LOCUS       NC_003888              10399 bp    DNA     linear   CON 03-AUG-2016
DEFINITION  Streptomyces coelicolor A3(2) chromosome, complete genome.
ACCESSION   NC_003888
VERSION     NC_003888.3
KEYWORDS    RefSeq; complete genome.
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces; Streptomyces
            albidoflavus group.
REFERENCE   1  (bases 1 to 8667507)
  AUTHORS   Hsiao,N.H. and Kirby,R.
  TITLE     Comparative genomics of Streptomyces avermitilis, Streptomyces
            cattleya, Streptomyces maritimus and Kitasatospora aureofaciens
            using a Streptomyces coelicolor microarray system
  JOURNAL   Antonie Van Leeuwenhoek 93 (1-2), 1-25 (2008)
   PUBMED   17588127
REFERENCE   2  (bases 1 to 8667507)
  AUTHORS   Bentley,S.D., Chater,K.F., Cerdeno-Tarraga,A.M., Challis,G.L.,
            Thomson,N.R., James,K.D., Harris,D.E., Quail,M.A., Kieser,H.,
            Harper,D., Bateman,A., Brown,S., Chandra,G., Chen,C.W., Collins,M.,
            Cronin,A., Fraser,A., Goble,A., Hidalgo,J., Hornsby,T., Howarth,S.,
            Huang,C.H., Kieser,T., Larke,L., Murphy,L., Oliver,K., O'Neil,S.,
            Rabbinowitsch,E., Rajandream,M.A., Rutherford,K., Rutter,S.,
            Seeger,K., Saunders,D., Sharp,S., Squares,R., Squares,S., Taylor,K.,
            Warren,T., Wietzorrek,A., Woodward,J., Barrell,B.G., Parkhill,J. and
            Hopwood,D.A.
  TITLE     Complete genome sequence of the model actinomycete Streptomyces
            coelicolor A3(2)
  JOURNAL   Nature 417 (6885), 141-147 (2002)
   PUBMED   12000953
REFERENCE   3  (bases 1 to 8667507)
  AUTHORS   Redenbach,M., Kieser,H.M., Denapaite,D., Eichner,A., Cullum,J.,
            Kinashi,H. and Hopwood,D.A.
  TITLE     A set of ordered cosmids and a detailed genetic and physical map for
            the 8 Mb Streptomyces coelicolor A3(2) chromosome
  JOURNAL   Mol. Microbiol. 21 (1), 77-96 (1996)
   PUBMED   8843436
REFERENCE   4  (bases 1 to 8667507)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-MAY-2002) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
  REMARK    Direct Submission
REFERENCE   5  (bases 1 to 8667507)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAY-2002) Sanger Institute, Wellcome Trust Genome
            Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
  REMARK    Direct Submission
COMMENT     ##antiSMASH-Data-START##
            Version     :: 8.0.1
            Run date    :: 2025-05-26 12:13:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start :: 1995499
            Orig. end   :: 2005898
            ##antiSMASH-Data-END##
            REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645882.
            On Jun 22, 2003 this sequence version replaced NC_003888.2.
            RefSeq Category: Reference Genome
            MOD: Model Organism
            UPR: UniProt Genome
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="8"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5399
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            complement(852..1334)
                     /db_xref="GeneID:1097296"
                     /gene_synonym="SCI39.09c"
                     /locus_tag="SCO1862"
     CDS             complement(852..1334)
                     /codon_start=1
                     /db_xref="GeneID:1097296"
                     /gene_synonym="SCI39.09c"
                     /locus_tag="SCO1862"
                     /note="SCI39.09c, possible integral membrane protein, len:
                     160 aa. Contains possible hydrophobic membrane spanning
                     regions"
                     /product="hypothetical protein"
                     /protein_id="NP_626129.1"
                     /transl_table=11
                     /translation="MFLVLLLIVVVAVVSAVGLTGHGASVLAARRARGTGAGPALRALA
                     AFAGAAAVAMYAWGLLHVTGAVMESDGGAGSAPAPPCRTTGNEERALHVIDQSVSFLPL
                     GFVCETTGGGEYTSDDVPGYVNPATAALALTAVAGAVGAGYASEARARATARGGGG"
     gene            complement(1446..2666)
                     /db_xref="GeneID:1097297"
                     /gene_synonym="SCI39.10c"
                     /locus_tag="SCO1863"
     CDS             complement(1446..2666)
                     /codon_start=1
                     /db_xref="GeneID:1097297"
                     /gene_synonym="SCI39.10c"
                     /locus_tag="SCO1863"
                     /note="SCI39.10c, unknown, len: 406 aa. High content in
                     arginine amino acid residues and also highly hydrophilic"
                     /product="hypothetical protein"
                     /protein_id="NP_626130.1"
                     /transl_table=11
                     /translation="MRVSGIPSDSSFRKAGPGRPLPRLLGGPPGGLRVGLHAPLDQRGT
                     QCRQAALHGPARRVRTVVVDPDHLARQRAAARRQRQRRVGLQGTGHQRGRVDVRRRAQC
                     RRHRRRVPRLVHVRLQAAQRERAGPGGRRRGRVPRHHRAGALRLDALDAGLQREHLQLR
                     RRVQQRLAPAVDPALLPVEERQVRPPRGVRVRRHAGPGPLAHRHRRDARRAAHRLLRAD
                     DAQVHAPGVRQHRLRAHRGHGVQVEQRAVRPDHLADLRDRVGVAGRRLGVHQGHEVDLR
                     VFGQGPADLLGGDGRVERHGEVVHGRAAVPQPVAEGLPVRSRDDVQRDGAGPRGGADGA
                     LQRQQRLALHDHHVLAGAEQVRDPVLDRGETSGAQRGEVQEGMGHGGALFGDGGCAARV
                     RGVRSRE"
     misc_feature    complement(2674..2687)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.99"
