LOCUS       NC_003888              24559 bp    DNA     linear   CON 03-AUG-2016
DEFINITION  Streptomyces coelicolor A3(2) chromosome, complete genome.
ACCESSION   NC_003888
VERSION     NC_003888.3
KEYWORDS    .
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645882.
            On Jun 22, 2003 this sequence version replaced NC_003888.2.
            RefSeq Category: Reference Genome
            MOD: Model Organism
            UPR: UniProt Genome
            COMPLETENESS: full length.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2023-11-22 14:16:39
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 246525
            Orig. end    :: 271084
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..24559
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14559]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14559
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..24559
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..24559
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03604))"
                     /tool="antismash"
     misc_feature    142..234
                     /gene_synonym="SCF20.02"
                     /locus_tag="SCO0256"
                     /note="Pfam match to entry PF00678 adh_short_C2, Short
                     chain dehydrogenase/reductase C-terminus, score 35.90,
                     E-value 8.9e-07"
     misc_feature    262..276
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.84"
                     /tool="antismash"
     gene            343..1344
                     /db_xref="GeneID:1095681"
                     /gene_synonym="SCF20.03"
                     /locus_tag="SCO0257"
     CDS             343..1344
                     /codon_start=1
                     /db_xref="GeneID:1095681"
                     /gene_synonym="SCF20.03"
                     /locus_tag="SCO0257"
                     /note="SCF20.03, hypothetical protein, len: 333 aa; similar
                     to TR:Q9Y9P8 (EMBL:AP000063) hypothetical protein APE2240
                     from Aeropyrum pernix (324 aa) fasta scores; opt: 728,
                     z-score: 908.5, E(): 0, (51.7% identity in 298 aa overlap)"
                     /product="hypothetical protein"
                     /protein_id="NP_624588.1"
                     /transl_table=11
                     /translation="MYSKDGENYFIVDAHVALWDARRENQRNIHGKQFIDCFYDYHRNL
                     SPASELWPYEDFLYQGGERLMKDLFTDGYVDHAIFQPAHLGAFYNTGFGQTEEAFALTR
                     KHPGMLTYNHCFDPRFEEAGLKQLREDAARFGLKGVKLYTAEWKGDSRGYKLSDPWTYR
                     YLDACRELGIKNIHVHKGPTIRPLDRDAFDVADVDAAASDFTDLNFVVEHCGLPRLEDF
                     CWIATQEPNVHAGLAVAIPFMHTRPRYFAQIIGELLYWLDEDRIQFSSDYALWTPRWIV
                     EQFVDFRIPDDMTGEYPQLTVAQKKKILGLNAAAMYDIEVPAGLGLAEPAVV"
     PFAM_domain     379..1299
                     /aSDomain="Amidohydro_2"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF04909.17"
                     /db_xref="GO:0016787"
                     /description="Amidohydrolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0257_0079"
                     /evalue="5.10E-44"
                     /gene_ontologies="GO:0016787: hydrolase activity"
                     /label="SCO0257"
                     /locus_tag="SCO0257"
                     /protein_end="319"
                     /protein_start="12"
                     /score="151.3"
                     /tool="antismash"
                     /translation="DAHVALWDARRENQRNIHGKQFIDCFYDYHRNLSPASELWPYEDF
                     LYQGGERLMKDLFTDGYVDHAIFQPAHLGAFYNTGFGQTEEAFALTRKHPGMLTYNHCF
                     DPRFEEAGLKQLREDAARFGLKGVKLYTAEWKGDSRGYKLSDPWTYRYLDACRELGIKN
                     IHVHKGPTIRPLDRDAFDVADVDAAASDFTDLNFVVEHCGLPRLEDFCWIATQEPNVHA
                     GLAVAIPFMHTRPRYFAQIIGELLYWLDEDRIQFSSDYALWTPRWIVEQFVDFRIPDDM
                     TGEYPQLTVAQKKKILGLNAAAMYDI"
     gene            1346..2155
                     /db_xref="GeneID:1095682"
                     /gene_synonym="SCF20.04"
                     /locus_tag="SCO0258"
     CDS             1346..2155
                     /codon_start=1
                     /db_xref="GeneID:1095682"
                     /gene_synonym="SCF20.04"
                     /locus_tag="SCO0258"
                     /note="SCF20.04, hypothetical protein, len: 269 aa; similar
                     to TR:BAA81254 (EMBL:AP000063) hypothetical protein from
                     Aeropyrum pernix (238 aa) fasta scores; opt: 228, z-score:
                     274.4, E(): 6.4e-08, (29.7% identity in 232 aa overlap)."
                     /product="hypothetical protein"
                     /protein_id="NP_624589.1"
                     /transl_table=11
                     /translation="MWAAQLEVAARAALDTVYDPELDEPVTDLGFVRSLTAEDGRVTVH
                     LRLPTSFCSPNFAYLMASDAKDALSALPGAREVTVLLDDHHDSDLINRGLAADAGYRGT
                     FGHEAEQDLEELRGIFRRKAHTAAMERALTALLRARPDLAEEQLGDVVLGDLPDTSATR
                     ALLRRRAALGLGTAPADPALVDDDGRPCPRGEVPLRLRFARSVRISIDGNAHFCRGLLR
                     TRYPQSAADQSARPEEFPAGGEPVGAGETVPAGELFRLSAPAKENVS"
     PFAM_domain     1370..1588
                     /aSDomain="FeS_assembly_P"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF01883.22"
                     /description="Iron-sulfur cluster assembly protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0258_0080"
                     /evalue="7.70E-20"
                     /label="SCO0258"
                     /locus_tag="SCO0258"
                     /protein_end="81"
                     /protein_start="8"
                     /score="71.0"
                     /tool="antismash"
                     /translation="AARAALDTVYDPELDEPVTDLGFVRSLTAEDGRVTVHLRLPTSFC
                     SPNFAYLMASDAKDALSALPGAREVTVL"
     gene            2152..3177
                     /db_xref="GeneID:1095683"
                     /gene_synonym="SCF1.01; SCF20.05"
                     /locus_tag="SCO0259"
     CDS             2152..3177
                     /NRPS_PKS="Domain: PKS_ER (119-244). E-value: 4.3e-09.
                     Score: 27.7. Matches aSDomain:
                     nrpspksdomains_SCO0259_PKS_ER.1"
                     /codon_start=1
                     /db_xref="GeneID:1095683"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040:alcohol dehydrogenase (Score: 298.3; E-value:
                     9.9e-91)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCF1.01; SCF20.05"
                     /locus_tag="SCO0259"
                     /note="SCF1.01, partial CDS, probable alcohol
                     dehydrogenase, len: >167aa; similar the C-terminal region
                     of many eg. SW:ADH3_SULSO NAD-dependent alcohol
                     dehydrogenase from Sulfolobus solfataricus (347 aa) fasta
                     scores; opt: 274, z-score: 304.7, E(): 1.3e-09, (31.8%
                     identity in 170 aa overlap). Also similar to C-terminal
                     region of TR:BAA82700 (EMBL:AB017438) from Streptomyces
                     coelicolor (346 aa) fasta scores; opt: 372, z-score: 409.3,
                     E(): 2e-15, (40.7% identity in 167 aa overlap).; SCF20.05,
                     probable alcohol dehydrogenase (zinc-binding), len: >236aa;
                     similar to many eg. alcohol dehydrogenases eg.
                     SW:ADH1_SULSO NAD-dependent alcohol dehydrogenase from
                     Sulfolobus solfataricus (347 aa) fasta scores; opt: 476,
                     z-score: 530.0, E(): 3.7e-22, (35.4% identity in 243 aa
                     overlap). Also similar to TR:BAA82700 (EMBL:AB017438)
                     hypothetical protein from Streptomyces coelicolor (346 aa)
                     fasta scores; opt: 591, z-score: 655.8, E(): 3.7e-29,
                     (42.8% identity in 243 aa overlap). Contains Pfam match to
                     entry PF00107 adh_zinc, Zinc-binding dehydrogenases and
                     Prosite match to PS00059 Zinc-containing alcohol
                     dehydrogenases signature."
                     /product="alcohol dehydrogenase"
                     /protein_id="NP_733495.1"
                     /sec_met_domain="ADH_N (E-value: 7e-33, bitscore: 111.6,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.5e-18, bitscore:
                     64.3, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAVQVVGYGKNLEMAEVPAPEVTGPYDVIVRIGGAGVCRTDLHI
                     LEGQWAEKSGVELPYTIGHENAGWVHAVGSAVTNVSEGDKVIVHPLITCGLCRACRAGD
                     DVHCENNRFPGIDTAGGYAEYLKTSARSVVRLDDSLEPADVAALADAGLTAYHAAAKAA
                     RRLRPGDRCVVIGAGGLGHIGIQVLGALTAAEIVVVDRNPDAVDLAVSVGADHGVLADG
                     GHVDRVRELTGGHGAEAVIDFVGEGGSTGDGIGMLRRAGDYHVVGYGENIDVPTIDVIS
                     AEINFIGNLVGSYNDLCELMVLAARGRVRLHTAKYSLDRFQDALDDLDGGRIRGRAILV
                     P"
     misc_feature    2164..2859
                     /gene_synonym="SCF1.01; SCF20.05"
                     /locus_tag="SCO0259"
                     /note="Pfam match to entry PF00107 adh_zinc, Zinc-binding
                     dehydrogenases, score 17.10, E-value 1.1e-10"
     PFAM_domain     2233..2556
                     /aSDomain="ADH_N"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF08240.15"
                     /description="Alcohol dehydrogenase GroES-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0259_0081"
                     /evalue="1.80E-32"
                     /label="SCO0259"
                     /locus_tag="SCO0259"
                     /protein_end="135"
                     /protein_start="27"
                     /score="111.6"
                     /tool="antismash"
                     /translation="DVIVRIGGAGVCRTDLHILEGQWAEKSGVELPYTIGHENAGWVHA
                     VGSAVTNVSEGDKVIVHPLITCGLCRACRAGDDVHCENNRFPGIDTAGGYAEYLKTSAR
                     SVVR"
     misc_feature    2338..2382
                     /gene_synonym="SCF1.01; SCF20.05"
                     /locus_tag="SCO0259"
                     /note="PS00059 Zinc-containing alcohol dehydrogenases
                     signature."
     aSDomain        2509..2883
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCO0259_PKS_ER.1"
                     /evalue="4.30E-09"
                     /label="SCO0259_PKS_ER.1"
                     /locus_tag="SCO0259"
                     /protein_end="244"
                     /protein_start="119"
                     /score="27.7"
                     /tool="antismash"
                     /translation="GGYAEYLKTSARSVVRLDDSLEPADVAALADAGLTAYHAAAKAAR
                     RLRPGDRCVVIGAGGLGHIGIQVLGALTAAEIVVVDRNPDAVDLAVSVGADHGVLADGG
                     HVDRVRELTGGHGAEAVIDFV"
     PFAM_domain     2686..3054
                     /aSDomain="ADH_zinc_N"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00107.29"
                     /description="Zinc-binding dehydrogenase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0259_0082"
                     /evalue="1.10E-17"
                     /label="SCO0259"
                     /locus_tag="SCO0259"
                     /protein_end="301"
                     /protein_start="178"
                     /score="64.3"
                     /tool="antismash"
                     /translation="GLGHIGIQVLGALTAAEIVVVDRNPDAVDLAVSVGADHGVLADGG
                     HVDRVRELTGGHGAEAVIDFVGEGGSTGDGIGMLRRAGDYHVVGYGENIDVPTIDVISA
                     EINFIGNLVGSYNDLCELM"
     PFAM_domain     3230..3457
                     /aSDomain="ABM"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF03992.19"
                     /description="Antibiotic biosynthesis monooxygenase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0260_0083"
                     /evalue="3.90E-21"
                     /label="SCO0260"
                     /locus_tag="SCO0260"
                     /protein_end="76"
                     /protein_start="0"
                     /score="75.1"
                     /tool="antismash"
                     /translation="MIFITAKFRVLPEHADQWPQVVEDFTRATRAEPGCLWFDWSRSLD
                     DPTEYVLVEAFRDDEAGAAHVGSAHFKAAQQ"
     gene            3230..3559
                     /db_xref="GeneID:1095684"
                     /gene_synonym="SCF1.02"
                     /locus_tag="SCO0260"
     CDS             3230..3559
                     /codon_start=1
                     /db_xref="GeneID:1095684"
                     /gene_synonym="SCF1.02"
                     /locus_tag="SCO0260"
                     /note="SCF1.02, unknown, len: 109 aa; similar to TR:O06569
                     (EMBL:Z95585) hypothetical protein from Mycobacterium
                     tuberculosis (107 aa) fasta scores; opt: 433, z-score:
                     595.2, E(): 8.7e-26, (56.6% identity in 106 aa overlap)"
                     /product="hypothetical protein"
                     /protein_id="NP_624590.1"
                     /transl_table=11
                     /translation="MIFITAKFRVLPEHADQWPQVVEDFTRATRAEPGCLWFDWSRSLD
                     DPTEYVLVEAFRDDEAGAAHVGSAHFKAAQQTLPPHLATTPRIVNANVPQDDWSLLGEM
                     AVDAG"
     gene            complement(3639..4166)
                     /db_xref="GeneID:1095685"
                     /gene_synonym="SCF1.03c"
                     /locus_tag="SCO0261"
     CDS             complement(3639..4166)
                     /codon_start=1
                     /db_xref="GeneID:1095685"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 124.5;
                     E-value: 7.6e-38)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCF1.03c"
                     /locus_tag="SCO0261"
                     /note="SCF1.03c, probable acetyltransferase, len: 175 aa;
                     similar to many e.g. SW:MAA_ECOLI maltose
                     O-acetyltransferase from Escherichia coli (182 aa) fasta
                     scores; opt: 365, z-score: 432.1, E(): 1.1e-16, (43.6%
                     identity in 140 aa overlap). Contains Pfam match to entry
                     PF00132 hexapep, Bacterial transferase hexapeptide (four
                     repeats) and Prosite match to PS00101 Hexapeptide-repeat
                     containing-transferases signature"
                     /product="acetyltransferase"
                     /protein_id="NP_624591.1"
                     /transl_table=11
                     /translation="MYVHTPEFARHAERIVEVTDATSRLNVLPFSDSAGRSELLSVVFG
                     GPLPESVTIYPPFFTEYGLNTTFGENVFVNQGCTFMDKGGIRIGNRVMIAPKASLVTGG
                     HPLPLAERRAHLSFAPIVVEDDVWIGTAAVITQGVTIGAGAVVAAGAVVTRDVPAGTVV
                     AGVPARVIKQIG"
     misc_feature    complement(3696..3782)
                     /gene_synonym="SCF1.03c"
                     /locus_tag="SCO0261"
                     /note="PS00101 Hexapeptide-repeat containing-transferases
                     signature."
     misc_feature    complement(3696..3800)
                     /gene_synonym="SCF1.03c"
                     /locus_tag="SCO0261"
                     /note="Pfam match to entry PF00132 hexapep, Bacterial
                     transferase hexapeptide (four repeats), score 49.50,
                     E-value 3.2e-12"
     PFAM_domain     complement(3702..3809)
                     /aSDomain="Hexapep_2"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF14602.9"
                     /description="Hexapeptide repeat of succinyl-transferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0261_0084"
                     /evalue="3.90E-08"
                     /label="SCO0261"
                     /locus_tag="SCO0261"
                     /protein_end="155"
                     /protein_start="119"
                     /score="33.0"
                     /tool="antismash"
                     /translation="PIVVEDDVWIGTAAVITQGVTIGAGAVVAAGAVVTR"
     gene            4280..5215
                     /db_xref="GeneID:1095686"
                     /gene_synonym="SCF1.04"
                     /locus_tag="SCO0262"
     CDS             4280..5215
                     /codon_start=1
                     /db_xref="GeneID:1095686"
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 148; E-value: 5.5e-45)"
                     /gene_kind="regulatory"
                     /gene_synonym="SCF1.04"
                     /locus_tag="SCO0262"
                     /note="SCF1.04, probable LysR-family transcriptional
                     regulator, len: 311 aa; similar to many transcriptional
                     regulators especially in the N-terminal region, e.g.
