2SC7G11.09c"
                     /locus_tag="SCO5247"
     CDS             complement(6601..7509)
                     /codon_start=1
                     /db_xref="GeneID:1100688"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="2SC7G11.09c"
                     /locus_tag="SCO5247"
                     /note="2SC7G11.09c, possible deaminase, len: 302 aa;
                     similar to SW:1A1D_PYRHO (EMBL:AP000001) Pyrococcus
                     horikoshii 1-aminocyclopropane-1-carboxylate deaminase (EC
                     4.1.99.4) PHBE027, 325 aa; fasta scores: opt: 274 z-score:
                     309.9 E(): 8.6e-10; 29.7% identity in 283 aa overlap"
                     /product="deaminase"
                     /protein_id="NP_629393.1"
                     /sec_met_domain="PALP (E-value: 5.8e-18, bitscore: 64.1,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGTDTRQLAALRPRLPSPLHEVADGRFERHGVRLLLKRDDLIHP
                     ELVGNKWRKLAPNLATADGRTVVTFGGAYSNHLRAAAAAGRLLGLPTVGVVRGQELAGL
                     PLNPSLARCAADGMRLHFVDRSTYRRKSEPETLAALLRAAGAEGAVVVPEGGSNADAVR
                     GCRALGEELGTHADVAAVACGTGGTLAGLAAGLPRGRRALGIPVLKGGFLEGDIRRLQE
                     RAFGGPRGDWSLEDRFHHGGYARTTPGLDAFAADFEHRHGLPVERVYVAKMLYALLTLT
                     EEGAFPRGTTLAAVVTGRPFP"
     PFAM_domain     complement(6619..7461)
                     /aSDomain="PALP"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00291.28"
                     /description="Pyridoxal-phosphate dependent enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5247_0516"
                     /evalue="1.50E-17"
                     /label="SCO5247"
                     /locus_tag="SCO5247"
                     /protein_end="297"
                     /protein_start="16"
                     /score="64.1"
                     /tool="antismash"
                     /translation="PSPLHEVADGRFERHGVRLLLKRDDLIHPELVGNKWRKLAPNLAT
                     ADGRTVVTFGGAYSNHLRAAAAAGRLLGLPTVGVVRGQELAGLPLNPSLARCAADGMRL
                     HFVDRSTYRRKSEPETLAALLRAAGAEGAVVVPEGGSNADAVRGCRALGEELGTHADVA
                     AVACGTGGTLAGLAAGLPRGRRALGIPVLKGGFLEGDIRRLQERAFGGPRGDWSLEDRF
                     HHGGYARTTPGLDAFAADFEHRHGLPVERVYVAKMLYALLTLTEEGAFPRGTTLAAVVT
                     "
     gene            complement(7623..8201)
                     /db_xref="GeneID:1100689"
                     /gene_synonym="2SC7G11.10c"
                     /locus_tag="SCO5248"
     CDS             complement(7623..8201)
                     /codon_start=1
                     /db_xref="GeneID:1100689"
                     /gene_synonym="2SC7G11.10c"
                     /locus_tag="SCO5248"
                     /note="2SC7G11.10c, hypothetical protein, len: 192 aa;
                     similar to TR:O06288 (EMBL:Z95557) Mycobacterium
                     tuberculosis hypothetical 30.6 kDa protein MTCY07H7.28c,
                     275 aa; fasta scores: opt: 180 z-score: 221.9 E(): 6.8e-05;
                     31.8% identity in 176 aa overlap"
                     /product="hypothetical protein"
                     /protein_id="NP_629394.1"
                     /transl_table=11
                     /translation="MSASSFLKALKAEGLTVVQVGDWRDHNRNHKGPWGPVHGVMIHHT
                     VTKGSARTVDICRKGYEGLPGPLCHGVVTKDGKVHLVGYGRANHAGLGDDDVLRAVIAE
                     KALPRDNEANTDGNRHFYGFECENLGDGDDPWPAAQLEAIERAAAAVCRHHGWNERSVI
                     GHLEWQPGKVDPRGFTMTSMRNRIRDRLK"
     PFAM_domain     complement(7677..8099)
                     /aSDomain="Amidase_2"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF01510.28"
                     /db_xref="GO:0008745"
                     /db_xref="GO:0009253"
                     /description="N-acetylmuramoyl-L-alanine amidase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5248_0517"
                     /evalue="2.40E-20"
                     /gene_ontologies="GO:0008745: N-acetylmuramoyl-L-alanine
                     amidase activity"
                     /gene_ontologies="GO:0009253: peptidoglycan catabolic
                     process"
                     /label="SCO5248"
                     /locus_tag="SCO5248"
                     /protein_end="175"
                     /protein_start="34"
                     /score="73.4"
                     /tool="antismash"
                     /translation="GPVHGVMIHHTVTKGSARTVDICRKGYEGLPGPLCHGVVTKDGKV
                     HLVGYGRANHAGLGDDDVLRAVIAEKALPRDNEANTDGNRHFYGFECENLGDGDDPWPA
                     AQLEAIERAAAAVCRHHGWNERSVIGHLEWQPGKVDP"
     misc_feature    8225..8238
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.81"
                     /tool="antismash"
     misc_feature    8320..8334
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.5"
                     /tool="antismash"
     misc_feature    8428..8441
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.09"
                     /tool="antismash"
     gene            8509..9915
                     /db_xref="GeneID:1100690"
                     /gene_synonym="2SC7G11.11"
                     /locus_tag="SCO5249"
     CDS             8509..9915
                     /codon_start=1
                     /db_xref="GeneID:1100690"
                     /gene_synonym="2SC7G11.11"
                     /locus_tag="SCO5249"
                     /note="2SC7G11.11, possible nucleotide-binding protein,
                     len: 468 aa; highly similar to TR:Q54255 (EMBL:L76204)
                     Streptomyces griseus sporulation protein, 470 aa; fasta
                     scores: opt: 2008 z-score: 2272.9 E(): 0; 64.1% identity in
                     462 aa overlap. Contains Pfam match to entry PF00027
                     cNMP_binding, Cyclic nucleotide-binding domain"
                     /product="nucleotide-binding protein"
                     /protein_id="NP_629395.1"
                     /transl_table=11
                     /translation="MSVGEEVRTEQTRPQQSLGTAAARNLATTTKSVPQMQEISSRWLL
                     RSLPWVDIQGGTYRVNRRLTFAVGDGRVTFVKTGDRVEVVPAELGELPALRSYEDDEVL
                     SELAQRCEQREFGPGEVIASFGARADEVYLLAHGKVEKIGTGPYGDDAVLGVLADGAYF
                     GDQALLDGDAIWEYTARTVTACTVLVLPRQEVDQVAERADSLREHLEQRRSIPEQRTNR
                     HGEKEIDLAAGHSGEPDIPHTFVDYEARPREYELSVAQTVLRIHSRVADLYNQPMNQTE
                     QQIRLTVEALKERQEHELINNREFGLLHNCEYDQRIQPHDGVPGPDDLDELLSRRRGTK
                     LLLAHPRAIAAIGRELNKRGLVPETIDVAGNRIPTWRGVPIYPCNKIPVTEARTSSIIA
                     MRTGEQDQGVIGLRATGIPDEIEPSLSVRFMGINEQAVIKYLVTAYYSAAVLVPDALGV
                     LENVEIGRWR"
     misc_feature    8836..9120
                     /gene_synonym="2SC7G11.11"
                     /locus_tag="SCO5249"
                     /note="Pfam match to entry PF00027 cNMP_binding, Cyclic
                     nucleotide-binding domain, score 72.00, E-value 1.3e-17"
     PFAM_domain     8848..9108
                     /aSDomain="cNMP_binding"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00027.32"
                     /description="Cyclic nucleotide-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5249_0518"
                     /evalue="3.70E-16"
                     /label="SCO5249"
                     /locus_tag="SCO5249"
                     /protein_end="200"
                     /protein_start="113"
                     /score="59.1"
                     /tool="antismash"
                     /translation="REFGPGEVIASFGARADEVYLLAHGKVEKIGTGPYGDDAVLGVLA
                     DGAYFGDQALLDGDAIWEYTARTVTACTVLVLPRQEVDQVAE"
     PFAM_domain     9154..9906
                     /aSDomain="PCLP"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF19307.2"
                     /description="Phage capsid-like protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5249_0519"
                     /evalue="6.00E-137"
                     /label="SCO5249"
                     /locus_tag="SCO5249"
                     /protein_end="466"
                     /protein_start="215"
                     /score="454.8"
                     /tool="antismash"
                     /translation="PEQRTNRHGEKEIDLAAGHSGEPDIPHTFVDYEARPREYELSVAQ
                     TVLRIHSRVADLYNQPMNQTEQQIRLTVEALKERQEHELINNREFGLLHNCEYDQRIQP
                     HDGVPGPDDLDELLSRRRGTKLLLAHPRAIAAIGRELNKRGLVPETIDVAGNRIPTWRG
                     VPIYPCNKIPVTEARTSSIIAMRTGEQDQGVIGLRATGIPDEIEPSLSVRFMGINEQAV
                     IKYLVTAYYSAAVLVPDALGVLENVEIGR"
     misc_feature    complement(9958..9973)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.47"
                     /tool="antismash"
     misc_feature    complement(9964..18555)
                     /note="previously sequenced DNA fragment. EMBL:AF104994
                     Streptomyces coelicolor A3(2) periplasmic binding protein
                     (atrA), permease (AtrB), ATP-binding protein (atrC),
                     methyltransferase (metZ), signal peptidase, Ni-containing
                     superoxide dismutase (sodN), puromycin N-acetyltransferase
                     (pat), and geranyl transferase (gtr) genes, complete cds;
                     and unknown genes."