                     /tool="antismash"
     misc_feature    complement(2788..2803)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    2798..2813
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    2932..2944
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     misc_feature    2958..2970
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     gene            2969..3481
                     /db_xref="GeneID:1097298"
                     /gene_synonym="SCI39.11"
                     /locus_tag="SCO1864"
     CDS             2969..3481
                     /codon_start=1
                     /db_xref="GeneID:1097298"
                     /gene_synonym="SCI39.11"
                     /locus_tag="SCO1864"
                     /note="SCI39.11, probable acetyltransferase, len: 170 aa;
                     similar to SW:ECTA_MARHA (EMBL:U66614) Marinococcus
                     halophilus L-2,4-diaminobutyric acid acetyltransferase (EC
                     2.3.1.*) EctA, 172 aa; fasta scores: opt: 443 Z-score:
                     540.9 bits: 106.5 E(): 1.5e-22; 42.675% identity in 157 aa
                     overlap. Contains Pfam match to entry PF00583 Acetyltransf,
                     Acetyltransferase (GNAT) family"
                     /product="acetyltransferase"
                     /protein_id="NP_626131.1"
                     /transl_table=11
                     /translation="MTAAQADLQIDRPRVADGAALWRIARDSEVLDLNSSYSYLLWCRD
                     FAATSAVVRDGHGVPVGFITGYVRPDSPDTLLVWQVAVDGTYRGRGLAATLVDGLADRV
                     ARERGITILETTISPDNTASQRLFTSFAERRGARLEREVLFDTAVFPDGPHEPEVLYRI
                     GPLSAGG"
     aSDomain        2996..3466
                     /aSDomain="TIGR02406"
                     /aSTool="tigrfam"
                     /description="ectoine_EctA: diaminobutyrate
                     acetyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO1864_0025"
                     /evalue="9.10E-60"
                     /identifier="TIGR02406"
                     /label="SCO1864"
                     /locus_tag="SCO1864"
                     /protein_end="166"
                     /protein_start="9"
                     /score="199.2"
                     /tool="antismash"
                     /translation="IDRPRVADGAALWRIARDSEVLDLNSSYSYLLWCRDFAATSAVVR
                     DGHGVPVGFITGYVRPDSPDTLLVWQVAVDGTYRGRGLAATLVDGLADRVARERGITIL
                     ETTISPDNTASQRLFTSFAERRGARLEREVLFDTAVFPDGPHEPEVLYRIGPL"
     PFAM_domain     3086..3358
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00583.28"
                     /db_xref="GO:0016747"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO1864_0264"
                     /evalue="1.60E-13"
                     /gene_ontologies="GO:0016747: acyltransferase activity,
                     transferring groups other than amino-acyl groups"
                     /label="SCO1864"
                     /locus_tag="SCO1864"
                     /protein_end="130"
                     /protein_start="39"
                     /score="51.1"
                     /tool="antismash"
                     /translation="LLWCRDFAATSAVVRDGHGVPVGFITGYVRPDSPDTLLVWQVAVD
                     GTYRGRGLAATLVDGLADRVARERGITILETTISPDNTASQRLFTS"
     misc_feature    3122..3370
                     /gene_synonym="SCI39.11"
                     /locus_tag="SCO1864"
                     /note="Pfam match to entry PF00583 Acetyltransf,
                     Acetyltransferase (GNAT) family, score 57.60, E-value
                     2.6e-13"
     regulatory      3597..3601
                     /regulatory_class="ribosome_binding_site"
     gene            3611..4882
                     /db_xref="GeneID:1097299"
                     /gene_synonym="SCI39.12"
                     /locus_tag="SCO1865"
     CDS             3611..4882
                     /EC_number="2.6.1.76"
                     /NRPS_PKS="Domain: Aminotran_3 (29-366). E-value: 1.5e-72.
                     Score: 236.4. Matches aSDomain:
                     nrpspksdomains_SCO1865_Aminotran_3.1"
                     /codon_start=1
                     /db_xref="GeneID:1097299"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCI39.12"
                     /locus_tag="SCO1865"
                     /note="catalyzes the reversible formation of
                     diaminobutyrate and 2-oxoglutarate from glutamate and
                     L-aspartic beta-semialdehyde"
                     /product="diaminobutyrate--2-oxoglutarate aminotransferase"
                     /protein_id="NP_626132.1"
                     /sec_met_domain="Aminotran_3 (E-value: 2.2e-76, bitscore:
                     256.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETVESEVRSYCRGWPTVFDRAVGSRMYDEDGHEY
                     LDFFAGAGSLNYGHNNAVLKRALIDYLERDGVTHGLDMSTTAKRRFLETFQNTILRPRD
                     LPYKVMFPGPTGTNAVESALKLARKVKGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYFDGTVEDFIWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARA
                     EWLRALADLCERQDMLLIVDDIQMGCGRTGAFFSFEEAGITPDIVTVSKSISGYGMPMA
                     LTLFKPELDVWEPGEHNGTFRGNNPAFVTATATLEAYWADGSAMEKQTRKRGEQVEQHM
                     IAITEENLADVKEYRGRGLVWGLEFHDKDRAGRVAKRAFELGLLIETSGPESEVVKLLP
                     ALTITPDELDEGMKTLARAVRETA"
     aSDomain        3626..4876