                     SW:OXYR_MYCAV regulator of hydrogen peroxide responsive
                     genes from Mycobacterium avium (311 aa) fasta scores; opt:
                     292, z-score: 329.4, E(): 5.5e-11, (36.6% identity in 191
                     aa overlap). Contains Pfam match to entry PF00126 HTH_1,
                     Bacterial regulatory helix-turn-helix protein, lysR family
                     and Prosite match to PS00044 Bacterial regulatory proteins,
                     lysR family signature."
                     /product="LysR family transcriptional regulator"
                     /protein_id="NP_624592.1"
                     /transl_table=11
                     /translation="MDVEALRTFVVVAGVGQFQAAADELGISQQAVSKRIAALERHVAV
                     TLVVRSSRGSRLSLDGQVFLPHAKKVLTAVEQAERAVNPGSRPLRVDVLNRRISPAQAV
                     YRFYRSRPETDLDAVTLDKENAAQAAQAVLEGVVDASFRALPADRVPTGITAERLLDEP
                     LELLVGPGHPLADAPRISPVDLAGHRIWIPGIRPGTEWAAFYQALSEAFGLSIDALGPN
                     FGDEALMDALADSASLATLVGRGDRYLWPRTHDLRRIPLHDPTPFYPHLLLFRTGDRHP
                     VLTALRDHLRTTAPRTPHDAWTPDWTVTVH"
     misc_feature    4286..4705
                     /gene_synonym="SCF1.04"
                     /locus_tag="SCO0262"
                     /note="Pfam match to entry PF00126 HTH_1, Bacterial
                     regulatory helix-turn-helix protein, lysR family, score
                     83.50, E-value 4.3e-21"
     PFAM_domain     4289..4465
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00126.30"
                     /db_xref="GO:0003700"
                     /db_xref="GO:0006355"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0262_0085"
                     /evalue="7.00E-17"
                     /gene_ontologies="GO:0003700: DNA-binding transcription
                     factor activity"
                     /gene_ontologies="GO:0006355: regulation of DNA-templated
                     transcription"
                     /label="SCO0262"
                     /locus_tag="SCO0262"
                     /protein_end="62"
                     /protein_start="3"
                     /score="61.3"
                     /tool="antismash"
                     /translation="EALRTFVVVAGVGQFQAAADELGISQQAVSKRIAALERHVAVTLV
                     VRSSRGSRLSLDGQ"
     misc_feature    4328..4420
                     /gene_synonym="SCF1.04"
                     /locus_tag="SCO0262"
                     /note="PS00044 Bacterial regulatory proteins, lysR family
                     signature."
     PFAM_domain     4586..5158
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF03466.23"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0262_0086"
                     /evalue="4.00E-14"
                     /label="SCO0262"
                     /locus_tag="SCO0262"
                     /protein_end="293"
                     /protein_start="102"
                     /score="52.6"
                     /tool="antismash"
                     /translation="AVYRFYRSRPETDLDAVTLDKENAAQAAQAVLEGVVDASFRALPA
                     DRVPTGITAERLLDEPLELLVGPGHPLADAPRISPVDLAGHRIWIPGIRPGTEWAAFYQ
                     ALSEAFGLSIDALGPNFGDEALMDALADSASLATLVGRGDRYLWPRTHDLRRIPLHDPT
                     PFYPHLLLFRTGDRHPVLTALRDHLRTT"
     gene            complement(5239..6354)
                     /db_xref="GeneID:1095687"
                     /gene_synonym="SCF1.05c"
                     /locus_tag="SCO0263"
     CDS             complement(5239..6354)
                     /codon_start=1
                     /db_xref="GeneID:1095687"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079:oxidoreductase (Score: 151.1; E-value: 7.9e-46)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCF1.05c"
                     /locus_tag="SCO0263"
                     /note="SCF1.05c, possible oxidoreductase, len: 371 aa;
                     weakly similar to many e.g. TR:O69945 (EMBL:AL023862)
                     oxidoreductase from Streptomyces coelicolor (430 aa) fasta
                     scores; opt: 224, z-score: 247.7, E(): 2e-06, (26.0%
                     identity in 392 aa overlap). Contains Pfam match to entry
                     PF01408 GFO_IDH_MocA, Oxidoreductase family."
                     /product="oxidoreductase"
                     /protein_id="NP_624593.1"
                     /transl_table=11
                     /translation="MNTPGSALADLARSGRPIGVGVIGLGAHGSWAERSHLPALRAVGG
                     FELRALSTSSKQSAERSGHKHGVRRAFGTAAELAACDEVDLVVVAVKVPHHRELVRTVL
                     NAGKSVLCEWPLGNGLAEAEDMARLARAHAVPTVVGLQARSHPAFAYTRHLVADGYVGE
                     VLSTTVVGSGGAWGATVGPADHHVLDAANGATLLTVPFGHALDGVASVLGEPEELRIQA
                     ASRRTSAVDTETGRPVPMTAADQVVASGRLPGGAVATFHYRGGMSRGTNFRWEINGTEG
                     DLVLTAPVGHPQLSPLTLEGGRGTSTALAPLTVPEAYARVARLEPRADAPAYAVAHAYQ
                     RFLDDLREGTAHVPDFAHGVVRHRSIEQYLP"
     misc_feature    complement(5530..6303)
                     /gene_synonym="SCF1.05c"
                     /locus_tag="SCO0263"
                     /note="Pfam match to entry PF01408 GFO_IDH_MocA,
                     Oxidoreductase family, score 86.40, E-value 5.9e-22"
     misc_feature    complement(5876..5878)
                     /gene_synonym="SCF1.05c"
                     /locus_tag="SCO0263"
                     /note="TTA leucine codon. Possible target for bldA
                     regulation"
     PFAM_domain     complement(5938..6300)
                     /aSDomain="GFO_IDH_MocA"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF01408.25"
                     /db_xref="GO:0000166"
                     /description="Oxidoreductase family, NAD-binding Rossmann
                     fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0263_0087"
                     /evalue="1.30E-14"
                     /gene_ontologies="GO:0000166: nucleotide binding"
                     /label="SCO0263"
                     /locus_tag="SCO0263"
                     /protein_end="139"
                     /protein_start="18"
                     /score="55.0"
                     /tool="antismash"
                     /translation="GVGVIGLGAHGSWAERSHLPALRAVGGFELRALSTSSKQSAERSG
                     HKHGVRRAFGTAAELAACDEVDLVVVAVKVPHHRELVRTVLNAGKSVLCEWPLGNGLAE
                     AEDMARLARAHAVPTVV"
     gene            6421..6873
                     /db_xref="GeneID:1095688"
                     /gene_synonym="SCF1.06"
                     /locus_tag="SCO0264"
     CDS             6421..6873
                     /codon_start=1
                     /db_xref="GeneID:1095688"
                     /gene_functions="regulatory (smcogs) SMCOG1135:MarR family
                     transcriptional regulator (Score: 62.1; E-value: 6.9e-19)"
                     /gene_kind="regulatory"
                     /gene_synonym="SCF1.06"
                     /locus_tag="SCO0264"
                     /note="SCF1.06, possible transcriptional regulator, len:
                     150 aa; weakly similar to many e.g. TR:AAD32748
                     (EMBL:AF127374) transcriptional repressor from Streptomyces
                     lavendulae (163 aa) fasta scores; opt: 142, z-score: 184.9,
                     E(): 0.0062, (27.3% identity in 128 aa overlap). Contains
                     Pfam match to entry PF01047 MarR, MarR family and probable
                     helix-turn-helix motif (+3.47 SD) 68-89aa."
                     /product="transcriptional regulator"
                     /protein_id="NP_624594.1"
                     /transl_table=11
                     /translation="MSTRGRAPDPQEGTSEAALDPIGLWSAFKRAHEVVRTRVIADAAE
                     AAGLSEPDLTILADLNKAGGALRQSELAASLGWDRTRVSHQLTRMSKRELVTRRRANGV
                     IVVLTDAGHQAITAVYPGLDAAVRRHFTDKLSTQEVETLAAVLDRL"
     PFAM_domain     6562..6723
                     /aSDomain="MarR_2"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF12802.10"
                     /db_xref="GO:0003700"
                     /db_xref="GO:0006355"
                     /description="MarR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0264_0088"
                     /evalue="1.60E-08"
                     /gene_ontologies="GO:0003700: DNA-binding transcription
                     factor activity"
                     /gene_ontologies="GO:0006355: regulation of DNA-templated
                     transcription"
                     /label="SCO0264"
                     /locus_tag="SCO0264"
                     /protein_end="101"
                     /protein_start="47"
                     /score="34.6"
                     /tool="antismash"
                     /translation="GLSEPDLTILADLNKAGGALRQSELAASLGWDRTRVSHQLTRMSK
                     RELVTRRRA"
     misc_feature    6565..6870
                     /gene_synonym="SCF1.06"
                     /locus_tag="SCO0264"
                     /note="Pfam match to entry PF01047 MarR, MarR family, score
                     42.90, E-value 7.3e-09"
     gene            6974..7765
                     /db_xref="GeneID:1095689"
                     /gene_synonym="SCF1.07"
                     /locus_tag="SCO0265"
     CDS             6974..7765
                     /codon_start=1
                     /db_xref="GeneID:1095689"
                     /gene_synonym="SCF1.07"
                     /locus_tag="SCO0265"
                     /note="SCF1.07, possible hydroxylase, len: 263 aa; similar
                     to many from Streptomyces sp. eg. TR:Q55078 (EMBL:U50973)
                     daunomycin C-14 hydroxylase from Streptomyces sp. strain C5
                     (275 aa) fasta scores; opt: 302, z-score: 356.8, E():
                     1.7e-12, (39.3% identity in 270 aa overlap). Also similar
                     to TR:CAB45588 (EMBL:AL079355) hydroxylase from
                     Streptomyces coelicolor (263 aa) fasta scores; opt: 746,
                     z-score: 870.2, E(): 0, (44.3% identity in 262 aa
                     overlap)."
                     /product="hydroxylase"
                     /protein_id="NP_624595.1"
                     /transl_table=11
                     /translation="MITNDFAPGSPCWLDLGSPDVAGTAAFYGGVFGWTYEAMGEDAEG
                     GMFRKDGKIVAGLGRLTEEGARSAWMIYYSVTDADATTQAVQRAGGTVRVAPTDLDDWG
                     RMAQYSDPSGGQFAVWQPGRTRGVELVDQPGTLCWTELYTSDAAAAKEFYGGVLGWRFG
                     DMAVPGGEGTYSLITPSGLSEDRMHGGLMQLDERDLTLTGGRAYWHPVFAVTDCDAAVS
                     AVTAHGGSVQMGPADAEGVGRLAVCLDPSKADFVVLAPASG"
     PFAM_domain     7025..7330
                     /aSDomain="Glyoxalase_6"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF18029.4"
                     /description="Glyoxalase-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0265_0089"
                     /evalue="3.50E-09"
                     /label="SCO0265"
                     /locus_tag="SCO0265"
                     /protein_end="119"
                     /protein_start="17"
                     /score="37.5"
                     /tool="antismash"
                     /translation="SPDVAGTAAFYGGVFGWTYEAMGEDAEGGMFRKDGKIVAGLGRLT
                     EEGARSAWMIYYSVTDADATTQAVQRAGGTVRVAPTDLDDWGRMAQYSDPSGGQFAV"
     PFAM_domain     7400..7744
                     /aSDomain="Glyoxalase_6"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF18029.4"
                     /description="Glyoxalase-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0265_0090"
                     /evalue="1.10E-08"
                     /label="SCO0265"
                     /locus_tag="SCO0265"
                     /protein_end="257"
                     /protein_start="142"
                     /score="35.9"
                     /tool="antismash"
                     /translation="YTSDAAAAKEFYGGVLGWRFGDMAVPGGEGTYSLITPSGLSEDRM
                     HGGLMQLDERDLTLTGGRAYWHPVFAVTDCDAAVSAVTAHGGSVQMGPADAEGVGRLAV
                     CLDPSKADFVV"
     gene            complement(7807..8784)
                     /db_xref="GeneID:1095690"
                     /gene_synonym="SCF1.08c"
                     /locus_tag="SCO0266"
     CDS             complement(7807..8784)
                     /codon_start=1
                     /db_xref="GeneID:1095690"
                     /gene_functions="regulatory (smcogs) SMCOG1260:AraC family
                     transcriptional regulator (Score: 60.7; E-value: 2.8e-18)"
                     /gene_kind="regulatory"
                     /gene_synonym="SCF1.08c"
                     /locus_tag="SCO0266"
                     /note="SCF1.08c, possible transcriptional regulator, len:
                     325aa; similar to many eg. TR:CAB43482 (EMBL:Y18527) PobR
                     regulator from Pseudomonas sp. strain HR199 (293 aa) fasta
                     scores; opt: 254, z-score: 302.3, E(): 1.8e-09, (30.3%
                     identity in 254 aa overlap). Also similar to TR:O88020
                     (EMBL:AL031107) transcriptional regulator from Streptomyces
                     coelicolor (301 aa) fasta scores; opt: 318, z-score: 376.7,
                     E(): 1.3e-13, (37.2% identity in 253 aa overlap). Contains
                     Pfam match to entry PF00165 HTH_2, Bacterial regulatory
                     helix-turn-helix proteins, araC family."
                     /product="transcriptional regulator"
                     /protein_id="NP_624596.1"
                     /transl_table=11
                     /translation="MALLVRCPGRLPRVSIEPLAPGPGIGVSGRAMVKTGHVSAIRQMT
                     YQPPGRGAASVETMTFGRLRELNDGGTQRADFHVLAVVDAGRGSVTVDFRLHPLQDRSA
                     VWIPPGAVHRWDDVAEVEGHLVLFVPTAPVTHATRELVASPDPAAHWIVPAADWPFVDA
                     ARGHLRLEASAPPSDSSTELPAILLSALIARLHPPHAEARLAHPVVRLFRSSVEANFRQ
                     HHDAGYYARTLGYAPRTLSRAVRQATGRTAKAYLVERLVLEAKRLLAHERLTAARCAGV
                     LGFPDASNFSVFFHKATGERPGAWQAAATGPGVPTASTPPEPVT"
     misc_feature    complement(7858..8097)
                     /gene_synonym="SCF1.08c"
                     /locus_tag="SCO0266"
                     /note="Pfam match to entry PF00165 HTH_2, Bacterial
                     regulatory helix-turn-helix proteins, araC family, score
                     14.90, E-value 0.00057"
     PFAM_domain     complement(7864..8100)
                     /aSDomain="HTH_18"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF12833.10"
                     /db_xref="GO:0003700"
                     /db_xref="GO:0006355"
                     /db_xref="GO:0043565"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0266_0091"
                     /evalue="1.50E-17"
                     /gene_ontologies="GO:0003700: DNA-binding transcription
                     factor activity"
                     /gene_ontologies="GO:0006355: regulation of DNA-templated
                     transcription"
                     /gene_ontologies="GO:0043565: sequence-specific DNA
                     binding"
                     /label="SCO0266"
                     /locus_tag="SCO0266"
                     /protein_end="307"
                     /protein_start="228"
                     /score="63.7"
                     /tool="antismash"
                     /translation="YARTLGYAPRTLSRAVRQATGRTAKAYLVERLVLEAKRLLAHERL
                     TAARCAGVLGFPDASNFSVFFHKATGERPGAWQA"
     gene            8786..9562
                     /db_xref="GeneID:1095691"
                     /gene_synonym="SCF1.09"
                     /locus_tag="SCO0267"
     CDS             8786..9562
                     /NRPS_PKS="Domain: Thioesterase (20-197). E-value: 8.7e-10.
