LOCUS       NC_003888              21086 bp    DNA     linear   CON 03-AUG-2016
DEFINITION  Streptomyces coelicolor A3(2) chromosome, complete genome.
ACCESSION   NC_003888
VERSION     NC_003888.3
KEYWORDS    RefSeq; complete genome.
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces; Streptomyces
            albidoflavus group.
REFERENCE   1  (bases 1 to 8667507)
  AUTHORS   Hsiao,N.H. and Kirby,R.
  TITLE     Comparative genomics of Streptomyces avermitilis, Streptomyces
            cattleya, Streptomyces maritimus and Kitasatospora aureofaciens
            using a Streptomyces coelicolor microarray system
  JOURNAL   Antonie Van Leeuwenhoek 93 (1-2), 1-25 (2008)
   PUBMED   17588127
REFERENCE   2  (bases 1 to 8667507)
  AUTHORS   Bentley,S.D., Chater,K.F., Cerdeno-Tarraga,A.M., Challis,G.L.,
            Thomson,N.R., James,K.D., Harris,D.E., Quail,M.A., Kieser,H.,
            Harper,D., Bateman,A., Brown,S., Chandra,G., Chen,C.W., Collins,M.,
            Cronin,A., Fraser,A., Goble,A., Hidalgo,J., Hornsby,T., Howarth,S.,
            Huang,C.H., Kieser,T., Larke,L., Murphy,L., Oliver,K., O'Neil,S.,
            Rabbinowitsch,E., Rajandream,M.A., Rutherford,K., Rutter,S.,
            Seeger,K., Saunders,D., Sharp,S., Squares,R., Squares,S., Taylor,K.,
            Warren,T., Wietzorrek,A., Woodward,J., Barrell,B.G., Parkhill,J. and
            Hopwood,D.A.
  TITLE     Complete genome sequence of the model actinomycete Streptomyces
            coelicolor A3(2)
  JOURNAL   Nature 417 (6885), 141-147 (2002)
   PUBMED   12000953
REFERENCE   3  (bases 1 to 8667507)
  AUTHORS   Redenbach,M., Kieser,H.M., Denapaite,D., Eichner,A., Cullum,J.,
            Kinashi,H. and Hopwood,D.A.
  TITLE     A set of ordered cosmids and a detailed genetic and physical map for
            the 8 Mb Streptomyces coelicolor A3(2) chromosome
  JOURNAL   Mol. Microbiol. 21 (1), 77-96 (1996)
   PUBMED   8843436
REFERENCE   4  (bases 1 to 8667507)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-MAY-2002) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
  REMARK    Direct Submission
REFERENCE   5  (bases 1 to 8667507)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAY-2002) Sanger Institute, Wellcome Trust Genome
            Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
  REMARK    Direct Submission
COMMENT     ##antiSMASH-Data-START##
            Version     :: 8.0.1
            Run date    :: 2025-05-26 12:13:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start :: 5671015
            Orig. end   :: 5692101
            ##antiSMASH-Data-END##
            REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645882.
            On Jun 22, 2003 this sequence version replaced NC_003888.2.
            RefSeq Category: Reference Genome
            MOD: Model Organism
            UPR: UniProt Genome
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21086
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="13"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21086
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21086
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11086](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11086
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(260..1576)
                     /db_xref="GeneID:1100653"
                     /gene_synonym="aroA2; SC7E4.09c"
                     /locus_tag="SCO5212"
     CDS             complement(260..1576)
                     /EC_number="2.5.1.19"
                     /codon_start=1
                     /db_xref="GeneID:1100653"
                     /gene_synonym="aroA2; SC7E4.09c"
                     /locus_tag="SCO5212"
                     /note="catalyzes the formation of
                     5-O-(1-carboxyvinyl)-3-phosphoshikimate from
                     phosphoenolpyruvate and 3-phosphoshikimate in tryptophan
                     biosynthesis"
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="NP_629359.1"
                     /transl_table=11
                     /translation="MTVNPTHTALWPAPHASGAVDATVHVPGSKSVTNRALVLAALASE
                     PGWLRRPLRSRDTLLMAEALRTLGVEIEEGVGPEGTGEFWRVIPAGLRGPATVDVGNAG
                     TVMRFLPPVATLADGAVRFDGDPRSYERPLHGVIDALRVLGARIDDDGRGALPLTVHGG
                     GALEGGPVEIDASSSSQFVSALLLSGPRFNQGVEVRHTGSALPSMPHIRMTVDMLRAVG
                     AQVDTPESGGEPNVWRVTPGALLGRDLTVEPDLSNAQPFLAAALVTGGKVVIPDWPSRT
                     TQPGDRLREIFTDMGGSCELTDFGLVFTGSGAIHGIDVDLSEVGELTPGIAAVAALADS
                     PSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRRLHGGVFHTYDDHRM
                     ATAGAVLGLAVEGVQIENVATTAKTLPDFPDLWTGMLGA"
     aSDomain        complement(272..1510)
                     /aSDomain="TIGR01356"
                     /aSTool="tigrfam"
                     /description="aroA: 3-phosphoshikimate
                     1-carboxyvinyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO5212_0058"
                     /evalue="6.70E-113"
                     /identifier="TIGR01356"
                     /label="SCO5212"
                     /locus_tag="SCO5212"
                     /protein_end="435"
                     /protein_start="22"
                     /score="375.6"
                     /tool="antismash"
                     /translation="TVHVPGSKSVTNRALVLAALASEPGWLRRPLRSRDTLLMAEALRT
                     LGVEIEEGVGPEGTGEFWRVIPAGLRGPATVDVGNAGTVMRFLPPVATLADGAVRFDGD
                     PRSYERPLHGVIDALRVLGARIDDDGRGALPLTVHGGGALEGGPVEIDASSSSQFVSAL
                     LLSGPRFNQGVEVRHTGSALPSMPHIRMTVDMLRAVGAQVDTPESGGEPNVWRVTPGAL
                     LGRDLTVEPDLSNAQPFLAAALVTGGKVVIPDWPSRTTQPGDRLREIFTDMGGSCELTD
                     FGLVFTGSGAIHGIDVDLSEVGELTPGIAAVAALADSPSTLRGVAHLRLHETDRLAALT
                     KEINELGGDVTETADGLHIRPRRLHGGVFHTYDDHRMATAGAVLGLAVEGVQIENVATT
                     AKTLPDFPDLWTGM"
     misc_feature    complement(281..1537)
                     /gene_synonym="aroA2; SC7E4.09c"
                     /locus_tag="SCO5212"
                     /note="Pfam match to entry PF00275 EPSP_syntase, EPSP
                     synthase (3-phosphoshikimate 1-carboxyvinyltransferase),
                     score 399.20, E-value 3.9e-116"
     PFAM_domain     complement(287..1528)
                     /aSDomain="EPSP_synthase"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00275.23"
                     /db_xref="GO:0016765"
                     /description="EPSP synthase (3-phosphoshikimate
                     1-carboxyvinyltransferase)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5212_0488"
                     /evalue="1.20E-107"
                     /gene_ontologies="GO:0016765: transferase activity,
                     transferring alkyl or aryl (other than methyl) groups"
                     /label="SCO5212"
                     /locus_tag="SCO5212"
                     /protein_end="430"
                     /protein_start="16"
                     /score="360.4"
                     /tool="antismash"
                     /translation="SGAVDATVHVPGSKSVTNRALVLAALASEPGWLRRPLRSRDTLLM
                     AEALRTLGVEIEEGVGPEGTGEFWRVIPAGLRGPATVDVGNAGTVMRFLPPVATLADGA
                     VRFDGDPRSYERPLHGVIDALRVLGARIDDDGRGALPLTVHGGGALEGGPVEIDASSSS
                     QFVSALLLSGPRFNQGVEVRHTGSALPSMPHIRMTVDMLRAVGAQVDTPESGGEPNVWR
                     VTPGALLGRDLTVEPDLSNAQPFLAAALVTGGKVVIPDWPSRTTQPGDRLREIFTDMGG
                     SCELTDFGLVFTGSGAIHGIDVDLSEVGELTPGIAAVAALADSPSTLRGVAHLRLHETD
                     RLAALTKEINELGGDVTETADGLHIRPRRLHGGVFHTYDDHRMATAGAVLGLAVEGVQI
                     ENVATTAKTLPDFPD"
     gene            complement(1700..2422)
                     /db_xref="GeneID:1100654"
                     /gene_synonym="SC7E4.10c"
                     /locus_tag="SCO5213"
     CDS             complement(1700..2422)
                     /codon_start=1
                     /db_xref="GeneID:1100654"
                     /gene_synonym="SC7E4.10c"
                     /locus_tag="SCO5213"
                     /note="SC7E4.10c, possible integral membrane protein, len:
                     240 aa; similar to TR:CAB89063 (EMBL:AL353872) Streptomyces
                     coelicolor integral membrane protein SC5G8.12, 322 aa;
                     fasta scores: opt: 126 z-score: 158.5 E(): 0.23; 25.6%
                     identity in 160 aa overlap. Contains possible hydrophobic
                     membrane spanning regions"
                     /product="hypothetical protein"
                     /protein_id="NP_629360.1"
                     /transl_table=11
                     /translation="MDHLATASLTSLWDEVSGIQPDPDLWVVVATLVAALAVVATRGSW
                     RIARNAITIAHEGGHGLVALLTGRTLTGITLHSDTSGLTVSRGKPHGVGMILTAVAGYT
                     APPLLGLGGAALLAAGRITLLLWLATALLVALLVMVRNAYGVLTVVVTGGTFVLVSWLA
                     GPQVQAAFAYAVVWFLLLGGVRPAFELQAKRSRGGAGDSDADQLARLTHAPAGVWFFLF
                     HAVSLCSLIGGARWLLEL"
     PFAM_domain     complement(1727..2335)
                     /aSDomain="Peptidase_M50B"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF13398.9"
                     /description="Peptidase M50B-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5213_0489"
                     /evalue="1.70E-59"
                     /label="SCO5213"
                     /locus_tag="SCO5213"
                     /protein_end="232"
                     /protein_start="29"
                     /score="200.9"
                     /tool="antismash"
                     /translation="ATLVAALAVVATRGSWRIARNAITIAHEGGHGLVALLTGRTLTGI
                     TLHSDTSGLTVSRGKPHGVGMILTAVAGYTAPPLLGLGGAALLAAGRITLLLWLATALL
                     VALLVMVRNAYGVLTVVVTGGTFVLVSWLAGPQVQAAFAYAVVWFLLLGGVRPAFELQA
                     KRSRGGAGDSDADQLARLTHAPAGVWFFLFHAVSLCSLIG"
     PFAM_domain     2473..3225
                     /aSDomain="SRAP"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF02586.17"
                     /db_xref="GO:0003697"
                     /db_xref="GO:0006974"
                     /db_xref="GO:0018142"
                     /description="SOS response associated peptidase (SRAP)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5214_0490"
                     /evalue="3.90E-67"
                     /gene_ontologies="GO:0003697: single-stranded DNA binding"
                     /gene_ontologies="GO:0006974: DNA damage response"
                     /gene_ontologies="GO:0018142: protein-DNA covalent
                     cross-linking"
                     /label="SCO5214"
                     /locus_tag="SCO5214"
                     /protein_end="251"
                     /protein_start="0"
                     /score="226.1"
                     /tool="antismash"
                     /translation="MCGRYAASRRPEDLAGIFEIEKWEPKESLEPDYNVAPTKEVYAVL
                     DRPLKDVEDPEPVRQLRKLKWGLVPSWSKTPEGGARMINARAETVHEKPSYRRAFSTRR
                     CILPADGYYEWVTGKQERDLEVEGRKKRPRKQPYFVTPADGSVFAMAGLYEFWRDRTLP
                     DDHPQAWWVTCSVITTEAETTPLAVAPADGPHALADIHPRMPLMLTPDRWDDWLDPART
                     DPDELTSLLAPPPTGLMRAFPVSTAVSNV"
     gene            2473..3288
                     /db_xref="GeneID:1100655"
                     /gene_synonym="SC7E4.11"
                     /locus_tag="SCO5214"
     CDS             2473..3288
                     /codon_start=1
                     /db_xref="GeneID:1100655"
                     /gene_synonym="SC7E4.11"
                     /locus_tag="SCO5214"
                     /note="SC7E4.11, hypothetical protein, len: 271 aa; similar
                     to TR:O05872 (EMBL:Z95121) Mycobacterium tuberculosis
                     hypothetical 27.6 kD protein MTCY20B11.01c, 252 aa; fasta
                     scores: opt: 383 z-score: 460.8 E(): 3.4e-18; 39.6%
                     identity in 283 aa overlap"
                     /product="hypothetical protein"
                     /protein_id="NP_629361.1"
                     /transl_table=11
                     /translation="MCGRYAASRRPEDLAGIFEIEKWEPKESLEPDYNVAPTKEVYAVL
                     DRPLKDVEDPEPVRQLRKLKWGLVPSWSKTPEGGARMINARAETVHEKPSYRRAFSTRR
                     CILPADGYYEWVTGKQERDLEVEGRKKRPRKQPYFVTPADGSVFAMAGLYEFWRDRTLP
                     DDHPQAWWVTCSVITTEAETTPLAVAPADGPHALADIHPRMPLMLTPDRWDDWLDPART
                     DPDELTSLLAPPPTGLMRAFPVSTAVSNVRNNGPELLEELEAPEEGTLF"
     misc_feature    3247..6154
                     /note="previously sequenced DNA fragment. EMBL:SAJ010320
                     Streptomyces coelicolor sigR and rsrA genes"
     regulatory      3305..3308
                     /regulatory_class="ribosome_binding_site"
     gene            3311..3946
                     /db_xref="GeneID:1100656"
                     /gene_synonym="SC7E4.12"
                     /locus_tag="SCO5215"
     CDS             3311..3946
                     /codon_start=1
                     /db_xref="GeneID:1100656"
                     /gene_synonym="SC7E4.12"
                     /locus_tag="SCO5215"
                     /note="SC7E4.12, hypothetical protein, len: 211 aa; similar
                     to TR:P96267 (EMBL:Z84724) Mycobacterium tuberculosis
                     hypothetical 21.7 kD protein MTCY22G10.18c, 209 aa; fasta
                     scores: opt: 255 z-score: 287.1 E(): 1.6e-08; 29.8%
                     identity in 205 aa overlap"
                     /product="hypothetical protein"
                     /protein_id="NP_629362.1"
                     /transl_table=11
                     /translation="MTEAVETDAGPARITWHRAKQPRLVLAVSHGAGGGIEARDLKALA
                     AALPAHGVSVALVEQPWRVAGRKLAPAPKTLDTGWRGVWPALAAPGLPVISGGRSAGAR
                     VACRTAGELGARAVLALSFPLHPPGRPEKSRADELLGAGVPTLVVQGGNDPFGRPHEFP
                     EAPGGTYDLIEVPYGDHGFAVPKRAEISQERALELITDGVAQWAGSLG"
     PFAM_domain     3383..3931