                     /aSDomain="TIGR00709"
                     /aSTool="tigrfam"
                     /description="dat: 2,4-diaminobutyrate 4-transaminase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO1865_0027"
                     /evalue="1.30E-137"
                     /identifier="TIGR00709"
                     /label="SCO1865"
                     /locus_tag="SCO1865"
                     /protein_end="422"
                     /protein_start="5"
                     /score="457.0"
                     /tool="antismash"
                     /translation="PDLSVFETVESEVRSYCRGWPTVFDRAVGSRMYDEDGHEYLDFFA
                     GAGSLNYGHNNAVLKRALIDYLERDGVTHGLDMSTTAKRRFLETFQNTILRPRDLPYKV
                     MFPGPTGTNAVESALKLARKVKGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLV
                     HGTPMPFDNYFDGTVEDFIWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARAEWLRA
                     LADLCERQDMLLIVDDIQMGCGRTGAFFSFEEAGITPDIVTVSKSISGYGMPMALTLFK
                     PELDVWEPGEHNGTFRGNNPAFVTATATLEAYWADGSAMEKQTRKRGEQVEQHMIAITE
                     ENLADVKEYRGRGLVWGLEFHDKDRAGRVAKRAFELGLLIETSGPESEVVKLLPALTIT
                     PDELDEGMKTLARAVRET"
     aSDomain        3638..4870
                     /aSDomain="TIGR02407"
                     /aSTool="tigrfam"
                     /description="ectoine_ectB: diaminobutyrate--2-oxoglutarate
                     aminotransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO1865_0026"
                     /evalue="1.30E-205"
                     /identifier="TIGR02407"
                     /label="SCO1865"
                     /locus_tag="SCO1865"
                     /protein_end="420"
                     /protein_start="9"
                     /score="680.7"
                     /tool="antismash"
                     /translation="VFETVESEVRSYCRGWPTVFDRAVGSRMYDEDGHEYLDFFAGAGS
                     LNYGHNNAVLKRALIDYLERDGVTHGLDMSTTAKRRFLETFQNTILRPRDLPYKVMFPG
                     PTGTNAVESALKLARKVKGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTP
                     MPFDNYFDGTVEDFIWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARAEWLRALADL
                     CERQDMLLIVDDIQMGCGRTGAFFSFEEAGITPDIVTVSKSISGYGMPMALTLFKPELD
                     VWEPGEHNGTFRGNNPAFVTATATLEAYWADGSAMEKQTRKRGEQVEQHMIAITEENLA
                     DVKEYRGRGLVWGLEFHDKDRAGRVAKRAFELGLLIETSGPESEVVKLLPALTITPDEL
                     DEGMKTLARAVR"
     PFAM_domain     3689..4867
                     /aSDomain="Aminotran_3"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00202.24"
                     /db_xref="GO:0008483"
                     /db_xref="GO:0030170"
                     /description="Aminotransferase class-III"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO1865_0265"
                     /evalue="5.60E-76"
                     /gene_ontologies="GO:0008483: transaminase activity"
                     /gene_ontologies="GO:0030170: pyridoxal phosphate binding"
                     /label="SCO1865"
                     /locus_tag="SCO1865"
                     /protein_end="419"
                     /protein_start="26"
                     /score="256.0"
                     /tool="antismash"
                     /translation="TVFDRAVGSRMYDEDGHEYLDFFAGAGSLNYGHNNAVLKRALIDY
                     LERDGVTHGLDMSTTAKRRFLETFQNTILRPRDLPYKVMFPGPTGTNAVESALKLARKV
                     KGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGTVEDFIWF
                     ERLLEDQGSGLNKPAAVIVETVQGEGGINVARAEWLRALADLCERQDMLLIVDDIQMGC
                     GRTGAFFSFEEAGITPDIVTVSKSISGYGMPMALTLFKPELDVWEPGEHNGTFRGNNPA
                     FVTATATLEAYWADGSAMEKQTRKRGEQVEQHMIAITEENLADVKEYRGRGLVWGLEFH
                     DKDRAGRVAKRAFELGLLIETSGPESEVVKLLPALTITPDELDEGMKTLARAV"
     aSDomain        3698..4708
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCO1865_Aminotran_3.1"
                     /evalue="1.50E-72"
                     /label="SCO1865_Aminotran_3.1"
                     /locus_tag="SCO1865"
                     /protein_end="366"
                     /protein_start="29"
                     /score="236.4"
                     /tool="antismash"
                     /translation="DRAVGSRMYDEDGHEYLDFFAGAGSLNYGHNNAVLKRALIDYLER
                     DGVTHGLDMSTTAKRRFLETFQNTILRPRDLPYKVMFPGPTGTNAVESALKLARKVKGR
                     ESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGTVEDFIWFERL
                     LEDQGSGLNKPAAVIVETVQGEGGINVARAEWLRALADLCERQDMLLIVDDIQMGCGRT
                     GAFFSFEEAGITPDIVTVSKSISGYGMPMALTLFKPELDVWEPGEHNGTFRGNNPAFVT
                     ATATLEAYWADGSAMEKQTRKRGEQVEQHMIAITEENLADVKEYRGRGLVWGLEFH"
     misc_feature    3710..4528
                     /gene_synonym="SCI39.12"
                     /locus_tag="SCO1865"
                     /note="Pfam match to entry PF00202 aminotran_3,
                     Aminotransferase class-III pyridoxal-phosphate, score
                     235.70, E-value 2e-81"
     misc_feature    4412..4441
                     /gene_synonym="SCI39.12"
                     /locus_tag="SCO1865"
                     /note="PS00599 Aminotransferases class-II
                     pyridoxal-phosphate attachment site"
     misc_feature    4661..4813
                     /gene_synonym="SCI39.12"
                     /locus_tag="SCO1865"