     regulatory      9991..9996
                     /regulatory_class="ribosome_binding_site"
     gene            10001..11161
                     /db_xref="GeneID:1100691"
                     /gene_synonym="2SC7G11.12; gtr"
                     /locus_tag="SCO5250"
     CDS             10001..11161
                     /codon_start=1
                     /db_xref="GeneID:1100691"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /gene_synonym="2SC7G11.12; gtr"
                     /locus_tag="SCO5250"
                     /note="2SC7G11.12, gtr, polyprenyl synthetase, len: 386 aa;
                     previously sequenced as TR:Q9RGW1 (EMBL:AF104994)
                     Streptomyces coelicolor A3(2) geranyl transferase Gtr, 386
                     aa. Contains Pfam match to entry PF00348 polyprenyl_synt,
                     Polyprenyl synthetases and match to Prosite entry PS00723
                     Polyprenyl synthetases signature 1"
                     /product="polyprenyl synthetase"
                     /protein_id="NP_629396.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.1e-59, bitscore:
                     200.8, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTETRRGATATCRPTGAPERHGPIGTQREKEPGEPSDGQGEAVVE
                     GHEAALLLSESRASVDPELRSAIATLPESMRRVALYHFGWQHADGTPAAGNAGKAIRPA
                     LVLTAAAALGGPGARAAAVRAAAAVELVHNFTLLHDDVMDRDATRRHRPTAWTVFGDAD
                     AILAGDALQALALRLFAADPHPASAAAATRLADCVMELCEGQHADTAMERRPPDEVTLD
                     ETLVMAEAKTGALLGCACAVGALYAGAATEDVEALDAFGREAGMAFQLIDDVIGIWGDP
                     RHTGKPAGADLAARKKSLPVVAALTSGTPAAAELAELYTGPYDENKEDLERTALAVERA
                     GGRDWAQAQAADRMARAMQELARAVPEPEAAGGLLALAEFVTRRST"
     misc_feature    10256..11041
                     /gene_synonym="2SC7G11.12; gtr"
                     /locus_tag="SCO5250"
                     /note="Pfam match to entry PF00348 polyprenyl_synt,
                     Polyprenyl synthetases, score 157.60, E-value 2.1e-43"
     PFAM_domain     10286..10993
                     /aSDomain="polyprenyl_synt"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00348.20"
                     /db_xref="GO:0008299"
                     /description="Polyprenyl synthetase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5250_0520"
                     /evalue="6.20E-57"
                     /gene_ontologies="GO:0008299: isoprenoid biosynthetic
                     process"
                     /label="SCO5250"
                     /locus_tag="SCO5250"
                     /protein_end="331"
                     /protein_start="95"
                     /score="192.7"
                     /tool="antismash"
                     /translation="NAGKAIRPALVLTAAAALGGPGARAAAVRAAAAVELVHNFTLLHD
                     DVMDRDATRRHRPTAWTVFGDADAILAGDALQALALRLFAADPHPASAAAATRLADCVM
                     ELCEGQHADTAMERRPPDEVTLDETLVMAEAKTGALLGCACAVGALYAGAATEDVEALD
                     AFGREAGMAFQLIDDVIGIWGDPRHTGKPAGADLAARKKSLPVVAALTSGTPAAAELAE
                     LYTGPYDENKEDLE"
     misc_feature    10409..10453
                     /gene_synonym="2SC7G11.12; gtr"
                     /locus_tag="SCO5250"
                     /note="PS00723 Polyprenyl synthetases signature 1"
     regulatory      11481..11484
                     /regulatory_class="ribosome_binding_site"
     gene            11493..12131
                     /db_xref="GeneID:1100692"
                     /gene_synonym="2SC7G11.13; pat"
                     /locus_tag="SCO5251"
     CDS             11493..12131
                     /codon_start=1
                     /db_xref="GeneID:1100692"
                     /gene_synonym="2SC7G11.13; pat"
                     /locus_tag="SCO5251"
                     /note="2SC7G11.13, pat, acetyltransferase, len: 212 aa;
                     previously sequenced as TR:Q9RGW2 (EMBL:AF104994)
                     Streptomyces coelicolor A3(2) puromycin N-acetyltransferase
                     Pat, 210 aa. Contains Pfam match to entry PF00583
                     Acetyltransf, Acetyltransferase (GNAT) family"
                     /product="acetyltransferase"
                     /protein_id="NP_629397.1"
                     /transl_table=11
                     /translation="MGVVIRTAGEDDRELVVRLLDEAFQDDPVSSWVFPGTEYRRRTHH
                     RLMAAFADAVLADGRVDLTEDGAACALWLPVPAGEPAGDGPGAEQGSESGEGAEDGPAR
                     IRAAVDPENERVELIARLTDGIHPSGRAHAYLWMIGVVPERQGEGLGTALIGTVLDRCD
                     REGLPAYLEASSARGKALYERLGFEFTGRALDLPDGPRMWPMWREPRTP"
     misc_feature    11679..12056
                     /gene_synonym="2SC7G11.13; pat"
                     /locus_tag="SCO5251"
                     /note="Pfam match to entry PF00583 Acetyltransf,
                     Acetyltransferase (GNAT) family, score 30.60, E-value
                     3.6e-05"
     PFAM_domain     11877..12053
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00583.28"
                     /db_xref="GO:0016747"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5251_0521"
                     /evalue="3.30E-09"
                     /gene_ontologies="GO:0016747: acyltransferase activity,
                     transferring groups other than amino-acyl groups"
                     /label="SCO5251"
                     /locus_tag="SCO5251"
                     /protein_end="187"
                     /protein_start="128"
                     /score="37.1"
                     /tool="antismash"
                     /translation="SGRAHAYLWMIGVVPERQGEGLGTALIGTVLDRCDREGLPAYLEA
                     SSARGKALYERLGF"
     regulatory      12197..12200
                     /regulatory_class="ribosome_binding_site"
     gene            12207..12791
                     /db_xref="GeneID:1100693"
                     /gene_synonym="2SC7G11.14"
                     /locus_tag="SCO5252"
     CDS             12207..12791
                     /codon_start=1
                     /db_xref="GeneID:1100693"
                     /gene_synonym="2SC7G11.14"
                     /locus_tag="SCO5252"
                     /note="2SC7G11.14, hypothetical protein, len: 194 aa;
                     previously sequenced as TR:Q9RGW3 (EMBL:AF104994)
                     Streptomyces coelicolor A3(2) hypothetical 18.8 kDa
                     protein, 169 aa"
                     /product="hypothetical protein"
                     /protein_id="NP_629398.1"
                     /transl_table=11
                     /translation="MRKLTYFVACSIDGFIGGPDGDASFMVPFVDEEFFEFLKSEYPET
                     LPTHGRRPLGIDDLPNKRFDTIVQGRASYDLALKEGVTSPYAHLREYVASRTLTESPDP
                     NVEIISTDLVGRVRELKAEDSAFGIYLCGGSAVAGELVDEVDELVVKTYPVVLGTGMPM
                     FGSGFEVSAFVPDSVRTFGNGVVVRTYHRKR"
     PFAM_domain     12210..12767
                     /aSDomain="RibD_C"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF01872.20"
                     /db_xref="GO:0008703"
                     /db_xref="GO:0009231"
                     /description="RibD C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5252_0522"
                     /evalue="2.60E-08"
                     /gene_ontologies="GO:0008703:
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity"
                     /gene_ontologies="GO:0009231: riboflavin biosynthetic
                     process"
                     /label="SCO5252"
                     /locus_tag="SCO5252"
                     /protein_end="187"
                     /protein_start="1"
                     /score="34.0"
                     /tool="antismash"
                     /translation="RKLTYFVACSIDGFIGGPDGDASFMVPFVDEEFFEFLKSEYPETL
                     PTHGRRPLGIDDLPNKRFDTIVQGRASYDLALKEGVTSPYAHLREYVASRTLTESPDPN
                     VEIISTDLVGRVRELKAEDSAFGIYLCGGSAVAGELVDEVDELVVKTYPVVLGTGMPMF
                     GSGFEVSAFVPDSVRTFGNGVVV"
     gene            12818..13039
                     /db_xref="GeneID:1100694"
                     /gene_synonym="2SC7G11.15"
                     /locus_tag="SCO5253"
     CDS             12818..13039
                     /codon_start=1
                     /db_xref="GeneID:1100694"
                     /gene_synonym="2SC7G11.15"
                     /locus_tag="SCO5253"
                     /note="2SC7G11.15, unknown, len: 73 aa"
                     /product="hypothetical protein"
                     /protein_id="NP_629399.1"
                     /transl_table=11
                     /translation="MDSDTYACPVCGQPVEAVVRRHKTLGIWVPEWAPGPCGNPKCEAG
                     PGKNAGAAEAEARPGRPEHSRETVTENP"
     misc_feature    complement(12849..12864)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.64"
                     /tool="antismash"
     gene            complement(13147..13542)
                     /db_xref="GeneID:1100695"
                     /gene_synonym="2SC7G11.16c; sodN"
                     /locus_tag="SCO5254"
     CDS             complement(13147..13542)
                     /codon_start=1
                     /db_xref="GeneID:1100695"
                     /gene_synonym="2SC7G11.16c; sodN"
                     /locus_tag="SCO5254"
                     /note="2SC7G11.16c, sodN, superoxide dismutase, len: 131
                     aa; previously sequenced as TR:O51921 (EMBL:AF104994)
                     Streptomyces coelicolor superoxide dismutase (EC 1.15.1.1)
                     SodN, 131 aa"
                     /product="superoxide dismutase"
                     /protein_id="NP_629400.1"
                     /transl_table=11
                     /translation="MLSRLFAPKVTVSAHCDLPCGVYDPAQARIEAESVKAVQEKMAGN
                     DDPHFQTRATVIKEQRAELAKHHVSVLWSDYFKPPHFEKYPELHQLVNDTLKALSAAKG
                     SKDPATGQKALDYIAQIDKIFWETKKA"
     aSDomain        complement(13150..13542)
                     /aSDomain="TIGR02753"
                     /aSTool="tigrfam"
                     /description="sodN: superoxide dismutase, Ni"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO5254_0069"
                     /evalue="1.20E-59"
                     /identifier="TIGR02753"
                     /label="SCO5254"
                     /locus_tag="SCO5254"
                     /protein_end="131"
                     /protein_start="0"
                     /score="198.6"
                     /tool="antismash"
                     /translation="MLSRLFAPKVTVSAHCDLPCGVYDPAQARIEAESVKAVQEKMAGN
                     DDPHFQTRATVIKEQRAELAKHHVSVLWSDYFKPPHFEKYPELHQLVNDTLKALSAAKG
                     SKDPATGQKALDYIAQIDKIFWETKKA"
     PFAM_domain     complement(13156..13512)
                     /aSDomain="Sod_Ni"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF09055.14"
                     /db_xref="GO:0004784"
                     /db_xref="GO:0016151"
                     /db_xref="GO:0016209"
                     /description="Nickel-containing superoxide dismutase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5254_0523"
                     /evalue="6.70E-43"
                     /gene_ontologies="GO:0004784: superoxide dismutase
                     activity"
                     /gene_ontologies="GO:0016151: nickel cation binding"
                     /gene_ontologies="GO:0016209: antioxidant activity"
                     /label="SCO5254"
                     /locus_tag="SCO5254"
                     /protein_end="129"
                     /protein_start="10"
                     /score="146.4"
                     /tool="antismash"
                     /translation="TVSAHCDLPCGVYDPAQARIEAESVKAVQEKMAGNDDPHFQTRAT
                     VIKEQRAELAKHHVSVLWSDYFKPPHFEKYPELHQLVNDTLKALSAAKGSKDPATGQKA
                     LDYIAQIDKIFWETK"
     gene            13685..14125
                     /db_xref="GeneID:1100696"
                     /gene_synonym="2SC7G11.17"
                     /locus_tag="SCO5255"
     CDS             13685..14125
                     /codon_start=1
                     /db_xref="GeneID:1100696"
                     /gene_synonym="2SC7G11.17"
                     /locus_tag="SCO5255"
                     /note="2SC7G11.17, signal peptidase, len: 146 aa;
                     previously sequenced as TR:O51920 (EMBL:AF104994)
                     Streptomyces coelicolor signal peptidase-like protein, 148
                     aa. Contains Pfam match to entry PF00461 Peptidase_S26,
                     Signal peptidase I and match to Prosite entry PS00501
                     Signal peptidases I serine active site"
                     /product="signal peptidase"
                     /protein_id="NP_629401.1"
                     /transl_table=11
                     /translation="MMPEQLSQETERARGALPFGPAEVTGPSMVPTLHHGDVLLVHWGA
                     RVRPGDVVVLRHPFQQDLLVVKRAAERRGAGWWVLGDNAFAGGDSTDYGVVPQDLVLGR
                     VRFRYRPPRAGQRSPLAVVRWALSAVRPVPADRSASRRLRAR"
     PFAM_domain     13751..13933
                     /aSDomain="Peptidase_S24"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00717.26"