                     Score: 31.2. Matches aSDomain:
                     nrpspksdomains_SCO0267_Thioesterase.1"
                     /codon_start=1
                     /db_xref="GeneID:1095691"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036:alpha/beta hydrolase fold protein (Score: 106.3;
                     E-value: 3.8e-32)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCF1.09"
                     /locus_tag="SCO0267"
                     /note="SCF1.09, possible hydrolase, len: 258 aa; similar to
                     many e.g. TR:O67982 (EMBL:AF003947) 3-oxoadipate
                     enol-lactone hydrolase from Rhodococcus opacus (400 aa)
                     fasta scores; opt: 259, z-score: 300.,1 E(): 2.4e-09,
                     (31.5% identity in 251 aa overlap). Contains Pfam match to
                     entry PF00561 abhydrolase, alpha/beta hydrolase fold"
                     /product="hydrolase"
                     /protein_id="NP_624597.1"
                     /sec_met_domain="PF00561 (E-value: 1.4e-14, bitscore: 53.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.6e-18, bitscore:
                     67.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTQHTLVPVYDHRTGTGPTLVFLHYWGGSARTWDLVVDRLPGR
                     AVVAVDFRGWGRSRALPGPYTLGRFADDTLAVLADAGITDYVLVGHSMGGKVAQLVAAT
                     RPAGLRAIVLVGSGPAKPAARVTPEYREALSHAYDSAESVAGARDHVLTATELPAALKA
                     RIVTDSRNVTDAARIEWPLRGIAQDITEHTRRIDVPALVVAGEHDQVEPAGVLRDNLVP
                     YLARADFVVVPRTGHLIPLEAPADLADAVTAFATAV"
     aSDomain        8846..9376
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCO0267_Thioesterase.1"
                     /evalue="8.70E-10"
                     /label="SCO0267_Thioesterase.1"
                     /locus_tag="SCO0267"
                     /protein_end="197"
                     /protein_start="20"
                     /score="31.2"
                     /tool="antismash"
                     /translation="TLVFLHYWGGSARTWDLVVDRLPGRAVVAVDFRGWGRSRALPGPY
                     TLGRFADDTLAVLADAGITDYVLVGHSMGGKVAQLVAATRPAGLRAIVLVGSGPAKPAA
                     RVTPEYREALSHAYDSAESVAGARDHVLTATELPAALKARIVTDSRNVTDAARIEWPLR
                     GIAQDITEHTRRID"
     PFAM_domain     8849..9535
                     /aSDomain="Abhydrolase_6"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF12697.10"
                     /description="Alpha/beta hydrolase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0267_0092"
                     /evalue="8.40E-18"
                     /label="SCO0267"
                     /locus_tag="SCO0267"
                     /protein_end="250"
                     /protein_start="21"
                     /score="65.9"
                     /tool="antismash"
                     /translation="LVFLHYWGGSARTWDLVVDRLPGRAVVAVDFRGWGRSRALPGPYT
                     LGRFADDTLAVLADAGITDYVLVGHSMGGKVAQLVAATRPAGLRAIVLVGSGPAKPAAR
                     VTPEYREALSHAYDSAESVAGARDHVLTATELPAALKARIVTDSRNVTDAARIEWPLRG
                     IAQDITEHTRRIDVPALVVAGEHDQVEPAGVLRDNLVPYLARADFVVVPRTGHLIPLEA
                     PADLADA"
     misc_feature    8918..9550
                     /gene_synonym="SCF1.09"
                     /locus_tag="SCO0267"
                     /note="Pfam match to entry PF00561 abhydrolase, alpha/beta
                     hydrolase fold, score 82.90, E-value 6.7e-21"
     CDS_motif       9041..9094
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SCO0267_0001"
                     /evalue="4.90E-07"
                     /label="NRPS-te1"
                     /locus_tag="SCO0267"
                     /protein_end="103"
                     /protein_start="85"
                     /score="22.3"
                     /tool="antismash"
                     /translation="YVLVGHSMGGKVAQLVAA"
     aSDomain        9756..9914
                     /aSDomain="TIGR04451"
                     /aSTool="tigrfam"
                     /description="lanti_SCO0268: lantipeptide, SCO0268 family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO0268_0005"
                     /evalue="3.10E-40"
                     /identifier="TIGR04451"
                     /label="SCO0268"
                     /locus_tag="SCO0268"
                     /protein_end="53"
                     /protein_start="0"
                     /score="134.0"
                     /tool="antismash"
                     /translation="MRTEIVLSHEAPELDLDLDLRVSDLPEQAASFGEGTFTSPSSYAI
                     GTRCPICC"
     gene            9756..9917
                     /db_xref="GeneID:1095692"
                     /gene_synonym="SCF1.10"
                     /locus_tag="SCO0268"
     CDS             9756..9917
                     /codon_start=1
                     /db_xref="GeneID:1095692"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) strep_PEQAXS"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCF1.10"
                     /locus_tag="SCO0268"
                     /note="SCF1.10, unknown, len:53 aa"
                     /product="hypothetical protein"
                     /protein_id="NP_624598.1"
                     /sec_met_domain="strep_PEQAXS (E-value: 1.3e-40, bitscore:
                     136.0, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTEIVLSHEAPELDLDLDLRVSDLPEQAASFGEGTFTSPSSYAI
                     GTRCPICC"
     CDS_motif       9756..9842
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MRTEIVLSHEAPELDLDLDLRVSDLPEQA"
                     /locus_tag="SCO0268_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9843..9917
                     /prepeptide="core"
                     /locus_tag="SCO0268_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-8.70"
                     /molecular_weight="2329.6"
                     /monoisotopic_mass="2328.1"
                     /core_sequence="ASFGEGTFTSPSSYAIGTRCPICC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRTEIVLSHEAPELDLDLDLRVSDLPEQA"
                     /leader_location="[9755:9842](+)"
                     /alternative_weights="2347.6"
                     /alternative_weights="2365.6"
                     /alternative_weights="2383.7"
                     /alternative_weights="2401.7"
     gene            10001..13162
                     /db_xref="GeneID:1095693"
                     /gene_synonym="SCF1.11"
                     /locus_tag="SCO0269"
     CDS             10001..13162
                     /codon_start=1
                     /db_xref="GeneID:1095693"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     988; E-value: 7.5e-299)"
                     /gene_kind="biosynthetic"
                     /gene_synonym="SCF1.11"
                     /locus_tag="SCO0269"
                     /note="SCF1.11, unknown, len: 1053aa; similar to large
                     proteins thought to be involved in the post-translational
                     modification of lantibiotics eg. SW:SPAB_BACSU subtilin
                     modification protein from Bacillus subtilis (1030 aa) fasta
                     scores; opt: 346, z-score: 367.5, E(): 4.2e-13, (22.6%
                     identity in 1041 aa overlap)."
                     /product="hypothetical protein"
                     /protein_id="NP_624599.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.9e-172,
                     bitscore: 573.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.2e-20,
                     bitscore: 72.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 7.9e-33, bitscore:
                     113.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAESEAHRAAAVFEVREPVLVRMASRPRGAAPATVDAAEPVSGA
                     RQLAADPLLGQAVRVASGSLAHSLARLTTDEGASALGRKRTLSAARTLTRYARRAGARP
                     TPFGLFAGVGTARFGSVAKAGPGTGEVAVRLDGAWLRRRVLAWLEEPSVRRRVDVVLND
                     LCFVRDGRLYLRTGAQEQSVRDNALVGAVRERARNPVPYADLLVSLAERFPALDAERLD
                     GQLAGLLQHGFLLTSITPHRIDVALLDGIEAVLDGALPDDARALRDVRAACARHQQDPP
                     GMGGDSWQDALDAVRRLDVPGTGDDAHARPPLHVDLHVPGEFVVPEAVGREVCRYAAAI
                     WAITPQWTTLAYMRDYRERFIERYGTACAVPLGELVDPHRGLGLPSEYGAEPVYARGGP
                     GDEADGPRRAMIGELLQEAVLSGGDLVLTDEVVGRLGEVAGHDPAAAPPRSLELCFQVL
                     SESTAALDRGEFRLLGSPHIGAWTAGATAGRFAAAAGLTDELARLAAESTDDTVITAQV
                     ELMPHEPRGLNIVQVPRLLPYRIPVGVPDDRRDPRCLDWRSLLVAAGSDGLRLLDPRSG
                     RPVRPVLPHMLALDTQAPPVARFLMDLATARPRVWSGWNWAGHDALPYLPRVRYGRVVA
                     VPGRWLPGRRLRDAARAQGAGAWEQGLDAWRRRLSVPDRLQIARNDQMYPVDLRERWDR
                     DLLRAELTAAQPRFVLYEDLTADGAGLGWNGGHSTEIVVPLAAARRAAGRTAPGRAEPA
                     RGRTIPPVRPVPVRPAPVRIHLPGEDWLFVKWYAEPSAHDALLTEHLPALLSEVEDEVD
                     RWFFLRYQDPEPHLRLRFHGEPGALNGRVLPAISRVTRVLVESGALRTMALDTYRPESD
                     RYGGEAVQEAAERFFRTDSLSALVQLRALRGPARALPGAVLAGLGHAVLLESLGDWDWC
                     GWVDRMFTKTVEHEVYQRHRAVADRLIGPGRAVSSAAAALGAPSLGALWSESPEPRAYG
                     ELILSAPEADRDEALLSLLHMRHNRLFGIDRAAEARGYAVLRGAVRTHAGRRRHESGSG
                     IGSGR"
     PFAM_domain     10148..12091
                     /aSDomain="Lant_dehydr_N"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF04738.16"
                     /description="Lantibiotic dehydratase, N terminus"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0269_0093"
                     /evalue="2.10E-172"
                     /label="SCO0269"
                     /locus_tag="SCO0269"
                     /protein_end="697"
                     /protein_start="49"
                     /score="574.7"
                     /tool="antismash"
                     /translation="ADPLLGQAVRVASGSLAHSLARLTTDEGASALGRKRTLSAARTLT
                     RYARRAGARPTPFGLFAGVGTARFGSVAKAGPGTGEVAVRLDGAWLRRRVLAWLEEPSV
                     RRRVDVVLNDLCFVRDGRLYLRTGAQEQSVRDNALVGAVRERARNPVPYADLLVSLAER
                     FPALDAERLDGQLAGLLQHGFLLTSITPHRIDVALLDGIEAVLDGALPDDARALRDVRA
                     ACARHQQDPPGMGGDSWQDALDAVRRLDVPGTGDDAHARPPLHVDLHVPGEFVVPEAVG
                     REVCRYAAAIWAITPQWTTLAYMRDYRERFIERYGTACAVPLGELVDPHRGLGLPSEYG
                     AEPVYARGGPGDEADGPRRAMIGELLQEAVLSGGDLVLTDEVVGRLGEVAGHDPAAAPP
                     RSLELCFQVLSESTAALDRGEFRLLGSPHIGAWTAGATAGRFAAAAGLTDELARLAAES
                     TDDTVITAQVELMPHEPRGLNIVQVPRLLPYRIPVGVPDDRRDPRCLDWRSLLVAAGSD
                     GLRLLDPRSGRPVRPVLPHMLALDTQAPPVARFLMDLATARPRVWSGWNWAGHDALPYL
                     PRVRYGRVVAVPGRWLPGRRLRDAARAQGAGAWEQGLDAWRRRLSVPDRLQIARNDQMY
                     PVDLRERWDRDLL"
     aSDomain        10475..10723
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_SCO0269_Lanthipeptide_LanB_RRE.1"
                     /evalue="4.40E-23"
                     /identifier="RREFam001.1"
                     /label="SCO0269"
                     /locus_tag="SCO0269"
                     /protein_end="241"
                     /protein_start="158"
                     /score="72.8"
                     /tool="antismash"
                     /translation="VVLNDLCFVRDGRLYLRTGAQEQSVRDNALVGAVRERARNPVPYA
                     DLLVSLAERFPALDAERLDGQLAGLLQHGFLLTSITPH"
     aSDomain        12338..13099
                     /aSDomain="TIGR03891"
                     /aSTool="tigrfam"
                     /description="thiopep_ocin: thiopeptide-type bacteriocin
                     biosynthesis domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_SCO0269_0006"
                     /evalue="4.80E-58"
                     /identifier="TIGR03891"
                     /label="SCO0269"
                     /locus_tag="SCO0269"
                     /protein_end="1033"
                     /protein_start="779"
                     /score="195.1"
                     /tool="antismash"
                     /translation="WLFVKWYAEPSAHDALLTEHLPALLSEVEDEVDRWFFLRYQDPEP
                     HLRLRFHGEPGALNGRVLPAISRVTRVLVESGALRTMALDTYRPESDRYGGEAVQEAAE
                     RFFRTDSLSALVQLRALRGPARALPGAVLAGLGHAVLLESLGDWDWCGWVDRMFTKTVE
                     HEVYQRHRAVADRLIGPGRAVSSAAAALGAPSLGALWSESPEPRAYGELILSAPEADRD
                     EALLSLLHMRHNRLFGIDRAAEARGYAVLRGA"
     PFAM_domain     12338..13099
                     /aSDomain="Lant_dehydr_C"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF14028.9"
                     /description="Lantibiotic biosynthesis dehydratase C-term"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0269_0094"
                     /evalue="5.40E-32"
                     /label="SCO0269"
                     /locus_tag="SCO0269"
                     /protein_end="1033"
                     /protein_start="779"
                     /score="111.8"
                     /tool="antismash"
                     /translation="WLFVKWYAEPSAHDALLTEHLPALLSEVEDEVDRWFFLRYQDPEP
                     HLRLRFHGEPGALNGRVLPAISRVTRVLVESGALRTMALDTYRPESDRYGGEAVQEAAE
                     RFFRTDSLSALVQLRALRGPARALPGAVLAGLGHAVLLESLGDWDWCGWVDRMFTKTVE
                     HEVYQRHRAVADRLIGPGRAVSSAAAALGAPSLGALWSESPEPRAYGELILSAPEADRD
                     EALLSLLHMRHNRLFGIDRAAEARGYAVLRGA"
     gene            13159..14559
                     /db_xref="GeneID:1095694"
                     /gene_synonym="SCF1.12"
                     /locus_tag="SCO0270"
     CDS             13159..14559
                     /codon_start=1
                     /db_xref="GeneID:1095694"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     389.1; E-value: 3.8e-118)"
                     /gene_kind="biosynthetic"
                     /gene_synonym="SCF1.12"
                     /locus_tag="SCO0270"
                     /note="SCF1.12, unknown, len: 466 aa; similar to proteins
                     predicted to be involved in lantibiotic biosynthesis eg.