                     /aSDomain="Abhydrolase_11"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF20408.1"
                     /description="Alpha/beta hydrolase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5215_0491"
                     /evalue="1.90E-29"
                     /label="SCO5215"
                     /locus_tag="SCO5215"
                     /protein_end="207"
                     /protein_start="24"
                     /score="102.8"
                     /tool="antismash"
                     /translation="VLAVSHGAGGGIEARDLKALAAALPAHGVSVALVEQPWRVAGRKL
                     APAPKTLDTGWRGVWPALAAPGLPVISGGRSAGARVACRTAGELGARAVLALSFPLHPP
                     GRPEKSRADELLGAGVPTLVVQGGNDPFGRPHEFPEAPGGTYDLIEVPYGDHGFAVPKR
                     AEISQERALELITDGVAQWA"
     misc_feature    complement(4134..4148)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.77"
                     /tool="antismash"
     regulatory      4197..4202
                     /regulatory_class="ribosome_binding_site"
     gene            4204..4887
                     /db_xref="GeneID:1100657"
                     /gene_synonym="SC7E4.13; sigR"
                     /locus_tag="SCO5216"
     CDS             4204..4887
                     /codon_start=1
                     /db_xref="GeneID:1100657"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /gene_synonym="SC7E4.13; sigR"
                     /locus_tag="SCO5216"
                     /note="Member of the extracytoplasmic function sigma
                     factors which are active under specific conditions; binds
                     with the catalytic core of RNA polymerase to produce the
                     holoenzyme and directs bacterial core RNA polymerase to
                     specific promoter elements to initiate transcription; this
                     sigma factor is involved in heat shock and oxidative stress
                     response"
                     /product="RNA polymerase sigma factor RpoE"
                     /protein_id="NP_629363.1"
                     /transl_table=11
                     /translation="MGPVTGTDAGTEHGQAEQPEGRGTGAESTAERSARFERDALEFLD
                     QMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINSYRKK
                     QREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKQALQAIPEEFRIAV
                     YLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARDRGLVPAGAGESNEA
                     KGSGS"
     misc_feature    4226..4241
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.19"
                     /tool="antismash"
     aSDomain        4282..4842
                     /aSDomain="TIGR02947"
                     /aSTool="tigrfam"
                     /description="SigH_actino: RNA polymerase sigma-70 factor,
                     TIGR02947 family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO5216_0059"
                     /evalue="1.10E-108"
                     /identifier="TIGR02947"
                     /label="SCO5216"
                     /locus_tag="SCO5216"
                     /protein_end="213"
                     /protein_start="26"
                     /score="359.2"
                     /tool="antismash"
                     /translation="ESTAERSARFERDALEFLDQMYSAALRMTRNPADAEDLVQETYAK
                     AYASFHQFREGTNLKAWLYRILTNTFINSYRKKQREPQRSAAEEIEDWQLARAESHMST
                     GLRSAESQALDHLPDSDVKQALQAIPEEFRIAVYLADVEGFAYKEIADIMGTPIGTVMS
                     RLHRGRRQLRGMLEDYARDRGLVP"
     aSDomain        4324..4806
                     /aSDomain="TIGR02937"
                     /aSTool="tigrfam"
                     /description="sigma70-ECF: RNA polymerase sigma factor,
                     sigma-70 family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO5216_0060"
                     /evalue="8.50E-27"
                     /identifier="TIGR02937"
                     /label="SCO5216"
                     /locus_tag="SCO5216"
                     /protein_end="201"
                     /protein_start="40"
                     /score="91.8"
                     /tool="antismash"
                     /translation="LEFLDQMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNL
                     KAWLYRILTNTFINSYRKKQREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLP
                     DSDVKQALQAIPEEFRIAVYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGM"
     PFAM_domain     4330..4521
                     /aSDomain="Sigma70_r2"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF04542.17"
                     /db_xref="GO:0003700"
                     /db_xref="GO:0006352"
                     /db_xref="GO:0006355"
                     /description="Sigma-70 region 2"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5216_0492"
                     /evalue="5.40E-18"
                     /gene_ontologies="GO:0003700: DNA-binding transcription
                     factor activity"
                     /gene_ontologies="GO:0006352: DNA-templated transcription
                     initiation"
                     /gene_ontologies="GO:0006355: regulation of DNA-templated
                     transcription"
                     /label="SCO5216"
                     /locus_tag="SCO5216"
                     /protein_end="106"
                     /protein_start="42"
                     /score="64.7"
                     /tool="antismash"
                     /translation="FLDQMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKA
                     WLYRILTNTFINSYRKKQR"
     misc_feature    4348..4515
                     /gene_synonym="SC7E4.13; sigR"
                     /locus_tag="SCO5216"
                     /note="Pfam match to entry PF00776 Sigma70_ECF, Sigma-70
                     factor (ECF subfamily), score 96.80, E-value 4.1e-25"
     misc_feature    4384..4479
                     /gene_synonym="SC7E4.13; sigR"
                     /locus_tag="SCO5216"
                     /note="PS01063 Sigma-70 factors ECF subfamily signature"
     PFAM_domain     4645..4797
                     /aSDomain="Sigma70_r4_2"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF08281.15"
                     /db_xref="GO:0003677"
                     /db_xref="GO:0003700"
                     /db_xref="GO:0006352"
                     /db_xref="GO:0006355"
                     /db_xref="GO:0016987"
                     /description="Sigma-70, region 4"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5216_0493"
                     /evalue="1.10E-13"
                     /gene_ontologies="GO:0003677: DNA binding"
                     /gene_ontologies="GO:0003700: DNA-binding transcription
                     factor activity"
                     /gene_ontologies="GO:0006352: DNA-templated transcription
                     initiation"
                     /gene_ontologies="GO:0006355: regulation of DNA-templated
                     transcription"
                     /gene_ontologies="GO:0016987: sigma factor activity"
                     /label="SCO5216"
                     /locus_tag="SCO5216"
                     /protein_end="198"
                     /protein_start="147"
                     /score="50.7"
                     /tool="antismash"
                     /translation="VKQALQAIPEEFRIAVYLADVEGFAYKEIADIMGTPIGTVMSRLH
                     RGRRQL"
     gene            4884..5201
                     /db_xref="GeneID:1100658"
                     /gene_synonym="rsrA; SC7E4.14"
                     /locus_tag="SCO5217"
     CDS             4884..5201
                     /codon_start=1
                     /db_xref="GeneID:1100658"
                     /gene_synonym="rsrA; SC7E4.14"
                     /locus_tag="SCO5217"
                     /note="SC7E4.14, rsrA, anti-sigma factor, len: 105 aa;
                     identical to previously sequenced TR:Q9RL96 (EMBL:AJ010320)
                     Streptomyces coelicolor anti-sigma factor RsrA, 105 aa"
                     /product="anti-sigma factor"
                     /protein_id="NP_629364.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEILDHLYEFLDKEMPDSDCVKFEHHFEECSPCL
                     EKYGLEQAVKKLVKRCCGQDDVPGDLRAKVMGRLDLIRSGQSVPEHDVAAAPSSSAPQE
                     S"
     aSDomain        4893..5138
                     /aSDomain="TIGR02949"
                     /aSTool="tigrfam"
                     /description="anti_SigH_actin: anti-sigma factor, TIGR02949
                     family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO5217_0061"
                     /evalue="1.90E-35"
                     /identifier="TIGR02949"
                     /label="SCO5217"
                     /locus_tag="SCO5217"
                     /protein_end="85"
                     /protein_start="3"
                     /score="118.7"
                     /tool="antismash"
                     /translation="GEPHETDCSEILDHLYEFLDKEMPDSDCVKFEHHFEECSPCLEKY
                     GLEQAVKKLVKRCCGQDDVPGDLRAKVMGRLDLIRSG"
     aSDomain        4911..5135
                     /aSDomain="TIGR03988"
                     /aSTool="tigrfam"
                     /description="antisig_RsrA: mycothiol system anti-sigma-R
                     factor"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO5217_0062"
                     /evalue="1.20E-30"
                     /identifier="TIGR03988"
                     /label="SCO5217"
                     /locus_tag="SCO5217"
                     /protein_end="84"
                     /protein_start="9"
                     /score="103.4"
                     /tool="antismash"
                     /translation="DCSEILDHLYEFLDKEMPDSDCVKFEHHFEECSPCLEKYGLEQAV
                     KKLVKRCCGQDDVPGDLRAKVMGRLDLIRS"
     PFAM_domain     4914..5015
                     /aSDomain="zf-HC2"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF13490.9"
                     /description="Putative zinc-finger"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5217_0494"
                     /evalue="6.40E-08"
                     /label="SCO5217"
                     /locus_tag="SCO5217"
                     /protein_end="44"
                     /protein_start="10"
                     /score="32.8"
                     /tool="antismash"
                     /translation="CSEILDHLYEFLDKEMPDSDCVKFEHHFEECSPC"
     regulatory      5320..5324
                     /regulatory_class="ribosome_binding_site"
     gene            5330..6655
                     /db_xref="GeneID:1100659"
                     /gene_synonym="SC7E4.15"
                     /locus_tag="SCO5218"
     CDS             5330..6655
                     /codon_start=1
                     /db_xref="GeneID:1100659"
                     /gene_synonym="SC7E4.15"
                     /locus_tag="SCO5218"
                     /note="SC7E4.15, possible integral membrane protein, len:
                     441 aa; similar to TR:Q9X1H8 (EMBL:AE001797) Thermotoga
                     maritima conserved hypothetical protein TM1467, 426 aa;
                     fasta scores: opt: 471 z-score: 536.1 E(): 2.2e-22; 29.0%
                     identity in 352 aa overlap. Contains possible N-terminal
                     signal peptide sequence and possible hydrophobic membrane
                     spanning regions"
                     /product="hypothetical protein"
                     /protein_id="NP_629365.1"
                     /transl_table=11
                     /translation="MDAVPARARVYVAVVALTALLCLRPLPAVRAPWWAVLLLAGLYAG
                     SELVARSRFVGTCYPVLLAGAFLLPPPAAALVALPGALLAPVPRRPLGLRRVWRAAQLT
                     LAVWAAACVHWRLGGRDAVVEPAFPYALVPAGAAVLAFCLVLTVLDGGILTLADHVPPS
                     RAWRGLLSRSLAPIAVHGLAGLMMAVLWRSPYGPVAALLVLLPMCVAWWAFAQYHRERA
                     AHQATIRALVQAVDIKDGYTRGHSERVGQASMMIARELGMDDERVETLRFAGILHDVGK
                     LGVPTRLLRKDGPLTPEERRVIELHPEYGHEMVRGIRFLGEARAAVLHHHERLDGSGYP
                     YGLAGDRIPESARVVAVADAFDAMTSTRSYSRARPVATALAELQRCAGGQFDPRMVRAL
                     VRALGRHGWRPSVTADSPLTRTAGPAPDRGEDARDSVGRGAP"
     aSDomain        6056..6325
                     /aSDomain="TIGR00277"
                     /aSTool="tigrfam"
                     /description="HDIG: HDIG domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO5218_0063"
                     /evalue="1.30E-07"
                     /identifier="TIGR00277"
                     /label="SCO5218"
                     /locus_tag="SCO5218"
                     /protein_end="332"
                     /protein_start="242"
                     /score="29.4"
                     /tool="antismash"
                     /translation="RGHSERVGQASMMIARELGMDDERVETLRFAGILHDVGKLGVPTR
                     LLRKDGPLTPEERRVIELHPEYGHEMVRGIRFLGEARAAVLHHHE"
     PFAM_domain     6059..6421
                     /aSDomain="HD"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF01966.25"
                     /description="HD domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5218_0495"
                     /evalue="2.20E-20"
                     /label="SCO5218"
                     /locus_tag="SCO5218"
                     /protein_end="364"
                     /protein_start="243"
                     /score="73.2"
                     /tool="antismash"
                     /translation="GHSERVGQASMMIARELGMDDERVETLRFAGILHDVGKLGVPTRL
                     LRKDGPLTPEERRVIELHPEYGHEMVRGIRFLGEARAAVLHHHERLDGSGYPYGLAGDR
                     IPESARVVAVADAFDAM"
     gene            6661..7917
                     /db_xref="GeneID:1100660"
                     /gene_synonym="SC7E4.16"
                     /locus_tag="SCO5219"
     CDS             6661..7917
                     /codon_start=1
                     /db_xref="GeneID:1100660"
                     /gene_synonym="SC7E4.16"
                     /locus_tag="SCO5219"
                     /note="SC7E4.16, possible lipoprotein, len: 418 aa.