                     /description="Peptidase S24-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5255_0524"
                     /evalue="1.90E-08"
                     /label="SCO5255"
                     /locus_tag="SCO5255"
                     /protein_end="83"
                     /protein_start="22"
                     /score="34.2"
                     /tool="antismash"
                     /translation="EVTGPSMVPTLHHGDVLLVHWGARVRPGDVVVLRHPFQQDLLVVK
                     RAAERRGAGWWVLGDN"
     aSDomain        13751..14002
                     /aSDomain="TIGR02754"
                     /aSTool="tigrfam"
                     /description="sod_Ni_protease: nickel-type superoxide
                     dismutase maturation protease"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO5255_0070"
                     /evalue="8.30E-25"
                     /identifier="TIGR02754"
                     /label="SCO5255"
                     /locus_tag="SCO5255"
                     /protein_end="106"
                     /protein_start="22"
                     /score="85.1"
                     /tool="antismash"
                     /translation="EVTGPSMVPTLHHGDVLLVHWGARVRPGDVVVLRHPFQQDLLVVK
                     RAAERRGAGWWVLGDNAFAGGDSTDYGVVPQDLVLGRVR"
     misc_feature    13754..13858
                     /gene_synonym="2SC7G11.17"
                     /locus_tag="SCO5255"
                     /note="Pfam match to entry PF00461 Peptidase_S26, Signal
                     peptidase I, score 14.90, E-value 0.0014"
     misc_feature    13760..13783
                     /gene_synonym="2SC7G11.17"
                     /locus_tag="SCO5255"
                     /note="PS00501 Signal peptidases I serine active site"
     gene            complement(14029..14658)
                     /db_xref="GeneID:1100697"
                     /gene_synonym="2SC7G11.18c"
                     /locus_tag="SCO5256"
     CDS             complement(14029..14658)
                     /codon_start=1
                     /db_xref="GeneID:1100697"
                     /gene_synonym="2SC7G11.18c"
                     /locus_tag="SCO5256"
                     /note="2SC7G11.18c, hypothetical protein, len: 209 aa;
                     similar to TR:CAB70944 (EMBL:AL137778) Streptomyces
                     coelicolor hypothetical 20.3 kDa protein SCL2.32, 186 aa;
                     fasta scores: opt: 314 z-score: 396.2 E(): 1.3e-14; 36.6%
                     identity in 183 aa overlap"
                     /product="hypothetical protein"
                     /protein_id="NP_629402.1"
                     /transl_table=11
                     /translation="MELAYYSDYAVRLVNTEEPSRGQDSLTSVEAVRELFGANQSAARR
                     ASDADVTRFRSVRGRLRAVFEAADGGDETLAVDLLNSLLLEFPVSPQISGHDHRAEDGS
                     PLWHMHLADHPSNATAGFAAIAAMGLAFHLTEYGVDRLGLCEAAPCRNAYLDTSTNRSR
                     RYCSDRCATRANVAAYRARKRLEADRSAGTGLTADSAQRTTASGER"
     PFAM_domain     complement(14110..14238)
                     /aSDomain="zf-CGNR"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF11706.11"
                     /description="CGNR zinc finger"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5256_0526"
                     /evalue="3.10E-15"
                     /label="SCO5256"
                     /locus_tag="SCO5256"
                     /protein_end="183"
                     /protein_start="140"
                     /score="55.9"
                     /tool="antismash"
                     /translation="RLGLCEAAPCRNAYLDTSTNRSRRYCSDRCATRANVAAYRARK"
     PFAM_domain     complement(14269..14634)
                     /aSDomain="ABATE"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF07336.14"
                     /description="Putative stress-induced transcription
                     regulator"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5256_0525"
                     /evalue="2.10E-17"
                     /label="SCO5256"
                     /locus_tag="SCO5256"
                     /protein_end="130"
                     /protein_start="8"
                     /score="64.2"
                     /tool="antismash"
                     /translation="YAVRLVNTEEPSRGQDSLTSVEAVRELFGANQSAARRASDADVTR
                     FRSVRGRLRAVFEAADGGDETLAVDLLNSLLLEFPVSPQISGHDHRAEDGSPLWHMHLA
                     DHPSNATAGFAAIAAMGL"
     regulatory      14746..14751
                     /regulatory_class="ribosome_binding_site"
     gene            14757..15566
                     /db_xref="GeneID:1100698"
                     /gene_synonym="2SC7G11.19; metZ"
                     /locus_tag="SCO5257"
     CDS             14757..15566
                     /codon_start=1
                     /db_xref="GeneID:1100698"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="2SC7G11.19; metZ"
                     /locus_tag="SCO5257"
                     /note="2SC7G11.19, metZ, methyltransferase, len: 269 aa;
                     previously sequenced as TR:Q9RGW5 (EMBL:AF104994)
                     Streptomyces coelicolor A3(2) methyltransferase MetZ, 268
                     aa"
                     /product="methyltransferase"
                     /protein_id="NP_629403.1"
                     /transl_table=11
                     /translation="MTNADTTTATTAGTTATTTATAGADWQAWQRSWDRQQEWYMPDRE
                     ERFRIMLDMVEALVGPAPRVLDLACGTGTITARLLDRFPDATSTGVDLDPALLAIAEGT
                     FAGDDRVSFVAADLKDPDWPAKLPYDAYDAVLTATALHWFHAEPLADLYGRVAELVRDG
                     GVFMNADHMIDEATPRINAAERAQRHARMDAAKGQGALDWAEWWQLAAEDPVLAGPTAR
                     RFEIYGEHADGEMPSAAWHARVLREKGFGEARPVWCSPSDTLLLAVK"
     PFAM_domain     14949..15248
                     /aSDomain="Methyltransf_25"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF13649.9"
                     /description="Methyltransferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5257_0527"
                     /evalue="2.00E-15"
                     /label="SCO5257"
                     /locus_tag="SCO5257"
                     /protein_end="164"
                     /protein_start="64"
                     /score="57.3"
                     /tool="antismash"
                     /translation="VLDLACGTGTITARLLDRFPDATSTGVDLDPALLAIAEGTFAGDD
                     RVSFVAADLKDPDWPAKLPYDAYDAVLTATALHWFHAEPLADLYGRVAELVRDGG"
     stem_loop       complement(15581..15634)
                     /note="possible stem loop. Score 64: 24/26 (92%) matches, 0
                     gaps"
     gene            complement(15645..16406)
                     /db_xref="GeneID:1100699"
                     /gene_synonym="2SC7G11.20c; atrC"
                     /locus_tag="SCO5258"
     CDS             complement(15645..16406)
                     /codon_start=1
                     /db_xref="GeneID:1100699"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /gene_synonym="2SC7G11.20c; atrC"
                     /locus_tag="SCO5258"
                     /note="2SC7G11.20c, atrC, ATP-binding protein, len: 253 aa;
                     previously sequenced as TR:Q9RGW6 (EMBL:AF104994)
                     Streptomyces coelicolor A3(2) ATP-binding protein AtrC, 239
                     aa. Contains Pfam match to entry PF00005 ABC_tran, ABC
                     transporter and matches to Prosite entries PS00017
                     ATP/GTP-binding site motif A (P-loop) and PS00211 ABC
                     transporters family signature"
                     /product="ATP-binding protein"
                     /protein_id="NP_629404.1"
                     /transl_table=11
                     /translation="MTAMVKAEGVHKSFGAVEVLKGIDLEVKQGEVFCLIGPSGSGKST
                     FLRCINHLEKINAGRLYVDGELVGYRQKGDKLYELKDSEVALKRRDIGMVFQRFNLFPH
                     MTAVENVMEAPVQVKGMSRAQARERARGLLERVGLADKAGNYPSQLSGGQQQRVAIARA
                     LAMDPKLMLFDEPTSALDPELVGDVLDVMRDLAESGMTMVVVTHEMGFAREVGDSLVFM
                     DNGVVVESGNPRDVLTDPQHDRTKAFLSKVL"
     misc_feature    complement(15732..16319)
                     /gene_synonym="2SC7G11.20c; atrC"
                     /locus_tag="SCO5258"
                     /note="Pfam match to entry PF00005 ABC_tran, ABC
                     transporter, score 228.00, E-value 1.4e-64"
     PFAM_domain     complement(15873..16349)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00005.30"
                     /db_xref="GO:0005524"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5258_0528"
                     /evalue="3.60E-33"
                     /gene_ontologies="GO:0005524: ATP binding"
                     /label="SCO5258"
                     /locus_tag="SCO5258"
                     /protein_end="178"
                     /protein_start="19"
                     /score="115.1"
                     /tool="antismash"
                     /translation="LKGIDLEVKQGEVFCLIGPSGSGKSTFLRCINHLEKINAGRLYVD
                     GELVGYRQKGDKLYELKDSEVALKRRDIGMVFQRFNLFPHMTAVENVMEAPVQVKGMSR
                     AQARERARGLLERVGLADKAGNYPSQLSGGQQQRVAIARALAMDPKLMLFDEPTS"
     misc_feature    complement(15915..15959)
                     /gene_synonym="2SC7G11.20c; atrC"
                     /locus_tag="SCO5258"
                     /note="PS00211 ABC transporters family signature"
     misc_feature    complement(16275..16298)
                     /gene_synonym="2SC7G11.20c; atrC"
                     /locus_tag="SCO5258"
                     /note="PS00017 ATP/GTP-binding site motif A (P-loop)"
     gene            complement(16403..17353)
                     /db_xref="GeneID:1100700"
                     /gene_synonym="2SC7G11.21c; atrB"
                     /locus_tag="SCO5259"
     CDS             complement(16403..17353)
                     /codon_start=1
                     /db_xref="GeneID:1100700"
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /gene_synonym="2SC7G11.21c; atrB"
                     /locus_tag="SCO5259"
                     /note="2SC7G11.21c, atrB, permease, len: 316 aa; previously
                     sequenced as TR:Q9RGW7 (EMBL:AF104994) Streptomyces
                     coelicolor A3(2) permease AtrB, 313 aa. Contains Pfam match
                     to entry PF00528 BPD_transp, Binding-protein-dependent
                     transport systems inner membrane component and match to
                     Prosite entry PS00402 Binding-protein-dependent transport
                     systems inner membrane comp sign. Also contains possible
                     hydrophobic membrane spanning regions"
                     /product="permease"
                     /protein_id="NP_629405.1"
                     /transl_table=11
                     /translation="MTVDIDKTAGGPAGTPPTPPEAIKAIPVRHYGRYVSAVVAIALLA
                     AVVYAFSQGKINWGAIPDYFFDDRVLTGMGKTLLITVLAMLIGVVGGILLAVMRLSKNP
                     VTSSIAWFYIWFFRGTPVLVQLVVWFNLGLVFEYINLGPFYRDEWSDFMTPFLTALLGL
                     GLNEAAYMAEICRAGLLAVDEGQTEAAHALGMSHTKTLRRIVVPQAMRVIVPPTGNEVI
                     NMLKTTSLVSVVQYAELFRVAQDIGQTSGAPAEMLFLAAAWYLLLTSVFSVGQYYLERY
                     YARGSSRSLPPTPMQKIRANLFSLSNRSSTTGGAA"
     regulatory      complement(16411..16417)
                     /gene_synonym="2SC7G11.21c; atrB"
                     /locus_tag="SCO5259"
                     /regulatory_class="ribosome_binding_site"
     PFAM_domain     complement(16514..17092)
                     /aSDomain="BPD_transp_1"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00528.25"
                     /db_xref="GO:0016020"
                     /db_xref="GO:0055085"
                     /description="Binding-protein-dependent transport system
                     inner membrane component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5259_0529"
                     /evalue="1.40E-21"
                     /gene_ontologies="GO:0016020: membrane"
                     /gene_ontologies="GO:0055085: transmembrane transport"
                     /label="SCO5259"
                     /locus_tag="SCO5259"
                     /protein_end="280"
                     /protein_start="87"
                     /score="77.2"
                     /tool="antismash"
                     /translation="GVVGGILLAVMRLSKNPVTSSIAWFYIWFFRGTPVLVQLVVWFNL
                     GLVFEYINLGPFYRDEWSDFMTPFLTALLGLGLNEAAYMAEICRAGLLAVDEGQTEAAH
                     ALGMSHTKTLRRIVVPQAMRVIVPPTGNEVINMLKTTSLVSVVQYAELFRVAQDIGQTS
                     GAPAEMLFLAAAWYLLLTSVFSVGQYYLER"
     misc_feature    complement(16610..16822)
                     /gene_synonym="2SC7G11.21c; atrB"
                     /locus_tag="SCO5259"
                     /note="Pfam match to entry PF00528 BPD_transp,
                     Binding-protein-dependent transport systems inner membrane
                     component, score 63.60, E-value 4.4e-15"
     misc_feature    complement(16733..16819)
                     /gene_synonym="2SC7G11.21c; atrB"
                     /locus_tag="SCO5259"
                     /note="PS00402 Binding-protein-dependent transport systems
                     inner membrane comp sign."