                     SW:SPAC_BACSU subtilin biosynthesis protein from Bacillus
                     subtilis (441 aa) fasta scores; opt: 502, z-score: 549.2,
                     E(): 3.2e-23, (28.9% identity in 405 aa overlap)"
                     /product="hypothetical protein"
                     /protein_id="NP_624600.1"
                     /sec_met_domain="LANC_like (E-value: 2e-62, bitscore:
                     209.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGTTEGGSPEHTMDGFSGSGTREAPAGESPRALRERAGAVSAEI
                     LDRLADPAATVAATRIPAQAADDGVAEPIWAELTLGSGSPGLALAFAGASRDAARQVPR
                     AHAYLTAGTRAVSGRPGTAGGVFKGPGALAFAVLLAHRTTGGYVSALQRFDAYQRDLVR
                     TVLPPVEDRPLPTIGHYEVVRGLTGVGRYLLARAESCEEPLTAVLDYLVRLSLGTVEHQ
                     GADVPRWWALDAPRIGSEAAFPGGHLNLGLSHGVAGPLALLALAWEQGVRVPRQREAME
                     ATAALLRTWAVADRYGLFWPGYLSFAQWQRGPAAYDGTAKWPAWCYGAPGVSRALQLAG
                     RALGRADFSDLARASVERLLVLPRPAWGIDDHALCHGWAGALHQLGRLNEGWQDSRLAE
                     LRDGIAADLVSAFDPELPFGLRFTMTKVPFGSDVSGYLDGAAGVALALDSYAAAGTPAD
                     WDMPLLLA"
     PFAM_domain     13381..14547
                     /aSDomain="LANC_like"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF05147.16"
                     /db_xref="GO:0031179"
                     /description="Lanthionine synthetase C-like protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0270_0095"
                     /evalue="8.10E-65"
                     /gene_ontologies="GO:0031179: peptide modification"
                     /label="SCO0270"
                     /locus_tag="SCO0270"
                     /protein_end="463"
                     /protein_start="74"
                     /score="218.8"
                     /tool="antismash"
                     /translation="WAELTLGSGSPGLALAFAGASRDAARQVPRAHAYLTAGTRAVSGR
                     PGTAGGVFKGPGALAFAVLLAHRTTGGYVSALQRFDAYQRDLVRTVLPPVEDRPLPTIG
                     HYEVVRGLTGVGRYLLARAESCEEPLTAVLDYLVRLSLGTVEHQGADVPRWWALDAPRI
                     GSEAAFPGGHLNLGLSHGVAGPLALLALAWEQGVRVPRQREAMEATAALLRTWAVADRY
                     GLFWPGYLSFAQWQRGPAAYDGTAKWPAWCYGAPGVSRALQLAGRALGRADFSDLARAS
                     VERLLVLPRPAWGIDDHALCHGWAGALHQLGRLNEGWQDSRLAELRDGIAADLVSAFDP
                     ELPFGLRFTMTKVPFGSDVSGYLDGAAGVALALDSYAAAGTPADWDMPL"
     misc_feature    complement(14572..14587)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     gene            14841..15794
                     /db_xref="GeneID:1095695"
                     /gene_synonym="SCF1.13"
                     /locus_tag="SCO0271"
     CDS             14841..15794
                     /codon_start=1
                     /db_xref="GeneID:1095695"
                     /gene_functions="transport (smcogs) SMCOG1067:putative ABC
                     transporter permease protein (Score: 308; E-value:
                     9.9e-94)"
                     /gene_kind="transport"
                     /gene_synonym="SCF1.13"
                     /locus_tag="SCO0271"
                     /note="SCF1.13, possible binding-protein-dependent
                     transport protein, len: 317aa; similar to many predicted
                     membrane transporters eg. TR:CAB41203 (EMBL:AL049661)
                     binding-protein-dependent transport protein from
                     Streptomyces coelicolor (327 aa) fasta scores; opt: 624,
                     z-score: 720.7, E(): 8.8e-33, (35.9% identity in 320 aa
                     overlap). Contains Pfam match to entry PF00528 BPD_transp,
                     Binding-protein-dependent transport systems inner membrane
                     component, Prosite match to PS00402
                     Binding-protein-dependent transport systems inner membrane
                     comp sign. and possible membrane spanning hydrophobic
                     regions."
                     /product="binding-protein-dependent transport protein"
                     /protein_id="NP_624601.1"
                     /transl_table=11
                     /translation="MGAHTAVAPPHPGAGTSPGGASAPRRTRRPRDDRKAAWLFLAPAL
                     LGFALFYAYPTVRGIYYSLTDYSLIATPDFVGGDNYSRLIGDEQFWNALQVTGYYVLVN
                     IVSQTLLALVLATLMHRLTRSVALRAMLLVPWLVPNVTVGLLWMWLLDTNLGLVNHVLN
                     SMGMGTTGFFTSPDWAMPSVAAVNTWAYTGYTALLLYAGMLQVPQYLYESASLDGAGEW
                     RMFTRITLPLLRPVLSLVLVVSLIGSFQIFDTIAVTTKGGPVSATRVIYYYIYEQAFTN
                     FHMGYASAVAVVLALILGVLTAVQMRLLRASRSDLA"
     PFAM_domain     15165..15764
                     /aSDomain="BPD_transp_1"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00528.25"
                     /db_xref="GO:0016020"
                     /db_xref="GO:0055085"
                     /description="Binding-protein-dependent transport system
                     inner membrane component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0271_0096"
                     /evalue="7.20E-17"
                     /gene_ontologies="GO:0016020: membrane"
                     /gene_ontologies="GO:0055085: transmembrane transport"
                     /label="SCO0271"
                     /locus_tag="SCO0271"
                     /protein_end="308"
                     /protein_start="108"
                     /score="61.9"
                     /tool="antismash"
                     /translation="TLLALVLATLMHRLTRSVALRAMLLVPWLVPNVTVGLLWMWLLDT
                     NLGLVNHVLNSMGMGTTGFFTSPDWAMPSVAAVNTWAYTGYTALLLYAGMLQVPQYLYE
                     SASLDGAGEWRMFTRITLPLLRPVLSLVLVVSLIGSFQIFDTIAVTTKGGPVSATRVIY
                     YYIYEQAFTNFHMGYASAVAVVLALILGVLTAVQMRL"
     misc_feature    15444..15665
                     /gene_synonym="SCF1.13"
                     /locus_tag="SCO0271"
                     /note="Pfam match to entry PF00528 BPD_transp,
                     Binding-protein-dependent transport systems inner membrane
                     component, score 58.30, E-value 1.7e-13"
     misc_feature    15447..15533
                     /gene_synonym="SCF1.13"
                     /locus_tag="SCO0271"
                     /note="PS00402 Binding-protein-dependent transport systems
                     inner membrane comp sign."
     gene            15805..16695
                     /db_xref="GeneID:1095696"
                     /gene_synonym="SCF1.14"
                     /locus_tag="SCO0272"
     CDS             15805..16695
                     /codon_start=1
                     /db_xref="GeneID:1095696"
                     /gene_functions="transport (smcogs) SMCOG1069:putative ABC
                     transporter permease protein (Score: 287; E-value:
                     2.3e-87)"
                     /gene_kind="transport"
                     /gene_synonym="SCF1.14"
                     /locus_tag="SCO0272"
                     /note="SCF1.14, possible binding-protein-dependent
                     transport protein, len: 296aa; similar to many predicted
                     membrane transporters eg. TR:O53483 (EMBL:AL021899) sugar
                     transport protein from Mycobacterium tuberculosis (280 aa)
                     fasta scores; opt: 594, z-score: 708.0, E(): 4.5e-32,
                     (34.6% identity in 283 aa overlap). Contains Pfam match to
                     entry PF00528 BPD_transp, Binding-protein-dependent
                     transport systems inner membrane component, Prosite match
                     to PS00402 Binding-protein-dependent transport systems
                     inner membrane comp sign. and possible membrane spanning
                     hydrophobic regions."
                     /product="binding-protein-dependent transport protein"
                     /protein_id="NP_624602.1"
                     /transl_table=11
                     /translation="MTHIRTRVSPGRIAAWALLVVALFATVFPFYWMVRTALTPAADLY
                     TDSTGLVPDHPTMINFLRVLGLTSQEEAVAAGGSGAQVDFLRYLLNSVVYSGLIAVLQT
                     LFCAMAGYAFARLRFPGRDLVFGVLIAALMVPPIFTVLPNFVLVKDLGWLNTFVGMVAP
                     SVLMTPFAVFFLRQFFLSVPREVEEAAILDGVGPWGIFWRVVMPMTRGPLLTVGLTTTV
                     WAWKDYLWPLLSGRDEETRVLTVALGIFQQQSPNTQPDWTGLMAGSALSVLPVLVLLIL
                     LGRRLVESLNFTGMK"
     PFAM_domain     16132..16662
                     /aSDomain="BPD_transp_1"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00528.25"
                     /db_xref="GO:0016020"
                     /db_xref="GO:0055085"
                     /description="Binding-protein-dependent transport system
                     inner membrane component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0272_0097"
                     /evalue="4.40E-20"
                     /gene_ontologies="GO:0016020: membrane"
                     /gene_ontologies="GO:0055085: transmembrane transport"
                     /label="SCO0272"
                     /locus_tag="SCO0272"
                     /protein_end="286"
                     /protein_start="109"
                     /score="72.3"
                     /tool="antismash"
                     /translation="AGYAFARLRFPGRDLVFGVLIAALMVPPIFTVLPNFVLVKDLGWL
                     NTFVGMVAPSVLMTPFAVFFLRQFFLSVPREVEEAAILDGVGPWGIFWRVVMPMTRGPL
                     LTVGLTTTVWAWKDYLWPLLSGRDEETRVLTVALGIFQQQSPNTQPDWTGLMAGSALSV
                     LPVLVLLILLGRRL"
     misc_feature    16336..16566
                     /gene_synonym="SCF1.14"
                     /locus_tag="SCO0272"
                     /note="Pfam match to entry PF00528 BPD_transp,
                     Binding-protein-dependent transport systems inner membrane
                     component, score 64.10, E-value 3.1e-15"
     misc_feature    16339..16425
                     /gene_synonym="SCF1.14"
                     /locus_tag="SCO0272"
                     /note="PS00402 Binding-protein-dependent transport systems
                     inner membrane comp sign."
     gene            16760..18109
                     /db_xref="GeneID:1095697"
                     /gene_synonym="SCF1.15; SCF85.01"
                     /locus_tag="SCO0273"
     CDS             16760..18109
                     /codon_start=1
                     /db_xref="GeneID:1095697"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143:sugar-binding lipoprotein (Score: 346.7; E-value:
                     3.9e-105)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCF1.15; SCF85.01"
                     /locus_tag="SCO0273"
                     /note="SCF85.01, unknown, partial CDS, len: >264 aa. Weakly
                     similar to several hypotheticals e.g. Mycobacterium
                     tuberculosis TR:O53485 (EMBL; AL021899) lipoprotein
                     component of sugar transport system (439 aa), fasta scores
                     opt: 258 z-score: 307.2 E(): 9.3e-10 27.9% identity in 222
                     aa overlap and Thermotoga maritima TR:AAD35892 (EMBL;
                     AE001748) sugar ABC transporter, periplasmic sugar-binding
                     protein TM0810 (420 aa), fasta scores opt: 169 z-score:
                     203.2 E(): 0.00058 25.1% identity in 263 aa overlap.;
                     SCF1.15, partial CDS, possible substrate binding protein
                     (extracellular) (binding-protein-dependent transport), len:
                     >221aa; similar to many the N-terminal region of undefined
                     function eg. SW:YURO_BACSU hypothetical ABC transporter
                     extracellular binding protein from Bacillus subtilis (422
                     aa) fasta scores; opt: 224, z-score: 276.0, E(): 5.2e-08,
                     (26.1% identity in 161 aa overlap). Contains possible
                     N-terminal signal sequence."
                     /product="substrate binding protein"
                     /protein_id="NP_733496.1"
                     /transl_table=11
                     /translation="MRPRHLRAGAALLCLAALTTLVSCGSSDEAGDGRTTVDYWLWDDL
                     QLPAYQECATAFEKANPDIAVRITQTAWNQYWQNLTTQLVSGEAPDVWTNQATYYPQFA
                     AGNQLLDLQPYVERDGLDVSAYQAGLADTWVKDDKRYGLPKDWDTMAVVYNTDMLKRQG
                     VDLAALNDLTWNPADGGTLEQVIARATVDSEGRNGLDPAFDKDHVEVYGFLPEWADGAQ
                     GQNGWGNFAAANGFEYLDKNPWGTHYKFDDPRLAETVSWFRHLIDKGYAPRLDQQSSVA
                     RTELLIAGKGAMSLAGSFTVSSFTGPKVKQDFGFAAMPVGPAGRKSALNGLADSVWAGT
                     DHKEEAWKWVKYLASADCQDRVAAHGVVFPALKSSTEKALAAHEADGDDVRAFTDAVGT
                     KGVTFQLPVTEHGTEISPLVQDAIQSAILGQEDAADALESVNGKVNGLFD"
     PFAM_domain     16904..17830
                     /aSDomain="SBP_bac_1"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF01547.28"
                     /description="Bacterial extracellular solute-binding
                     protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0273_0098"
                     /evalue="3.90E-28"
                     /label="SCO0273"
                     /locus_tag="SCO0273"
                     /protein_end="357"
                     /protein_start="48"
                     /score="99.5"
                     /tool="antismash"
                     /translation="AYQECATAFEKANPDIAVRITQTAWNQYWQNLTTQLVSGEAPDVW
                     TNQATYYPQFAAGNQLLDLQPYVERDGLDVSAYQAGLADTWVKDDKRYGLPKDWDTMAV
                     VYNTDMLKRQGVDLAALNDLTWNPADGGTLEQVIARATVDSEGRNGLDPAFDKDHVEVY
                     GFLPEWADGAQGQNGWGNFAAANGFEYLDKNPWGTHYKFDDPRLAETVSWFRHLIDKGY
                     APRLDQQSSVARTELLIAGKGAMSLAGSFTVSSFTGPKVKQDFGFAAMPVGPAGRKSAL
                     NGLADSVWAGTDHKEEAWKWVKYLASAD"
     regulatory      18229..18234
                     /regulatory_class="ribosome_binding_site"
     gene            18239..19738
                     /db_xref="GeneID:1095698"
                     /gene_synonym="SCF85.02"
                     /locus_tag="SCO0274"
     CDS             18239..19738
                     /codon_start=1
                     /db_xref="GeneID:1095698"
                     /gene_synonym="SCF85.02"
                     /locus_tag="SCO0274"
                     /note="SCF85.02, possible alpha-galactosidase, len: 499 aa.
                     Similar to many alpha galactosidases e.g. Thermus aquaticus
                     TR:AAD32628(EMBL; AF135399) alpha-galactosidase (476 aa),
                     fasta scores opt: 1329 z-score: 1530.0 E(): 0 45.8%
                     identity in 487 aa overlap"
                     /product="alpha-galactosidase"
                     /protein_id="NP_624603.1"
                     /transl_table=11
                     /translation="MAQLVELGGRTLAVELAGDAPPRAVEGGLLLPPGRTAVLHGLGDA
                     LFYRHGHNSWSPCGWRRLSEAPLRIESAERRLTADDTVWDDPARHHSSAVAALEGPDGR
                     VLLLGALGLDVPRLTADRDTLTGWCERDGAPWFLALGSEEEVFAAYARHLGDRLGRSDK
                     RAGNVWCSWYAYYESITEEQLTKDVTALRGLPFDVVQVDDGWERAVGDWEANDKFPSGM
                     RALADRITDAGLRPGLWIAPFIVLPGSRTARQRPELLLRDGRGEPVVAGHNWGVGYWTL
                     DLTLPAAQEHLRETIRRVVREWGFTYLKLDFVGAGAVPGVRFADVGREEAYRTGLSIVR
                     EAAGPDAYLLGSGAPLLPSLGLVDAIRSGPDVAPMWEHYATQDPSDALARNAVVNTVHR
                     LWQSPLLEVDPDVVYFRSRLNLLTEQQQGLLRDLADVCGFRAVSDPPGWLLPEELKAME
                     AYLTGRPEVRRLGRYRFALDGREVDFGAAVTPGDEQRYPLA"
     PFAM_domain     18737..19174
                     /aSDomain="Melibiase"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF02065.21"
                     /description="Melibiase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0274_0099"
                     /evalue="2.80E-15"
                     /label="SCO0274"
                     /locus_tag="SCO0274"
                     /protein_end="312"
                     /protein_start="166"
                     /score="56.2"
                     /tool="antismash"
                     /translation="NVWCSWYAYYESITEEQLTKDVTALRGLPFDVVQVDDGWERAVGD
                     WEANDKFPSGMRALADRITDAGLRPGLWIAPFIVLPGSRTARQRPELLLRDGRGEPVVA
                     GHNWGVGYWTLDLTLPAAQEHLRETIRRVVREWGFTYLKLDF"
     gene            19831..20988
                     /db_xref="GeneID:1095699"
                     /gene_synonym="SCF85.03"
                     /locus_tag="SCO0275"
     CDS             19831..20988
                     /codon_start=1
                     /db_xref="GeneID:1095699"
                     /gene_functions="other (smcogs) SMCOG1108:ROK family
                     protein (Score: 254.9; E-value: 2.2e-77)"
                     /gene_kind="other"
                     /gene_synonym="SCF85.03"
                     /locus_tag="SCO0275"
                     /note="SCF85.03, possible transcriptional repressor
                     protein, len: 385 aa. Low similarity to many repressor
                     proteins e.g. Anaerocellum thermophilum SW:XYLR_ANATH
                     (EMBL; Z69782)xylose repressor (399 aa), fasta scores opt:
                     325 z-score: 375.7 E(): 1.4e-13 23.3% identity in 395 aa
                     overlap and Streptomyces coelicolor TR:O50502 (EMBL;
                     AL009199) probable transcriptional repressor protein
                     SC7B7.05 (403 aa), fasta scores opt: 402 z-score: 463.7
                     E(): 1.8e-18 29.7% identity in 404 aa overlap. Contains a
                     Pfam match to entry PF00480 ROK, ROK family and has a
                     possible helix turn helix motif between aa 30..51."