                     Contains correctly situated match to Prosite entry PS00013
                     Prokaryotic membrane lipoprotein lipid attachment site,
                     possible N-terminal region signal peptide sequence and
                     possible hydrophobic membrane spanning regions"
                     /product="lipoprotein"
                     /protein_id="NP_629366.1"
                     /transl_table=11
                     /translation="MQPPARSSPPAAVLLVPGCAGLLALGCLASVLGAGPAQRPVALAF
                     GGLVVLGELTRRTGAEAREAAPLGAAGALAYALLGDVAGQPAHHGVAETVTVVLAASLL
                     GSVPYVARGSGPVLDHLARRVLTVGFAAVCFRPLSNQGVFDDWSGPAYALLLLGLLALT
                     TLCDAVLAAAPAHARTGWPFGPLLREELRGMVGITSAVCATGAVMALAVSVAGLWALPV
                     FSVPLLLAQLSYRRYAAVRATYRQTIASLARATEIAGYTPAGHARRVAGLGVAVGRDLG
                     LSGAELTVLEYAALMHDIGQLSLVDPVPAGATAGLPVTEQRRIALLGGAVVRQTGVDAA
                     VAVVVERQADPCREQPVAARIVRVVNAYDEKARDAGPGGVLTALEELRLATAGDYAPEV
                     VEALARVLSRGSLTEPAAG"
     misc_feature    6709..6741
                     /gene_synonym="SC7E4.16"
                     /locus_tag="SCO5219"
                     /note="PS00013 Prokaryotic membrane lipoprotein lipid
                     attachment site"
     gene            8032..9012
                     /db_xref="GeneID:1100661"
                     /gene_synonym="SC7E4.17"
                     /locus_tag="SCO5220"
     CDS             8032..9012
                     /codon_start=1
                     /db_xref="GeneID:1100661"
                     /gene_synonym="SC7E4.17"
                     /locus_tag="SCO5220"
                     /note="SC7E4.17, unknown, len: 326 aa"
                     /product="hypothetical protein"
                     /protein_id="NP_629367.1"
                     /transl_table=11
                     /translation="MRIFGKARHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRDIGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLRTPGGATDAGEPLGMDLGSAAVRLSPEGEAEVVWGRRLDPARVEVLSIPL
                     PSSGRRWGEVVLHDGVPHGERTTSAGHSYPVFDEIELWAPSPVPTWVVLLEAATESDRD
                     ALEQLAADAGFAAEDWSSSVRLLCRMCSESRMPSDEGDGEHLDPHDHSEPGHPGPLGHR
                     TDGQLWVPERECGVAAPAGLVKGLLDGWVADSPDSRDWRDLEEVC"
     gene            9092..9742
                     /db_xref="GeneID:1100662"
                     /gene_synonym="SC7E4.18"
                     /locus_tag="SCO5221"
     CDS             9092..9742
                     /codon_start=1
                     /db_xref="GeneID:1100662"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SC7E4.18"
                     /locus_tag="SCO5221"
                     /note="SC7E4.18, probable polypeptide deformylase, len: 216
                     aa; similar to SW:DEF_FREDI (EMBL:Y10305) Fremyella
                     diplosiphon polypeptide deformylase (EC 3.5.1.31) Def, 187
                     aa; fasta scores: opt: 353 z-score: 430.0 E(): 1.8e-16;
                     33.8% identity in 145 aa overlap and to TR:Q9XAQ2
                     (EMBL:AL078618) Streptomyces coelicolor polypeptide
                     deformylase SC10A7.23, 208 aa; fasta scores: opt: 680
                     z-score: 796.7 E(): 0; 59.8% identity in 169 aa overlap.
                     Contains Pfam match to entry PF01327 Pep_deformylase,
                     Polypeptide deformylase"
                     /product="polypeptide deformylase"
                     /protein_id="NP_629368.1"
                     /transl_table=11
                     /translation="MAQQDTDQQHPGVLPVDDEGFVVDSQDCEEREADWRGRGTSRPIT
                     VVGNPVLHKECEDVTDFGEEFQQLVADMFASQRTAEGVGLAANQIGVSKKVFVYDCPDD
                     EGVRHVGVVCNPRLVELPADRRRLDDSNEGCLSVPTAYAPLARPDYAEVTGQDEKGNPV
                     KVRGTGYFARCLQHETDHLYGYLYIDRLSKRERKDALRQMAENEPRYPVVAND"
     PFAM_domain     9215..9679
                     /aSDomain="Pep_deformylase"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF01327.24"
                     /db_xref="GO:0042586"
                     /description="Polypeptide deformylase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5221_0496"
                     /evalue="1.20E-45"
                     /gene_ontologies="GO:0042586: peptide deformylase activity"
                     /label="SCO5221"
                     /locus_tag="SCO5221"
                     /protein_end="196"
                     /protein_start="41"
                     /score="155.1"
                     /tool="antismash"
                     /translation="RPITVVGNPVLHKECEDVTDFGEEFQQLVADMFASQRTAEGVGLA
                     ANQIGVSKKVFVYDCPDDEGVRHVGVVCNPRLVELPADRRRLDDSNEGCLSVPTAYAPL
                     ARPDYAEVTGQDEKGNPVKVRGTGYFARCLQHETDHLYGYLYIDRLSKRER"
     misc_feature    9218..9652
                     /gene_synonym="SC7E4.18"
                     /locus_tag="SCO5221"
                     /note="Pfam match to entry PF01327 Pep_deformylase,
                     Polypeptide deformylase, score 183.80, E-value 2.7e-51"
     aSDomain        9230..9700
                     /aSDomain="TIGR00079"
                     /aSTool="tigrfam"
                     /description="pept_deformyl: peptide deformylase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO5221_0064"
                     /evalue="3.90E-39"
                     /identifier="TIGR00079"
                     /label="SCO5221"
                     /locus_tag="SCO5221"
                     /protein_end="203"
                     /protein_start="46"
                     /score="131.8"
                     /tool="antismash"
                     /translation="VGNPVLHKECEDVTDFGEEFQQLVADMFASQRTAEGVGLAANQIG
                     VSKKVFVYDCPDDEGVRHVGVVCNPRLVELPADRRRLDDSNEGCLSVPTAYAPLARPDY
                     AEVTGQDEKGNPVKVRGTGYFARCLQHETDHLYGYLYIDRLSKRERKDALRQM"
     regulatory      9988..9991
                     /regulatory_class="ribosome_binding_site"
     gene            10001..11086
                     /db_xref="GeneID:1100663"
                     /gene_synonym="SC7E4.19"
                     /locus_tag="SCO5222"
     CDS             10001..11086
                     /codon_start=1
                     /db_xref="GeneID:1100663"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /gene_synonym="SC7E4.19"
                     /locus_tag="SCO5222"
                     /note="SC7E4.19, possible lyase, len: 361 aa; similar to
                     SW:PTLS_STRSQ (EMBL:U05213) Streptomyces sp. pentalenene
                     synthase (EC 4.6.1.5), 336 aa; fasta scores: opt: 254
                     z-score: 317.5 E(): 3.3e-10; 23.8% identity in 311 aa
                     overlap. Contains match to Prosite entry PS00904 Protein
                     prenyltransferases alpha subunit repeat signature and a TTA
                     leucine codon, possible target for bldA regulation"
                     /product="lyase"
                     /protein_id="NP_629369.1"
                     /sec_met_domain="T1TS (E-value: 1.8e-63, bitscore: 214.3,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHAFPHGTTATPTAIAVPPSLRLPVIEAAFPRQLHPYWPKLQETT
                     RTWLLEKRLMPADKVEEYADGLCYTDLMAGYYLGAPDEVLQAIADYSAWFFVWDDRHDR
                     DIVHGRAGAWRRLRGLLHTALDSPGDHLHHEDTLVAGFADSVRRLYAFLPATWNARFAR
                     HFHTVIEAYDREFHNRTRGIVPGVEEYLELRRLTFAHWIWTDLLEPSSGCELPDAVRKH
                     PAYRRAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLITHHSLTLEEAIGEVRRRVE
                     ECITEFLAVERDALRFADELADGTVRGKELSGAVRANVGNMRNWFSSVYWFHHESGRYM
                     VDSWDDRSTPPYVNNEAAGEK"
     misc_feature    10262..10291
                     /gene_synonym="SC7E4.19"
                     /locus_tag="SCO5222"
                     /note="PS00904 Protein prenyltransferases alpha subunit
                     repeat signature"
     PFAM_domain     10268..10855
                     /aSDomain="Terpene_syn_C_2"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF19086.3"
                     /description="Terpene synthase family 2, C-terminal metal
                     binding"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5222_0497"
                     /evalue="3.80E-36"
                     /label="SCO5222"
                     /locus_tag="SCO5222"
                     /protein_end="285"
                     /protein_start="89"
                     /score="124.9"
                     /tool="antismash"
                     /translation="DYSAWFFVWDDRHDRDIVHGRAGAWRRLRGLLHTALDSPGDHLHH
                     EDTLVAGFADSVRRLYAFLPATWNARFARHFHTVIEAYDREFHNRTRGIVPGVEEYLEL
                     RRLTFAHWIWTDLLEPSSGCELPDAVRKHPAYRRAALLSQEFAAWYNDLCSLPKEIAGD
                     EVHNLGISLITHHSLTLEEAIGEVRRRVEECIT"
     misc_feature    10883..10885
                     /gene_synonym="SC7E4.19"
                     /locus_tag="SCO5222"
                     /note="TTA leucine codon. Possible target for bldA
                     regulation"
     misc_feature    10883..10885
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11083..12468
                     /db_xref="GeneID:1100664"
                     /gene_synonym="SC7E4.20"
                     /locus_tag="SCO5223"
     CDS             11083..12468
                     /codon_start=1
                     /db_xref="GeneID:1100664"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SC7E4.20"
                     /locus_tag="SCO5223"
                     /note="SC7E4.20, probable cytochrome P450, len: 461 aa;
                     similar to SW:CP51_HUMAN (EMBL:U23942) Homo sapiens
                     cytochrome P450 51 (EC 1.14.14.1) Cyp51, 503 aa; fasta
                     scores: opt: 532 z-score: 587.2 E(): 3.1e-25; 25.7%
                     identity in 447 aa overlap. Contains Pfam match to entry
                     PF00067 p450, Cytochrome P450"
                     /product="cytochrome P450"
                     /protein_id="NP_629370.1"
                     /sec_met_domain="p450 (E-value: 2.6e-70, bitscore: 236.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVESVNPETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPL
                     AFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGV
                     ATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAV
                     RVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALAD
                     LHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAS
                     TIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWV
                     LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYA
                     MKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRP
                     VAR"
     misc_feature    11152..12363
                     /gene_synonym="SC7E4.20"
                     /locus_tag="SCO5223"
                     /note="Pfam match to entry PF00067 p450, Cytochrome P450,
                     score 221.80, E-value 1e-62"
     PFAM_domain     11170..12390
                     /ASF="active site cysteine inconclusive"
                     /aSDomain="p450"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00067.25"
                     /db_xref="GO:0004497"
                     /db_xref="GO:0005506"
                     /db_xref="GO:0016705"
                     /db_xref="GO:0020037"
                     /description="Cytochrome P450"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5223_0498"
                     /evalue="6.60E-70"
                     /gene_ontologies="GO:0004497: monooxygenase activity"
                     /gene_ontologies="GO:0005506: iron ion binding"
                     /gene_ontologies="GO:0016705: oxidoreductase activity,
                     acting on paired donors, with incorporation or reduction of
                     molecular oxygen"
                     /gene_ontologies="GO:0020037: heme binding"
                     /label="SCO5223"
                     /locus_tag="SCO5223"
                     /protein_end="436"
                     /protein_start="29"
                     /score="236.2"
                     /tool="antismash"
                     /translation="GVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPE
                     LTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGP
                     IMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFR
                     GMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEA
                     KDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGG
                     RPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAI
                     QRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALA
                     TKYRFEQV"
     gene            complement(12482..13450)
                     /db_xref="GeneID:1100665"
                     /gene_synonym="SC7E4.21c"
                     /locus_tag="SCO5224"
     CDS             complement(12482..13450)
                     /codon_start=1
                     /db_xref="GeneID:1100665"
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /gene_synonym="SC7E4.21c"
                     /locus_tag="SCO5224"
                     /note="SC7E4.21c, probable araC-family transcriptional
                     regulator, len: 322 aa; similar to TR:Q9S166
                     (EMBL:AB023785) Streptomyces griseus transcriptional
                     activator for strR, AdpA, 405 aa; fasta scores: opt: 1005
                     z-score: 1177.5 E(): 0; 49.2% identity in 325 aa overlapand
                     to TR:CAB87229 (EMBL:AL163641) Streptomyces coelicolor
                     araC-family transcriptional regulator AdpA, 398 aa; fasta
                     scores: opt: 990 z-score: 1160.1 E(): 0; 48.9% identity in
                     313 aa overlap. Contains Pfam match to entry PF00165
                     HTH_AraC, Bacterial regulatory helix-turn-helix proteins,
                     araC family and match to Prosite entry PS00041 Bacterial
                     regulatory proteins, araC family signature. Contains also a
                     possible helix-turn-helix motif at residues 230..251 (+3.72
                     SD)"
                     /product="AraC family transcription regulator"
                     /protein_id="NP_629371.1"
                     /transl_table=11
                     /translation="MLRNVAAVLLDGAHPFELGVVCEVFGIDRSDEGLPVYDFAVVSAE
                     GPTLGTHVGGLTVSTPYGLERLEEADLIAVPAGSDFVRREYPPDLLDALRRATDRGTRV
                     LSVCSGVFVLGAAGLLDGRQCAVHWHHAAELARQHPRARVAPDVLYVDEDPVVTSAGTA
                     AGIDACLHIVRKEQGPEVANRIARRMVVPPHRDGGQAQYIERPLPRSSCDTVGEVLAWM
                     EQHLDEEVTVEQLAVRAHMSPRTFARRFQQETGTTPYRWILRQRVLLAQRLLEATDETM
                     DTIAWRAGFGTAAALRHQFTRALDTTPHAYRRTFRGPEAAA"
     misc_feature    complement(12506..12766)
                     /gene_synonym="SC7E4.21c"
                     /locus_tag="SCO5224"
                     /note="Pfam match to entry PF00165 HTH_AraC, Bacterial
                     regulatory helix-turn-helix proteins, araC family, score
                     79.70, E-value 6e-20"
     PFAM_domain     complement(12512..12748)
                     /aSDomain="HTH_18"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF12833.10"
                     /db_xref="GO:0003700"
                     /db_xref="GO:0006355"
                     /db_xref="GO:0043565"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5224_0500"
                     /evalue="5.70E-21"
                     /gene_ontologies="GO:0003700: DNA-binding transcription
                     factor activity"
                     /gene_ontologies="GO:0006355: regulation of DNA-templated
                     transcription"
                     /gene_ontologies="GO:0043565: sequence-specific DNA
                     binding"
                     /label="SCO5224"
                     /locus_tag="SCO5224"
                     /protein_end="313"
                     /protein_start="234"
                     /score="74.7"
                     /tool="antismash"
                     /translation="LAVRAHMSPRTFARRFQQETGTTPYRWILRQRVLLAQRLLEATDE
                     TMDTIAWRAGFGTAAALRHQFTRALDTTPHAYRR"
     misc_feature    complement(12527..12655)
                     /gene_synonym="SC7E4.21c"
                     /locus_tag="SCO5224"
                     /note="PS00041 Bacterial regulatory proteins, araC family
                     signature"
     PFAM_domain     complement(12929..13429)
                     /aSDomain="DJ-1_PfpI"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF01965.27"
                     /description="DJ-1/PfpI family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5224_0499"
                     /evalue="3.10E-13"
                     /label="SCO5224"
                     /locus_tag="SCO5224"
                     /protein_end="174"
                     /protein_start="7"
                     /score="50.0"
                     /tool="antismash"
                     /translation="VLLDGAHPFELGVVCEVFGIDRSDEGLPVYDFAVVSAEGPTLGTH
                     VGGLTVSTPYGLERLEEADLIAVPAGSDFVRREYPPDLLDALRRATDRGTRVLSVCSGV
                     FVLGAAGLLDGRQCAVHWHHAAELARQHPRARVAPDVLYVDEDPVVTSAGTAAGIDACL
                     HIVR"
     misc_feature    complement(13492..17478)
                     /note="previously sequenced DNA fragment. EMBL:AJ276618
                     Streptomyces coelicolor A3(2) nrdX gene, nrdL gene and nrdM
                     gene"
     gene            complement(13722..14753)
                     /db_xref="GeneID:1100666"
                     /gene_synonym="nrdM; SC7E4.22c"
                     /locus_tag="SCO5225"
     CDS             complement(13722..14753)
                     /codon_start=1
                     /db_xref="GeneID:1100666"
                     /gene_synonym="nrdM; SC7E4.22c"
                     /locus_tag="SCO5225"
                     /note="SC7E4.22c, nrdM, ribonucleotide-diphosphate
                     reductase small chain, len: 343 aa; identical to previously
                     sequenced TR:CAB82486 (EMBL:AJ276618) Streptomyces
                     coelicolor A3(2) ribonucleotide-diphosphate reductase small
                     chain (EC 1.17.4.1) NrdM, 343 aa. Contains Pfam match to
                     entry PF00268 ribonuc_red, Ribonucleotide reductases and a
                     possible hydrophobic membrane spanning region"
                     /product="ribonucleotide-diphosphate reductase small chain"
                     /protein_id="NP_629372.1"
                     /transl_table=11
                     /translation="MTTETPAHPTTKNLLDPGFELTLRPMRYPDFYERYRDAIKNTWHV
                     EEVDLHSDVADLAKLSPMEQHLIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLS
                     RQLFEEAVHVQFYLTLLDTYLPDPEDRAAAFAAVENIPSIREKAEFCFRWMDSVESIDR
                     LETKADRRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMH
                     MSFAFDVVDTVRKEEPELFDDQLREQVTDMLREAVEAELQFARDLCGDGLPGMNTDSMR
                     QYLECVADQRLTRLGFAPVYGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDLS
                     EDF"
     misc_feature    complement(13767..14627)
                     /gene_synonym="nrdM; SC7E4.22c"
                     /locus_tag="SCO5225"
                     /note="Pfam match to entry PF00268 ribonuc_red,
                     Ribonucleotide reductases, score 222.30, E-value 1e-75"
     PFAM_domain     complement(13836..14690)
                     /aSDomain="Ribonuc_red_sm"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00268.24"
                     /db_xref="GO:0009263"
                     /description="Ribonucleotide reductase, small chain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5225_0501"
                     /evalue="1.10E-81"
                     /gene_ontologies="GO:0009263: deoxyribonucleotide
                     biosynthetic process"
                     /label="SCO5225"
                     /locus_tag="SCO5225"
                     /protein_end="306"
                     /protein_start="21"
                     /score="274.5"
                     /tool="antismash"
                     /translation="TLRPMRYPDFYERYRDAIKNTWHVEEVDLHSDVADLAKLSPMEQH
                     LIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEEAVHVQFYLTLLDTYL
                     PDPEDRAAAFAAVENIPSIREKAEFCFRWMDSVESIDRLETKADRRRFLLNLICFAACI
                     EGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMSFAFDVVDTVRKEEPELFDD
                     QLREQVTDMLREAVEAELQFARDLCGDGLPGMNTDSMRQYLECVADQRLTRLGFAPVYG
                     SENP"
     gene            complement(14753..17128)
                     /db_xref="GeneID:1100667"
                     /gene_synonym="nrdL; SC7E4.23c"
                     /locus_tag="SCO5226"
     CDS             complement(14753..17128)
                     /codon_start=1
                     /db_xref="GeneID:1100667"
                     /gene_synonym="nrdL; SC7E4.23c"
                     /locus_tag="SCO5226"
                     /note="SC7E4.23c, nrdL, ribonucleotide-diphosphate
                     reductase large chain, len: 791 aa; identical to previously
                     sequenced TR:CAB82485 (EMBL:AJ276618) Streptomyces
                     coelicolor A3(2) ribonucleotide-diphosphate reductase large
                     chain (EC 1.17.4.1) NrdL, 791 aa. Contains Pfam match to
                     entry PF00317 ribonucleo_red, Ribonucleotide reductase and
                     match to Prosite entry PS00089 Ribonucleotide reductase
                     large subunit signature"
                     /product="ribonucleotide-diphosphate reductase large chain"
                     /protein_id="NP_629373.1"
                     /transl_table=11
                     /translation="MTIAPADPASATPVTATGEPDGPGAALLRTLTGLTADLPGADPGR
                     VAAAALRGRSARADEAELRELATEAAAGLISEDPVYSRLAARLLTIGIRAEAASQGVVT
                     FTDSVATGHREGLIADRTAAFVRLHADRLDALIDQDADDRFGYFGLRTLYSRYLLRHPI
                     TRKAVETPQHFLLRVAAGLAEDDTVRAADEVAALYGLMSRLDYLPSSPTLFNSGTRHAQ
                     MSSCYLLDSPKDELDSLYDRLHQVARLSKHAGGIGIAYSRVRARGSLIRGTNGHSNGIV
                     PFLKTLDASVAAVNQGGRRKGAAAVYLETWHADVEEFLELRDNTGEDARRTHNLNLAHW
                     IPDEFMRRVDADGTWSLFSPADVPELTDLWGEEFDAAYRRAEEAGLARRTLPARELYGR
                     MMRTLAQTGNGWMTFKDTANRTANQTATPGHVVHSSNLCTEILEVTDDGETAVCNLGSV
                     NLGAFVDPAHGDMDWERLDATVRTAVTFLDRVVDINFYPTEQAGRSNARWRPVGLGAMG
                     LQDVFFQLRLPFDSPEAKALSTRIAERIMLAAYETSADLAERNGPLPAWEKTRTARGVL
                     HPDHYGVEPAWPERWAALRARMATTGLRNSLLLAIAPTATIASIAGVYECIEPQVSNLF
                     KRETLSGEFLQVNSYLVDDLKRLGVWDARTREALREANGSVQGFTWIPEDVRALYRTAW
                     EIPQRGLIDMAAARTPYLDQAQSLNLFLETPTIGKLSSMYAYAWKQGLKTTYYLRSRPA
                     TRIARAAARATTVPVQAAPDPEAVACSLENPESCEACQ"
     regulatory      complement(14764..14767)
                     /gene_synonym="nrdL; SC7E4.23c"
                     /locus_tag="SCO5226"
                     /regulatory_class="ribosome_binding_site"
     aSDomain        complement(14876..16690)
                     /aSDomain="TIGR02506"
                     /aSTool="tigrfam"
                     /description="NrdE_NrdA: ribonucleoside-diphosphate
                     reductase, alpha subunit"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO5226_0065"
                     /evalue="1.60E-221"
                     /identifier="TIGR02506"
                     /label="SCO5226"
                     /locus_tag="SCO5226"
                     /protein_end="751"
                     /protein_start="146"
                     /score="735.0"
                     /tool="antismash"
                     /translation="YFGLRTLYSRYLLRHPITRKAVETPQHFLLRVAAGLAEDDTVRAA
                     DEVAALYGLMSRLDYLPSSPTLFNSGTRHAQMSSCYLLDSPKDELDSLYDRLHQVARLS
                     KHAGGIGIAYSRVRARGSLIRGTNGHSNGIVPFLKTLDASVAAVNQGGRRKGAAAVYLE
                     TWHADVEEFLELRDNTGEDARRTHNLNLAHWIPDEFMRRVDADGTWSLFSPADVPELTD
                     LWGEEFDAAYRRAEEAGLARRTLPARELYGRMMRTLAQTGNGWMTFKDTANRTANQTAT
                     PGHVVHSSNLCTEILEVTDDGETAVCNLGSVNLGAFVDPAHGDMDWERLDATVRTAVTF
                     LDRVVDINFYPTEQAGRSNARWRPVGLGAMGLQDVFFQLRLPFDSPEAKALSTRIAERI
                     MLAAYETSADLAERNGPLPAWEKTRTARGVLHPDHYGVEPAWPERWAALRARMATTGLR
                     NSLLLAIAPTATIASIAGVYECIEPQVSNLFKRETLSGEFLQVNSYLVDDLKRLGVWDA
                     RTREALREANGSVQGFTWIPEDVRALYRTAWEIPQRGLIDMAAARTPYLDQAQSLNLFL
                     ETPTIGKLSSMYAYAWKQGLKTTYYLRSR"
     PFAM_domain     complement(14885..16459)
                     /aSDomain="Ribonuc_red_lgC"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF02867.18"
                     /description="Ribonucleotide reductase, barrel domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5226_0503"
                     /evalue="2.90E-176"
                     /label="SCO5226"
                     /locus_tag="SCO5226"
                     /protein_end="748"
                     /protein_start="223"
                     /score="587.2"
                     /tool="antismash"
                     /translation="SSCYLLDSPKDELDSLYDRLHQVARLSKHAGGIGIAYSRVRARGS