     aSDomain        complement(16823..17146)
                     /aSDomain="TIGR01726"
                     /aSTool="tigrfam"
                     /description="HEQRo_perm_3TM: amino ABC transporter,
                     permease protein, 3-TM region, His/Glu/Gln/Arg/opine
                     family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO5259_0071"
                     /evalue="3.50E-17"
                     /identifier="TIGR01726"
                     /label="SCO5259"
                     /locus_tag="SCO5259"
                     /protein_end="177"
                     /protein_start="69"
                     /score="60.7"
                     /tool="antismash"
                     /translation="VLTGMGKTLLITVLAMLIGVVGGILLAVMRLSKNPVTSSIAWFYI
                     WFFRGTPVLVQLVVWFNLGLVFEYINLGPFYRDEWSDFMTPFLTALLGLGLNEAAYMAE
                     ICRA"
     gene            complement(17384..18346)
                     /db_xref="GeneID:1100701"
                     /gene_synonym="2SC7G11.22c; atrA"
                     /locus_tag="SCO5260"
     CDS             complement(17384..18346)
                     /codon_start=1
                     /db_xref="GeneID:1100701"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="2SC7G11.22c; atrA"
                     /locus_tag="SCO5260"
                     /note="2SC7G11.22c, atrA, hypothetical protein, len: 321
                     aa; identical to previously sequenced TR:Q9RGW8
                     (EMBL:AF104994) Streptomyces coelicolor A3(2) periplasmic
                     binding protein AtrA, 321 aa. Contains Pfam match to entry
                     PF00497 SBP_bac_3, Bacterial extracellular solute-binding
                     proteins, family 3 and correctly situated match to Prosite
                     entry PS00013 Prokaryotic membrane lipoprotein lipid
                     attachment site. Also contains possible N-terminal region
                     signal peptide sequence"
                     /product="hypothetical protein"
                     /protein_id="NP_629406.1"
                     /transl_table=11
                     /translation="MTARSTRRTTAAHSRLAAVGAIAVAGALLLTGCGDQTENGDSGGS
                     DTQSAGGAPLADKLPQSIRDKGTIKVGSDIAYAPVEFKDDSGKTVGIDPDLADALGKQL
                     GVKFEFENGTFDTLITGLRSKRYDIAMSAMTDTKDRQEGIDGDTGKKVGQGVDFVDYFT
                     AGVSIYTKKGDDQGIKTWSDLCGKKLVVQRGTVSEDLAKAENEKCPAGKKISMQPFDND
                     QQAQTRLRAGGADAGSSDFPVAAYAVKTSGGGKDFELVGEQVEAAPYGIAVAKDNTQLR
                     DALKAALDAVIANGEYKKIMDKWGVSEGAITEATVNGGK"
     PFAM_domain     complement(17432..18142)
                     /aSDomain="SBP_bac_3"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00497.23"
                     /description="Bacterial extracellular solute-binding
                     proteins, family 3"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5260_0530"
                     /evalue="1.10E-66"
                     /label="SCO5260"
                     /locus_tag="SCO5260"
                     /protein_end="305"
                     /protein_start="68"
                     /score="224.7"
                     /tool="antismash"
                     /translation="IKVGSDIAYAPVEFKDDSGKTVGIDPDLADALGKQLGVKFEFENG
                     TFDTLITGLRSKRYDIAMSAMTDTKDRQEGIDGDTGKKVGQGVDFVDYFTAGVSIYTKK
                     GDDQGIKTWSDLCGKKLVVQRGTVSEDLAKAENEKCPAGKKISMQPFDNDQQAQTRLRA
                     GGADAGSSDFPVAAYAVKTSGGGKDFELVGEQVEAAPYGIAVAKDNTQLRDALKAALDA
                     VIANGEYKKIMDKWG"
     misc_feature    complement(17432..18223)
                     /gene_synonym="2SC7G11.22c; atrA"
                     /locus_tag="SCO5260"
                     /note="Pfam match to entry PF00497 SBP_bac_3, Bacterial
                     extracellular solute-binding proteins, family 3, score
                     154.50, E-value 1.8e-42"
     misc_feature    complement(18248..18280)
                     /gene_synonym="2SC7G11.22c; atrA"
                     /locus_tag="SCO5260"
                     /note="PS00013 Prokaryotic membrane lipoprotein lipid
                     attachment site"
     misc_feature    complement(18447..18462)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.94"
                     /tool="antismash"
     misc_feature    18735..18745
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    complement(18942..18957)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.76"
                     /tool="antismash"
     gene            18986..20215
                     /db_xref="GeneID:1100702"
                     /gene_synonym="2SC7G11.23"
                     /locus_tag="SCO5261"
     CDS             18986..20215
                     /codon_start=1
                     /db_xref="GeneID:1100702"
                     /gene_synonym="2SC7G11.23"
                     /locus_tag="SCO5261"
                     /note="2SC7G11.23, probable malate oxidoreductase, len: 409
                     aa; similar to SW:MAOX_BACST (EMBL:M19485) Bacillus
                     stearothermophilus NAD-dependent malic enzyme (EC
                     1.1.1.38), 478 aa; fasta scores: opt: 1385 z-score: 1470.9
                     E(): 0; 55.0% identity in 391 aa overlap. Contains 2x Pfam
                     matches to entry PF00390 malic, Malic enzyme"
                     /product="malate oxidoreductase"
                     /protein_id="NP_629407.1"
                     /transl_table=11
                     /translation="MAAEIVNPRSDSEAGAEQEAGAEPLDSFDPAFALHRGGKMAVQAT
                     VPIRDKEDLSLAYTPGVAKVCSAIAEQPDLVHDYTWKSSVVAVVTDGTAVLGLGDIGPE
                     ASLPVMEGKAILFKQFGGVDAVPIALNCTDADEIVETVVRLAPSFGGVNLEDISAPRCF
                     EIERKLQERLDIPVFHDDQHGTAVVTLAALRNAARLSGRTLGELRAVISGAGAAGVAIA
                     KMLVEAGIGDVAVADRKGVVSADREDLTPVKQELASFTNKAGLSGPLEAALAGADVFIG
                     VSGGTVPEPAVASMAEGAFVFAMANPNPEVHPEVAHKYAAVVATGRSDFPNQINNVLAF
                     PGIFAGALQVRASRITEGMKLAAAEALASVVGDDLAADYVIPSPFDERVAPAVTAAVAA
                     AARAEGVARR"
     PFAM_domain     19100..19384
                     /aSDomain="malic"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00390.22"
                     /db_xref="GO:0004471"
                     /description="Malic enzyme, N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5261_0531"
                     /evalue="1.20E-21"
                     /gene_ontologies="GO:0004471: malate dehydrogenase
                     (decarboxylating) (NAD+) activity"
                     /label="SCO5261"
                     /locus_tag="SCO5261"
                     /protein_end="133"
                     /protein_start="38"
                     /score="77.5"
                     /tool="antismash"
                     /translation="KMAVQATVPIRDKEDLSLAYTPGVAKVCSAIAEQPDLVHDYTWKS
                     SVVAVVTDGTAVLGLGDIGPEASLPVMEGKAILFKQFGGVDAVPIALNCT"
     PFAM_domain     19385..19495
                     /aSDomain="malic"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00390.22"
                     /db_xref="GO:0004471"
                     /description="Malic enzyme, N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5261_0532"