                     /product="transcriptional repressor protein"
                     /protein_id="NP_624604.1"
                     /transl_table=11
                     /translation="MATTGTDMSRMREMNQLSIVGALRGNPPSTVTELASRSGLSRPAV
                     DVLVQSLVADGWAEVEEPGASSVVGRPARRYRFRATAGHVLGIDIGVHKILVILSDLEG
                     NLVRTVRHPAAPEAAPAERLAAVDRVVDEVLASAGMAAGDIWAVTVGVTGPVDRSGRTS
                     LSSPLPGWSEADPAAHLGTRFSCPVQVENDCKLAAVAERWRGVAQDADDIVYLLAGLRT
                     GAGLILDGTLRRGHGGAAGEIGALKAVRWLTAPDHLQSCPGMPATAAEGEAAAWVFQAA
                     RDGDRDARTAVRRYTRDLAVGVAALVLALDPQVVVYGGGFSRSADVVLGPLHRELTKHC
                     LRMPELRASTLGDESVALGAVRLALDEVDSRLLSDGLAAPTAPRR"
     PFAM_domain     19870..20019
                     /aSDomain="MarR_2"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF12802.10"
                     /db_xref="GO:0003700"
                     /db_xref="GO:0006355"
                     /description="MarR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0275_0100"
                     /evalue="4.80E-09"
                     /gene_ontologies="GO:0003700: DNA-binding transcription
                     factor activity"
                     /gene_ontologies="GO:0006355: regulation of DNA-templated
                     transcription"
                     /label="SCO0275"
                     /locus_tag="SCO0275"
                     /protein_end="63"
                     /protein_start="13"
                     /score="36.2"
                     /tool="antismash"
                     /translation="MNQLSIVGALRGNPPSTVTELASRSGLSRPAVDVLVQSLVADGWA
                     EVEEP"
     PFAM_domain     20086..20928
                     /aSDomain="ROK"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00480.23"
                     /description="ROK family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0275_0101"
                     /evalue="9.00E-38"
                     /label="SCO0275"
                     /locus_tag="SCO0275"
                     /protein_end="366"
                     /protein_start="85"
                     /score="130.5"
                     /tool="antismash"
                     /translation="LGIDIGVHKILVILSDLEGNLVRTVRHPAAPEAAPAERLAAVDRV
                     VDEVLASAGMAAGDIWAVTVGVTGPVDRSGRTSLSSPLPGWSEADPAAHLGTRFSCPVQ
                     VENDCKLAAVAERWRGVAQDADDIVYLLAGLRTGAGLILDGTLRRGHGGAAGEIGALKA
                     VRWLTAPDHLQSCPGMPATAAEGEAAAWVFQAARDGDRDARTAVRRYTRDLAVGVAALV
                     LALDPQVVVYGGGFSRSADVVLGPLHRELTKHCLRMPELRASTLGDESVALGAVRLALD
                     "
     misc_feature    20089..20562
                     /gene_synonym="SCF85.03"
                     /locus_tag="SCO0275"
                     /note="Pfam match to entry PF00480 ROK, ROK family, score
                     95.10, E-value 3.4e-27"
     gene            21060..22313
                     /db_xref="GeneID:1095700"
                     /gene_synonym="SCF85.04"
                     /locus_tag="SCO0276"
     CDS             21060..22313
                     /codon_start=1
                     /db_xref="GeneID:1095700"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079:oxidoreductase (Score: 167.7; E-value: 7.3e-51)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCF85.04"
                     /locus_tag="SCO0276"
                     /note="SCF85.04, possible oxidoreductase, len: 417 aa.
                     Weakly similar to many including: Bacillus subtilis
                     TR:O34371 (EMBL:AF008220) YteT (428 aa), fasta scores opt:
                     296 z-score: 340.2 E(): 1.3e-11 25.3% identity in 379 aa
                     overlap and Alcaligenes sp. (strain BR60) SW:CBAC_ALCSB
                     (EMBL; U18133) 1-carboxy-3-chloro-3,4-dihydroxycyclo
                     hexa-1,5-diene dehydrogenase (497 aa), fasta scores opt:
                     300 z-score: 345.3 E(): 7e-12 32.4% identity in 216 aa
                     overlap. Contains a Pfam match to entry PF01408
                     GFO_IDH_MocA, Oxidoreductase family"
                     /product="oxidoreductase"
                     /protein_id="NP_624605.1"
                     /transl_table=11
                     /translation="MSTRDQIPDRHLRVGVVGVGQRADMAALVNRSGAARIVSCADPDP
                     RGREDARRLFGADVVVHDRYERMLDDELDAVFVLTPDHLHTEPALCFLAAGVAVFVEKP
                     LTITVADCDALLMAAFRSRTRLYVGHNLRHLPVLRRMRELIDDGAVGRVRAVWCRHFVG
                     HGGDFYFKDWHAQRANTTGLLLQKGAHDLDVVHWLAGGFSRNVVAQGALAVYGDNPRRA
                     TQETVPPGQRMPDWFDPEVWPPSALRDLNPVVDVEDISMMLARLDNGVLASYQQCHFTP
                     DYWRNYTVIGDEGRLENFGDGIDGDAARVDVWNRRRSGYRADADLSVPVVASDEETHGG
                     ADRALVEEFLRFAAAGGPTETSPVAAREAVAAAVAATTSLRSGSTPVDVPPLDPAIVRH
                     FAEHQPAEGADGSGPQPR"
     PFAM_domain     21093..21449
                     /aSDomain="GFO_IDH_MocA"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF01408.25"
                     /db_xref="GO:0000166"
                     /description="Oxidoreductase family, NAD-binding Rossmann
                     fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0276_0102"
                     /evalue="2.10E-19"
                     /gene_ontologies="GO:0000166: nucleotide binding"
                     /label="SCO0276"
                     /locus_tag="SCO0276"
                     /protein_end="130"
                     /protein_start="11"
                     /score="70.6"
                     /tool="antismash"
                     /translation="LRVGVVGVGQRADMAALVNRSGAARIVSCADPDPRGREDARRLFG
                     ADVVVHDRYERMLDDELDAVFVLTPDHLHTEPALCFLAAGVAVFVEKPLTITVADCDAL
                     LMAAFRSRTRLYVGH"
     misc_feature    21093..21935
                     /gene_synonym="SCF85.04"
                     /locus_tag="SCO0276"
                     /note="Pfam match to entry PF01408 GFO_IDH_MocA,
                     Oxidoreductase family, score 148.90, E-value 8.6e-41"
     PFAM_domain     21483..22226
                     /aSDomain="GFO_IDH_MocA_C"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF02894.20"
                     /description="Oxidoreductase family, C-terminal alpha/beta
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0276_0103"
                     /evalue="1.10E-20"
                     /label="SCO0276"
                     /locus_tag="SCO0276"
                     /protein_end="389"
                     /protein_start="141"
                     /score="74.5"
                     /tool="antismash"
                     /translation="RELIDDGAVGRVRAVWCRHFVGHGGDFYFKDWHAQRANTTGLLLQ
                     KGAHDLDVVHWLAGGFSRNVVAQGALAVYGDNPRRATQETVPPGQRMPDWFDPEVWPPS
                     ALRDLNPVVDVEDISMMLARLDNGVLASYQQCHFTPDYWRNYTVIGDEGRLENFGDGID
                     GDAARVDVWNRRRSGYRADADLSVPVVASDEETHGGADRALVEEFLRFAAAGGPTETSP
                     VAAREAVAAAVAATTSLRSGSTPVDV"
     gene            complement(22495..23163)
                     /db_xref="GeneID:1095701"
                     /gene_synonym="SCF85.05c"
                     /locus_tag="SCO0277"
     CDS             complement(22495..23163)
                     /codon_start=1
                     /db_xref="GeneID:1095701"
                     /gene_synonym="SCF85.05c"
                     /locus_tag="SCO0277"
                     /note="SCF85.05c, unknown, len:222 aa. Low similarity to
                     Haemophilus influenzae SW:PEPE_HAEIN (EMBL; U32740)
                     peptidase E (EC 3.4.-.-) (alpha-aspartyl dipeptidase) (226
                     aa), fasta scores opt: 134 z-score: 169.6 E(): 0.043 24.4%
                     identity in 209 aa overlap."
                     /product="hypothetical protein"
                     /protein_id="NP_624606.1"
                     /transl_table=11
                     /translation="MNFLLTASGLRNETLRDALRDMLGKPFGSANVVFVPTASVADPGD
                     HGWVVADMNRLHGLGWREFDILELNGLPQQMVLDRLLHADVVYVEGGNHYHLARSITGN
                     GLVDGFLEALQSRVYVGVSAGSMIFSRNLTGHSADVIGDATDLHVLGATSVEPPFGLFD
                     WYLKPHLYSPDFPERDDAWADRITARADFPIYFIDDETAVRVRDGKADVVSEGRWRFHP
                     "
     PFAM_domain     complement(22528..23157)
                     /aSDomain="Peptidase_S51"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF03575.20"
                     /db_xref="GO:0006508"
                     /db_xref="GO:0008236"
                     /description="Peptidase family S51"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0277_0104"
                     /evalue="1.50E-54"
                     /gene_ontologies="GO:0006508: proteolysis"
                     /gene_ontologies="GO:0008236: serine-type peptidase
                     activity"
                     /label="SCO0277"
                     /locus_tag="SCO0277"
                     /protein_end="212"
                     /protein_start="2"
                     /score="184.9"
                     /tool="antismash"
                     /translation="FLLTASGLRNETLRDALRDMLGKPFGSANVVFVPTASVADPGDHG
                     WVVADMNRLHGLGWREFDILELNGLPQQMVLDRLLHADVVYVEGGNHYHLARSITGNGL
                     VDGFLEALQSRVYVGVSAGSMIFSRNLTGHSADVIGDATDLHVLGATSVEPPFGLFDWY
                     LKPHLYSPDFPERDDAWADRITARADFPIYFIDDETAVRVRDGKADV"
     regulatory      23247..23252
                     /regulatory_class="ribosome_binding_site"
     gene            23258..23872
                     /db_xref="GeneID:1095702"
                     /gene_synonym="SCF85.06"
                     /locus_tag="SCO0278"
     CDS             23258..23872
                     /codon_start=1
                     /db_xref="GeneID:1095702"
                     /gene_synonym="SCF85.06"
                     /locus_tag="SCO0278"
                     /note="SCF85.06, MutT domain containing protein, len: 204.
                     Similar to the MutT domains of other proteins e.g. Bacillus
                     subtilis SW:YZGD_BACSU (EMBL:U17168) hypothetical 45.4 KD
                     protein in thiaminase (413 aa), fasta scores opt: 138
                     z-score: 176.6 E(): 0.017 36.1% identity in 97 aa overlap.
                     Contains a Pfam match to entry PF00293 mutT, Bacterial MutT
                     protein."