                     LIRGTNGHSNGIVPFLKTLDASVAAVNQGGRRKGAAAVYLETWHADVEEFLELRDNTGE
                     DARRTHNLNLAHWIPDEFMRRVDADGTWSLFSPADVPELTDLWGEEFDAAYRRAEEAGL
                     ARRTLPARELYGRMMRTLAQTGNGWMTFKDTANRTANQTATPGHVVHSSNLCTEILEVT
                     DDGETAVCNLGSVNLGAFVDPAHGDMDWERLDATVRTAVTFLDRVVDINFYPTEQAGRS
                     NARWRPVGLGAMGLQDVFFQLRLPFDSPEAKALSTRIAERIMLAAYETSADLAERNGPL
                     PAWEKTRTARGVLHPDHYGVEPAWPERWAALRARMATTGLRNSLLLAIAPTATIASIAG
                     VYECIEPQVSNLFKRETLSGEFLQVNSYLVDDLKRLGVWDARTREALREANGSVQGFTW
                     IPEDVRALYRTAWEIPQRGLIDMAAARTPYLDQAQSLNLFLETPTIGKLSSMYAYAWKQ
                     GLKTTYYL"
     misc_feature    complement(14888..16726)
                     /gene_synonym="nrdL; SC7E4.23c"
                     /locus_tag="SCO5226"
                     /note="Pfam match to entry PF00317 ribonucleo_red,
                     Ribonucleotide reductase, score 723.60, E-value 7.5e-271"
     misc_feature    complement(15290..15358)
                     /gene_synonym="nrdL; SC7E4.23c"
                     /locus_tag="SCO5226"
                     /note="PS00089 Ribonucleotide reductase large subunit
                     signature"
     PFAM_domain     complement(16469..16699)
                     /aSDomain="Ribonuc_red_lgN"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00317.24"
                     /db_xref="GO:0004748"
                     /db_xref="GO:0005524"
                     /db_xref="GO:0006260"
                     /description="Ribonucleotide reductase, all-alpha domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5226_0502"
                     /evalue="1.60E-20"
                     /gene_ontologies="GO:0004748: ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor"
                     /gene_ontologies="GO:0005524: ATP binding"
                     /gene_ontologies="GO:0006260: DNA replication"
                     /label="SCO5226"
                     /locus_tag="SCO5226"
                     /protein_end="220"
                     /protein_start="143"
                     /score="73.0"
                     /tool="antismash"
                     /translation="RFGYFGLRTLYSRYLLRHPITRKAVETPQHFLLRVAAGLAEDDTV
                     RAADEVAALYGLMSRLDYLPSSPTLFNSGTRH"
     gene            complement(17125..17400)
                     /db_xref="GeneID:1100668"
                     /gene_synonym="nrdX; SC7E4.24c"
                     /locus_tag="SCO5227"
     CDS             complement(17125..17400)
                     /codon_start=1
                     /db_xref="GeneID:1100668"
                     /gene_synonym="nrdX; SC7E4.24c"
                     /locus_tag="SCO5227"
                     /note="SC7E4.24c, nrdX, redoxin, len: 91 aa; identical to
                     previously sequenced TR:CAB82484 (EMBL:AJ276618)
                     Streptomyces coelicolor A3(2) redoxin NrdX, 91 aa. Doubtful
                     CDS: Frameplot and Correlation Scores indicate that this
                     CDS might not be a gene"
                     /product="redoxin"
                     /protein_id="NP_629374.1"
                     /transl_table=11
                     /translation="MLMLAVAAGESGANPELSRNGVLACIRTSSHVRARLSSPRTCRQC
                     ARPPWPGCHDVRASRSGPVDATPRALVSCPLPSLRRAPCRARECST"
     regulatory      complement(17137..17140)
                     /gene_synonym="nrdX; SC7E4.24c"
                     /locus_tag="SCO5227"
                     /regulatory_class="ribosome_binding_site"
     misc_feature    complement(17390..17403)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.46"
                     /tool="antismash"
     misc_feature    complement(17397..17411)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 24.21"
                     /tool="antismash"
     misc_feature    complement(17428..17442)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 25.12"
                     /tool="antismash"
     gene            complement(17479..17985)
                     /db_xref="GeneID:1100669"
                     /gene_synonym="SC7E4.25c"
                     /locus_tag="SCO5228"
     CDS             complement(17479..17985)
                     /codon_start=1
                     /db_xref="GeneID:1100669"
                     /gene_synonym="SC7E4.25c"
                     /locus_tag="SCO5228"
                     /note="SC7E4.25c, possible acetyltransferase, len: 168 aa;
                     similar to TR:Q9S2P7 (EMBL:AL096872) Streptomyces
                     coelicolor acetyltransferase SC5F7.12c, 169 aa; fasta
                     scores: opt: 151 z-score: 187.3 E(): 0.0058; 36.2% identity
                     in 141 aa overlap. Contains Pfam match to entry PF00583
                     Acetyltransf, Acetyltransferase (GNAT) family"
                     /product="acetyltransferase"
                     /protein_id="NP_629375.1"
                     /transl_table=11
                     /translation="MDFVIRRATAEEYDTLGEITAQAYLRDGLLDFGESDSYLDELRDV
                     AKRAAAAEVLVAVADDAVLGGATFVPSGGPMADIARPGEAEIRMLAVAREARGRGAGEA
                     LVRACADRARAVPGCTGVVLSTQAAMRTAHRLYERLGFVRTPDRDWNPLPELDDIMLLT
                     YELTL"
     misc_feature    complement(17557..17973)
                     /gene_synonym="SC7E4.25c"
                     /locus_tag="SCO5228"
                     /note="Pfam match to entry PF00583 Acetyltransf,
                     Acetyltransferase (GNAT) family, score 67.20, E-value
                     3.4e-16"
     PFAM_domain     complement(17560..17868)
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00583.28"
                     /db_xref="GO:0016747"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5228_0504"
                     /evalue="3.80E-15"
                     /gene_ontologies="GO:0016747: acyltransferase activity,
                     transferring groups other than amino-acyl groups"
                     /label="SCO5228"
                     /locus_tag="SCO5228"
                     /protein_end="142"
                     /protein_start="39"
                     /score="56.3"
                     /tool="antismash"
                     /translation="DELRDVAKRAAAAEVLVAVADDAVLGGATFVPSGGPMADIARPGE
                     AEIRMLAVAREARGRGAGEALVRACADRARAVPGCTGVVLSTQAAMRTAHRLYERLGF"
     gene            complement(18058..19656)
                     /db_xref="GeneID:1100670"
                     /gene_synonym="SC7E4.26c"
                     /locus_tag="SCO5229"
     CDS             complement(18058..19656)
                     /codon_start=1
                     /db_xref="GeneID:1100670"
                     /gene_synonym="SC7E4.26c"
                     /locus_tag="SCO5229"
                     /note="SC7E4.26c, probable permease, len: 4532 aa; similar
                     to TR:Q47552 (EMBL:L01152) Escherichia coli proline
                     permease (fragment) PutP, 489 aa; fasta scores: opt: 333
                     z-score: 378.7 E(): 1.3e-13; 23.8% identity in 495 aa
                     overlap. Contains Pfam match to entry PF00474 SSF,
                     Sodium:solute symporter family. Contains also possible
                     hydrophobic membrane spanning regions"
                     /product="permease"
                     /protein_id="NP_629376.1"
                     /transl_table=11
                     /translation="MNGVALAVFIFFFVLVTAMGFLAARWRRAENEHSLDEWGLGGRSF
                     GTWVTWFLLGGDLYTAYTFVAVPAAIYAAGASGFFAVPYTILVYPLIFTFLPRLWSVSH
                     KHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQLVGIQAVLDVMGVGGGEDTN
                     WFVKDLPLLIAFGVLAAYTYSSGLRAPALIAFVKDTLIYIVIAVAIIYIPIKLGGFDDI
                     FASASDKFTAAGKGGVVPDAGGQWTYATLALGSALALFMYPHSITATLSSRSREVIRRN
                     TTILPLYSLMLGLLALLGFMAIAAGVKVDNGQLAIPQLFENMFPDWFAGVAFAAIGIGA
                     LVPAAIMSIAAANLFTRNIYKDFIKPDATPQQETKVSKLVSLLVKVGALIFVLGMDKTV
                     AINFQLLGGIWILQTFPALVGGLFTRWFHRWALLGGWAVGMVYGTVAAYGVASPTQKHF
                     GGSSDEIPGIGEIGYIGLTAFVLNVLVTVVLTFVLRAVKAPDGVDETRPSDYTADAGDP
                     GVQVELPPATAGSSH"
     misc_feature    complement(18340..19539)
                     /gene_synonym="SC7E4.26c"
                     /locus_tag="SCO5229"
                     /note="Pfam match to entry PF00474 SSF, Sodium:solute
                     symporter family, score -80.90, E-value 5.6e-05"
     PFAM_domain     complement(18451..19539)
                     /aSDomain="SSF"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00474.20"
                     /db_xref="GO:0016020"
                     /db_xref="GO:0022857"
                     /db_xref="GO:0055085"
                     /description="Sodium:solute symporter family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5229_0505"
                     /evalue="7.10E-19"
                     /gene_ontologies="GO:0016020: membrane"
                     /gene_ontologies="GO:0022857: transmembrane transporter
                     activity"
                     /gene_ontologies="GO:0055085: transmembrane transport"
                     /label="SCO5229"
                     /locus_tag="SCO5229"
                     /protein_end="402"
                     /protein_start="39"
                     /score="68.1"
                     /tool="antismash"
                     /translation="LGGRSFGTWVTWFLLGGDLYTAYTFVAVPAAIYAAGASGFFAVPY
                     TILVYPLIFTFLPRLWSVSHKHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQ
                     LVGIQAVLDVMGVGGGEDTNWFVKDLPLLIAFGVLAAYTYSSGLRAPALIAFVKDTLIY
                     IVIAVAIIYIPIKLGGFDDIFASASDKFTAAGKGGVVPDAGGQWTYATLALGSALALFM
                     YPHSITATLSSRSREVIRRNTTILPLYSLMLGLLALLGFMAIAAGVKVDNGQLAIPQLF
                     ENMFPDWFAGVAFAAIGIGALVPAAIMSIAAANLFTRNIYKDFIKPDATPQQETKVSKL
                     VSLLVKVGALIFVLGMDKTVAIN"
     gene            complement(19665..19949)
                     /db_xref="GeneID:1100671"
                     /gene_synonym="SC7E4.27c"
                     /locus_tag="SCO5230"
     CDS             complement(19665..19949)
                     /codon_start=1
                     /db_xref="GeneID:1100671"
                     /gene_synonym="SC7E4.27c"
                     /locus_tag="SCO5230"
                     /note="SC7E4.27c, possible integral membrane protein, len:
                     94 aa. Contains possible hydrophobic membrane spanning
                     regions"
                     /product="hypothetical protein"
                     /protein_id="NP_629377.1"
                     /transl_table=11
                     /translation="MISEGTEPRMPEDTEVSREPVVTPVRVVIGFCLVAPFVAMLWVGS
                     YAKTDPAFIGIPFFYWYQMAWVLISTLLTVTAYKLWQRDQRGRREGGTK"
     PFAM_domain     complement(19683..19856)
                     /aSDomain="DUF3311"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF11755.11"
                     /description="Protein of unknown function (DUF3311)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5230_0506"
                     /evalue="5.70E-26"
                     /label="SCO5230"
                     /locus_tag="SCO5230"
                     /protein_end="89"
                     /protein_start="31"
                     /score="90.4"
                     /tool="antismash"
                     /translation="CLVAPFVAMLWVGSYAKTDPAFIGIPFFYWYQMAWVLISTLLTVT
                     AYKLWQRDQRGRR"
     misc_feature    19975..19987
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.33"
                     /tool="antismash"
     misc_feature    complement(19993..20007)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.75"
                     /tool="antismash"
     misc_feature    complement(20051..20066)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.33"
                     /tool="antismash"
     gene            complement(20057..20821)
                     /db_xref="GeneID:1100672"
                     /gene_synonym="SC7E4.28c"
                     /locus_tag="SCO5231"
     CDS             complement(20057..20821)
                     /codon_start=1
                     /db_xref="GeneID:1100672"
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /gene_synonym="SC7E4.28c"
                     /locus_tag="SCO5231"
                     /note="SC7E4.28c, probable gntR-family transcriptional
                     regulator, len: 254 aa; similar to SW:HUTC_PSEPU
                     (EMBL:M33922) Pseudomonas putida histidine utilization
                     repressor HutC, 248 aa; fasta scores: opt: 355 z-score:
                     415.1 E(): 1.2e-15; 31.6% identity in 234 aa overlap.
                     Contains Pfam match to entry PF00392 gntR, Bacterial
                     regulatory proteins, gntR family and match to Prosite entry
                     PS00043 Bacterial regulatory proteins, gntR family
                     signature. Contains also a possible helix-turn-helix motif
                     at residues 45..66 (+3.08 SD)"
                     /product="GntR family transcriptional regulator"
                     /protein_id="NP_629378.1"
                     /transl_table=11
                     /translation="MSTDVSSAENEGGATVRTARVPKYYRLKKHLLDMTRTQTPGTPVP
                     PERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRA
                     QGLEPTSQLLDIGYITADDRLAGLLDITAGGRVLRIERLRMANGEPMAIETTHLSAKRF
                     PALRRSLVKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRH
                     SQDRTGQPVEWVRSVYRGDRYKFVARLKRPQD"
     PFAM_domain     complement(20090..20512)
                     /aSDomain="UTRA"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF07702.16"
                     /db_xref="GO:0003677"
                     /db_xref="GO:0006355"
                     /description="UTRA domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5231_0508"
                     /evalue="4.10E-42"
                     /gene_ontologies="GO:0003677: DNA binding"
                     /gene_ontologies="GO:0006355: regulation of DNA-templated
                     transcription"
                     /label="SCO5231"
                     /locus_tag="SCO5231"
                     /protein_end="244"
                     /protein_start="103"
                     /score="143.5"
                     /tool="antismash"
                     /translation="AQGLEPTSQLLDIGYITADDRLAGLLDITAGGRVLRIERLRMANG
                     EPMAIETTHLSAKRFPALRRSLVKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGL
                     LGTDVGLPMLMLSRHSQDRTGQPVEWVRSVYRGDRYK"
     misc_feature    complement(20570..20707)
                     /gene_synonym="SC7E4.28c"
                     /locus_tag="SCO5231"
                     /note="Pfam match to entry PF00392 gntR, Bacterial
                     regulatory proteins, gntR family, score 65.80, E-value
                     8.7e-19"
     PFAM_domain     complement(20570..20716)
                     /aSDomain="GntR"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00392.24"
                     /db_xref="GO:0003700"
                     /db_xref="GO:0006355"
                     /description="Bacterial regulatory proteins, gntR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO5231_0507"
                     /evalue="1.90E-16"
                     /gene_ontologies="GO:0003700: DNA-binding transcription
                     factor activity"
                     /gene_ontologies="GO:0006355: regulation of DNA-templated
                     transcription"
                     /label="SCO5231"
                     /locus_tag="SCO5231"
                     /protein_end="84"
                     /protein_start="35"
                     /score="59.6"
                     /tool="antismash"
                     /translation="RTQTPGTPVPPERTLAAEFDTSRTTVRQALQELVVEGRLERIQGK
                     GTFV"
     misc_feature    complement(20618..20692)
                     /gene_synonym="SC7E4.28c"
                     /locus_tag="SCO5231"
                     /note="PS00043 Bacterial regulatory proteins, gntR family
                     signature"
     misc_feature    20955..20970
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.22"
                     /tool="antismash"
ORIGIN
        1 tgaggtcgcc gaccagggcc acccggtcac ccacgatcgc cgccttgcgg cccagctcgc
       61 gcgccttcat cgccatgacg acccggtcgt cgacgaggca ggtcagccgg ccgcggtcca
      121 cggtgaggac caggccctcg gcggcgtcct cgtgcttggg ccggatgtgg gtgcgcggtc
      181 ggttgccctt gcggttgggg cgggagcgga tgtcgtcctc gtcggtgtgc ttgccgtagc
      241 ggcgcatggc gatccgtccc tacgccccga gcatcccggt ccacaggtcg gggaagtcgg
      301 gcagggtctt ggcggtcgtc gccacgttct cgatctgcac gccctccacc gcgagaccga
      361 gaacggcgcc ggcggtggcc atgcggtggt cgtcgtaggt gtggaagacg ccgccgtgca
      421 gacggcgcgg gcggatgtgc agaccgtcgg cggtctcggt gacgtcaccg ccgagttcgt
      481 tgatctcctt ggtgagcgcg gccagccggt ccgtctcgtg cagccgcaga tgggccacgc
      541 cgcgcagggt cgagggggag tccgcgaggg cggcgacggc cgcgatcccc ggggtcagct
      601 cgccgacctc gctcaggtcg acgtcgatgc cgtggatcgc acccgatccg gtgaacacga
      661 gtccgaagtc cgtcagttcg caggaaccgc ccatgtcggt gaagatctcg cgcagccggt
      721 cgccgggctg ggtggtgcgg gacggccagt cggggatcac caccttgccg ccggtcacca
      781 gcgccgccgc caggaacggc tgcgcgttcg acaggtccgg ctcgacggtc aggtcccggc
      841 cgagcagcgc acccggcgtg acccgccaca cgttcggctc gccgccggac tcgggggtgt
      901 cgacctgggc gccgaccgcg cgcagcatgt cgaccgtcat gcggatgtgc ggcatggagg
      961 gcagcgcgga accggtgtgg cgcacctcga cgccctggtt gaagcgcggc ccggacagca
     1021 gcagggcgct gacgaactgg gaggaggagg acgcgtcgat ctcgaccggg ccgccctcca
     1081 gggccccgcc gccgtgcacg gtcagcggca gcgcgccgcg cccgtcgtcg tcgatgcggg
     1141 cgcccaggac gcgcagcgcg tcgatcacgc cgtgcagcgg acgctcgtac gaccgcgggt
     1201 cgccgtcgaa acggacggcg ccgtcggcca gcgtggcgac cggcggcagg aagcgcatga
     1261 ccgtgccggc gttgccgacg tcgaccgtgg ccgggccgcg cagccccgcc gggatgaccc
     1321 gccagaactc gccggtgccc tcggggccga cgccctcctc gatctcgacg cccagcgtgc
     1381 gcagcgcctc ggccatcagc agggtgtcgc gggagcgcag cgggcggcgc agccagccgg
     1441 gctcggaggc gagggcggcc agcaccaggg cgcggttggt gaccgacttg gacccgggca
     1501 cgtggacggt cgcgtcgacg gctccgctcg cgtgcggggc gggccagagg gcggtgtgcg
     1561 tggggttcac ggtcatgggg cccactttaa tggctgagga cgatcggaga tcttgatcaa
     1621 aagcgccgaa acctgaccga aagcgcaaca gtgcacttgc cgtgcatata tgcggagcgg
     1681 gtggagggcg cccggcgtct cacagctcca gtagccagcg cgccccgccg atcagcgagc
     1741 acagcgacac cgcgtggaag aggaagaacc acactcccgc cggcgcgtgg gtcagccgcg
     1801 ccaactggtc ggcgtccgag tcgccggcgc cgccccgcga ccgcttggcc tgcagctcga
     1861 aggccgggcg cactccgccg aggagaagga accagaccac cgcgtacgcg aacgccgcct
     1921 gcacctgcgg cccggccagc cacgacacca ggacgaacgt gccgccggtg accacgaccg
     1981 tcagcacccc gtacgcgttg cggaccatca ccagcagggc caccagcagc gccgtcgcca
     2041 gccacagcag cagcgtgatg cgcccggccg ccagcagtgc ggcgccgccg aggccgagca
     2101 gcggcggagc ggtgtaaccg gcgaccgcgg tgaggatcat gccgacgccg tgcggcttgc
     2161 cccggctcac cgtcagaccg ctggtgtccg agtgcagggt gatcccggtg agggtacggc
     2221 cggtcagcag ggccaccagg ccgtgaccgc cctcgtgcgc gatggtgatc gcgttgcgcg
     2281 ctatccgcca cgatccgcgc gtcgcgacga cggcgagcgc cgccaccagg gtcgcgacca
     2341 ccacccacag gtcgggatcg ggctggatgc cggagacctc gtcccacagg gaggtgagcg
     2401 aggccgttgc gaggtggtcc atgttcgggg agggctcctc gtactagcgc ggggtctggc
     2461 agtgtggcac gtatgtgcgg acggtatgcg gcgagtcgtc gacccgagga tctcgcggga
     2521 atcttcgaga tcgagaagtg ggagcccaag gagagcttgg aacccgacta caacgtggcc
     2581 cccaccaagg aggtctacgc cgtcctggac cgtcccctga aagacgtcga ggacccggag
     2641 ccggttcgcc agctgcggaa gctgaagtgg ggcctcgtcc cctcctggtc caagacgccc
     2701 gagggcggcg cccggatgat caacgcccgc gcggagaccg tccacgagaa gccctcctac
     2761 cgccgcgcct tcagcacccg gcgctgcatc ctgcccgccg acggctacta cgagtgggtc
     2821 accggcaagc aggagcgaga cctggaggtc gaagggcgca agaagcggcc gcgcaagcag
     2881 ccgtacttcg tgacccccgc cgacggctcc gtgttcgcca tggccgggct ctacgagttc
     2941 tggcgggaca ggacgctgcc cgacgaccat ccgcaggcat ggtgggtgac gtgctcggtg
     3001 atcacgaccg aggccgagac cacaccactc gccgtcgccc cggccgacgg tccgcacgcc
     3061 ctggccgaca tccacccccg gatgccgctg atgctgacgc cggaccgctg ggacgactgg
     3121 ctcgatccgg cgcgcaccga ccccgacgag ctgacctccc tgctggcacc cccgcccacc
     3181 ggcctgatgc gggccttccc cgtctcgacg gccgtgagca acgtccgcaa caacggaccg
     3241 gagctgctcg aggagctgga agcaccggaa gagggcacac tcttctgacg tgacggatgc
     3301 gacagaggtt gtgacagagg cggtcgagac ggatgcgggc cccgcccgca tcacctggca
     3361 ccgggcgaag cagccccggc tggtgctcgc cgtgagccac ggggccggcg gcggcatcga
     3421 ggcgcgcgac ctgaaggcgc tggcggccgc actgcccgcc cacggggtga gcgtggccct
     3481 cgtcgagcag ccctggcggg tggcgggcag gaagctggcg cccgcgccga agaccctcga
     3541 caccgggtgg cggggcgtct ggcccgcgct cgccgccccc ggcctgccgg tgatctcggg
     3601 cggccgcagc gccggcgccc gtgtcgcctg ccgcaccgcc ggcgaactgg gcgcccgcgc
     3661 cgtcctcgcc ctcagcttcc ccctgcaccc gccgggcagg ccggagaagt cccgcgccga
     3721 cgagctgctc ggggccggcg tgcccaccct cgtggtccag ggcggcaacg accccttcgg
     3781 caggccgcac gagttccccg aggcgcccgg agggacctac gacctgatcg aggtgccgta
     3841 cggcgaccac ggcttcgccg tgcccaaacg ggcggagatc agccaggaaa gggcgctgga
     3901 gctgatcacc gacggcgtgg cccagtgggc cggctcactc ggctgaacgc ctgggaatga
     3961 ccggcggacg gccactgttg tgccgttcgt acgttgctga gaatcagcac cgacgccgta
     4021 ggagaggaag tccgccgcat gggttcagcc ttctgcccga gtcgcagcag ccgcgccgac
     4081 ctggactgga ccgtgctgca cgctgccaag accgccccta ttcgggcggc gggcggaccg
     4141 gatcgtcgtc tatcctccga ttcgagtgag accggtctcg gtttcacgac gacatcggag
     4201 gaggtgggtc cggtcactgg gaccgacgca gggaccgaac acggccaggc ggagcagccc
     4261 gagggccggg gtacgggcgc ggagtcgacc gcggagcgca gcgcgcgctt cgagcgggac
     4321 gcgctggagt tcctcgacca gatgtactcg gccgcgctgc gcatgacgcg taatccggcc
     4381 gacgccgagg acctggtgca ggagacctac gccaaggcgt acgcgtcctt ccaccagttc
     4441 cgcgagggca ccaacctcaa ggcgtggctg taccgcatcc tcaccaacac cttcatcaac
     4501 tcgtaccgca agaagcagcg cgaaccccag cgcagcgcgg ccgaggagat cgaggactgg
     4561 cagctcgccc gtgccgagtc gcacatgtcg acgggtctgc gctccgcgga gtcgcaggcg
     4621 ctcgaccacc tgcccgactc ggacgtgaag caggcgctcc aggcgatccc cgaggaattc
     4681 cgtatcgccg tgtatctggc ggacgtcgag ggctttgcct acaaggagat cgcggacatc
     4741 atggggacac ccatcggtac ggtgatgtcc cggctgcacc gtggacgccg tcagctgcgc
     4801 ggcatgctgg aggactacgc ccgcgaccgc ggtctggtcc ccgccggcgc cggagagtcg
     4861 aacgaagcga aaggctcggg gtcatgagct gcggagagcc gcacgagacg gattgcagcg
     4921 aaatcctcga tcatctctac gagtttctcg acaaagagat gccggactcg gactgcgtga
     4981 agttcgagca ccacttcgag gagtgctcgc cctgcctgga gaagtacggg ctggagcagg
     5041 ccgtgaagaa gctggtcaag cggtgctgcg ggcaggacga cgtgcccggt gacctgcggg