                     /evalue="4.40E-06"
                     /gene_ontologies="GO:0004471: malate dehydrogenase
                     (decarboxylating) (NAD+) activity"
                     /label="SCO5261"
                     /locus_tag="SCO5261"
                     /protein_end="170"
                     /protein_start="133"
                     /score="26.8"
                     /tool="antismash"
                     /translation="DADEIVETVVRLAPSFGGVNLEDISAPRCFEIERKLQ"
     misc_feature    19499..19669
                     /gene_synonym="2SC7G11.23"
                     /locus_tag="SCO5261"
                     /note="Pfam match to entry PF00390 malic, Malic enzyme,
                     score 22.00, E-value 0.00016"
     PFAM_domain     19535..20134
                     /aSDomain="Malic_M"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF03949.18"
                     /db_xref="GO:0051287"
                     /description="Malic enzyme, NAD binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5261_0533"
                     /evalue="5.30E-20"
                     /gene_ontologies="GO:0051287: NAD binding"
                     /label="SCO5261"
                     /locus_tag="SCO5261"
                     /protein_end="383"
                     /protein_start="183"
                     /score="71.9"
                     /tool="antismash"
                     /translation="GTAVVTLAALRNAARLSGRTLGELRAVISGAGAAGVAIAKMLVEA
                     GIGDVAVADRKGVVSADREDLTPVKQELASFTNKAGLSGPLEAALAGADVFIGVSGGTV
                     PEPAVASMAEGAFVFAMANPNPEVHPEVAHKYAAVVATGRSDFPNQINNVLAFPGIFAG
                     ALQVRASRITEGMKLAAAEALASVVGDDLAADYVIPS"
     misc_feature    19961..20107
                     /gene_synonym="2SC7G11.23"
                     /locus_tag="SCO5261"
                     /note="Pfam match to entry PF00390 malic, Malic enzyme,
                     score 28.70, E-value 3.3e-06"
ORIGIN
        1 tgcgccgggt cggctcgatc gcgatcgtgc acgagacgct ctcccagaac ctggacgagc
       61 gcgtggagtt cgacgagatc gccgaccgcg tgctggcgat ggtggcggag atctcgccgg
      121 gcaaggtcac cggccggcgc accggacgct tcggcatcct cgacgccgag gtcgccaccc
      181 cgctgtccat ggtgctgacc gaggtgctgc agaacgccct ggagcacggc ttccgggacg
      241 gcgacaccgg cacggtcgag gtctcggcgg tccgcggcgg cacgaccaag gaggcccggc
      301 tgctggtcac cgtccaggac gacggggtcg gcctgcccga ggacttcgac ccgcaccgct
      361 ccggcaacct cggcctgcag atcgtccgca ccctggtcga gggcgagctg ggcggcgcct
      421 tcgacatggt ccaggcggcg gagcgcgggt gccgcgtgat cctcgacatc ccggtgcccg
      481 ccgagaagta gcgcgagaag cagaacgagg gacgagaagc ggcgcgaggg aacgacaagc
      541 agcgcgacaa gcggaaccgg gacagcggca ccggaagcgg gcaagcaaaa agccccggac
      601 cggtgaaggt ccgaggccag tgctcgtgcg atacatcgtc cgatgcgcat cgggggtact
      661 gcgcgctgcg gctcgggagc gggggatgcg tactcgctgt acgcgccgcc aagctgaggc
      721 tgtcagtagg ggtgggttgt caggcggagg cctgacgagc ccggttgcgg gcggcacggc
      781 gcttcattgc gcggcgctcg tcctcgctga gaccacccca gacgccggag tcctggccgg
      841 actcgagcgc ccactgcagg cactgctcca tgacggggca gcgacggcag acggccttgg
      901 cttcctcgat ctgcagcagc gcgggaccgg tgttgccgat ggggaagaag agctcggggt
      961 cttcctcgcg gcaaacggcg cggtgacgcc agtccatggc tgctacctct ccttggtatt
     1021 acatgctggg atgcttgtga atgtgaacgc tttcacgaat ccctcaacaa gggaagggcc
     1081 taccgccagg ttcgctggcg tggtcctgtg gtttgaagag gggttccggt gatctgtgga
     1141 tgccggtcct gcgggctgtc ccgatcgcca agaagagact cgcaaacctc ggcgacggat
     1201 acaacccctt ccggaaagtt ttttttgatt cttcggtgtc gactaggtca cagccgtact
     1261 tccatggggt ggatcctggt ctaaacgttc gagtgaaagg actttcgccc cttctgctca
     1321 cacaatcaca cgcagtgcac ggcgtacgcc tgtgaacgtc acgctggtcc gcaaccccag
     1381 gtggtcaccg tccatctgaa ggggcagggg caccttcgaa tgcaaggtga actccgtcag
     1441 atcgtgcagg gagaccgcgt ggcggccccg cggcccgcgc tcgggggacg aagtgagcaa
     1501 ctgggtgcca taccgggcaa ccgcggccgt cgacagccgg ctcaggccga acacgtcgag
     1561 ggcggtgtcg aacgacgcct cgggagaggc gtagatcggg cggttcccga ggaacgtcca
     1621 ggggcaggtg ttcgaaacta tggacaggac cagatcggtg accgggtcct cgcccgcccg
     1681 ctccagagtg atcgtcccgc tgcggcggtg cggctcgccg atgagctgac gcaccacctg
     1741 gcggacgtag agggcgtgcg tggacttcct gccgcgctcg cggtgctgct cgacacggcc
     1801 gaccaccccg gcgtcgaacc ccagaccggc gttgaaggtg aaccagcggg ccggaaccgc
     1861 ttcgtcctcc gaaccgggcg tacccgacgc cagcccgagg ccgacggtcc gctcgctgcc
     1921 ctcgcgcagg gcgtccagca gggctccggt ggcctccacc gcgtggttgg gcaggccgag
     1981 ggcgcgggcg aagacgttgg tgctaccgcc cgggaccacc gcgagaccgg gcaggtggtc
     2041 cgggtcgggg cccgcgtgca gcaggccgtt gacgacctcg ttcaccgtgc cgtcgccgcc
     2101 gagggccacc accaggtcga tgtcgtcgcc ctgtgccgcc tgccggccga ggtcgcgcgc
     2161 gtggccgcgg tactcggtgg tgaccgcttc cagcttcatc tcgctcgcga gcgcgtggat
     2221 cagcacgtcg cgcgtgcgcg cactcgtggt ggttgccgcc ggattgacca cgagaagtgc
     2281 acgcatggtg tgcagggtac ctactgggtg gtactcggcc cagaccgagg tgaagatggt
     2341 caccggcgga cggcacgcgt gatacggggg acaccgcggc ggacacgggg gcgccgaggg
     2401 ctaccctttc ggggtgagca gtgagcagac ccccaccccc gcctccgcaa ccgccgaaga
     2461 gacgacccct cgccccggcc ggctgaccgc cgcggccgcg atcgccgcac tggaggggct
     2521 ggcgctcgtc gtcggcggcg gctggatgct cgtggagggc ctcaccggac accccgacga
     2581 ccggacctcg gccgtcaccg gcggagtcac cctgatcgtc ctcgccctgc tgccgctgct
     2641 cgcagcccgc ggactgatcg cccggcgggg ctggagccgg gggcccgccg tgatcacgca
     2701 gatcatggcg ctgccggtcg cctacaacat ggtgcgggcc gacagcctgg ccgtaccggc
     2761 gggcatcgtg ctcggtgtcg tggccgtcac cgcgctggtg ctgctcgtca atccgacgac
     2821 cacccaggcc ctcggtatcc gggggcccgg caacgccggg aagcagccgt aaggcacccg
     2881 ccgaccggcg gttactcctc gacgagcagc ttctcccgca gctgtgccag cgtgcgggcc
     2941 agcagccggg acacgtgcat ctgggagatg ccgacctcct gcgcgatctg ggactgggtc
     3001 atgttgccga agaagcgcag cagcaggatg cgcttctccc gcggtggcag gtcctcgagg
     3061 agcggcttga gcgactcccg gtactcgacg ccctccaggg cctcgtcctc ggcaccgagg
     3121 gtgtcggcga ccgccggtga ctcgtcgtcg gtgtccggga cgtccaggga cagcgtggag
     3181 tacgcgttgg ccgactccag gccctccagg acctcctcct ccgagatcga cagcttctcg
     3241 gccagctcgt ggaccgtggg ggagcggccg tgcagctggg acagctccgc cgtggccgtc
     3301 gtcagggcca gccgcagctc ctggagccgg cgcgggaccc gcaccgccca gcccttgtcc
     3361 cggaagtgcc gcttgatctc accgacgacc gtgggcgtcg cgtacgtgga gaactccacg
     3421 ccgcggtccg ggtcgaaccg gtccaccgac ttgatcaggc cgatggtggc gacctgggtc
     3481 aggtcgtcca ggggctcgcc gcggttgcgg aagcggcgcg cgaggtgctc gaccagcggc
     3541 aggtgcatgc ggaccagccg attgcgcagc tccgcgtact ccgggctgtc cttctccagc
     3601 gtgcgcaact cggcgaacag gagacgcgcc ccgctgcggt cctgcgggtc gtgccgtgtg
     3661 ccctgcgtgc cccgtgcacc cggcgcgtgg ccgtcggcgt gtcgctcgtg ctcgctcatc
     3721 gtcccgcccg tcgccctttc ccgagccctc gcctccgctc ggacgggccg gacgggggtc
     3781 tccccggtcc gctgcccctc gcccggaacg gcggccccgg gcgaggtctc gtcctccgga
     3841 tgcggccggg cctgctcggg gatgccgtcg atgccgtccg ccgtgcgtcg cgcctcgttc
     3901 ggagaacgtg tgccctcggc cggcagctcc cgtgtaccgc gctcttcgtc ccgcaccggc
     3961 ccgtccccgt ccctcacgtc ggcccgggtc ccgcgccgcg ctgtttgtag aggctgatcg
     4021 aaacggtttt gtcctcgtcc acggcggagg agaccttgcc cgcgagggcg gagagcaccg
     4081 tccaggcgaa ggtgtcccgg gacggcgcgt ggccgtccgt ggtcggcgcc gagacggtga