                     /product="MutT domain-containing protein"
                     /protein_id="NP_624607.1"
                     /transl_table=11
                     /translation="MTSSDHPLKASLDEPRAHLLDLIGAVEPWDDLEHTHLESARHWIA
                     GGAPLYRVRKPDVPPMHLVSYFAVLDDTRGQLLLVAHRKAGLWLPAGGHVESGEDPWAA
                     VVRECREELGIEAVASPVAGELPFFLTVTGTRGQGPHTDVSLWYLLDADAHTVTDYDRG
                     EFSAVRWLTHEQVLAASAELLDPHMHRFARKLAWARAGRGG"
     PFAM_domain     23447..23806
                     /aSDomain="NUDIX"
                     /aSTool="clusterhmmer"
                     /database="35.0"
                     /db_xref="PF00293.31"
                     /description="NUDIX domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_SCO0278_0105"
                     /evalue="8.10E-20"
                     /label="SCO0278"
                     /locus_tag="SCO0278"
                     /protein_end="183"
                     /protein_start="63"
                     /score="71.3"
                     /tool="antismash"
                     /translation="VSYFAVLDDTRGQLLLVAHRKAGLWLPAGGHVESGEDPWAAVVRE
                     CREELGIEAVASPVAGELPFFLTVTGTRGQGPHTDVSLWYLLDADAHTVTDYDRGEFSA
                     VRWLTHEQVLAASAEL"
     misc_feature    23489..23602
                     /gene_synonym="SCF85.06"
                     /locus_tag="SCO0278"
                     /note="Pfam match to entry PF00293 mutT, Bacterial mutT
                     protein, score 22.80, E-value 5.1e-05"
     regulatory      23939..23942
                     /regulatory_class="ribosome_binding_site"
     misc_feature    complement(24437..24451)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.2"
                     /tool="antismash"
     misc_feature    24438..24452
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.04"
                     /tool="antismash"
ORIGIN
        1 cgccacggca tcaccgtcaa cgcgtactgc ccgggcatcg tcggcaccga catgtgggac
       61 ctgatcgacg agcggctggc cgaggaggcg ggcatcgaga agggccaggc catcaagaag
      121 cacgcggagt cgatcgccct cggccgggtc gaggaacccg ccgacgtagc ggccttcgtc
      181 tcctacctgg cctcacggga ctcggactac atgaccggcc agtcggtgat gatcgacggc
      241 ggtatccagt tcgcctgacc cgcgccgtcc ggcccttctg ccccgcaccg ccgaacaccg
      301 gcccgttcgg cccaccgtcc accgcgaacc gaggagtgac cgatgtattc caaggacggc
      361 gagaactatt tcatcgtgga cgcgcacgtc gccctctggg acgcgcgccg cgagaaccag
      421 cgcaacatcc acggcaagca gttcatcgac tgcttctacg actaccaccg caacctgagc
      481 ccggcgtcgg agctctggcc gtacgaggac ttcctgtacc agggcggcga gcggctgatg
      541 aaggacctgt tcaccgacgg gtacgtggac cacgcgatct tccagccggc gcatctcggg
      601 gcgttctaca acaccggctt cgggcagacc gaggaggcct tcgcgctcac gcgcaagcat
      661 cccggcatgc tcacctacaa ccactgcttc gacccgcgct tcgaggaggc gggcctgaag
      721 caactgcgcg aggacgccgc ccgcttcggc ctgaagggcg tcaagctcta caccgccgag
      781 tggaagggcg actcccgcgg ctacaagctc agcgacccgt ggacctaccg ctacctggac
      841 gcctgccggg agctgggcat caagaacatc cacgtccaca agggccccac catccggccg
      901 ctggaccggg acgccttcga cgtggccgac gtcgacgcgg cagccagcga cttcaccgac
      961 ctgaacttcg tggtcgagca ctgcggtctg ccccgcctcg aggacttctg ctggatcgcc
     1021 acccaggagc ccaacgtgca cgcggggctc gccgtcgcga tcccgttcat gcacacccgg
     1081 ccccgctact tcgcgcagat catcggcgag ctgctgtact ggctggacga ggaccgcatc
     1141 cagttctcca gcgactacgc gctgtggacg cccaggtgga tcgtcgagca gttcgtcgac
     1201 ttccggatcc ccgacgacat gacgggcgag tacccgcagc tcaccgtcgc ccagaagaag
     1261 aagatcctcg ggctgaacgc ggccgccatg tacgacatcg aggtcccggc gggcctcggc
     1321 ctcgccgagc cggcggtggt ctgacatgtg ggccgcgcaa ctcgaggtgg cggcgcgcgc
     1381 cgcgctcgac acggtgtacg accccgagct ggacgagccc gtcaccgacc tcggcttcgt
     1441 gcgctcgctg accgccgagg acggccgcgt caccgtgcac ctgcggctgc cgacctcgtt
     1501 ctgctcaccg aacttcgcat acctcatggc ctccgacgcc aaggacgcgc tcagcgccct
     1561 gcccggtgcc cgggaggtca cggtcctgct cgacgaccac cacgactccg atctcatcaa
     1621 ccgggggctg gccgccgacg ccgggtaccg cggcaccttc ggccacgagg cggagcagga
     1681 cctggaggag ctgcggggca tcttccggcg caaggcgcac accgccgcga tggaacgggc
     1741 gctcaccgcg ctgctgcgcg cccggcccga cctggccgag gaacagctcg gcgacgtcgt
     1801 cctcggcgac ctgccggaca cctctgccac ccgggcactg ctgcgccgcc gcgccgccct
     1861 cgggctcggc accgcccctg ccgacccggc gctcgtggac gacgacggcc ggccctgccc
     1921 gcggggggag gtcccgttgc ggctgcggtt cgcccgctcc gtgcgcatct ccatcgacgg
     1981 caacgcccac ttctgccggg gcctgctgcg cacccggtac ccgcagtccg cggccgacca
     2041 gtccgcgcgc ccggaggagt tccccgcggg cggggaaccc gtaggggccg gggaaaccgt
     2101 acccgcgggt gagctcttcc ggctctccgc tccggcgaag gagaacgtct cgtgaaagca
     2161 gtccaggtgg tgggctacgg caagaacctc gagatggccg aggtcccggc ccccgaggtc
     2221 accggcccgt acgacgtgat cgtcaggatc ggcggcgccg gggtgtgccg taccgacctc
     2281 cacatcctgg aggggcagtg ggccgagaag tcgggggtgg agctgccgta cacgatcggt
     2341 cacgagaacg ccgggtgggt gcacgcggtc ggcagcgccg tcaccaacgt gtccgagggc
     2401 gacaaggtca tcgtgcaccc gctgatcacc tgcgggctgt gccgggcgtg ccgggccggt
     2461 gacgatgtgc actgcgagaa caaccggttc ccgggcatcg acaccgcggg cggttacgcc
     2521 gagtatctga agacctccgc gcgcagtgtc gtacggctcg acgactccct cgaaccggcg
     2581 gacgtcgccg ctctcgccga cgcgggcctc acggcgtacc acgcggcggc caaggcggcc
     2641 cggagactga ggccgggcga ccgctgcgtc gtgatcggcg cgggcggtct cgggcacatc
     2701 ggcatccagg tgctgggcgc cctcaccgct gccgagatcg tcgtcgtcga ccgcaatccc
     2761 gacgcggtcg acctggccgt ctccgtcggg gccgaccacg gtgtcctcgc cgacggcggc
     2821 cacgtggacc gggtgcgcga gctgaccggc gggcacggag cggaagcggt gatcgacttc
     2881 gtcggtgagg gcggctccac cggggacggc atcggcatgc tgcgtcgggc cggcgactac
     2941 cacgtggtcg gttacggcga gaacatcgac gtcccgacca tcgacgtcat ctccgccgag
     3001 atcaacttca tcggcaacct cgtcggttcc tacaacgacc tgtgcgagct gatggtcctc
     3061 gcggcgcggg gccgcgtgcg cctgcacacc gccaagtact ctctcgaccg tttccaggac
     3121 gccctggacg acctggacgg cggccgcatc cggggccgcg cgatccttgt cccgtgaccc
     3181 ggccccgggt gacggagccc cgagcacgca caacgaagga agcaagacct tgatcttcat
     3241 caccgcgaag ttccgtgtcc tccccgagca tgccgaccaa tggccgcagg tcgtggagga
     3301 cttcacccgc gcgacgcggg ccgaaccggg atgcctgtgg ttcgactggt cccgcagcct
     3361 cgacgacccg accgagtacg tcctcgtgga agccttccgg gacgacgagg ccggtgcggc
     3421 ccacgtgggc tcggcgcact tcaaggcggc ccagcagacg ctgccgcccc acctcgcgac
     3481 gacccccagg atcgtcaacg ccaacgtgcc ccaggacgac tggtcgctgc tcggcgagat
     3541 ggcggtcgac gcgggctgac gccggcgagc gtggcagagg ggcgacagcc ggtcgtacgg
     3601 ctgccgcccc ctcggccggt ccggcggccc ggccgaggtc agccgatctg cttgatcacg
     3661 cgggcgggca ctcccgcgac gacggtgccc gcagggacat cacgggtgac caccgcaccg
     3721 gcagccacta ccgcgcccgc accgatggtc accccctgcg tgatcacggc ggccgtgccg
     3781 atccacacgt cgtcctcgac gacgatcggg gcgaaggaga ggtgtgcgcg gcgctcggcc
     3841 aggggcagcg gatggcctcc ggtgacgagg ctggccttcg gggcgatcat gactcggttc
     3901 ccgatgcgga tgcctccctt gtccatgaag gtgcatccct gattgacgaa gacgttctcc
     3961 ccgaacgtcg tgttcagccc gtactcggtg aagaacggcg ggtagatcgt caccgattcc
     4021 ggcagtgggc ctccgaacac aacggaaagt agttccgaac gacctgcact gtcgctgaac
     4081 ggaagcacgt tcagtcgaga cgtcgcatcg gtcacctcca cgatccgctc cgcatgacgt
     4141 gcgaactcgg gcgtatggac atacatgatc tgctccgtgc gggtggacat gcgccgatcc
     4201 catcaccgcg cggaaccgtc gatcaaacaa cccgcaccgc atcggacaca acccgcagtt
     4261 gtggaagtag gctgatggcg tggatgtgga agcgctgcgg acgttcgtgg tcgtcgccgg
     4321 ggtcggccag ttccaggccg ccgccgacga gctgggaatc agccagcagg cggtctccaa
     4381 gcggatcgcg gccctggaga ggcatgtcgc ggtcacgctc gtggtgcgaa gttcccgagg
     4441 ttcccggctg agcctggacg ggcaggtctt cctgccgcac gccaagaagg tcctgaccgc
     4501 cgtcgagcag gccgagcggg ccgtcaaccc cggaagccgc ccgttgcgcg tcgatgtcct
     4561 caatcggcgc atctcccccg cccaggccgt ctaccggttc taccgctccc gccccgagac
     4621 ggacctggac gcggtcacgc tggacaagga gaacgccgca caggccgcac aggcggtgct
     4681 cgaaggggtg gtcgacgcgt ccttccgcgc cttgccggca gaccgggtcc cgaccgggat
     4741 caccgccgaa cgactcctgg acgaacccct ggaactgctc gtcggccccg gccacccgct
     4801 ggccgacgcg ccccggatca gcccggtgga cctggccggc caccgcatct ggatccccgg
     4861 gatcaggccg ggtacggagt gggccgcgtt ctaccaggca ctgtccgagg ccttcggcct
     4921 gagcatcgac gcgctcggcc ccaacttcgg tgacgaggcc ctgatggacg cgctggccga
     4981 ctcggcctca ctggccaccc tcgtcgggcg gggagaccgg tatctgtggc cccgaaccca
     5041 cgatctgcgg cgcatcccgt tgcacgaccc gacaccgttc tacccgcacc tgctgctgtt
     5101 ccgcaccgga gaccggcacc ccgtgctgac cgcgctgcgt gaccacctgc gcaccacggc
     5161 cccgcgtacc ccgcacgacg cgtggacgcc ggactggaca gtgacagtgc actgatcgtg
     5221 cgtctcccgg accggcattc agggcaggta ctgctcaatg ctgcggtggc ggacgacgcc
     5281 gtgcgcgaag tcgggtacgt gtgcggtgcc ctcccgcagg tcgtccagga accgttggta
     5341 ggcgtgggcg accgcatagg ccggcgcgtc ggcccggggt tccagtcgcg cgacacgggc
     5401 gtacgcttcc ggcaccgtca ggggtgcgag ggcggtggac gttccgcggc cgccctcaag
     5461 ggtgagcggg ctgagctgcg ggtggccgac cggggcggtg aggacgaggt cgccctcggt
     5521 gccgttgatc tcccagcgga aattggttcc ccgggacatt cctccgcggt agtggaatgt
     5581 ggcgaccgct ccgcccggca gccgtcccga ggccaccacc tggtctgcgg cggtcatcgg
     5641 cacgggccgc ccggtctcgg tgtccacggc cgacgtacgc cgggacgccg cctggatccg
     5701 cagttcctcg ggctctccga ggaccgacgc gactccgtcg agggcgtgac cgaagggaac
     5761 ggtcagcagc gtcgcgccgt tcgccgcgtc gagtacatgg tggtcggcgg ggccgacggt
     5821 ggcgccccaa gcgccgccgg agccgacgac cgtcgtggac agcacctccc ccacgtaacc
     5881 gtcggccacg agatgccggg tgtaggcgaa cgccgggtgg gaccgtgcct ggagaccgac
     5941 gacggtcggc acggcgtgag cgcgcgccaa ccgagccatg tcctccgcct cggcgagccc
     6001 gttgcccagc ggccactcgc acagcacgct cttgccggcg ttcagcaccg tccgtacgag
     6061 ttcccggtgg tgcggcacct tcaccgccac gaccacgagg tccacctcgt cgcaggccgc
     6121 cagttcggcg gccgtaccga aggcacggcg cacaccgtgc ttgtgtccgg agcgctccgc
     6181 cgattgcttc gaactcgtac tcagggcccg cagctcgaat cccccgacgg cacgcagggc
     6241 ggggaggtga gagcgttcgg cccagctccc gtgcgccccg agtcctatga ctcccacgcc
     6301 gatgggcctg ccggagcggg ccaggtcggc aagcgctgac ccgggtgtgt tcatgattcg
     6361 tcaccttttc caacggacct gctagcgttg acatctcaac actaggaagg gtgcgttgac
     6421 atgtcaacac gcggccgggc tcccgatccg caggagggca cgagcgaggc agcactggat
     6481 cccatcggtc tgtggtccgc cttcaagcgc gcccacgagg tggtccgaac ccgcgtgata
     6541 gccgacgccg cggaggcggc gggcctctcc gagccggacc tgaccatcct cgccgacctc
     6601 aacaaggcgg gaggcgcctt gcgccagagc gaactcgccg cgtcgctcgg ctgggaccgc
     6661 acccgcgtct cccaccagct cacccgcatg agcaagcgcg aactcgtcac ccggcggcgc
     6721 gccaacggcg tgatcgtcgt tctcacggac gccgggcatc aggccatcac cgccgtgtac
     6781 cccggcctgg acgccgcggt acgccgccac ttcaccgaca agctctccac gcaggaggtc
     6841 gaaacactgg ccgccgtcct tgaccggctg taaccgtccc ggccccgcca ccacacggtg
     6901 tgccggcgcg acgggcgaga gtcaccacgg agtgtcacgc tggatcacac aggaactgcg
     6961 aaagggaacg tccgtgatca ccaacgactt cgcccccggc tccccctgct ggctcgacct
     7021 cgggtccccg gacgtcgccg ggacggcggc cttctacggc ggcgtgttcg ggtggacgta
     7081 cgaggccatg ggggaagacg cggaaggcgg catgttccgc aaggacggca agatcgtcgc
     7141 cggtctcggc aggctcaccg aggaaggcgc gcgctccgcc tggatgatct actactccgt