                     /note="Pfam match to entry PF00202 aminotran_3,
                     Aminotransferase class-III pyridoxal-phosphate, score
                     28.60, E-value 2.2e-09"
     regulatory      4983..4988
                     /regulatory_class="ribosome_binding_site"
     PFAM_domain     5001..5381
                     /aSDomain="Ectoine_synth"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF06339.15"
                     /db_xref="GO:0019491"
                     /db_xref="GO:0033990"
                     /description="Ectoine synthase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO1866_0266"
                     /evalue="4.00E-52"
                     /gene_ontologies="GO:0019491: ectoine biosynthetic process"
                     /gene_ontologies="GO:0033990: ectoine synthase activity"
                     /label="SCO1866"
                     /locus_tag="SCO1866"
                     /protein_end="127"
                     /protein_start="0"
                     /score="175.9"
                     /tool="antismash"
                     /translation="MIVRSFKEFEGTDRHVKSASGTWESTRIVLAKEKVGFSVHETILY
                     AGTETSMWYANHIEAVVCTKGDAELTDRETGKTYHITPGTMYLLDGHERHTLKVKEDFH
                     CICVFNPPVTGREDHDENGVYPL"
     gene            5001..5399
                     /db_xref="GeneID:1097300"
                     /gene="ectC"
                     /gene_synonym="SCI39.13"
                     /locus_tag="SCO1866"
     CDS             5001..5399
                     /codon_start=1
                     /db_xref="GeneID:1097300"
                     /gene="ectC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /gene_synonym="SCI39.13"
                     /locus_tag="SCO1866"
                     /note="N-acetyldiaminobutyrate dehydratase; catalyzes the
                     formation of the osmoprotectant ecotoine from
                     gamma-N-acetyl-alpha,gamma-diaminobutyric acid"
                     /product="L-ectoine synthase"
                     /protein_id="NP_626133.1"
                     /sec_met_domain="ectoine_synt (E-value: 7.3e-54, bitscore:
                     179.8, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKEFEGTDRHVKSASGTWESTRIVLAKEKVGFSVHETILY
                     AGTETSMWYANHIEAVVCTKGDAELTDRETGKTYHITPGTMYLLDGHERHTLKVKEDFH
                     CICVFNPPVTGREDHDENGVYPLLTEEV"
     gene            5463..6305
                     /db_xref="GeneID:1097301"
                     /gene_synonym="SCI39.14"
                     /locus_tag="SCO1867"
     CDS             5463..6305
                     /codon_start=1
                     /db_xref="GeneID:1097301"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCI39.14"
                     /locus_tag="SCO1867"
                     /note="SCI39.14, possible hydroxylase, len: 280 aa; similar
                     to TR:O06499 (EMBL:D78338) Dactylosporangium L-proline
                     4-hydroxylase, 272 aa; fasta scores: opt: 458 Z-score:
                     529.1 bits: 105.7 E(): 7.1e-22; 34.351% identity in 262 aa
                     overlap"
                     /product="hydroxylase"
                     /protein_id="NP_626134.1"
                     /sec_met_domain="PhyH (E-value: 1.4e-41, bitscore: 141.9,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATPRQDPVVWGSPDAPGPVSAGDLQALDRDGFLAIDQLITPDEV
                     GEYQRELERLTTDPAIRADERSIVEPQSKEIRSVFEVHKISEVFAKLVRDERVVGRARQ
                     ILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPNMRTISVSIALTENYDTNG
                     GLMIMPGSHKTFLGCAGATPKDNYKKSLQMQDAGTPSDEGLTKMASEYGIKLFTGKAGS
                     ATWFDCNCMHGSGDNITPFPRSNVFIVFNSVENTAVEPFAAPIRRPEFIGARDFTPVK"
     aSDomain        5472..6302
                     /aSDomain="TIGR02408"
                     /aSTool="tigrfam"
                     /description="ectoine_ThpD: ectoine hydroxylase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO1867_0028"
                     /evalue="1.10E-153"
                     /identifier="TIGR02408"
                     /label="SCO1867"
                     /locus_tag="SCO1867"
                     /protein_end="280"
                     /protein_start="3"
                     /score="508.3"
                     /tool="antismash"
                     /translation="PRQDPVVWGSPDAPGPVSAGDLQALDRDGFLAIDQLITPDEVGEY
                     QRELERLTTDPAIRADERSIVEPQSKEIRSVFEVHKISEVFAKLVRDERVVGRARQILG
                     SDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPNMRTISVSIALTENYDTNGGLM
                     IMPGSHKTFLGCAGATPKDNYKKSLQMQDAGTPSDEGLTKMASEYGIKLFTGKAGSATW
                     FDCNCMHGSGDNITPFPRSNVFIVFNSVENTAVEPFAAPIRRPEFIGARDFTPVK"
     PFAM_domain     5547..6191
                     /aSDomain="PhyH"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF05721.16"
                     /description="Phytanoyl-CoA dioxygenase (PhyH)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO1867_0267"
                     /evalue="3.70E-41"
                     /label="SCO1867"
                     /locus_tag="SCO1867"
                     /protein_end="243"
                     /protein_start="28"
                     /score="141.9"
                     /tool="antismash"
                     /translation="DRDGFLAIDQLITPDEVGEYQRELERLTTDPAIRADERSIVEPQS
                     KEIRSVFEVHKISEVFAKLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHS
                     DFETWHAEDGLPNMRTISVSIALTENYDTNGGLMIMPGSHKTFLGCAGATPKDNYKKSL
                     QMQDAGTPSDEGLTKMASEYGIKLFTGKAGSATWFDCNCMHGSGDNITPFPR"
     gene            complement(6387..7481)
                     /db_xref="GeneID:1097302"
                     /gene_synonym="SCI39.15c"
                     /locus_tag="SCO1868"
     CDS             complement(6387..7481)
                     /NRPS_PKS="Domain: Aminotran_5 (28-305). E-value: 5.1e-23.
                     Score: 73.5. Matches aSDomain:
                     nrpspksdomains_SCO1868_Aminotran_5.1"
                     /codon_start=1
                     /db_xref="GeneID:1097302"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCI39.15c"
                     /locus_tag="SCO1868"
                     /note="SCI39.15c, conserved hypothetical protein, len: 364
                     aa; similar to SW:YCBU_BACSU (EMBL:AB000617) Bacillus
                     subtilis hypothetical protein homologue of class-V proteins
                     of pyridoxal-phosphate-dependent aminotransferase YcbU, aa;
                     fasta scores: opt: 277 Z-score: 303.9 bits: 64.9 E():
                     2.5e-09; 27.707% identity in 314 aa overlap"
                     /product="hypothetical protein"
                     /protein_id="NP_626135.1"
                     /sec_met_domain="Aminotran_5 (E-value: 6.5e-18, bitscore:
                     63.6, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDGEVTGPHSGAMESFENLVRTEFAPKTTYLNTASTGLLPARTLA
                     AMRDAAASAAEGQPLDMFADVEASRAAYARLVGVPATRVATGASVATFSGLVAASLPPG
                     AEVLTAEADFSSLVNPLYTRGDLKVRSVPLERLAESVGPDTALVAVSSVQSADGRLADL
                     AALRDAARAHGARTLIDASQSNGWLPLAAGDFDFVVAVAYKWVLCPRGVAFLVVPEDLG
                     AAAGLTPLFAGWASGEHPWDSCYGPVEELAHSARRFDESPALFSYTGARHSLALIEELG
                     VDAVHAHDTGLADRFRAGVRSLGHEPVDAPGSAIVSVPGLGHRQGELGGAGVQVSDRAG
                     NLRAAFHAYNTAADVDRLLDVLAG"
     PFAM_domain     complement(6567..7394)
                     /aSDomain="Aminotran_5"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00266.22"
                     /description="Aminotransferase class-V"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO1868_0268"
                     /evalue="1.60E-17"
                     /label="SCO1868"
                     /locus_tag="SCO1868"
                     /protein_end="305"
                     /protein_start="29"
                     /score="63.6"
                     /tool="antismash"
                     /translation="YLNTASTGLLPARTLAAMRDAAASAAEGQPLDMFADVEASRAAYA
                     RLVGVPATRVATGASVATFSGLVAASLPPGAEVLTAEADFSSLVNPLYTRGDLKVRSVP
                     LERLAESVGPDTALVAVSSVQSADGRLADLAALRDAARAHGARTLIDASQSNGWLPLAA
                     GDFDFVVAVAYKWVLCPRGVAFLVVPEDLGAAAGLTPLFAGWASGEHPWDSCYGPVEEL
                     AHSARRFDESPALFSYTGARHSLALIEELGVDAVHAHDTGLADRFRAGVRSLGH"
     aSDomain        complement(6567..7397)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCO1868_Aminotran_5.1"
                     /evalue="5.10E-23"
                     /label="SCO1868_Aminotran_5.1"
                     /locus_tag="SCO1868"
                     /protein_end="305"
                     /protein_start="28"
                     /score="73.5"
                     /tool="antismash"
                     /translation="TYLNTASTGLLPARTLAAMRDAAASAAEGQPLDMFADVEASRAAY
                     ARLVGVPATRVATGASVATFSGLVAASLPPGAEVLTAEADFSSLVNPLYTRGDLKVRSV
                     PLERLAESVGPDTALVAVSSVQSADGRLADLAALRDAARAHGARTLIDASQSNGWLPLA
                     AGDFDFVVAVAYKWVLCPRGVAFLVVPEDLGAAAGLTPLFAGWASGEHPWDSCYGPVEE
                     LAHSARRFDESPALFSYTGARHSLALIEELGVDAVHAHDTGLADRFRAGVRSLGH"
     gene            complement(7541..8254)
                     /db_xref="GeneID:1097303"
                     /gene_synonym="SCI39.16c"
                     /locus_tag="SCO1869"
     CDS             complement(7541..8254)
                     /codon_start=1
                     /db_xref="GeneID:1097303"
                     /gene_synonym="SCI39.16c"
                     /locus_tag="SCO1869"
                     /note="SCI39.16c, conserved hypothetical protein, len: 237
                     aa; similar to TR:O68911 (EMBL:AF058302) Streptomyces
                     roseofulvus FrnE protein, 216 aa; fasta scores: opt: 528
                     Z-score: 605.5 bits: 119.3 E(): 3.9e-26; 46.919% identity
                     in 211 aa overlap and to TR:Q9ZA40 (EMBL:AJ011500)
                     Streptomyces violaceoruber disulphide bond-forming protein
                     Gra-ORF19, 220 aa; fasta scores: opt: 316 Z-score: 366.6
                     bits: 75.1 E(): 7.9e-13; 37.104% identity in 221 aa
                     overlap"
                     /product="hypothetical protein"
                     /protein_id="NP_626136.1"
                     /transl_table=11
                     /translation="MRVEIWSDIACPWCYVGKARFEKALAAFPHRDGVEVVHRSFELDP
                     GRAKDDVQPVLTMLTAKYGMSQEQAQAGEDNLGAQAAAEGLAYRTRDRDHGSTFDLHRL
                     LHLAKERGRHEALLDAFYRGNFADERSVFNDDERLVELAVGAGLDAEEVRAVLADPAAY
                     ADEVRADEREAAQLGATGVPFFVLDRAYGVSGAQPAEVFTQALTQAWGERTPLKLIDDG
                     GAEACGPDGCAVPGH"