     5101 ccaaggtgat gggacggctg gacctgatcc ggtccgggca gtccgtgccg gaacacgacg
     5161 tcgcggccgc accgtcgtcg tcggccccgc aggagtcctg agtcgccctg agcgtcgcga
     5221 ctcggccaga agtcactcgt acgtgctaat ccgcgggtta tctgcccgcg gcctccccgc
     5281 cgccgtccta ggctcctgag cctgacaggc gtggccaggg gaggggctga tggacgcggt
     5341 accggcgcgg gcacgtgtgt acgtggccgt cgtcgccctc accgccctgc tctgcctgcg
     5401 accgctgccc gcggtgcgcg cgccctggtg ggcggtgctg ctgctggcgg ggctgtacgc
     5461 ggggtccgag ctggtcgcgc ggtcccgctt cgtcgggacc tgctaccccg tcctgctcgc
     5521 cggcgccttc ctgctgccgc cgcccgccgc cgcgctcgtg gcactgccgg gagccctgct
     5581 ggccccggtg ccgcgccgtc ccctcggcct gcggcgcgtg tggcgggccg cgcagctgac
     5641 tctcgccgtg tgggccgcgg cctgtgtcca ctggcggctc gggggccggg acgcggtcgt
     5701 cgagcccgcc ttcccgtacg ccctcgtgcc ggccggggcg gccgtactcg ccttctgcct
     5761 ggtcctcacc gtgctggacg gcggcatcct caccctcgcc gaccacgtgc cgccgagccg
     5821 ggcgtggcgg ggactgctct cccggtcgct cgcgccgatc gccgtgcacg ggctcgccgg
     5881 gctcatgatg gccgtcctgt ggcgcagccc gtacggtccg gtggccgcgc tgctcgtgct
     5941 gctgccgatg tgcgtggcct ggtgggcctt cgcccagtac caccgtgagc gggccgcgca
     6001 ccaggcgacc atccgcgccc tcgtgcaggc cgtcgacatc aaggacggct acacgcgcgg
     6061 ccacagcgaa cgcgtcggcc aggcctccat gatgatcgcc cgcgagctgg gcatggacga
     6121 cgaacgcgtc gagaccctgc gcttcgccgg gatcctgcac gacgtgggca agctcggcgt
     6181 gcccacccgg ctgctgcgca aggacggccc gctgacgccc gaggagcgcc gggtgatcga
     6241 actgcacccc gagtacgggc acgagatggt gcgcggcatc cgcttcctgg gagaggcccg
     6301 cgccgccgtc ctgcaccacc acgaacggct ggacggcagc ggctatccct acgggctggc
     6361 cggcgaccgg atccccgagt cggcccgggt ggtggccgtc gccgacgcct tcgacgcgat
     6421 gacgtccacg cgctcctaca gcagggcccg gcccgtcgcg acggcgctgg cggagctcca
     6481 gcggtgtgcc ggcggacagt tcgacccgcg gatggtgcgg gcactggtcc gggccctcgg
     6541 ccggcacggc tggcgcccgt ccgtcacggc ggactccccg ctcacccgca ccgccggacc
     6601 ggcaccggac cggggcgagg acgcgcggga cagcgtcggc aggggagcgc catgacgtcc
     6661 ttgcagccgc cggcccggtc ctcgccgccg gcggccgtcc tcctcgtacc cggctgtgcc
     6721 gggctcctcg cgctcggatg tctcgcctcc gtgctggggg cggggcccgc ccagcggccc
     6781 gtcgcgctgg ccttcggagg gctggtcgtc ctcggtgagc tgacccggcg gaccggcgcc
     6841 gaggcccggg aggcggctcc gctcggtgcc gcgggcgcac tggcgtacgc gctgctcgga
     6901 gacgtcgccg ggcagcccgc gcaccacggt gtggccgaga ccgtcaccgt cgtgctcgcc
     6961 gcctcgctgc tcggcagcgt gccctacgtc gcgcgcggca gcgggcccgt cctcgaccac
     7021 ctggcgcggc gcgtgctcac cgtcggtttc gccgccgtgt gcttccggcc gctgtccaac
     7081 cagggcgtct tcgacgactg gagcggcccc gcctacgcgc tgctgctgct cgggctgctc
     7141 gccctgacca cgctgtgcga cgcggtgctc gccgcggcac ccgcgcacgc gcgcaccggc
     7201 tggcccttcg ggcccctgct gcgcgaagag ctgcgcggca tggtcgggat cacgtcggcg
     7261 gtgtgcgcga ccggcgcggt gatggcgctc gcggtgagcg tcgcgggact gtgggcgctc
     7321 cccgtcttct ccgtgcccct gctgctcgcc cagctctcct accggcggta cgcggccgtc
     7381 cgggccactt accggcagac catcgcctcc ctggcccgcg ccaccgagat cgccggatac
     7441 accccggccg ggcacgcgcg ccgcgtcgcc gggctcgggg tggccgtcgg ccgggacctg
     7501 gggctgtcgg gggccgagct gaccgtgctg gagtacgcgg ccctcatgca cgacatcggc
     7561 cagctgagcc tggtcgaccc ggtcccggcg ggtgccacgg ccggcctgcc ggtcaccgaa
     7621 cagcggcgga tcgcgctgct cggcggggcc gtcgtccgcc agaccggcgt cgacgcggcg
     7681 gtcgcggtgg tggtggagcg gcaggccgac ccctgccggg agcagccggt cgccgcgcgg
     7741 atcgtacgcg tcgtgaacgc ctacgacgag aaggcgcggg acgcgggtcc cggcggcgtc
     7801 ctgaccgcgc tggaggagct gcgcctggcc accgcgggcg actacgctcc ggaagtggtg
     7861 gaagcgctgg cccgggtcct ttcccgaggc agccttaccg agcccgcggc tgggtaaccc
     7921 atgggtaatg agcgcctccg cagccgtacg tggtttgatg cccgggagag ggtgtccggg
     7981 ggcgcgaaaa ggcacagcca gcccacagaa cggaactggc aggcgggaat cgtgaggatc
     8041 ttcggcaagg cacggcaccg gccctccgcc tcttggcggc aggccaccga ccgcgcgttc
     8101 acgctgatcg gcgacggtcg ctacgaggac gcgggcgcgc tgctgacgcg ggcggccgac
     8161 ctggagccct ggctgtcgga gtcctggttc aacctggcgc tgctgcacaa gttccggcac
     8221 gactgggaac aggcgagggc ggccggtctg cgggccgtcg cgctgctcga ccgggacatc
     8281 ggcgcccccg actggtggaa cgtcggcatc gccgcgaccg cccttcagga ctggccgctg
     8341 gcccgtcgcg cctggcaggc ctacgggctg cgcacccccg ggggcgccac ggacgcgggt
     8401 gagccgctcg gcatggacct cggcagcgcc gccgtacggc tgtccccgga gggcgaggcc
     8461 gaggtggtgt gggggcggcg gctggacccc gcccgcgtcg aggtgctgtc catcccgctg
     8521 ccgtcctccg gccggcgctg gggcgaggtc gttttgcacg acggcgtacc gcacggggag
     8581 cgcacgacct cggccgggca ctcctacccc gtcttcgacg agatcgagct gtgggcgccc
     8641 tcgccggtgc ccacctgggt ggtcctcctg gaggccgcca ccgagtccga ccgcgacgcc
     8701 ctggagcagc tggccgccga cgccgggttc gccgccgagg actggtcgtc ctccgtccgg
     8761 ctgctgtgcc ggatgtgctc ggagtcccgg atgccgtccg acgagggcga cggcgagcac
     8821 ctcgatccgc acgaccacag cgaacccgga caccccgggc ccctggggca ccgcaccgac
     8881 gggcagctgt gggtgccgga gcgggagtgc ggggtggccg cgccggccgg gctggtgaag
     8941 gggttgctgg acgggtgggt cgcggacagt ccggactccc gggactggcg ggacctggaa
     9001 gaggtctgct gagcagcccc gtagtctttg tcaggacact tcagcagcgt cagcatcacc
     9061 tttggttgta cgaggaaggc atacgtcggt catggcccag caggacaccg atcagcagca
     9121 cccgggcgtg ctccccgtgg acgacgaggg attcgtcgtc gacagccagg actgcgagga
     9181 gcgtgaggcc gactggcgcg ggcgcggcac ctcccgtccg atcacggtgg tcggcaaccc
     9241 ggtgctgcac aaggagtgcg aggacgtcac cgacttcggc gaggagttcc agcagctggt
     9301 ggccgacatg ttcgccagcc agcgcaccgc cgagggagtg ggcctggccg ccaaccagat
     9361 cggcgtctcc aagaaggtct tcgtctacga ctgccccgac gacgagggcg tccgccacgt
     9421 cggcgtggtc tgcaacccgc ggctcgtcga gctgccggcc gaccgccgcc gcctggacga
     9481 cagcaacgag ggctgcctgt ccgtgcccac cgcctacgcg ccgctcgccc gccccgacta
     9541 cgccgaggtg accgggcagg acgagaaggg caacccggtc aaggtgcgcg gcacggggta
     9601 cttcgcccgg tgtttgcagc acgagacgga ccacctgtac gggtacctgt acatcgaccg
     9661 gctctccaag cgcgaacgca aggacgcgct tcggcagatg gccgagaacg agccgcgcta
     9721 ccccgtggtc gcgaacgact gacaccgcct cacccgcccc acatctccct tgcgcacggc
     9781 gcctgttcgg gtcttccccg agcgggcgcc gttcgtctgt gcacgcgcat ggaaagccgc
     9841 cacacaacag gagaattccg gcaccagggg tagtgaatga agcaaatccg ttcccagaac
     9901 ggtcagttgt ggtgctgaat gggaagtgcg gggatacgca acggcgcacg ccccgctcag
     9961 cgagaggggt gcgccaccgg cggctgagag gggtttgttc gtgcatgctt tcccacacgg
    10021 caccacagcg acaccgaccg cgatcgcagt accgccatcg ctccgtctcc cggtgatcga
    10081 ggcggcattt ccccggcaac tgcacccgta ttggccgaag ctccaggaga caacccggac
    10141 ctggctgctc gaaaagcggc tcatgccggc ggacaaggtc gaggaatatg ccgacggtct
    10201 gtgctacacg gacctcatgg cgggctacta cctgggcgcc cccgacgagg tcctgcaggc
    10261 gatagcggac tacagcgcgt ggttcttcgt ctgggacgac cgtcacgacc gtgacatcgt
    10321 ccacggccgg gccggtgcct ggcggcgact gcgcggcctg ctgcacacgg cactggactc
    10381 acccggggac cacctgcacc acgaggacac gctggtggcc gggttcgccg acagtgtgcg
    10441 gcggctctac gccttcctgc cggccacctg gaacgcccgg ttcgcccggc acttccacac
    10501 ggtgatcgag gcgtacgacc gtgaattcca caaccgcacg cgcggaatcg tgcccggcgt
    10561 ggaggagtac ctcgaactgc gccggctcac gttcgcgcac tggatctgga ccgacctgct
    10621 ggagccgagt tcgggctgcg aactccccga cgccgtacgg aaacacccgg catatcgccg
    10681 ggcggcgttg ctgagtcagg aattcgccgc ctggtacaac gacctctgct cactgccaaa
    10741 ggaaatagcg ggagacgagg tccacaatct tggcatcagt ctcatcaccc accattcact
    10801 caccctggaa gaagccatcg gagaagtccg gcgtcgtgtc gaggaatgca tcacggaatt
    10861 cctcgccgtc gagcgggacg ccttacggtt cgccgacgaa ctcgccgacg gaaccgtacg
    10921 cggaaaggaa ctgagcggcg ccgtgcgggc caacgtcggc aatatgcgga actggttcag
    10981 ttccgtctac tggttccacc acgagtccgg ccggtacatg gtcgacagct gggacgaccg
    11041 gtccacgccc ccgtacgtca acaacgaagc ggcaggtgag aaatgaccgt cgagtccgtc
    11101 aaccccgaaa cccgcgcacc cgcggcaccg ggagcaccgg agctgcgcga gccgcccgtc
    11161 gcgggcggtg gcgttccgct gctcggccac ggctggcggc tggcccgcga cccgctggcc
    11221 ttcatgtccc agctgcgcga ccacggcgac gtcgtgcgca tcaagctcgg cccgaagacc
    11281 gtctacgccg tcacgaaccc cgagctgacc ggcgccctcg ccctgaaccc cgactaccac
    11341 atcgccggtc cgctgtggga gtcgctggag ggcctgctcg gcaaggaggg cgtggcgacc
    11401 gccaacggcc cgctccaccg ccgccagcgg cgcaccatcc agccggcgtt ccggctcgac
    11461 gccatccccg cctacgggcc gatcatggag gaggaggcgc acgcgctcac cgagcgctgg
    11521 cagccgggga agaccgtcga cgccacctcg gagtccttcc gggtcgccgt gcgcgtcgcg
    11581 gcccgctgcc tgctgcgcgg gcagtacatg gacgagcggg ccgagcggct ctgcgtcgcg
    11641 ctcgccaccg tcttccgggg catgtaccgg cggatggtgg tcccgctcgg gccgctgtac
    11701 cggctgccgc ttccggccaa ccgccgattc aacgacgcgt tggccgatct gcacctgctg
    11761 gtcgacgaga tcatcgccga gcgccgtgca tccggtcaaa agccggacga tttgctcacg
    11821 gcattgctgg aggcgaagga cgacaatggc gacccgatcg gggaacagga gatccacgac
    11881 caggtggtcg cgatactcac cccgggcagt gaaaccatcg cgtccacgat catgtggttg
    11941 ctccaggcac ttgccgacca tccggaacat gccgaccgca tacgcgacga agtcgaagcg
    12001 gtcaccggcg gacgtcccgt ggcattcgag gacgtccgga agctcaggca caccggcaat
    12061 gtcatcgtgg aggccatgcg tttgcgtccc gccgtatggg tattgacccg gcgcgcggtg
    12121 gccgagagcg aactcggtgg ctatcgcatt ccggccggtg cggacatcat ctacagtccg
    12181 tacgcaatcc aacgcgatcc gaagtcgtac gacgacaacc tggagttcga tcccgaccgg
    12241 tggctaccgg aacgcgcggc gaatgtgccg aaatacgcca tgaagccgtt cagcgcgggc
    12301 aagcggaagt gccccagtga ccacttttcg atggcccagc tcacgctgat cacggccgcg
    12361 ctcgccacga agtaccgctt cgaacaggtg gcgggctcga acgacgcggt ccgggtcggc
    12421 atcacgctgc gtccgcacga cctgctggtc aggcccgtgg cgcggtgacg acccggacgg
    12481 gtcaggcggc ggcctcgggg ccccggaagg tgcgccggta ggcgtgcggg gtggtgtcca
    12541 gggccctggt gaactggtgc ctcagggccg ccgccgtgcc gaaaccggcg cgccaggcga
    12601 tcgtgtccat cgtctcgtcc gtcgcttcca gcagccgctg ggccagcagt acgcgctggc
    12661 gcaggatcca gcggtagggg gtcgtcccgg tctcctgctg gaagcggcgg gcgaaggtgc
    12721 gcggggacat gtgcgcccgg accgccagct gctcgaccgt gacctcctcg tcgaggtgct
    12781 gctccatcca ggccagcacc tcgccgacgg tgtcgcagga ggagcgcggc agcggccgtt
    12841 cgatgtactg cgcctgcccg ccgtcccggt gcggaggcac caccatgcgc cgggcgatcc
    12901 ggttggcgac ctccggcccc tgctccttgc gcacgatgtg caggcaggca tcgataccgg
    12961 cggcggtccc ggccgacgtg accaccgggt cctcgtcgac gtagagcacg tccggcgcga
    13021 cccgggcccg cgggtgctgg cgggccagct cggccgcgtg gtgccagtgc accgcgcact
