LOCUS NC_003888 25538 bp DNA linear CON 03-AUG-2016 DEFINITION Streptomyces coelicolor A3(2) chromosome, complete genome. ACCESSION NC_003888 VERSION NC_003888.3 KEYWORDS . SOURCE Streptomyces coelicolor A3(2) ORGANISM Streptomyces coelicolor A3(2) Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group. COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL645882. On Jun 22, 2003 this sequence version replaced NC_003888.2. RefSeq Category: Reference Genome MOD: Model Organism UPR: UniProt Genome COMPLETENESS: full length. ##antiSMASH-Data-START## Version :: 7.1.0 Run date :: 2023-11-22 14:16:39 NOTE: This is a single region extracted from a larger record! Orig. start :: 166500 Orig. end :: 192038 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..25538 /aStool="rule-based-clusters" /category="terpene" /contig_edge="False" /core_location="[10000:15538]" /cutoff="20000" /detection_rule="(Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)" /neighbourhood="10000" /product="terpene" /protocluster_number="1" /tool="antismash" proto_core 10001..15538 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)" /neighbourhood="10000" /product="terpene" /protocluster_number="1" cand_cluster 1..25538 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)" /kind="single" /product="terpene" /protoclusters="1" /tool="antismash" region 1..25538 /candidate_cluster_numbers="1" /contig_edge="False" /product="terpene" /region_number="2" /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)" /tool="antismash" gene 391..837 /db_xref="GeneID:1095602" /gene_synonym="SCJ1.27" /locus_tag="SCO0178" CDS 391..837 /codon_start=1 /db_xref="GeneID:1095602" /gene_synonym="SCJ1.27" /locus_tag="SCO0178" /note="SCJ1.27, unknown, len: 148 aa. Weak similarity to Mycobacterium tuberculosis SW:YW23_MYCTU (EMBL; Z74025) hypothetical 33.9 KD protein MTCY39.23C (317 aa), fasta scores opt: 201 z-score: 231.7 E(): 1.5e-05 33.1% identity in 136 aa overlap and Mycobacterium tuberculosis TR:O06189 (EMBL; Z95387)hypothetical 31.7 KD protein MTCY1A10.09C (297 aa), fasta scores opt: 199 z-score: 229.8 E(): 1.9e-05 33.3% identity in 153 aa overlap." /product="hypothetical protein" /protein_id="NP_624514.1" /transl_table=11 /translation="MLVAQALSAAAVVVGHRGPHPFQGALIGSLATGLAAHSECPVVVV GEPENPAGPVALGVDGSAAGAAAVRLPGDFRAGCGHHRRARLDGLERADAASPRRETEP YACEPGMLAAEEGRLLAETLAGMCARYPEVRVERSTVHGVHGRR" PFAM_domain 394..525 /aSDomain="Usp" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00582.29" /description="Universal stress protein family" /detection="hmmscan" /domain_id="clusterhmmer_SCO0178_0047" /evalue="5.10E-08" /label="SCO0178" /locus_tag="SCO0178" /protein_end="45" /protein_start="1" /score="33.7" /tool="antismash" /translation="LVAQALSAAAVVVGHRGPHPFQGALIGSLATGLAAHSECPVVVV" gene complement(944..2014) /db_xref="GeneID:1095603" /gene_synonym="SCJ1.28c" /locus_tag="SCO0179" CDS complement(944..2014) /NRPS_PKS="Domain: PKS_ER (23-337). E-value: 