     PFAM_domain     complement(7637..8251)
                     /aSDomain="DSBA"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF01323.23"
                     /db_xref="GO:0016491"
                     /description="DSBA-like thioredoxin domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO1869_0269"
                     /evalue="6.80E-40"
                     /gene_ontologies="GO:0016491: oxidoreductase activity"
                     /label="SCO1869"
                     /locus_tag="SCO1869"
                     /protein_end="206"
                     /protein_start="1"
                     /score="137.0"
                     /tool="antismash"
                     /translation="RVEIWSDIACPWCYVGKARFEKALAAFPHRDGVEVVHRSFELDPG
                     RAKDDVQPVLTMLTAKYGMSQEQAQAGEDNLGAQAAAEGLAYRTRDRDHGSTFDLHRLL
                     HLAKERGRHEALLDAFYRGNFADERSVFNDDERLVELAVGAGLDAEEVRAVLADPAAYA
                     DEVRADEREAAQLGATGVPFFVLDRAYGVSGAQPAEVFTQAL"
     gene            complement(8347..8955)
                     /db_xref="GeneID:1097304"
                     /gene_synonym="SCI39.17c"
                     /locus_tag="SCO1870"
     CDS             complement(8347..8955)
                     /codon_start=1
                     /db_xref="GeneID:1097304"
                     /gene_synonym="SCI39.17c"
                     /locus_tag="SCO1870"
                     /note="SCI39.17c, unknown, len: 202 aa"
                     /product="hypothetical protein"
                     /protein_id="NP_626137.1"
                     /transl_table=11
                     /translation="MTLDLPELPFPLRPYGPDGRWSYADGVLTGVAGSRQDRFVPPTGE
                     SLESVSDAPRLLGAPDGDFQLIARVSVGFRGAFDAGVLYVHVGERAWAKLCLEYSPDVP
                     TVCTVVTRGHSDDCNSFTVEGDSVWFRVSRTGRAFAFHASLDGERWTFVRLFTLGDEEE
                     TGSALVGFLAQAPTGEGCTVTYDHLEFRPAWPADLRDGS"
     PFAM_domain     complement(8380..8898)
                     /aSDomain="DUF1349"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF07081.14"
                     /description="Protein of unknown function (DUF1349)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO1870_0270"
                     /evalue="7.60E-42"
                     /label="SCO1870"
                     /locus_tag="SCO1870"
                     /protein_end="192"
                     /protein_start="19"
                     /score="143.2"
                     /tool="antismash"
                     /translation="RWSYADGVLTGVAGSRQDRFVPPTGESLESVSDAPRLLGAPDGDF
                     QLIARVSVGFRGAFDAGVLYVHVGERAWAKLCLEYSPDVPTVCTVVTRGHSDDCNSFTV
                     EGDSVWFRVSRTGRAFAFHASLDGERWTFVRLFTLGDEEETGSALVGFLAQAPTGEGCT
                     VTYDHLEFRP"
     misc_feature    8925..8938
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 17.76"
                     /tool="antismash"
ORIGIN
        1 cgtagcggcg ttcgtggagc cggcgcatgt gggccgacca gcgcgggaac cgggactcgc
       61 cgccgtcggc cagcgcgggg aaggtggcga tgttgaccag ggtggggacg atggcgacgc
      121 cgcgctcggc gaagagcggg atcgtgtcgt cggtcagtcc cgtggcgtgc tccacgcagt
      181 cgatgcctgc ctcgaccagg tcgcgcaggg agtcctcggc gaagcagtgc gcggtgacgc
      241 gggcgcccag ccggtgggcc tcggcgatgg ccgcctccac ggcgccgcgc ggccagcagg
      301 ccgacaggtc gccgaggtcg cggtcgatcc agtcgccgac cagtttcacc cagccgtcgc
      361 cgcgccgggc ctcctgggcg acgtaggcga cgaggtcgtc gggctcgacc tcccaggcgt
      421 agttgcggat gtagcggcgg gtgcgggcga tgtgccggcc ggcccggatg atcttcggga
      481 ggtcctcgcg gtcgtcgatc cagcgggtgt cggagggcga gcccgcgtcc cggacgagga
      541 gggtgcccgc ctcccggtcg gtcagcgcct gcttctcggc cacgtccgcg gggacggcgc
      601 cgtgctggtc gaggccgacg tggcagtgcg cgtcgaccag gccgggcagg gcccatccct
      661 cgacggtgcg gacgtcggcg gcgcccgtgg ggcggtcgta ggagatccgt ccgtcgatca
      721 cccacacctc gtcccggacc tcctccggtc cgacgagcac ccgacccttc acgtgcagca
      781 ccgcgcgatc gctcatgccc cgcaccctaa acggtgcccg cacacccgta cggggccggt
      841 cacgggacgg gtcacccgcc tccgccgcgc gctgtcgcgc gggcgcgcgc ctcactcgcg
      901 tacccggccc cgacggcgcc cgcgacggcg gtcagggcca gggcggcggt ggcggggttg
      961 acgtagccgg ggacgtcgtc gctggtgtac tcgccgccgc cggtggtctc gcagacgaag
     1021 cccagcggca ggaaggagac cgactggtcg atgacgtgga gggcgcgctc ctcgttcccg
     1081 gtcgtgcggc agggcggcgc cggcgcggag cccgcgccgc cgtcggactc catgacggcg
     1141 ccggtcacgt gcagcagccc ccaggcgtac atagcgacgg cggcggcacc ggcgaaggcg
     1201 gcgagggcgc gcagagccgg tccggcgccc gttccccggg cgcggcgggc ggcgaggacg
     1261 ctcgcgccgt ggccggtcag gccgacggcg gacaccacgg cgaccacgac gatcagcagg
     1321 agtacgagga acacgggccc agtccatcag gcggtgatct cttcggctgt gacggaagcc
     1381 acgattccgg gcgtgggggt gtcgcaacgg aagcactccg gcgcgagtgc cggcggacgc
     1441 catggttact ctcgactccg tacgccgcgt acccgcgccg cacacccgcc gtcaccgaag
     1501 agagcaccgc cgtgacccat cccttcctgg acctcccccc gctgagcgcc ggacgtttcg
     1561 ccgcgatcga ggaccgggtc gcgcacctgc tcggcaccgg ccaggacgtg gtggtcatgc
     1621 agggcgaggc gctgctgccg ctggagggcg ccatccgcgc cgccgcgggg cccggcaccg
     1681 tcgcgctgaa cgtcgtcacg ggaccgtacg ggcagacctt cggcaactgg ctgcgggact
     1741 gcggcgcgac cgtgcacgac ctcgccgtgc cgttccacac ggccgtctcc gccgagcagg
     1801 tcggccgggc cctggccgaa cacccggaga tcgacttcgt gtccctggtg cacgccgagg
     1861 cggcgaccgg caacaccaac ccggtcgcgg agatcggcga ggtggtccgg gcgcacggcg
     1921 cgctgttcta cctggacgcc gtggcctcgg tgggcgcgga gccggtgctg ccggacgcct