     4141 cctcgagcga gtcgtcgacg aggcggaaga cacaactgag caccgagccg ggcacggcct
     4201 gctgcagcag gatcgcgcag gcctcgtcga ctgcgatgcg caggtcctcg atctcgtcga
     4261 gggtgaagtc caaacgagct gcgaggccgg ccgtcgccgt acgcagcacc gacaggtagg
     4321 cacccgcggc cggcagccgg acttcgacga agtcctgggt cgcgggctcg cctgcgatct
     4381 gggacaccct cacctccaag gtggtacaag cgttacaggg ccgagggacg cccctcggga
     4441 taacgcgaca cgtggttcag cggtgacgtt atcgcgctcc gaagtttcct gtccccgaga
     4501 ccccaacccc gtgctgtcac tcatagtaaa cacgcgaaca cgcacagtgg ctagggggtc
     4561 ggcgggccca aatcggaaga gcgcgcgccg ggttgacgta cccagacgtc agacggtcga
     4621 accgtcccgg gcacaggtca caccaggacg tgatcgacga agcaccagcg ccagctctcc
     4681 ccgggttcga aggtcctcat cagcgggtgg ccgctctcct tgtaatgcgc cgtcgcgtgc
     4741 cggttcggcg aggagtcgca gcagccgaca tgaccgcaga cgagacacaa cctcagctgc
     4801 accgggtccg tgccctcggc cagacactcg ggacaggtct cgccgcacgg ctcgggttcc
     4861 gggtgcggca gcgcgtcggc gtgcgtgcac tgtttcatga ttgccaggtt acgacgggcg
     4921 tgcggacgac cgcgcggaaa acgagggcgg gcgaggacga tggacgtgat gccgctgctg
     4981 ttgctggtgg cgggcagcgc cgcggtcgcc gcggcgggac ggcgcgtacc ggtgccggtg
     5041 ccgctgctcc tggtcgcggc cggcctggcg gtgagctatg tgcccggtgt gcccgactac
     5101 accctcgacc cgcacatcgt cctgcccctg ctgctgcccc cgctgctcta cacggcggcc
     5161 accgacagct cctacctgga cctgcgggcg caggcccggc ccgtggcgct gctgtccgtg
     5221 ggctacgtcc tgttcgccac cttcgtcgtc ggctgcgcgg cgtacctcat cgtgccgggc
     5281 ctgccgctga ccgcggccct ggtcctcggc gcggtcgtgg cgcccccgga cgccgtcgcg
     5341 gccacggcgg tcgcccgccg cgtggggctg ccctcccgga tcaccacgat cctccagggc
     5401 gagtccctgg tgaacgacgc caccgcgatc accgccttca aggtggcgct cgccgcggcc
     5461 gtcggcgagg gggcgacctg ggccggcggg atcggcgagt tcctcatcgc ggcggtgggc
     5521 ggcgtcggcg tcgggctggt gctgatggtg ccgctgcact ggctgcgcac ccacctgacg
     5581 gaggcgctgc tgcagaacac gctctccctg ctgatcccgt tcgtcgccta cgcggtcgcc
     5641 gagcaggtgc aggcctccgg ggtgctcgcg gtggtcgtcg tcgcgctcta cctcggccac
     5701 cgcgcgtggg aggtcgactt cgccacccgg ctccaggagg aggcggtgtg gaagatggtc
     5761 gcgttcgtcc tggagtcggc ggtgttcgcc ctcatcggac tccagctgcc cgtcgtcctc
     5821 aaaggcctgg gggagtacga gggtgccgac gccgcctggt acgccctcgc cgtcttcctg
     5881 gtggtcgccg tggcgaggtt cgtgtgggtg tacccggcga cctacctgcc ccggctgtcg
     5941 gcacgggtac gcgcgcgcga gggcgagctc tcctggaagg ggccgttcgt gatcggctgg
     6001 gccgggatgc ggggcgtggt ctccctggcc atcgccttct ccatcccgct caccgtgcac
     6061 gggggcgagc cctttcccga gcgcaacctc atcctgttcc tgaccttcac cacggtcatc
     6121 ggcacgctgg tcgtccaagg cgtcagcctg ccgccgctga tccgcctgct gaagttcccg
     6181 gcgcacgacg tgcaagcgga gacgctggcg gaggccaacg cacaggcgca ggcctcacgg
     6241 gtcgcggaac tgcgcctgga cgacctgctc gccgacgagc gcaacgctct tccggcgccg
     6301 ctcgccgacc gcctccgcat ggtcctggag cgccgccgca acgccgtctg ggaacggctc
     6361 ggccaggtca atcccgtcac cggcgagacc gtcgacgaca cctaccggcg actctcccgg
     6421 gagatgatca gcgccgagcg cgaggtcttc gtcaggctcc gggacggccg ctacatcgac
     6481 gacgagatgc tccggaccct gctgcgccgg ctggacctgg aggaggccgc cgcgtaccgg
     6541 gaggcgacgt gagcgggcgc aggggcacgc gggcgcgtcg gggcggcggt cccgacccgc
     6601 tcaggggaag ggccggccgg tgacgaccgc cgccagggtc gtcccgcgcg ggaaggcacc
     6661 ctcctcggtg agggtgagca gggcgtacag catcttggcg acgtagacgc gctccacggg
     6721 gaggccgtgg cggtgctcga aatccgcggc gaaggcgtcc agcccgggcg tcgtgcgggc
     6781 atagccgccg tggtggaagc ggtcctcaag gctccagtcg ccgcgcggcc cgccgaacgc
     6841 gcgctcctgg agccgccgta tgtcaccctc caggaagccg cccttgagca cgggtatgcc
     6901 gagagcccgc cgcccccggg ggagcccggc ggcgaggccg gcgagcgtgc caccggtgcc
     6961 gcaggcgacg gcggccacgt cggcgtgggt gcccagctcc tcgcccaggg cacggcagcc
     7021 gcggacggcg tccgcgttgc ttccgccctc ggggacgacg acggcgccct cggcgcccgc
     7081 cgcgcgcagc agggccgcca gggtctcggg ttcggacttg cgccggtacg tggagcggtc
     7141 gacgaagtgc agccgcatcc cgtcggcggc gcaccgggcc agtgaggggt tgagcggcag
     7201 gccggccagc tcctgaccgc ggaccacgcc caccgtgggc agtccgagca gccggccggc
     7261 cgcggcggcg gcccgcaggt ggttggagta ggcgccgccg aacgtgacga cggtgcgccc
     7321 gtcggccgtg gcgagattcg gtgccagctt gcgccacttg ttgccgacca gctcgggatg
     7381 gatcagatcg tcccgcttga gcagcagccg gacaccgtgg cgctcgaacc gtccgtcggc
     7441 cacctcgtgc agcggagagg gcagacgggg ccgcagggcg gcgagctgac gcgtgtcggt
     7501 gccggtcacc ccgccattgt cacgccaccg ggcgtcccgg ccacctcacg ccggcgcgct
     7561 ccgggcacct cggccggttc cggagcacct cggccggttc cggccacccc ggtcggtccg
     7621 ggtcacttca ggcggtcccg gatgcggttt cgcatggatg tcatcgtgaa tccgcgcgga
     7681 tccaccttgc ccggctgcca ctccaggtgg ccgatgacgg acctctcgtt ccagccgtgg
     7741 tggcggcaca cggccgcggc ggcccgctcg atcgcctcca gctgtgccgc cggccagggg
     7801 tcgtcgccgt cgcccaggtt ctcgcactcg aagccgtaga agtgccggtt gccgtcggtg
     7861 ttcgcctcgt tgtcccgggg cagcgccttc tccgcgatca ctgcgcgcag tacgtcgtcg
     7921 tcgccgagac cggcgtggtt ggccctgccg tacccgacca ggtggacctt gccgtccttg
     7981 gtgacgaccc cgtggcacag ggggcccggc agaccttcgt atcccttgcg gcagatgtcc
     8041 accgtccgcg cgctgccctt ggtgaccgtg tggtggatca tcacaccgtg cacgggaccc
     8101 cacgggccct tgtggttgcg gttgtggtcc cgccagtcgc cgacctggac gacggtgagg
     8161 ccctccgcct tcagtgcctt gaggaaactg ctcgcggaca tgggtgaggc cacggccggg
     8221 ctccttcacg ctgcgcgacg accgcccgac gcgaccgcct cgtacggagc ttgtaccgaa
     8281 acggagcaac tcctattact tgttcggccc gtgtgcgagt cgtttcggac aatctcatcc
     8341 cggccagggg gtgccgaagt cgaaacaagc ccccatatct gccccggccg cgtgtgatcc
     8401 attcccgctc gttcgtgtaa tagcaccggc acgctccgtg aggaaggctg gtccacgcac
     8461 atcgatgccg ggcgcagccg tccggcatga ccgggagggc aattccttat gtcggtaggc
     8521 gaagaggtcc gcaccgagca gaccaggccg cagcagagcc tcggcacggc ggccgcgcgg
     8581 aacctggcca ccaccaccaa gtccgttcct cagatgcagg agatcagctc tcgctggctg
     8641 ctgcgctcgc tcccctgggt ggacatccag ggcggcacgt accgggtcaa ccggcgtctg
     8701 accttcgccg tcggcgacgg ccgcgtgacg ttcgtgaaga ccggcgaccg cgtcgaggtc
     8761 gtccccgcgg agctgggcga gctgccggcc cttcggtcgt acgaggacga cgaggtcctg
     8821 tcggaactcg cgcagcgctg cgagcagcgg gagttcggcc ccggcgaggt gatcgcctcg
     8881 ttcggcgcgc gggccgacga ggtctacctg ctggcgcacg gcaaggtcga gaagatcggc
     8941 accggcccct acggcgacga cgcggtgctc ggcgtcctcg ccgacggcgc ctacttcggc
     9001 gaccaggcgc tcctcgacgg tgacgccatc tgggagtaca ccgcccgcac ggtcaccgcc
     9061 tgcacggtgc tcgtgctgcc ccgccaggag gtggaccagg tcgcggagcg ggccgactcc
     9121 ctgcgcgagc acctggagca gcggcgctcg atcccggagc agcgcaccaa caggcacggt
     9181 gagaaggaga tcgacctcgc ggccggtcac agcggcgagc cggacatccc gcacacgttc
     9241 gtcgactacg aggcccggcc gcgcgagtac gaactgagcg tcgcccagac cgtgctgcgc
     9301 atccactcgc gcgtggccga cctgtacaac cagccgatga accagaccga gcagcagatc
     9361 cgcctgacgg tcgaggcgct gaaggagcgc caggagcacg aactcatcaa caaccgggag
     9421 ttcgggctgc tgcacaactg cgagtacgac cagcgcatcc agccgcacga cggagtgccc
     9481 ggtcccgacg acctcgacga actgctgagc cgccggcgcg gcaccaagct gctcctcgcc
     9541 cacccgcgcg ccatcgccgc catcggccgc gagctcaaca agcgcggcct cgtccccgag
     9601 accatcgacg tcgccgggaa ccgcatcccg acctggcgcg gtgtgcccat ctacccgtgc
     9661 aacaagatcc cggtcaccga ggcccgtacg tcctcgatca tcgcgatgcg taccggcgag
     9721 caggaccagg gcgtcatcgg cctgcgggcc accggcatcc cggacgagat cgagccgagt
     9781 ctgtcggtgc gcttcatggg gatcaacgag caggcggtca tcaagtacct ggtcacggcc