4.7e-10. Score: 30.9. Matches aSDomain: nrpspksdomains_SCO0179_PKS_ER.1" /codon_start=1 /db_xref="GeneID:1095603" /gene_functions="biosynthetic-additional (rule-based-clusters) ADH_N" /gene_functions="biosynthetic-additional (rule-based-clusters) ADH_zinc_N" /gene_functions="biosynthetic-additional (smcogs) SMCOG1040:alcohol dehydrogenase (Score: 366.7; E-value: 1.7e-111)" /gene_kind="biosynthetic-additional" /gene_synonym="SCJ1.28c" /locus_tag="SCO0179" /note="SCJ1.28c,possible zinc-containing dehydrogenase, len: 356 aa. Similar to many including: Thermoanaerobacter brockii SW:ADH_THEBR (EMBL; X64841) NADP-dependent alcohol dehydrogenase (EC 1.1.1.2) (352 aa), fasta scores opt: 556 z-score: 601.1 E(): 4e-26 33.7% identity in 338 aa overlap and Halobacterium volcanii TR:O34179 (EMBL; U95372) dehydrogenase (389 aa), fasta scores opt: 715 z-score: 770.1 E(): 0 37.0% identity in 351 aa overlap. Contains a Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases and a PS00059 Zinc-containing alcohol dehydrogenases signature" /product="zinc-containing dehydrogenase" /protein_id="NP_624515.1" /sec_met_domain="ADH_N (E-value: 2.1e-29, bitscore: 100.4, seeds: 66, tool: rule-based-clusters)" /sec_met_domain="ADH_zinc_N (E-value: 4.2e-25, bitscore: 87.1, seeds: 86, tool: rule-based-clusters)" /transl_table=11 /translation="MKGYVFHGPGRSAWEDIPDPELKEPTDAIVRVDAVTICGTDLHIL KGDVPEVRPGTVLGHEAVGEIVEVGTDVRTVRPGDRVLVSCITACGRCRYCREGVYGQC LGGGGWILGHLINGTQAEYVRVPYADLSVHSLPGAVTDEDAVLLADIFPTAYEVGVLNG RVSPGDTVVVVGAGPIGLAAVATARLFAPERIVVVDLATARLEAARKLGAEAVADARED PEQLVADLTGGLGADVVIEAVGVPETFEMCTRVVRPGGHVANVGVHGRPATLHLEDLWS KNVTVTTGLVDTRSTPTLLRMAASGRLPTGQLVTHTFPLERMEEAYEVFSAAADTGALK VVLGGPKREVVAANAV" misc_feature complement(983..1987) /gene_synonym="SCJ1.28c" /locus_tag="SCO0179" /note="Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases, score 236.60, E-value 3.4e-67" aSDomain complement(1004..1945) /aSDomain="PKS_ER" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_SCO0179_PKS_ER.1" /evalue="4.70E-10" /label="SCO0179_PKS_ER.1" /locus_tag="SCO0179" /protein_end="337" /protein_start="23" /score="30.9" /tool="antismash" /translation="EPTDAIVRVDAVTICGTDLHILKGDVPEVRPGTVLGHEAVGEIVE VGTDVRTVRPGDRVLVSCITACGRCRYCREGVYGQCLGGGGWILGHLINGTQAEYVRVP YADLSVHSLPGAVTDEDAVLLADIFPTAYEVGVLNGRVSPGDTVVVVGAGPIGLAAVAT ARLFAPERIVVVDLATARLEAARKLGAEAVADAREDPEQLVADLTGGLGADVVIEAVGV PETFEMCTRVVRPGGHVANVGVHGRPATLHLEDLWSKNVTVTTGLVDTRSTPTLLRMAA SGRLPTGQLVTHTFPLERMEEAYEVFSAAADTG" PFAM_domain complement(1115..1483) /aSDomain="ADH_zinc_N" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00107.29" /description="Zinc-binding dehydrogenase" /detection="hmmscan" /domain_id="clusterhmmer_SCO0179_0049" /evalue="1.10E-24" /label="SCO0179" /locus_tag="SCO0179" /protein_end="300" /protein_start="177" /score="87.1" /tool="antismash" /translation="PIGLAAVATARLFAPERIVVVDLATARLEAARKLGAEAVADARED PEQLVADLTGGLGADVVIEAVGVPETFEMCTRVVRPGGHVANVGVHGRPATLHLEDLWS KNVTVTTGLVDTRSTPTLL" PFAM_domain