     7201 caccgacgcg gacgccacca ctcaggcggt gcagcgcgcc ggcggcacgg tgcgggtggc
     7261 gccgacggac ctggacgact ggggccggat ggctcagtac agtgacccgt ccggcggtca
     7321 gttcgccgta tggcagccgg gccggaccag gggcgtcgag ctcgtggacc agcccgggac
     7381 gctgtgctgg acggagctgt acacgagcga cgccgcggcg gccaaggagt tctacggcgg
     7441 ggtcctgggc tggcggttcg gcgacatggc ggtgccgggc ggcgaaggca cgtactccct
     7501 catcactcct tccggcctgt ccgaggaccg gatgcacggc ggcctgatgc agctcgacga
     7561 gcgggatctc accctgacgg gcggccgggc gtactggcac ccggtgttcg ccgtcaccga
     7621 ctgcgacgcc gcggtctccg cggtcacggc gcatggcggc agcgtgcaga tggggcctgc
     7681 cgacgcggag ggcgtcggac gtctggcggt gtgcctcgat ccgtcgaagg cggacttcgt
     7741 ggtgctggct ccggcctcgg gatgaccacc tgggcgcggc ggccgggcag cccccgccgc
     7801 ggctgatcac gtgacgggct ccggcggcgt cgaggcggtc ggaaccccgg ggccggtcgc
     7861 cgccgcctgc cacgcgcccg gacgctcgcc cgtggccttg tggaagaaca ccgagaagtt
     7921 ggacgcgtcg gggaagccga ggacgccggc gcagcgggcg gcggtgagtc gctcgtgcgc
     7981 gaggagccgc ttggcctcca gcacgagccg ttccacgagg tatgccttcg ccgtacggcc
     8041 ggtggcctgc cgcaccgcac gtgagagggt gcggggcgcg tatcccagcg tgcgggcgta
     8101 gtagccggcg tcgtggtgct gccggaagtt cgcctcgacg ctggagcgga acaggcggac
     8161 caccggatgg gcgagtcgtg cttcggcgtg cggcgggtgc agccgcgcga tgagtgcgga
     8221 gagcaggatc gcgggcagtt ccgtcgagga gtcactcggt ggggcggacg cttcgaggcg
     8281 gagatggccg cgcgccgcgt cgacgaaggg ccagtcggcg gcggggacga tccagtgcgc
     8341 tgccgggtcg ggggaggcga cgagttcgcg ggtggcgtgg gtgacgggag cggtcggcac
     8401 gaacagtacg aggtgcccct ccacctcggc gacgtcgtcc caccggtgca ccgcgccggg
     8461 gggaatccac accgcggacc ggtcctggag ggggtggagg cggaagtcga ccgtgacgga
     8521 gccgcgtccg gcgtcgacga cggcaaggac gtggaagtcg gcgcgctgcg tgccgccgtc
     8581 gttcagctcg cggaggcggc cgaacgtcat cgtctcgacc gaggcggcgc cgcggccggg
     8641 gggctggtag gtcatctgcc ggatcgcgct cacgtgtcca gttttcacca tcgcgcgacc
     8701 gctcacgccg atgcccggtc cgggtgcgag gggttcgatg gacacacggg gcagccgccc
     8761 cgggcatcga acgagaagag ccatcatgag caccacgcag cacacgcttg tgcccgttta
     8821 cgaccatcgg accgggaccg ggccgaccct tgtgttcctt cactactggg gtggttccgc
     8881 ccgcacctgg gacctcgtcg tcgaccgcct gccggggcgt gccgtggtcg cggtcgactt
     8941 ccgcgggtgg ggccggtcga gggcgctccc cggcccctac acgctcggtc ggttcgccga
     9001 cgacacgctc gccgtactcg cggacgcggg catcaccgac tacgtgctgg tgggacattc
     9061 gatggggggc aaggtcgccc agctggtggc ggccacccgg cccgcggggc tgcgcgcaat
     9121 cgttctcgtc ggctccggac ccgcgaagcc cgccgcccgg gtcactcccg agtaccggga
     9181 agccctgtcc cacgcctacg actccgccga gtccgtggcc ggggcacggg accacgtcct
     9241 cacggcgacc gagctgcccg ccgcgctcaa ggcgcggatc gtgaccgatt cacggaacgt
     9301 caccgacgcc gcccgcatcg agtggcccct gcgcggcatc gcgcaggaca tcaccgagca
     9361 cacccgccgg atcgacgtgc ccgctctcgt ggtcgccgga gaacacgacc aggtggaacc
     9421 ggccggtgta ctccgcgaca acctggtgcc ctacctcgcc cgagccgact tcgtggtggt
     9481 cccccgcacc ggacacctga tcccgctgga ggctccggcc gacctggccg acgccgtcac
     9541 cgcgttcgcc acggcggtct gaccgtcccc gcggctccgg gcgggctggg agcggggccc
     9601 gttgcgcccc atatccccgc gagcggccga cacttgatca atggctcgtt ttcgtctacc
     9661 gactgtcagt ggcgtgggca atggttgcgc atgtccgggc cccgaccggg gccccgcgtt
     9721 tcgagtccgt gcaccccaac acccaaggga gaagcatgcg taccgagatc gttctgtccc
     9781 acgaagcccc cgagctcgac ctcgacctgg acctgcgcgt ctccgatctc ccggagcagg
     9841 ccgcgtcgtt cggcgagggc accttcacgt cgccgagcag ctacgcgatc ggcacgcgct
     9901 gccccatctg ctgctgacgg accgaggccc cctcggggct cttccgagcg gggcggcccg
     9961 agtccgcccc gctttccgta cgacggcgag gagcacacac gtggcggcgg agtccgaagc
    10021 ccaccgggca gcagcggtct tcgaggtacg ggagcccgta ctggtccgga tggcgagccg
    10081 gccgcgggga gccgctccgg ccacggtcga cgcggccgag ccggtctccg gagcgcggca
    10141 gctcgccgcc gatcccctgc tcggccaggc ggtccgggtc gccagcggct cgctggccca
    10201 cagcctggcc cgtctgacca ccgacgaggg cgcctccgcc ctggggcgca agcggaccct
    10261 gagcgccgcg cggaccctga cccggtacgc tcgccgcgcc ggggcgcgcc ccaccccgtt
    10321 cggcctgttc gcgggtgtcg gcacagcccg gttcggttcc gtggccaagg ccgggccggg
    10381 gaccggtgag gtcgcggtcc ggctcgacgg ggcgtggctg cgccgacggg tactggcctg
    10441 gctcgaggag ccctccgtcc gccggcgcgt ggacgtcgta ctcaacgacc tgtgtttcgt
    10501 gcgggacggg cggctgtatc tgcgtaccgg tgcgcaggag cagtcggtgc gcgacaacgc
    10561 gctggtcggc gccgtgcgcg agcgggcgcg gaatccggtg ccgtacgcgg acctcctcgt
    10621 gtcgctggcg gaacgcttcc cggcgctgga cgccgagcgg ctcgacggtc agctggccgg
    10681 tctcctgcaa cacggcttcc tgctcacctc gatcaccccg caccgcatcg acgtcgcgct
    10741 gctcgacggc atcgaggcgg tcctggacgg ggcgcttccc gacgacgcgc gggcgctgcg
    10801 ggacgtacgg gcggcctgcg cccggcatca gcaggatcct ccggggatgg gcggcgactc
    10861 ctggcaggac gccctggacg cggtccgccg gctcgatgtc cccggaacgg gcgacgacgc
    10921 gcacgcccgg ccgcctctgc acgtggatct gcacgtgccc ggggagttcg tcgtccccga
    10981 ggcggtcggc cgggaggtgt gccggtacgc ggccgcgatc tgggcgatca ccccgcagtg
    11041 gacgacgctg gcgtacatgc gggactaccg cgagcgtttc atcgagcgct acggcaccgc
    11101 ctgtgccgtg ccgttgggcg agctggtcga cccgcaccgc ggactcggcc tgccctccga
    11161 gtacggcgcg gagccggtgt acgcgcgcgg cggccccggc gacgaggcgg acgggcccag
    11221 gcgcgcgatg atcggcgagc tgttgcagga ggccgtcctg tccggcggtg acctggtgct
    11281 gaccgacgag gtcgtagggc gtctgggcga ggtcgccggg cacgatcccg cagccgcgcc
    11341 gccgcgcagc ctcgaactct gcttccaggt gctctccgag agcaccgcgg cgctggaccg
    11401 cggtgagttc cggctgctcg gcagcccgca catcggcgcc tggaccgcgg gcgccaccgc
    11461 ggggcggttc gcggcggcgg ccggcctcac cgacgaactc gcccggctgg ccgccgagag
    11521 caccgacgac acggtgatca cggcgcaggt cgagctgatg ccccacgagc cgcgcgggct
    11581 caacatcgtc caagtgcccc ggctgctgcc gtaccgcatc cccgtcggcg tacccgacga
    11641 ccggcgcgac ccccgctgtc tggactggcg ctcgctgctc gtcgccgccg gctccgacgg
    11701 actgcggctg ctggatccgc ggagcggccg tccggtccgt cccgtgctgc cgcacatgct
    11761 ggccctggac acgcaggcgc cgccggtggc ccggttcctc atggatctcg cgaccgcccg
    11821 gccccgcgtg tggtcgggct ggaactgggc ggggcacgac gcgctgccgt atctgccgcg
    11881 ggtccggtac gggcgggtgg tggccgtgcc cgggcgctgg ttgccgggcc gacggctgcg
    11941 cgacgcggcc cgggcacagg gcgccggggc atgggagcag ggcctcgacg cctggcgacg
    12001 gcggctgtcc gtaccggacc ggctgcagat cgcgcgcaac gaccagatgt accccgtcga
    12061 cctgcgtgag cgttgggacc gggacctgtt gcgtgccgaa ctgacggccg cacagcctcg
    12121 gttcgtcctc tacgaggatc tgacggcgga cggcgccggg ctcggctgga acggcgggca
    12181 cagcacggag atcgtggtgc ccctcgcggc ggcgcgacgg gccgccgggc gcacggcgcc
    12241 ggggcgcgcc gagccggcgc ggggacggac catcccgccc gtgcggcccg ttcccgtccg
    12301 gcctgctccg gtccggatcc atctgccggg cgaggactgg ctgttcgtca agtggtacgc
    12361 cgaaccgtcg gcccacgacg ctctgctcac cgagcatctg cccgccttgc tctccgaggt
    12421 ggaggacgag gtcgaccgct ggttcttcct gcgctaccag gaccccgagc cgcatctgcg
    12481 actgcggttc cacggcgaac ccggggcgct gaacggtcgg gtgctgcccg cgatcagccg
    12541 ggtgactcgg gtcctcgtcg agagcggggc cctgcggacg atggccctcg acacgtaccg
    12601 gcccgagagc gaccggtacg ggggcgaggc cgtgcaggag gccgccgagc gcttcttccg
    12661 caccgacagc ctgtcggcgc tcgtgcagtt gcgcgcgctg cggggccccg cgcgggcgct
    12721 ccccggtgcc gtgctcgccg ggctcgggca cgcggtgctg ctggaatccc tcggggactg
    12781 ggactggtgc ggctgggtcg accggatgtt cacgaagacc gtggagcacg aggtctacca
    12841 gcggcaccgg gccgtcgccg accggctgat cgggccgggc cgcgcggtgt cgtcggccgc
    12901 ggcggcactc ggggcgccgt ccctcggcgc gctgtggtcc gagtcgcccg agccgcgcgc
    12961 ctacggggag ttgatcctgt ccgccccgga ggccgaccgc gacgaggccc tcctgtcgct
    13021 gctgcacatg cggcacaacc gcctcttcgg catcgaccgg gcggccgagg cgcgggggta
    13081 cgcggtgctg cgtggcgcgg tacgcaccca tgccggccgc cggcggcacg agagcgggag
    13141 cgggatcggg agcggacgat gagcggcacc accgagggcg ggtcaccgga gcacacgatg
    13201 gacgggttca gcgggagcgg gacgcgcgag gccccggccg gcgagtcccc tcgggccctc
    13261 cgggaacggg ccggagccgt ctccgccgag atcctggacc ggctcgccga ccccgccgcc
    13321 acggtggcgg ccacgcgcat ccccgcccag gcggcggacg acggggtggc cgaaccgatc
    13381 tgggccgagc tcaccctcgg cagcggcagc cccgggctgg cgctggcgtt cgcgggcgcc
    13441 tcccgggacg cggcgcggca ggtgccgcgc gcccacgcgt atctcacggc gggaacccgc
    13501 gccgtctcgg ggcggcccgg caccgcgggc ggggtcttca aggggccggg ggccctggcg
    13561 ttcgccgtgc tgctcgccca ccgcaccacc gggggctacg tctccgcgct ccagcgcttc
    13621 gacgcctacc agcgcgacct cgtgcggacc gtcctgccgc ccgtggagga ccggccgctg
    13681 cccaccatcg gtcactacga ggtggtccgt ggtctgaccg gcgtgggccg ctatctgctg
    13741 gcccgcgcgg agagctgcga ggagccgctg acggcggtgc tcgactacct cgtgcgcctg
    13801 tcgctcggca ccgtggagca ccaaggcgcg gacgtgccgc gctggtgggc cctggacgcg
    13861 cccaggatcg gctccgaggc ggcgttcccc ggaggccatc tcaacctggg cctctcgcac
    13921 ggcgtcgccg ggccgctcgc cctgctggcc ctggcctggg agcagggtgt gcgggtgccg
    13981 cggcagcggg aggccatgga ggcgacggcc gcgctgctgc ggacctgggc ggtcgcggac
    14041 cggtacggcc tcttctggcc cggctacctc tccttcgcgc agtggcaacg ggggcccgcc
    14101 gcctacgacg gcaccgcgaa gtggccggcc tggtgctacg gggctcccgg agtttcccgc
    14161 gccctgcaac tggccggacg ggcgctcggc cgggcggact tctccgacct cgcccgcgcc
    14221 tcggtggaac ggctgctggt cctcccccgg ccggcctggg gcatcgacga ccacgccctg
    14281 tgccacggtt gggccggggc gctgcaccag ctcggccggc tcaacgaggg gtggcaggac
    14341 tcgcggctgg ccgaactgcg ggacggcatc gccgccgacc tcgtctccgc cttcgaccct
    14401 gaactgccgt tcggactgcg cttcacgatg acgaaggtgc cgttcggctc cgacgtctcc
    14461 ggctacctcg acggggccgc cggtgtcgcg ctcgccctgg actcgtacgc ggcggccggc
    14521 acaccggccg actgggacat gccgttgctg ctggcctgac ccgcggggcc ggggacgatc
    14581 acgtgaccgc ccgttcacgg cgatccgggc tgccctcggc gttgcggaag gcagccgtct
    14641 gccgcgtcgc ggtctgagag tgcgcatggg ctcagcctcc gggaacggat ggggagtcag
    14701 ccgcccgacg gtgcctggcc tgccgacccg cctcgtcgtt atgcgacagc attgacaaag
    14761 tttcgctctt gctcatcaat atgttgtcca cggtgcccca ctggcaagag gtgcggcgcg
    14821 aatcccttcg gaggggaacc atgggcgcac acacggcggt ggcgccaccg catccaggtg
    14881 ccggtacgtc gccgggcggg gcctcggcgc cgcgccggac tcgccggccc cgcgacgacc
    14941 ggaaggcggc gtggctgttc ctggcgccgg ccctgctcgg cttcgcgctc ttctacgcgt
    15001 atccgaccgt gcggggcatc tactactcgc tcaccgacta cagcctcatc gccacgcccg
    15061 acttcgtcgg cggggacaac tacagccggc tgatcggcga cgagcagttc tggaacgcac
    15121 tgcaggtcac cggctactac gtcctggtga acatcgtgtc gcagaccctg ctggcactgg
    15181 tcctggcgac gctgatgcac cgtctgaccc gatcggtggc actgcgggcg atgctgctgg
    15241 tcccctggct ggtacccaac gtgaccgtgg gcctgctgtg gatgtggctg ctcgacacca
    15301 acctcggcct ggtcaaccat gtactgaact ccatgggcat gggcaccacg ggcttcttca
    15361 cctcccccga ctgggcgatg ccgagcgtgg ccgcggtcaa cacctgggcc tacaccggct
    15421 acacggcgct gctgctctac gccggcatgc ttcaggtccc gcagtacctc tacgagagcg
    15481 cctcgctgga cggggccggt gagtggcgga tgttcacgag gatcacgctg ccgctgctgc
    15541 ggccggtgct ctcgctggtg ctggtggtgt cgctcatcgg ctcgttccag atcttcgaca
    15601 cgatcgccgt gaccaccaag ggcgggccgg tcagcgccac ccgggtcatc tactactaca
    15661 tctacgaaca ggccttcacc aacttccaca tgggctacgc ctccgccgtg gccgtggtgc
    15721 tcgcgctcat cctcggcgtg ctgacggccg tacagatgcg cctgctgcgc gcttcccgct
    15781 cggacctggc ctgaggagca gaccatgaca cacatcagga ccagagtctc ccccggccgg
    15841 atcgccgcgt gggccctgct cgtcgtcgcg ctgttcgcga ccgtcttccc cttctactgg