     9841 tactactcgg ccgcggtcct cgtgccggac gcgctcggtg tgctggagaa cgtcgagatc
     9901 ggccgctggc ggtgacgtca ctgtcccgaa cgccgtgttc ccgccctccc gggcgggtac
     9961 acccccgggg tacggacggg cccaggggga aggtgagtcc atgacggaga cccggcgcgg
    10021 cgccaccgcg acgtgccgtc ccaccggggc gccggaaagg cacgggccca tcggcacaca
    10081 gcgcgagaag gagccggggg agccgtccga cgggcagggg gaggcggtgg tcgaagggca
    10141 cgaggcggcc ctgctcctga gcgagtcacg agcgtcggtc gatcccgaac tgcggtccgc
    10201 catcgcgacg ctgccggagt cgatgcgccg ggtcgcgctc taccacttcg gctggcagca
    10261 cgcggacggc acgcccgcgg cgggcaacgc gggcaaggcg atccgccccg cgctcgtcct
    10321 caccgcggcg gccgcgctcg gcggcccggg ggcccgcgcg gcggccgtcc gtgccgcggc
    10381 ggcggtggag ctggtccaca acttcaccct gctgcacgac gacgtgatgg accgcgacgc
    10441 cacccggcgg caccggccga ccgcgtggac cgtgttcggc gacgccgacg cgatcctggc
    10501 cggggacgca cttcaggcgc tcgccctgcg gctgttcgcc gccgacccgc atccggcgtc
    10561 cgcggcggcg gccacccggc tcgccgactg cgtcatggag ctgtgcgagg gccagcacgc
    10621 ggacacggcg atggagcggc gcccgccgga cgaggtgacc ctcgacgaga cgctcgtcat
    10681 ggccgaggcc aagacgggtg ccctgctggg ctgcgcctgt gccgtcggcg cgctgtacgc
    10741 gggcgccgcc acggaggacg tcgaggccct ggacgccttc ggccgtgagg cggggatggc
    10801 cttccagctc atcgacgacg tcatcggcat atggggcgac ccgcgccaca ccggcaagcc
    10861 ggccggtgcg gacctggccg cccgcaagaa gtcactgccg gtggtcgccg ccctcacctc
    10921 cggcaccccg gccgccgccg aactggccga gctgtacaca ggcccgtacg acgagaacaa
    10981 ggaggacctg gagcgcaccg ccctggccgt ggagcgggcc ggcggccggg actgggcaca
    11041 ggcccaggcg gccgaccgga tggcgagggc catgcaggag ctggcgcgtg ccgtgcccga
    11101 gccggaggcg gcgggcggcc tgctcgccct ggccgagttc gtgacgcggc gcagcacctg
    11161 agcgcagcac ctgagcgccg ccccggcccc ctcgcccgcc cggcgtcgtg gatcgccggg
    11221 ccggccacgc aagaccccgg agcccgtgca gggccgtacg gcacctgacc gacgtacggc
    11281 cgcaccgccg acggctccgg tccggcgggt cccgcacttc cccacggtgt gcggggcccg
    11341 cctccttgcc cttgcccgcc tgccctcgcc cccttgtccc cgcgcccgcg gacggcagcg
    11401 gcgcacgcac cggccgcgac tcagcggcta ggctcaaccg ccgtacggat gtgcgatgtt
    11461 gagccgccgg tgacgaggct gaggggcgag gtatgggtgt ggtgatccgc acggcggggg
    11521 aggacgaccg ggaactggtc gtccggctgc tggacgaggc cttccaggac gatccggtga
    11581 gcagttgggt cttccccggc acggagtacc gtcgccggac gcaccatcgg ctcatggccg
    11641 cgttcgccga cgccgtcctc gcggacggcc gcgtcgacct caccgaggac ggcgccgcct
    11701 gcgcgctgtg gctgcccgtc ccggcgggcg agcccgcggg cgacggaccg ggcgcagagc
    11761 aggggtccga gtccggggag ggcgccgagg acggccccgc ccggattcgt gcggccgtcg
    11821 acccggagaa cgagcgcgtg gagctgatag cccggctcac ggacgggatc cacccctccg
    11881 gccgggcgca cgcgtacctg tggatgatcg gcgtggtccc ggagcgtcag ggcgagggcc
    11941 tgggcaccgc gctgatcggg accgtcctcg accgctgcga ccgcgagggc ctgcccgcct
    12001 atctggaggc gagcagcgcc cgcgggaagg cgctctacga acgtctcggc ttcgagttca
    12061 ccggccgggc cctggatctg ccggacggcc cccgcatgtg gccgatgtgg cgcgagccgc
    12121 ggactccgtg atctcgtaat ccgctcccca aagaactaca cgcggagtac tgtgaacgta
    12181 gtggtcaaca tgagagggag accggtttgc gcaaactcac gtacttcgtc gcctgctcga
    12241 tcgacggctt catcggcggc ccggacggcg acgcgtcgtt catggtcccg ttcgtcgacg
    12301 aggagttctt cgagttcctg aagtcggagt atccggagac actgccgacc cacggccgtc
    12361 gtccgctggg catcgacgac ctgccgaaca agcggttcga cacgatcgtg caggggcgcg
    12421 ccagctacga cctggctctc aaggagggcg tcaccagccc ctatgcccac ctgcgcgaat
    12481 acgtcgcctc gcgcacgctc acggagtcgc ccgacccgaa cgtcgagatc atctcgacgg
    12541 atctggtcgg cagggtccgg gagctgaagg ccgaggacag cgccttcggc atctatctgt
    12601 gcggcggatc ggccgtggcc ggcgaactgg tcgacgaggt cgacgaactg gtcgtcaaga
    12661 cctaccccgt ggtgctcggc accggcatgc cgatgttcgg ctccggcttc gaggtctccg
    12721 cattcgtgcc ggattcggtg cggaccttcg gcaacggcgt cgtggtgcgt acgtaccacc
    12781 gcaagcgctg agccgcctgc cgctctaacc tgggggtatg gacagcgaca cgtacgcctg
    12841 tcccgtgtgc ggacagccag tcgaagcggt cgtccggcgc cacaagacgc tgggcatatg
    12901 ggtaccggaa tgggccccgg gcccgtgcgg caacccgaag tgcgaggcgg gtcccgggaa
    12961 gaacgccggg gccgccgaag ccgaggcgcg gcccgggagg ccggagcact cccgggaaac
    13021 ggtcaccgag aacccctgac cacgacaacg ccgaaggggc ccggccagga tggcgccggg
    13081 ccccttcggg ctgccctgcg gcctgcgatg gtgcaccgat cgccggcccc gggatgctga
    13141 cgtccgtcag gccttcttgg tctcccagaa gatcttgtcg atctgggcga tgtagtccag
    13201 ggccttctgg ccggtcgccg ggtccttcga gcccttggcg gccgacaggg ccttcagggt
    13261 gtcgttgacc agctggtgca gctccgggta cttctcgaag tgcgggggct tgaagtagtc
    13321 gctccacagc acggagacgt ggtgcttcgc gagctcggcg cgctgctcct tgatgaccgt
    13381 ggcgcgcgtc tggaagtgcg ggtcgtcgtt gccggccatc ttctcctgga cggccttcac
    13441 cgactccgcc tcgatgcggg cctgggcagg gtcgtacacg ccgcagggca ggtcgcagtg
    13501 ggcgctgacc gtgaccttgg gggcaaacag gcgggaaagc atgaagcgtt ccttcctcgt
    13561 gatcgtcttc tcagggggga cattactccc tgggagacct gatttcgcgg gtgcccccgt
    13621 gggcttagga caaaagtccg gggtgagact gagactggtg gaggaaagac cggggaggtg
    13681 ccgggtgatg ccggagcaac tgtcgcagga gaccgagcgc gccagagggg cgttgccctt
    13741 cgggccggcc gaggtgaccg ggccgtcgat ggtgcccacg ctgcaccacg gtgacgtgct
    13801 gctcgtgcac tggggggccc gggtccggcc gggtgacgtg gtcgtgctgc ggcacccctt
    13861 ccagcaggac ctgctcgtgg tcaagcgggc ggccgaacgg cgtggggccg gctggtgggt
    13921 gctcggggac aacgcgttcg cgggcgggga cagtaccgac tacggggtgg tcccgcagga
    13981 cctcgtcctc ggccgggtcc ggttccggta ccggccgccg cgggcgggtc agcgttcgcc
    14041 gctcgccgtg gtccgctggg cgctgtcggc ggtcaggccg gtgccggccg accggtccgc
    14101 ctccaggcgc ttgcgagcgc ggtaggccgc cacgttggcg cgggtggcgc agcggtcgga
    14161 gcagtagcgc cgggagcggt tggtggaggt gtccaggtag gcgttgcggc agggggccgc
    14221 ctcgcacagg cccagccggt cgaccccgta ctcggtgagg tggaaggcca ggcccatcgc
    14281 cgcgatggcc gcgaatccgg ccgtcgcgtt ggaggggtgg tccgccaggt gcatgtgcca
    14341 cagcgggctg ccgtcctccg cgcggtggtc gtggccggag atctgcgggc tcaccgggaa
    14401 ctccaggagc agtgagttca gcaggtccac ggcgagggtc tcgtcgccgc cgtcggccgc
    14461 ctcgaagacc gcgcgcagcc gcccccggac cgagcggaac cgcgtcacgt cggcgtcgga
    14521 cgcgcgccgg gccgccgact ggttggcgcc gaagagctca cggacggcct ccaccgaggt
    14581 cagggagtcc tgcccccgcg acggttcctc ggtgttgacg agacgtacgg cgtaatccga
    14641 gtaataggcc agttccactt gtagtcctta cgacggggct ctagggtcgt gcctgcggtc
    14701 gggtaacagc tgatcgtgca tccagggtat tacgcgacgc agtgcggagg ggctcgatga
    14761 cgaacgcgga cacgaccacg gccactacgg ccggcaccac ggccacgacc accgccacgg
    14821 ccggtgccga ctggcaggcc tggcagcgga gctgggaccg gcagcaggag tggtacatgc
    14881 cggaccggga ggaacggttc cggatcatgc tcgacatggt cgaggcgctc gtcggtcccg
    14941 cgccgcgcgt gctggacctg gcctgcggca ccggcaccat cacggcccgg ctgctggacc
    15001 ggttcccgga cgccacgagc accggcgtgg acctcgaccc cgccctcctc gccatcgccg
    15061 agggcacctt cgcgggcgac gaccgggtct cgttcgtcgc cgccgacctc aaggaccccg
    15121 actggccggc gaagctgccg tacgacgcgt acgacgccgt gctgaccgcc acggccctgc
    15181 actggttcca cgccgaaccc ctcgcggatc tctacggccg ggtcgcggag ctggtccgcg
    15241 acggcggtgt cttcatgaac gcggaccaca tgatcgacga agcgacgccc cggatcaacg
    15301 cggccgagcg cgcgcagcgg cacgcgcgga tggacgcggc caaggggcag ggcgccctgg
    15361 actgggccga gtggtggcag ctcgccgccg aggacccggt gctggccgga cccaccgccc
    15421 gccgcttcga gatctacggc gagcacgccg acggcgagat gccctcggcg gcgtggcacg