    13081 gccgcccgtc cagcaggccg gcggcgccca gcacgaagac gccggagcac acgctcagca
    13141 cgcgggtgcc ccggtccgtc gccctgcgca gggcgtccag caggtcgggc gggtactccc
    13201 ggcggacgaa gtcgctgccc gccggtaccg cgatcaggtc ggcctcctcc agccgctcca
    13261 gaccgtacgg cgtggagacg gtcagcccgc cgacgtgagt gcccagcgtg gggccctccg
    13321 cggagaccac cgcgaagtcg tacaccggca ggccctcgtc gctccggtcg atgccgaaga
    13381 cctcgcagac cacgcccagt tcgaagggat gcgcaccgtc cagcaggacg gccgccacgt
    13441 tccgcagcat gccgccagtg tgcctcgctg gtggcaggaa atcgaggcct tacggcagtc
    13501 ctgccactcc cggtaaggag tctccggcgc gacagtggtg tcatgaccgg aaaccagatc
    13561 gaagcccttg tcggaatgct cgcgaccttc ggactcctcg tcctcatgat cctcccctcg
    13621 gcgatcggca tcgtgcgcga ccggcgcatc gaccgccgga tcagggaggc gcgggaggac
    13681 ggggagaccc ggacccgcta cgggaaggag acccggagca ctcagaagtc ctcggacagg
    13741 tcgaccgtgc cctccaccgc cacctggtac gccgaggggc gccgctcgaa gaagttggtc
    13801 aactcctgaa cgccctgcaa ctccatgaag gagaaggggt tctcggagcc gtacaccggg
    13861 gcgaagccga gccgcgtcag acgctggtcg gccacgcact ccaggtactg ccgcatcgag
    13921 tcggtgttca tgcccgggag gccgtcgccg cacaggtcgc gcgcgaactg cagctcggcc
    13981 tcgacggcct ccctcagcat gtcggtgacc tgctcccgga gctggtcgtc gaacagctcc
    14041 ggctcctcct tgcgcacggt gtcgacgacg tcgaaggcga aggacatgtg catcgtctcg
    14101 tcccggaaca cccagttggt gccggtggcc aggccgtgca gcagaccccg gctgcggaac
    14161 cagtagacgt aggcgaaggc gccgtagaag aacaggccct cgatgcacgc cgcgaagcag
    14221 atcaggttga gcaggaagcg gcgccggtcg gccttggtct ccagccggtc gatcgactcg
    14281 accgagtcca tccacctgaa gcagaactcg gccttctccc ggatggacgg gatgttctcc
    14341 acggccgcga aggcggcggc gcggtcctcc gggtcgggca ggtaggtgtc gaggagcgtc
    14401 aggtagaact ggacgtggac ggcctcctcg aagagctggc gggacaggta cagccgcgcc
    14461 tcgggggagt tgatgtgctt gtagagggtc agcaccaggt tgttcgcgac gatcgagtcg
    14521 ccggtggcga agaaggccac gagccggccg atcaggtgct gctccatcgg gctgagcttc
    14581 gcgaggtcgg cgacgtccga gtggaggtcg acctcctcga cgtgccaggt gttcttgatg
    14641 gcgtcccggt agcgctcgta gaagtccggg tagcgcatgg ggcgcagggt cagctcgaag
    14701 cccgggtcga gcaggttctt ggtggtgggg tgcgcggggg tctcggtggt cattactggc
    14761 aggcctcgca ggactcgggg ttttccaggg agcaggcgac cgcttcgggg tccggggcgg
    14821 cctgcacggg gacggtggtg gcgcgggccg cggcgcgggc gatccgggtc gccgggcgcg
    14881 agcgcaggta gtacgtggtc ttcaggccct gcttccaggc gtacgcgtac atcgaggaga
    14941 gctttccgat ggtcggcgtc tccaggaaca ggttcagcga ctgggcctgg tcgaggtacg
    15001 gggtgcgggc ggcggccatg tcgatcaggc cgcgctgcgg gatctcccag gcggtgcggt
    15061 acagcgcgcg cacgtcctcg ggaatccagg tgaagccctg caccgagccg ttggcctcgc
    15121 gcagcgcctc acgggtgcgc gcgtcccaca cgccgagccg cttgaggtcg tccaccaggt
    15181 acgagttgac ctggaggaac tcgccggaca gcgtctcgcg cttgaacagg ttggagacct
    15241 gcggctcgat gcactcgtag acaccggcga tggaggcgat ggtcgcggtc ggggcgatgg
    15301 ccaggagcag ggagttgcgc agcccggtcg tcgccatgcg cgcgcgcagc gcggcccagc
    15361 gctccggcca ggcgggctcg acgccgtagt ggtccgggtg cagcacaccc cgggccgtac
    15421 gggtcttctc ccaggccggc agcgggccgt tgcgctcggc gaggtcggcg gaggtctcgt
    15481 acgcggcgag catgatccgc tcggcgatgc gggtggacag ggccttcgct tcgggggagt
    15541 cgaagggcag ccggagctgg aagaagacgt cctggaggcc catcgcgccg aggccgaccg
    15601 ggcgccagcg ggcgttggag cggcccgcct gctcggtcgg gtagaagttg atgtcgacga
    15661 cccggtccag gaaggtgacc gcggtgcgga cggtggcgtc caggcgctcc cagtccatgt
    15721 ccccgtgcgc cgggtcgacg aacgcgccga ggttgaccga gcccaggttg cagaccgcgg
    15781 tctccccgtc gtcggtgacc tccaggatct ccgtgcagag gttggaggag tggacgacgt
    15841 ggccgggggt cgcggtctgg ttggccgtgc ggttggcggt gtccttgaag gtcatccagc
    15901 cgttgccggt ctgcgcgagg gtgcgcatca tgcggccgta cagctcacgg gcgggcagcg
    15961 tcctgcgggc gagccccgcc tcctccgccc tgcggtaggc ggcgtcgaac tcctcgcccc
    16021 acaggtcggt cagctccggc acgtcggcgg gggagaacag cgaccaggtc ccgtcggcgt
    16081 ccacccggcg catgaactcg tccgggatcc agtgcgcgag gttcaggttg tgcgtacggc
    16141 gggcgtcctc gccggtgttg tcccgcagct ccaggaactc ctcgacgtcc gcgtgccagg
    16201 tctccaggta gaccgcggcc gcgcccttgc gccggccgcc ctggttcacg gccgccaccg
    16261 aggcgtccag cgtcttcagg aacgggacga tgccgttgga gtgcccgttg gtgccgcgga
    16321 tcagcgaacc ccgggcgcgg acgcgggagt aggcgatgcc gatgccgccg gcgtgcttgg
    16381 acaggcgggc cacctggtgg aggcggtcgt agagggagtc cagctcgtcc ttgggggagt
    16441 ccaggaggta gcaggacgac atctgggcgt gccgggtgcc ggagttgaag agggtggggg
    16501 aggagggcag gtagtccagg cggctcatca ggccgtacag cgcggcgacc tcgtccgccg
    16561 cgcgcaccgt gtcgtcctcg gcgagtccgg cggcgacccg cagcaggaag tgctggggcg
    16621 tctcgaccgc cttgcgggtg atcgggtggc ggagcaggta gcggctgtag agcgtacgca
    16681 ggccgaagta gccgaagcgg tcgtcggcgt cctggtcgat cagcgcgtcc aggcggtccg
    16741 cgtgcagccg tacgaaggcg gcggtgcggt cggcgatcag gccctcgcgg tggccggtgg
    16801 cgacggagtc ggtgaaggtg acgacgccct gggaggcggc ctcggcgcga atgccgatgg
    16861 tcagcaggcg ggcggccagc cgggagtaga ccgggtcctc ggagatcaga ccggcggccg
    16921 cctcggtggc cagctcgcgc agctcggcct cgtcggcgcg ggcggaccgg ccgcgcagtg
    16981 cggcggcggc cacccggccg gggtcggcgc cggggaggtc ggcggtcagc ccggtcaggg
    17041 tccgcagcag ggcggcaccg ggtccgtcgg gttccccggt cgccgtcacc ggggtcgctg
    17101 aagccggatc ggctggcgcg atggtcacgt ggagcactcc ctcgctcggc acggggcccg
    17161 gcggagggag ggcagggggc agctcacgag cgcacgcggc gtcgcgtcca ccggcccact
    17221 ccgcgaggcc cggacgtcat ggcacccggg ccagggcggc cgggcgcact gtcggcaggt
    17281 cctcggactg gacaggcgtg cgcgcacgtg cgaagacgta cggatgcacg caagtacacc
    17341 gttgcgggac agttccggat tcgcaccgga ttcccctgcg gcgacagcga gcatgagcat
    17401 acatcttgtg ccgggggacg cgagcacccc cagatgttgt gtcccggcgc ggtgccgtga
    17461 cggtgtgccg cggccgtgtc agagcgtcag ttcgtaggtg agcagcatga tgtcgtccag
    17521 ctccggcagg ggattccagt cgcggtcggg cgtgcggacg aagcccaggc gctcgtagag
    17581 gcggtgcgcg gtgcgcatgg cggcctgcgt cgacagcacg acgcccgtgc accccggcac
    17641 ggcccgggcg cggtcggcgc aggcccgcac gagggcctcg cccgccccgc ggccgcgtgc
    17701 ctcccgggcg acggcgagca tgcgtatctc ggcctcgccg gggcgcgcta tgtccgccat
    17761 ggggccgccg gacggcacga aggtcgcgcc gccgagcacc gcgtcgtcgg ccacggcgac
    17821 cagcacctcg gcggccgccg cccgcttggc cacgtcgcgc agctcgtcca ggtacgagtc
    17881 gctctccccg aagtcgagga ggccgtcgcg caggtaggcc tgcgcggtga tctcgccgag
    17941 ggtgtcgtac tcctcggccg tcgcccgccg gatcacgaag tccatgacgc cgagtgtgcc
    18001 cgacgggtac gacaacgggc cgccggattt ctccggcggc ccgcctcgaa ccagggatca
    18061 gtgcgagctg cccgccgtgg ccggcggcag ttccacctgg acgcccgggt cgccggcgtc
    18121 cgccgtgtag tcgctcggcc tggtctcgtc gacgccgtcg ggcgccttga ccgccctcag
    18181 gacgaaggtc aggaccacgg tgaccagcac gttcagcacg aaggcggtga ggccgatgta
    18241 gccgatctcg ccgatgccgg ggatctcgtc ggaggagccg ccgaagtgct tctgcgtcgg
    18301 cgaggcgaca ccgtaggcgg cgaccgtgcc gtagaccatg ccgaccgccc agccgccgag
    18361 cagcgcccag cggtggaacc agcgggtgaa caggccgccg accagggccg ggaaggtctg
    18421 caggatccag atgccgccca gcagctggaa gttgatcgcg acggtcttgt ccatgcccag
    18481 gacgaagatc agcgcgccca ccttcaccag gagcgacacc agcttggaga ccttggtctc
    18541 ctgctgcggc gtggcgtccg gcttgatgaa gtccttgtag atgttgcggg tgaagaggtt
    18601 cgcggccgcg atcgacatga tcgccgccgg gaccagggcg ccgatgccga tcgccgcgaa
    18661 cgccacgccc gcgaaccagt ccgggaacat gttctcgaac agctgcggga tcgccagctg
    18721 gccgttgtcc accttgaccc cggccgcgat cgccatgaag ccgagcagcg cgagcaggcc
    18781 cagcatcagc gagtacagcg gcaggatcgt ggtgttgcgg cggatcacct cacggctgcg
    18841 cgaggacagc gtggcggtga tcgagtgcgg gtacatgaag agcgccaggg ccgagccgag
    18901 cgccagggtc gcgtaggtcc actggccccc cgcgtccggc accacgccac ccttgcccgc
    18961 cgcggtgaac ttgtcgctcg ccgacgcgaa gatgtcgtcg aagccgccca gcttgatcgg
    19021 gatgtagatg atcgccaccg cgatgacgat gtagatcagc gtgtccttca cgaacgcgat
    19081 cagcgcgggc gcgcgcagtc ccgacgagta cgtgtacgcc gccagcacac cgaaggcgat
    19141 cagcagcggc aggtccttga cgaaccagtt ggtgtcctcg ccgccgccga cgcccatcac
    19201 gtcgaggacg gcctggatgc cgaccagctg gagcgcgatg tacggcatgg tcgccaggat
    19261 gccggtgacg gccaccgcca gcgacaggcc cttggagccg aaccggccgc gcacgaagtc
    19321 cgaggtcgtc acgtacccgt gcttgtgcga gaccgaccac aggcggggca ggaaggtgaa
    19381 gatcagcggg tagaccagga tcgtgtacgg caccgcgaag aagccggacg cgcccgccgc
    19441 gtagatcgcc gccgggacgg ccacgaaggt gtacgcggtg tacaggtcgc cgcccagcag
    19501 gaaccaggtg acccaggtgc cgaacgagcg gccgccgagg ccccactcgt cgaggctgtg
    19561 ctcgttctcg gcccggcgcc agcgggcggc caggaagccc atggcggtga cgaggacgaa
    19621 gaagaagatg aagacggcga gtgcgacgcc gttcacgccg tcgttcactt ggtcccgcct
    19681 tcccggcgcc cgcgctggtc gcgctgccac agcttgtacg cggtcaccgt cagcagggtg
    19741 gagatcagca cccaggccat ctggtaccag tagaagaacg ggatgccgat gaaggccggg
    19801 tccgtcttgg cgtacgaacc gacccacagc atggcgacga acggtgcgac gagacagaac
    19861 ccgatgacga cgcgcaccgg cgtcaccacc ggttctctgc tcacttctgt gtcttctggc
    19921 atgcgcggct ccgtcccctc gctgatcacc tcgtgcagtg cgcacgaaat gtaggtgacg
    19981 gtgtcaagac agcggaagac ctcgtccgta tatcggtcct caaccgcaat ctggggccgg
    20041 gtgagcgggc tctggtctag tcctggggcc gcttgaggcg ggccacgaac ttgtagcggt
    20101 cgccccggta caccgagcgg acccactcca ccggctggcc ggtgcggtcc tgggagtgcc
    20161 gggagagcat cagcatgggc aggccgacgt cggtgccgag cagaccggcc tcgcgcgggg
    20221 tggccaggga ggtctcgatg gtctcctcgg cctcggcgag atggacgtcg tacacctcgg
    20281 cgagcgcggt gtagagggac gtgtacttca ccagggagcg gcgcagggcg gggaagcgct
    20341 tcgcgctgag gtgggtggtc tcgatggcca tcggctcgcc gttggccatg cgcagccgct
    20401 cgatgcgcag cacccggccg ccggccgtga tgtccagcag cccggcgagc cggtcgtcgg
    20461 cggtgatgta gccgatgtcc agcagctgag aggtcggttc gaggccctgg gcccgcatgt
    20521 cctcggtgta cgaggtgagt tgcagcgcct gcgacacctt gggcttggcg acgaaggtgc
    20581 ccttgccctg gatgcgctcc aggcggccct cgaccaccag ctcctgcagg gcctggcgca
    20641 ccgtcgtgcg cgaggtgtcg aactcggcgg ccagggtgcg ctccggcggg accggtgtgc
    20701 ccggcgtctg ggtccgggtc atgtcgagca gatgcttctt cagacggtag tacttgggca
    20761 cgcgcgcggt acggacggtc gccccaccct cgttctccgc actgctgacg tcggtgctca
    20821 tgctctgcct tcccggctcc gggtgccgaa gcgaccgcta tccctgtcgg ccacggctca
    20881 catcgtggca cggcttcgtg ccgggatggc ccccgcacgc tccgtgatcc cttctgtata
    20941 cccgggggaa cacccttggt ctagtccata ggtgggtcgg acgccgctgg tacgcgcgtt
    21001 cgggggcgtc cccgcacgtc attcgatggg gggtggtaca cccggtcccg gtccgcccga
    21061 actgtcgctt gcgcaatgaa aggtcc
//