    15901 atggtccgca ccgcgctgac cccggcggcc gacctgtaca ccgattccac cgggctggtc
    15961 ccggaccacc ccacgatgat caacttcctg cgggtgctgg gactgaccag ccaggaggaa
    16021 gccgtggcgg ccgggggctc cggcgcgcag gtcgacttcc tgcggtacct gctcaactcg
    16081 gtggtctaca gcgggctgat cgccgtgctg cagacgctgt tctgcgcgat ggccggctac
    16141 gccttcgccc ggctgcgctt ccccggccga gacctggtct tcggggtgct gatcgccgcg
    16201 ctgatggtgc ccccgatctt caccgtgctg cccaacttcg tgctggtgaa ggacctgggc
    16261 tggctgaaca ccttcgtcgg catggtcgcg ccgagcgtgc tgatgacgcc gttcgcggtc
    16321 ttcttcctgc ggcagttctt cctgtcggtc ccccgcgagg tggaggaggc cgcgatcctg
    16381 gacggcgtgg gtccctgggg gatcttctgg cgggtggtga tgcccatgac ccggggcccg
    16441 ctgctcaccg tcggactcac caccacggtg tgggcctgga aggactacct gtggccgctg
    16501 ctgtccggcc gggacgagga gacgcgggta ctcaccgtcg ccctcggcat cttccagcag
    16561 cagtcgccca acacccagcc cgactggacc gggctgatgg cggggtccgc cctctccgtg
    16621 ctgcccgtgc tcgtcctcct gatcctcctc ggccgccggc tcgtcgagtc cctgaacttc
    16681 accggcatga agtgacccgc ccccgcggag ccaccgcccg cccccaccga tcccgtacga
    16741 gccaggaagg cccctcgcga tgagaccccg acacctgcgc gccggcgcgg ccctgctgtg
    16801 tctggccgcc ctcaccactc tcgtctcctg cggcagctcc gacgaggcgg gcgacgggcg
    16861 gaccaccgtc gactactggc tgtgggacga cctccagctc cccgcctacc aggagtgcgc
    16921 gaccgccttc gagaaggcca acccggacat tgcggtcagg atcacgcaga ccgcgtggaa
    16981 ccagtactgg cagaacctca ccacgcaact ggtctccggc gaggcgcccg acgtgtggac
    17041 caaccaggcc acctactatc cgcagttcgc cgccggcaac cagctcctgg acctccagcc
    17101 ctacgtggag cgggacgggc tcgacgtctc cgcctaccag gcgggcctcg ccgacacctg
    17161 ggtgaaggac gacaagcgct acggcctgcc caaggactgg gacaccatgg ccgtcgtcta
    17221 caacaccgac atgctgaaga ggcagggcgt ggacctcgcc gccctgaacg acctgacgtg
    17281 gaacccggcg gacggcggca ccctggagca ggtgatcgcc agggccacgg tggacagcga
    17341 gggccgcaac ggtctcgacc ccgccttcga caaggaccac gtggaggtct acggcttcct
    17401 gcccgaatgg gccgacggcg cccagggcca gaacggctgg ggcaacttcg ccgccgccaa
    17461 cgggttcgag tacctcgaca agaacccctg gggcacgcac tacaagttcg acgaccccag
    17521 actcgccgag accgtctcgt ggttccggca cctgatcgac aagggctacg cgccccgcct
    17581 cgaccagcag tcgagcgtgg ccaggaccga actgctcatc gccgggaagg gcgccatgtc
    17641 gctcgcgggc tccttcaccg tctccagctt caccgggccc aaggtcaagc aggacttcgg
    17701 gttcgcggcg atgccggtcg gcccggccgg ccgcaagagc gccctcaacg gcctcgcgga
    17761 ctccgtctgg gccggcacgg accacaagga ggaggcgtgg aagtgggtca agtacctcgc
    17821 gtcggccgac tgccaggacc gggtcgccgc gcacggtgtc gtctttcccg cgctgaagag
    17881 ttccaccgag aaggccctcg ccgcacacga ggccgacggt gacgacgtgc gcgccttcac
    17941 cgacgccgtc gggacgaagg gcgtcacctt ccagcttccc gtcaccgagc acggcaccga
    18001 gatcagtccc ctcgtgcagg acgccatcca gtcggcgatc ctcggccagg aggacgccgc
    18061 cgatgccctg gagtcggtca acggcaaggt gaacggcctc ttcgactagg cgcgggcgcc
    18121 cgcctcgtac gcgcgggcct ccccgtaccg cacgcacccc tgtccctgtc cgcaccgcgg
    18181 agtccatccg taccccaagc cccacccgta ccgcaggtac cgcaacgcaa ggagacccat
    18241 ggcccagctc gtagaactcg gcgggcgcac cctcgccgtc gagctcgcag gcgacgcgcc
    18301 gccccgagcc gtggaaggcg gtctgctgct gccacccggc cggacggccg tgctccacgg
    18361 tctcggggac gcgctcttct accgccacgg ccacaactcg tggagcccgt gcggctggcg
    18421 ccggctctcc gaggcgccgc tgcggatcga gagcgccgaa cgccgtctga ccgccgacga
    18481 caccgtgtgg gacgatcccg cccgccacca ctcgtcggcc gtcgccgccc tggaggggcc
    18541 ggacgggcgg gtgctgctgc tcggcgcgct cggcctcgac gtcccccgcc tgaccgccga
    18601 ccgggacacc ctcaccgggt ggtgcgagcg cgacggagcg ccctggttcc tcgccctcgg
    18661 cagcgaggag gaggtgttcg ccgcctacgc gcggcacctc ggcgaccggc tcgggcgcag
    18721 cgacaagcgg gcgggcaacg tgtggtgcag ctggtacgcg tactacgaga gcatcaccga
    18781 ggagcagctc accaaggacg tcacggcgct gcgcggcctg cccttcgacg tcgtccaggt
    18841 cgacgacggc tgggagcggg cggtgggcga ctgggaggcc aacgacaagt tcccgtccgg
    18901 gatgcgggcg ctggccgacc ggatcacgga cgccgggctg cggcccggac tgtggatcgc
    18961 cccgttcatc gtcctgcccg gctcccgtac cgcccggcag cggccggagc tgctgctgcg
    19021 cgacgggcgc ggcgagccgg tggtcgccgg gcacaactgg ggcgtcggct actggacgct
    19081 cgacctcacg ctgcccgcgg cgcaggagca cctgcgcgag acgatccgcc gggtcgtccg
    19141 ggagtggggg ttcacctacc tcaagctcga cttcgtcggc gccggcgccg tgcccggagt
    19201 gcgtttcgcc gacgtgggcc gcgaggaggc ctaccgcacc ggcctctcga tcgtccggga
    19261 ggcggcgggc ccggacgcct acctcctcgg cagcggcgcc ccgctgctgc cctcgctggg
    19321 gctggtcgac gccatccgca gcggccccga cgtcgcgccg atgtgggagc actacgccac
    19381 ccaggacccg tccgacgcgc tggcccgcaa cgccgtcgtc aacacggtgc accggttgtg
    19441 gcagtcaccg ctgctggagg tcgacccgga cgtcgtgtac ttccgcagcc gcctgaacct
    19501 gctgaccgag cagcagcagg ggctgctgcg cgacctggcc gacgtgtgcg gtttccgggc
    19561 cgtatccgac ccgccgggat ggctgctccc ggaggaactg aaggcgatgg aggcgtactt
    19621 gaccggccgc ccggaggtgc gccggctcgg gcgctaccgc ttcgcgctcg acggccggga
    19681 ggtggacttc ggcgcggccg tgacccccgg cgacgagcag cgctatcccc tcgcctgacc
    19741 tcgtacccgc acgcggccac cgccacgaat tagtaaactc ttcagcaata ttcggcggtg
    19801 gccaccgcaa cgcctccagg gagcaccaac atggcgacga ccggaacgga catgtcccgg
    19861 atgcgtgaga tgaaccagct gtccatcgtg ggagcactgc gcggcaaccc gccctccacg
    19921 gtcaccgagc tggcgtcccg ctccggcctg tcccgtcccg cggtggacgt gctggtgcag
    19981 tccctggtcg ccgacggctg ggcggaggtg gaggagccgg gggccagcag tgtggtgggg
    20041 cgtcccgcgc gccggtaccg gttcagggcc accgccgggc acgtgctggg catcgacatc
    20101 ggcgtgcaca agatcctcgt gatcctcagc gatctggagg ggaacctggt gcgcacggtg
    20161 cgccacccgg ccgccccgga ggcggcgccc gccgagcggc tggcggcggt ggaccgggtc
    20221 gtcgacgagg tgctggcgag cgcgggcatg gccgcgggcg acatctgggc cgtgaccgtc
    20281 ggggtgaccg gtccggtcga ccgcagcggc cggacctcgc tgtccagccc gctgcccggc
    20341 tggagcgagg ccgacccggc cgcccacctc ggcacccggt tctcctgccc cgtacaggtg
    20401 gagaacgact gcaagctggc cgccgtcgcc gaacggtggc ggggcgtcgc gcaggacgcc
    20461 gacgacatcg tgtacctcct cgccggtctg cgcaccggcg ccggtctcat cctcgacggc
    20521 accctgcgcc ggggccacgg cggcgccgcg ggagagatcg gcgcgctcaa ggccgtacgg
    20581 tggctcaccg cgcccgacca cctgcagtcc tgccccggga tgccggcgac cgccgcggag
    20641 ggcgaggcgg cggcctgggt cttccaggcc gcccgggacg gcgaccggga cgcccggacg
    20701 gccgtccggc gctacacccg cgacctcgcg gtgggggtgg ccgccctggt cctcgccctg
    20761 gacccgcagg tcgtcgtcta cggcggcggg ttctcccggt ccgccgacgt ggtcctcggt
    20821 cccctgcacc gcgagctgac caagcactgt ctgcggatgc cggagctgcg cgcctccacg
    20881 ctcggcgacg agagcgtggc gctgggggcg gtgcggctgg ccctggacga ggtcgacagc
    20941 cggctgctga gcgacggtct ggcggcgccg accgcacccc ggcggtaacg acagggccgg
    21001 gcacgcaccc ggcgctcgta cgcaacacca acacccgaca ggaacgaagg gacagcccag
    21061 tgagcacccg tgaccagata ccggaccggc acctgcgcgt cggcgtcgtc ggcgtcggac
    21121 agcgcgcgga catggccgcg ctggtgaacc gttccggcgc tgcccggatc gtgtcctgcg
    21181 ccgacccgga cccgcggggc cgggaggacg ccaggcgtct gttcggcgcg gacgtcgtgg
    21241 tgcacgaccg gtacgagcgg atgctcgacg acgagctgga cgccgtgttc gtcctcaccc
    21301 ccgaccacct gcacaccgaa cccgcgctgt gcttcctcgc ggcgggcgtg gcggtgttcg
    21361 tggagaagcc gctgaccatc acggtcgccg actgcgacgc gctgctcatg gcggcgttcc
    21421 gctcccgcac ccggctctac gtgggccaca acctgcgtca ccttcccgtg ctgcgccgga
    21481 tgcgcgagct gatcgacgac ggcgcggtcg gccgcgtccg cgcggtgtgg tgccgccact
    21541 tcgtcggcca cggcggggac ttctacttca aggactggca cgcgcagcgg gcgaacacca
    21601 ccggtctgct gctgcagaag ggcgcccacg acctcgacgt cgtccactgg ctcgccgggg
    21661 gcttctcccg caacgtggtc gcccagggtg cgctggccgt ctatggcgac aacccgcgcc
    21721 gggccacgca ggagacggtg ccgcccggtc agcgcatgcc cgactggttc gacccggagg
    21781 tctggccgcc gtccgccctg cgcgacctca accccgtcgt cgacgtcgag gacatcagca
    21841 tgatgctggc ccgcctggac aacggcgtcc tcgccagcta ccagcagtgc cacttcacgc
    21901 ccgactactg gcgcaactac accgtcatcg gcgacgaggg ccgcctggag aacttcggcg
    21961 acggcatcga cggcgatgcc gcacgggtcg acgtgtggaa ccggcgccgc tccggctacc
    22021 gtgccgacgc cgacctctcc gttccggtcg tggcgtccga cgaggagacg cacggcggcg
    22081 cggaccgggc gctcgtcgag gagttcctgc gcttcgccgc cgccggaggc ccgaccgaga
    22141 cctcacccgt ggccgcccgc gaggcggtcg ccgccgcggt cgccgccacg acctcgctgc
    22201 gctccggcag tacaccggtc gacgttcccc cgctcgaccc ggcgatcgtc cgccacttcg
    22261 cggagcacca gcccgccgag ggggccgacg ggagcggtcc gcagccccgg tgacagtggc
    22321 ggcgggatct ggcccaccga ccgccggtcg gtcgcgtccg cgccactgcg tcgcctcctg
    22381 gccgaccggc cggccgagtg ctcggcgcgg aactgcgccg acggctgaag agcgagctgc
    22441 cggttcctgc cacggtggtg cttcggccgg cgtcagcggc tcgctcgggc cgggtcacgg
    22501 gtggaagcgc caccggcctt cggaaacgac atccgccttg ccgtccctga cacgcaccgc
    22561 cgtctcgtcg tcgatgaagt agatcgggaa gtccgcccgc gcggtgatcc ggtcggccca
    22621 ggcgtcgtcc cgctcgggga agtcgggcga gtagaggtgg ggcttgaggt accagtcgaa
    22681 gagaccgaac ggcggctcca cgctcgtcgc accgagcacg tggaggtccg tggcgtcccc
    22741 gatgacgtcg gcggagtgtc cggtgagatt gcggctgaag atcatcgacc cggcgctgac
    22801 tcccacgtag acacggctct gcaacgcctc caggaagccg tcgaccaggc cgttgccggt
    22861 gatgctgcgc gcgaggtgat agtggttgcc gccttcgacg tagacgacgt cggcgtggag
    22921 cagccggtcg agcaccatct gctggggcag gccgttcagc tcaaggatgt cgaactcccg
    22981 ccagccgagg ccgtgcaggc ggttcatgtc cgcgacgacc cacccgtggt ccccggggtc
    23041 cgcgacggat gccgtgggaa cgaacacgac gttcgccgat ccgaacggtt tgcccagcat
    23101 gtcccgcagc gcatcccgca gtgtctcgtt gcgcaggccg ctcgccgtca gcaggaagtt
    23161 catcggacga gccaagcacg gctgacgggc ggcacgcaaa ccatccccgg gcccgcacga
    23221 acgcgcggtt gtcagtggcc cctgccagga tgcgccgatg acctcaagcg accacccgct
    23281 caaggcgtcc ctcgacgagc cgcgggccca cctcctcgat ctgatcggtg ctgtcgagcc
    23341 gtgggacgac ctggagcaca cccatctgga atccgccagg cactggatcg ccggcggcgc
    23401 ccctctctac cgggtgcgca agccggacgt tccgcccatg cacctggtga gctacttcgc
    23461 cgtccttgac gacacgcgcg ggcaactcct gctcgtggcg caccgcaagg cggggctgtg
    23521 gctgcctgcc ggaggacacg tcgagtcggg tgaggacccg tgggccgcgg tggtccgcga
    23581 gtgccgtgag gagctgggca tcgaggcggt ggcgtcgccc gtcgcgggtg agcttccgtt
    23641 cttcctgacc gtcaccggaa cccgggggca gggcccgcac accgacgtct cgctgtggta
    23701 cctcctcgat gccgacgccc acaccgtcac cgattacgac cggggcgagt tcagcgccgt
    23761 ccgctggctg acgcacgagc aggttctcgc cgcgtcggcc gaactgctcg acccccacat
    23821 gcaccgcttc gctcggaagc tggcgtgggc gcgggcgggt cggggcgggt gagaattgcg
    23881 gcgtcccctg ctcgagagcg gcggctgttt gtcggcacgt gtccaccccg agtccccgag
    23941 gacggtccac catgaccatg cagccctggt tcaacgaggc gaagctgggc atattcgtgc
    24001 actacggcat ctactcggtc gacggagtac ccgagtcctg ggcccttttc gaccaggtgg
    24061 tgccgcacga gcagtacatg cgccaactcg acggcttcac cgccgccgcc ttcgatccct
    24121 ccgcttgggc cgggctcttc gcgcgcgccg gggccggcta cgccgtgctg acggcacggc
    24181 accacgacgg agtggccctg tgggaaacgc ggttgagcga cctgagcgtg gtcgggcgta
    24241 cccccgcggg acgcgacctg gttgccgagt acgtgagcgc gatgcgcgac cggggcctca
    24301 gggccggtct gtactactcg cactccgact ggaaccatcc ggactacgca tcggtacggc
    24361 acccccggcc accgcatccc gaactggtcg acagccccta cgtctccccc gccccgggcg
    24421 ccgaggaccc gcgggcctgg gagcgctacc tcgactaccg ggacggccag gtgcgcgagc
    24481 tgctcacccg gttcggaccg gatctgctct ggttcgacgg cgagtgggag cgctcggccg
    24541 agcagtggcg gatgtccga
//