complement(1625..1939) /aSDomain="ADH_N" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF08240.15" /description="Alcohol dehydrogenase GroES-like domain" /detection="hmmscan" /domain_id="clusterhmmer_SCO0179_0048" /evalue="5.20E-29" /label="SCO0179" /locus_tag="SCO0179" /protein_end="130" /protein_start="25" /score="100.4" /tool="antismash" /translation="TDAIVRVDAVTICGTDLHILKGDVPEVRPGTVLGHEAVGEIVEVG TDVRTVRPGDRVLVSCITACGRCRYCREGVYGQCLGGGGWILGHLINGTQAEYVRVPYA D" misc_feature complement(1796..1840) /gene_synonym="SCJ1.28c" /locus_tag="SCO0179" /note="PS00059 Zinc-containing alcohol dehydrogenases signature, GHE.{2}G.{5}[GA].{2}[IVSAC], info count = 21.8" regulatory complement(2028..2033) /regulatory_class="ribosome_binding_site" misc_feature complement(2150..2164) /note="TFBS match to OsdR, Development and stress management regulator, confidence: medium, score: 26.9" /tool="antismash" gene complement(2205..3056) /db_xref="GeneID:1095604" /gene_synonym="SCJ1.29c" /locus_tag="SCO0180" CDS complement(2205..3056) /codon_start=1 /db_xref="GeneID:1095604" /gene_synonym="SCJ1.29c" /locus_tag="SCO0180" /note="SCJ1.29c, unknown, len: 283 aa. Similar to many including: Mycobacterium tuberculosis TR:O53472 (EMBL; AL021899) hypothetical 31.5 KD protein (294 aa), fasta scores opt: 329 z-score: 389.0 E(): 2.6e-14 32.1% identity in 293 aa overlap and Mycobacterium tuberculosis TR:O06189 (EMBL; Z95387) hypothetical 31.7 KD protein (297 aa), fasta scores opt: 330 z-score: 390.1 E(): 2.3e-14 31.8% identity in 296 aa overlap. Also similar to S. coelicolor SCJ1.16c (294 aa), fasta scores opt: 806 z-score: 748.1 E():0 46.1% identity in 295 aa overlap. Contains a Pfam match to entry PF00582 Usp, Universal stress protein family" /product="hypothetical protein" /protein_id="NP_624516.1" /transl_table=11 /translation="MYLPLVVGVDGSEPSLRAVDWAADEAALHAVPLWVVFGDLWERYE GAALAREPGKPSTDMQADDILAAAAIRAGRRHPDLVVTTETVPDEAEHALICAGRNASM IVMGSRGRSGIADRLLGSVSRTVAAGSDCPVVVLRGNHDNRAIGGRNGRIVVGVGEVSA SVLRLAFMEARLRQVPVAAVRAWRCPAHETIDHPLPAGEPARRYEERAARELEAALEDA PPDVAVRRYTVEGPARAVLPAASAEAGLLVIGRRTQGRLGRVAHAVLHRSACPVVVVPE RT" PFAM_domain complement(2217..2603) /aSDomain="Usp" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00582.29" /description="Universal stress protein family" /detection="hmmscan" /domain_id="clusterhmmer_SCO0180_0051" /evalue="2.40E-13" /label="SCO0180" /locus_tag="SCO0180" /protein_end="280" /protein_start="151" /score="50.9" /tool="antismash" /translation="GRIVVGVGEVSASVLRLAFMEARLRQVPVAAVRAWRCPAHETIDH PLPAGEPARRYEERAARELEAALEDAPPDVAVRRYTVEGPARAVLPAASAEAGLLVIGR RTQGRLGRVAHAVLHRSACPVVVVP" PFAM_domain complement(2640..3056) /aSDomain="Usp" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00582.29" /description="Universal stress protein family" /detection="hmmscan" /domain_id="clusterhmmer_SCO0180_0050" /evalue="1.30E-25" /label="SCO0180" /locus_tag="SCO0180" /protein_end="139" /protein_start="0" /score="90.7" /tool="antismash" /translation="MYLPLVVGVDGSEPSLRAVDWAADEAALHAVPLWVVFGDLWERYE