     1981 ggggcgtgga cctgtgcgtc atcggcgcgc agaaggcgat gggcggcccg gcgggcgtct
     2041 cggcggtgtc ggtgagcgag cgggcctggg cccgcatggc ggcgaacccg aacgccccgc
     2101 ggcggtcgta cctgtcgctc ctcgactgga aggagcgctg gatcgacggc gggcgcaagg
     2161 cgctgctgca cgcgccggcg cagttggaga tgctcgcgct ggaggcctgc gtcgagcgca
     2221 tcgaggcgga gggccccggc acggtgatgg cgcggcacgc gtccgcggcg gcggccaccc
     2281 gggccggcgc gctcgcgctg ggcggcctgg agccgtacgt gtacgaggcg ggggacgcgg
     2341 cgccggtggc gacgacactg cgcacgccgt cggacgtcga cgcgtccgcg ctggtggccc
     2401 gtgccctgga gtccgacccg gcgctgccgc tggcggcggg cggcggcgcg ctggcgggcg
     2461 agatgatccg ggtcaaccac tacggtccgg acgcgacgcg cggggccgtg cagggctgcc
     2521 tggcggcact gggtgccgcg ctggtcgagc ggggcgtgaa ggccgacccg gaggccgccc
     2581 ggcgggccgc cgaggaggcg tgggagcggg cggccgggcc cggcctttcg gaaggatgaa
     2641 tcggagggaa ttccggatac tcgcacaagc agaatttaag aattctactc agcgcagctt
     2701 cccgtattct tctgcccgct ttcttcggac ctaaacacaa agatttcacg actaacgatc
     2761 ttcacatttc ggacacgtct cgcacgggtt acgcgattgt gacccgatcc acatgctgcc
     2821 cgatttgcgg cttacgcacc cgtcaaatcg ccccataacg ccgtcgtctc gcgcggaagc
     2881 acgcgcccgc gtgataacac aagcggcact cattcgtaac cccatccggc gatgcaattt
     2941 cgaatttcgc tgggtaaatt caatttgcat gactgccgcg caagcagacc tgcaaatcga
     3001 tcgtccgaga gtggccgacg gcgccgccct gtggcggata gcgagggatt ccgaggtcct
     3061 cgacctgaac tcctcgtaca gctacctgct ctggtgccgg gacttcgccg ccacctcggc
     3121 cgtcgtccgc gacgggcacg gcgtgccggt cggcttcatc accggctacg tacggccgga
     3181 cagtcccgac accctgctcg tgtggcaggt ggcggtggac gggacgtacc gtggtcgtgg
     3241 gctcgcggca acgctggtcg acggactggc ggaccgggtg gcccgcgaac gcgggatcac
     3301 catcctggag acaacgatct ctcccgacaa cacggcgtcc caacgactgt tcacctcgtt
     3361 cgccgagcgc cgcggcgccc ggcttgagcg cgaagtcctg ttcgacacgg cggtgttccc
     3421 cgacgggccc cacgagcccg aggtcctgta ccgcatcgga cccctgtccg ccggcggctg
     3481 acccctcgcc gagccgtcgg ggcacccccg accgtccggc ccccagactt cccggccggg
     3541 accgcgaccg gtcccaccgg acccgtacga ccttcctctc ccaccctcac cccacgagga
     3601 gcgattcgtc gtgaccatca cccagcccga cctcagcgtc ttcgagaccg tcgagtccga
     3661 ggtgcgcagc tactgccgcg gctggcccac cgtcttcgac cgtgcggtcg gcagccgcat
     3721 gtacgacgag gacggccacg agtacctcga cttcttcgcc ggagcgggct cgctcaacta
     3781 cgggcacaac aacgcggtcc tgaaacgcgc cctgatcgac tacctggagc gggacggcgt
     3841 cacgcacggg ctcgacatgt cgacgacggc caagcgccgc ttcctggaga ccttccagaa
     3901 caccatcctg cggccccgcg acctgcccta caaggtcatg ttcccgggcc cgacgggcac
     3961 caacgccgtc gagtccgcgc tcaagctggc gcgcaaggtg aaggggcgcg agtcgatcgt
     4021 gtccttcacc aacgccttcc acggcatgtc gctgggctcc ctcgcggtga ccggcaacgc
     4081 cttcaagcgg gccggcgccg gcatcccgct ggtgcacggc acgcccatgc cgttcgacaa
     4141 ctacttcgac ggcaccgtcg aggacttcat ctggttcgag cgcctgctcg aggaccaggg
     4201 ctccggcctg aacaagccgg ccgccgtgat cgtcgagacc gtgcagggcg agggcggcat
     4261 caacgtcgcc cgcgccgagt ggctgcgcgc cctggccgac ctgtgcgagc gccaggacat
     4321 gctgctcatc gtcgacgaca tccagatggg ctgcggccgt accggcgcct tcttctcctt
     4381 cgaggaggcg ggcatcacgc cggacatcgt caccgtctcc aagtccatca gcggctacgg
     4441 catgccgatg gcgctgaccc tgttcaagcc ggagctggac gtctgggagc cgggcgagca
     4501 caacggcacc ttccgcggca acaacccggc cttcgtcact gcgaccgcca ccctggaggc
     4561 gtactgggcc gacgggtcgg cgatggagaa gcagacccgc aagcgcggcg agcaggtcga
     4621 gcagcacatg atcgccatca ccgaggagaa cctcgccgac gtcaaggagt accgcggccg
     4681 cggcctggtc tggggcctgg agttccacga caaggaccgc gcgggccggg tcgccaagcg
     4741 cgccttcgag ctggggctgc tcatcgagac ctccggcccc gagagcgagg tcgtcaagct
     4801 gctgccggcg ctcaccatca cgcccgacga gctggacgag ggcatgaaga ccctggccag
     4861 ggccgtgcgc gagaccgcgt gacggtctga cggcccggcc gtcgggcacc accaccacga
     4921 actcccggcg tcttcggtcc gcgcggccga ggacgccggg gccccttgca cacccttcac
     4981 ctaggaggca tcgcaaaacc gtgatcgtcc gttcgttcaa ggagttcgaa ggcaccgacc
     5041 ggcacgtgaa gagcgcgtcc ggcacctggg aaagcacccg gatcgtcctc gccaaggaga
     5101 aggtcggctt ctccgtgcac gagacgatcc tgtacgcggg tacggagacg tcgatgtggt
     5161 acgccaacca catcgaggcc gtcgtctgca ccaagggcga cgccgagttg accgaccgcg
     5221 agacggggaa gacgtaccac atcacgccgg gcacgatgta tctcctcgac ggccacgagc
     5281 ggcacacgct caaggtcaag gaggacttcc actgcatctg tgtcttcaac ccgcccgtca
     5341 ccggacggga ggatcacgac gagaacggcg tctacccgct gctcaccgag gaggtgtgag
     5401 tcaccgtgac caccacgacc acgaacgtca ctgatctcta tcccacccgc ggcgccaccg
     5461 aagtggccac ccctcggcag gacccggtcg tctggggctc cccggacgcg cccggccccg
     5521 tctctgcggg cgacctccag gcgctggacc gcgacggctt cctcgccatc gaccagctga
     5581 tcaccccgga cgaggtcggc gagtaccagc gtgagctgga gcgcctcacc accgacccgg
     5641 ccatccgcgc ggacgagcgc tcgatcgtcg agccgcagtc caaggagatc cggtcggtct
     5701 tcgaggtgca caagatcagt gaggtcttcg ccaagctggt gcgcgacgag cgcgtggtcg
     5761 ggcgggcgcg gcagatcctc ggctcggacg tgtacgtcca ccagtcgcgg atcaacgtca
     5821 agccgggctt cggggccagc ggtttctact ggcactcgga cttcgagacc tggcacgccg
     5881 aggacggcct gcccaacatg cgcacgatct cggtctcgat cgcgctcacc gagaactacg
     5941 acaccaacgg cggtctgatg atcatgccgg ggtcgcacaa gacgttcctc gggtgcgcgg
     6001 gggccacgcc gaaggacaac tacaagaagt ccctgcagat gcaggacgcg gggacgccgt
     6061 ccgacgaggg cctgacgaag atggcctcgg agtacggcat caagctgttc accggcaagg
     6121 ccggttcggc gacctggttc gactgcaact gcatgcacgg gtcgggcgac aacatcacgc