    15481 cgcgcgtgct gcgcgagaag ggcttcggcg aggcgcggcc ggtgtggtgc tcgccgtcgg
    15541 acaccctgct cctggcggtc aagtaggacc acgcgccgag gaccacgcgc cgaggggcgg
    15601 tacggagatc cgtaccgccc ctcggcgcgc gatcgtgcgg tcggtcagag gaccttggac
    15661 aggaacgcct tcgtccggtc gtgttgcggg tcggtcagca cgtcgcgcgg gttgcccgac
    15721 tcgaccacca cgccgttgtc catgaagacc aggctgtcgc cgacctcgcg ggcgaagccc
    15781 atctcgtggg tgacgacgac catcgtcatg ccggactccg cgaggtcgcg catgacgtcg
    15841 aggacgtcgc cgaccagctc ggggtcgagc gcggaggtcg gctcgtcgaa cagcatcagc
    15901 ttcgggtcca tcgccagggc ccgcgcgatg gcgacccgct gctgctggcc gccggagagc
    15961 tgcgaggggt agttgcccgc cttgtcggcc aggcccacgc gctccaggag gccccgcgca
    16021 cgctccctgg cctgggcccg gctcatgccc ttgacctgga ccggcgcctc catgacgttc
    16081 tccacggctg tcatgtgcgg gaacaggttg aagcgctgga agaccatgcc gatgtcccgg
    16141 cgcttgaggg cgacctcgct gtccttcagc tcgtagagct tgtcaccctt ctggcggtag
    16201 ccgaccagct cgccgtcgac gtacagacgt ccggcgttga tcttctcgag gtggttgata
    16261 cacctgagga aggtggactt gccggagccg gaggggccga tgaggcagaa cacctcgccc
    16321 tgcttcacct ccaggtcgat gcccttgagg acctcgacgg caccgaagga cttgtggacg
    16381 ccctcggcct tgaccatggc ggtcatgccg cacctcccgt cgtgctggag cggttcgaca
    16441 gggagaacag gttggccctg atcttctgca tcggggtggg cggcagactg cggctggagc
    16501 cgcgggcgta gtagcgctcc aggtagtact ggccgacgct gaagacggag gtcagcagca
    16561 ggtaccaggc cgccgcgagg aacagcatct cggccggtgc gccagaggtc tggccgatgt
    16621 cctgggcgac tctgaacaac tcggcgtact ggacgaccga caccagcgag gtcgtcttca
    16681 gcatgttgat gacctcgttg cccgtcggcg gcacgatcac gcgcatcgcc tgcgggacca
    16741 cgatccggcg cagcgtcttg gtgtggctca tgccgagcgc gtgcgccgcc tcggtctggc
    16801 cctcgtcgac cgcgagcagg ccggcgcggc agatctccgc catgtacgcc gcctcgttga
    16861 ggccgaggcc gagcagcgcc gtcaggaacg gcgtcatgaa gtccgaccac tcgtcgcggt
    16921 agaacgggcc gaggttgatg tactcgaaga ccaggccgag gttgaaccag accaccagct
    16981 gcaccaggac cggggtgccg cggaagaacc agatgtagaa ccacgcgatg gacgaggtca
    17041 ccgggttctt cgacagccgc atcacggcga gcaggatgcc gccgacgaca ccgatcagca
    17101 tcgcgaggac ggtgatcagg agcgtcttgc ccatgccggt caggacacgg tcgtcgaaga
    17161 agtagtccgg gatcgcgccc cagttgatct tgccctggga gaaggcgtag acgaccgcgg
    17221 ccagcagcgc gatcgcgacg accgcggaga cgtaccgccc gtagtgcctc accgggatgg
    17281 ccttgatggc ctcgggcggg gtcggcgggg tgccggccgg gccgcccgcc gtcttgtcga
    17341 tgtcaacagt cacggatgtt gcctttcagc gcccgccgcg cggtcacttg ccgccgttga
    17401 cggtggcctc ggtgatggcg ccttccgaca cgccccactt gtccatgatc ttcttgtact
    17461 cgccgttcgc gatcaccgcg tccagcgccg ccttcagggc gtcgcgcagc tgcgtgttgt
    17521 ccttggcgac cgctatgccg tacggcgcgg cctcgacctg ctcgccgacg agctcgaagt
    17581 ccttgccgcc gccggaggtc ttcacggcgt acgccgcgac cgggaagtcg gaggaaccgg
    17641 cgtccgcgcc gcccgcgcgc aggcgggtct gggcctgctg gtcgttgtcg aagggctgca
    17701 tggagatctt cttgccggcc gggcacttct cgttctcggc cttggcgagg tcctcggaga
    17761 ccgtgccgcg ctggaccacg agcttcttgc cgcacaggtc ggaccaggtc ttgatgccct
    17821 ggtcgtcgcc cttcttggtg tagatcgaga caccggcggt gaagtagtcg acgaagtcga
    17881 cgccctggcc gaccttcttg ccggtgtcgc cgtcgatgcc ctcctggcgg tccttggtgt
    17941 cggtcatcgc ggacatggcg atgtcgtacc gcttggagcg caggccggtg atcagggtgt
    18001 cgaaggtgcc gttctcgaac tcgaacttca caccgagctg cttgcccagg gcgtccgcga
    18061 ggtcggggtc gataccgacc gtcttgccgg agtcgtcctt gaactcgacg ggcgcgtacg
    18121 cgatgtccga gccgaccttg atggtgccct tgtcgcggat cgactgcggc agcttgtcgg
    18181 ccagcggagc accgccggcg gactgggtgt cgctgccgcc ggagtcgccg ttctcggtct
    18241 ggtcgccgca tccggtgagc agcagggcgc cggcgaccgc gatcgcaccg accgctgcta
    18301 gccgggagtg cgcggcggtc gtacgacggg tggagcgtgc ggtcatggtg gttcctccgg
    18361 cggatgaggg agttgccgat ggggacggtg gagttccggt gggacgggac gccggccggg
    18421 gtccggccgg tgccgtgggt cgacgagagc acacaccttc gagtgccgcg acctcgtgtg
    18481 attacggcat cttgccattc ggactcggcc attcaggggg gccgtcatgt caaaatcgga
    18541 taacgggtca ccccccgaac cgcaccaggt cggtacatca cgaccgaacc tttgcgggaa
    18601 tctgcccttc cggccggaag atctgcggaa tttctcgtta tccgaccatg gatcgcgggc
    18661 gagcaggggt gttgaaggtg tcgtgcgcgg gcctgtcaag gggtcgggag aggttgtccg
    18721 gaagcctggc tatgagccat gtcaccgaca tgcggcgttc ggggtccggc atgtgagctt
    18781 gcgcttatcg gactcgtcgc cgggggcgtc cgtcgggtaa gaaggttctt tacacccctc
    18841 atcaggggct cagggcgcgt gtgcggcgcg cccgtcgcgc gggggccacg tggcccagac
    18901 agccatctcc ctgtgcggtg cccgcccatt cctcaccagg agtggacaaa ccctcaaacc
    18961 atgaactctt aaggggtaag acaaagtggc agcggagatc gtcaatcctc gcagcgacag
    19021 cgaagccggt gcggagcagg aggcgggcgc cgagccgctc gactccttcg accccgcgtt
    19081 cgcgctgcac cgcggcggca agatggccgt gcaggccacc gtgccgatcc gcgacaagga
    19141 agacctgtcc ctggcgtaca cgcccggcgt cgcgaaagtg tgcagcgcga tcgccgagca
    19201 gcccgacctc gtccacgact acacctggaa gtcgtcggtc gtcgcggtcg tgacggacgg
    19261 cacggcggtg ctggggctcg gtgacatcgg gcccgaggcg tccctcccgg tgatggaggg
    19321 caaggccatc ctcttcaagc agttcggcgg cgtggacgcg gtcccgatcg ccctgaactg
    19381 cacggacgcc gacgagatcg tcgagaccgt ggtccggctc gcgccctcct tcggcggcgt
    19441 caacctggag gacatctcgg cgccgcggtg cttcgagatc gagcgcaagc tccaggagcg
    19501 cctggacatc ccggtcttcc acgacgacca gcacggcacg gccgtcgtga cgctggccgc
    19561 cctgcggaac gcggcgcggc tgagcgggcg gacgctgggt gagctgcggg cggtgatctc
    19621 gggcgcgggt gcggccgggg tcgccatcgc caagatgctg gtggaggccg gcatcgggga
    19681 cgtcgcggtc gccgaccgca agggtgtcgt ttcggccgac cgggaggacc tgaccccggt
    19741 caagcaggag ttggcctcct tcaccaacaa ggccgggctc tccggccccc tggaggcggc
    19801 gctcgcgggt gccgacgtct tcatcggcgt ctccggcggt acggtgcccg agccggcggt
    19861 ggcctcgatg gccgagggtg ccttcgtctt cgcgatggcc aacccgaacc cggaggtgca
    19921 tccggaggtc gcccacaagt acgcggcggt cgtcgcgacg gggcgctcgg acttcccgaa
    19981 ccagatcaac aacgtgctgg cgttcccggg catcttcgcg ggcgctctcc aggtgcgggc
    20041 gtcgcggatc accgagggca tgaagctggc ggcggccgag gcgctggcct ccgtggtggg
    20101 ggacgacctt gccgcggact atgtcattcc gtccccgttc gacgagcggg tcgcgccggc
    20161 cgtgacggcg gcggtggccg cggcggcccg ggcggagggg gttgcgcgcc ggtgacggtg
    20221 tgacgccccc ggtgtgatca ctgcggtgtg gtgagcggtc tcgtccctgg tgggcggggc
    20281 cgcttgtctt ttgggtgccg gtgccggtac gggtgcgggt gggggtgcgg gtgcgctggt
    20341 gctgggcggg ggtgggggcg ccggccggcg ctgggcgggt gccgctgcgc ccacccgtgc
    20401 cgccccagcg gcacgactgc ccgcagctgg ggggagggct ggcaggcgcg actgtccgca
    20461 gctggggggc gctggcaggc gtgactgacc cagctggggg ccggggtggc tggcaagagg
    20521 gggtgtgtca cacggggctg cggttccggt tggggggtgg ggaacctatc gtcagggtca
    20581 tgttcgctgt ctatgccgcc cgaatcgacc gcgaccagcc gttggccggc ctggagttgg
    20641 gagagcttcc ggctcccgag gcccggccgg gctggagcgt cgtcgatgtc agggccgcct
    20701 ccctcaacca ccacgacctg tggtccctgc gcggcgtcgg cctccccgag gaccggctgc
    20761 cgatgatcct cggctgcgac gccgccggga tcgacgcgga cggcaacgag gtcgtcctgc
    20821 actccgtgat cggccagacc ggccacggcg tcggccccaa ggagccccgc tccattctca
    20881 ccgagcgcta tccggggacg ttcgccgagc aggtcgccgt gccgacctgg aacatcctgc
    20941 ccaagcccaa ggagctctcc ttcgaggagg ccgcctgcct gccgaccgcc tggctgacgg
    21001 cgtaccggat gctgttcacc aacgccgggg tgcgtcccgg tgactcggtg ctggtgcagg
    21061 gcgccggcgg cggggtcgcc acggccgcga tcgtgctcgg caaggcggcc gggctgcggg
    21121 tcttcgccac cagccgggac gaggccaagc gcaagcgggc g
//