     6181 cgttcccgcg cagcaacgtg ttcatcgtgt tcaacagcgt ggagaacacg gcggtcgagc
     6241 cgttcgcggc tccgatccgg cggccggagt tcatcggggc gcgggacttc acgccggtga
     6301 agtgactcgc gtctgagact cgggcagggg ccttctcgtg tgggacggga ggcccctgcc
     6361 cgatgtttct tcccggcccg gccgggtcag cccgccagca cgtcgagcag ccggtccacg
     6421 tcggccgcgg tgttgtacgc gtggaaggcg gcccgcagat tgcccgcccg gtccgagacc
     6481 tggacgccgg ccccgcccag ctcgccctgc cggtgtccga gtcccggcac ggacacgatc
     6541 gcggagcccg gcgcgtccac cggctcgtgg cccagcgagc gcaccccggc gcggaaccgg
     6601 tcggcgagcc cggtgtcgtg ggcgtgcacc gcgtcgacgc ccagttcctc gatcagggcc
     6661 agggagtgcc gggcgccggt gtaggagaac agggcggggc tctcgtcgaa ccgccgggcg
     6721 gagtgcgcga gttcctccac ggggccgtag cagctgtccc aggggtgctc accggacgcc
     6781 cacccggcga acagcggtgt cagcccggcc gccgccccca ggtcctccgg tacgacgagg
     6841 aaggcgacgc cgcgcgggca caggacccac ttgtaggcga cggcgaccac gaagtcgaag
     6901 tcgccggcgg ccagcggcag ccacccgttc gactgcgagg cgtcgatcag cgtccgcgcc
     6961 ccgtgcgccc gggcggcgtc ccgcagcgcg gcgaggtcgg cgagccgccc gtcggcggac
     7021 tgcacggaac tgaccgcgac gagcgcggtg tcaggaccca ccgactcggc cagccgttcc
     7081 agcggcacac tgcgcacctt caggtcgccg cgcgtgtaca gcgggttcac cagggagctg
     7141 aagtcggcct ccgcggtgag gacttcggcg cccgggggca gcgacgcggc gacgagcccg
     7201 ctgaacgtgg cgacggacgc gccggtcgcg acccgggtgg cgggcactcc cacgaggcgg
     7261 gcgtacgcgg cccgggacgc ctcgacgtcg gcgaacatgt cgagcggctg cccctccgcg
     7321 gcggaggccg ccgcgtcgcg catggccgcg agggtccggg cggggagcag gccggtgctg
     7381 gcggtgttca gatacgtggt cttcggggcg aactcggtgc ggacgaggtt ctcgaagctc
     7441 tccatggcac cactgtgcgg ccccgtgacc tccccgtcca ttgcgtattt ctacgcgata
     7501 cccccaaggg acacttatga gtccgtcccg acctgccgat tcagtggccg gggaccgcgc
     7561 acccgtccgg gccgcaggcc tcggcgccgc cgtcgtcgat cagcttcagc ggcgtgcgct
     7621 cgccccacgc ctgggtcagt gcctgggtga agacctcggc cggctgggcg cccgagactc
     7681 cgtaggcccg gtcgagcacg aagaacggca ccccggtggc cccgagctgg gcggcctcgc
     7741 gctcgtcggc gcgcacctcg tcggcgtagg cggcggggtc ggcgagcacc gcgcggacct
     7801 cctcggcgtc cagcccggcg ccgacggcca gctccacgag ccgctcgtcg tcgttgaaca
     7861 cggagcgctc gtcggcgaag ttgccccggt agaaggcgtc gaggagcgcc tcgtgccgtc
     7921 cccgctcctt ggcgaggtgc agcaggcggt gcaggtcgaa ggtgctgccg tggtcgcggt
     7981 cccgggtgcg gtaggccagg ccctcggcgg cggcctgcgc gccgaggttg tcctcaccgg
     8041 cctgcgcctg ctcctggctc atgccgtact tggcggtgag catcgtcagc accggctgca
     8101 cgtcgtcctt ggcccgtccg gggtccagtt cgaacgaacg gtggaccacc tcgacgccgt
     8161 cacggtgcgg gaaggccgcg agcgccttct cgaagcgggc cttgcccacg tagcaccagg
     8221 ggcaggcgat gtcgctccag atctcgacgc gcatgtctcg gctcttctcc aggtcgtacg
     8281 gcggcggagg ccctctccgc cccgtacgtg aacgttcaag cagccgttct cattcccgcc
     8341 ccgcgctcag ctgccgtccc gcagatccgc gggccaggcc ggccggaact ccaggtggtc
     8401 gtaggtcacg gtgcagccct cccccgtcgg cgcctgcgcc aggaagccga ccagggcgga
     8461 gccggtctcc tcctcgtcgc ccagtgtgaa gagccgcacg aaggtccagc gctccccgtc
     8521 gagggaggcg tggaaggcga aggcccgtcc ggtccggctg acccggaacc agacggagtc
     8581 gccctccacg gtgaaggagt tgcagtcgtc ggagtgcccc cgggtgacca ccgtgcagac
     8641 ggtgggcacg tccggggagt actccagaca cagcttggcc caggcccgct cccccacgtg
     8701 cacgtagagc accccggcgt cgaaggcccc gcggaacccg acggacacac gggcgatcag
     8761 ctggaagtcc ccgtcgggcg cccccagcaa ccgcggcgcg tcggacacgg actccagcga
     8821 ctccccggtg ggcggcacga accggtcctg ccgggacccg gcgaccccgg tgagcacacc
     8881 gtcggcgtag gaccagcggc cgtcgggccc gtagggacgg aggggaaacg gcagttcggg
     8941 aaggtcaaga gtcatgcact gatcatcgca ggcggaggga agtcccctga ggggcgccgg
     9001 gctgtgtcga tctgcggctc cgccgcgcgg gcgcgacaag ccacgacggc gcgtgagccg
     9061 ccgaacaacc cgcgccccta cggcgcaacc gcggagcgct accgctcgag cactccgttg
     9121 aaccgccgcg gcagccccag cggattgtcg tcccggagct ccaccggcag cagcgcctcc
     9181 ggcaccccct gatacgccac cggccggagc caccgctcga tcgccgtacc ccccaccgac
     9241 gtggacgtcg aagtggtcgc cgggtaaggc cccccatgct gctgagccgc cgccacggca
     9301 acccccgtgg gccagccgtt gaccagcacc cgccccgcca acggcgtcac ctccgcgagg
     9361 agagccgtcc cggcaccctc tcccgccact tcctcggcag agagctgcac cgtcgccgtg
     9421 aggttccccg gcagccgcga cagcaccccc cggacctccc cctcgtcctg atagcgggcc
     9481 accacggtga ccggcccgaa gcactcctcc aggagcaggt cgtgctcgcc ctccgccgcc
     9541 agccgcgccg ccggcaccgt gaggaacccg gcgctgacgg tgtgctcgcc gcccgagccc
     9601 ggcgtcaccg gggagtccac gtcgggcagc gcggcgcgct cggcgacgcc tgcgacgaag
     9661 ttgtcccgca tgcggtggtc gaggagcaca ccggcgtcgg tggcgctgac cgcgtcggtg
     9721 agcgacttga ccaggccgtc gccggcgtcg cccgccggca cgagcaccag gccgggcttg
     9781 acgcagaact gcccgacgcc cagcgtcatg gagcccgcca ggcccgcgcc gatcgcctcc
     9841 gcccgctcca cggccgccgc ctccgtgacg acgaccgggt tcagcgagcc cagctcgccg
     9901 tggaacggga tcggcaccgg acgcgccgcc gccgcgtcga agagcgcgcg gccaccgcgg
     9961 acggagcccg tgaagcccgc cgcggcgacc agcgggtgct tgatcagctc gacgcccgcc
    10021 tcgaagccgt gcaccaggcc gaggaccccg tccgggatgc cgtgccgggc cgcggcccgg
    10081 cgcagcacct tggcgaccag ctcggacagg gccgggtggt cggggtgcgc cttgacgacg
    10141 accgggcagc cggccgcgag cgcgctcgcg gtgtcgccgc cggggacgga gaaggcgaag
    10201 gggaagttgg aggccgagta gacggcgacg acgccgagcg gcaccttgta gcggcgcagg
    10261 tcggggatgg gcggggtggc cgtgtcgtcg gggtggttga cgaccacgcc gaggtactcg
    10321 ccctcgtcga cgatgtcggc gaaggcccgc agctggtagc aggtgcgggc gagttcgccg
    10381 gtgagccgga ccgggccga
//