GAALAREPGKPSTDMQADDILAAAAIRAGRRHPDLVVTTETVPDEAEHALICAGRNASM IVMGSRGRSGIADRLLGSVSRTVAAGSDCPVVVLR" misc_feature complement(2643..2981) /gene_synonym="SCJ1.29c" /locus_tag="SCO0180" /note="Pfam match to entry PF00582 Usp, Universal stress protein family, score 34.80, E-value 2e-06" regulatory complement(3063..3070) /regulatory_class="ribosome_binding_site" gene complement(3084..4070) /db_xref="GeneID:1095605" /gene_synonym="SCJ1.30c" /locus_tag="SCO0181" CDS complement(3084..4070) /codon_start=1 /db_xref="GeneID:1095605" /gene_synonym="SCJ1.30c" /locus_tag="SCO0181" /note="SCJ1.30c, unknown, len: 328 aa. Similar to many including: Mycobacterium tuberculosis SW:YW23_MYCTU (EMBL; Z74025) hypothetical 33.9 KD protein MTCY39.23C (317 aa) fasta scores opt: 382 z-score: 439.2 E(): 4.2e-17 32.6% identity in 319 aa overlap and Mycobacterium tuberculosis TR:O53472 (EMBL; AL021899) hypothetical 31.5 KD protein (294 aa), fasta scores opt: 382 z-score: 439.2 E(): 4.2e-17 32.6% identity in 319 aa overlap. Contains a Pfam match to entry PF00582 Usp, Universal stress protein family." /product="hypothetical protein" /protein_id="NP_624517.1" /transl_table=11 /translation="MSEDEWPYPGAQLRDTLESEGPTREVRDMTRTITVGIDGSPESHA AAEWAAREAELRDLPVRLLHVWEPAPAVLAQDSILGAKTHQHWTERVPQKVGEGLRLRH PGVVVTSDQRSGPPADTLVRDADGAELLVLGSRAPSGLGGFLAGSVGQSVIAHSETPVV LVRAGEQAAGEHVVDSVGVPPAANRRRPVVVGLDIGSPDDGVLSFAFDEAQRRGTAVHV VSGWRPPPYYPSLTAGGVPDQGVARRKAADLTRLLLPWRQSYPDVEVVEASRPGSPADL LAEASHEASLVVVGRRIRPSPLGVHIGAVAHAVLHRVSAPVAVVAHP" misc_feature complement(3096..3419) /gene_synonym="SCJ1.30c" /locus_tag="SCO0181" /note="Pfam match to entry PF00582 Usp, Universal stress protein family, score 42.80, E-value 7.5e-09" PFAM_domain complement(3096..3503) /aSDomain="Usp" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00582.29" /description="Universal stress protein family" /detection="hmmscan" /domain_id="clusterhmmer_SCO0181_0053" /evalue="1.80E-17" /label="SCO0181" /locus_tag="SCO0181" /protein_end="325" /protein_start="189" /score="64.3" /tool="antismash" /translation="RPVVVGLDIGSPDDGVLSFAFDEAQRRGTAVHVVSGWRPPPYYPS LTAGGVPDQGVARRKAADLTRLLLPWRQSYPDVEVVEASRPGSPADLLAEASHEASLVV VGRRIRPSPLGVHIGAVAHAVLHRVSAPVAVV" PFAM_domain complement(3573..3986) /aSDomain="Usp" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00582.29" /description="Universal stress protein family" /detection="hmmscan" /domain_id="clusterhmmer_SCO0181_0052" /evalue="3.20E-26" /label="SCO0181" /locus_tag="SCO0181" /protein_end="166" /protein_start="28" /score="92.7" /tool="antismash" /translation="MTRTITVGIDGSPESHAAAEWAAREAELRDLPVRLLHVWEPAPAV LAQDSILGAKTHQHWTERVPQKVGEGLRLRHPGVVVTSDQRSGPPADTLVRDADGAELL VLGSRAPSGLGGFLAGSVGQSVIAHSETPVVLVR" gene complement(4156..4380) /db_xref="GeneID:1095606" /gene_synonym="SCJ1.31c" /locus_tag="SCO0182" CDS complement(4156..4380) /codon_start=1 /db_xref="GeneID:1095606" /gene_synonym="SCJ1.31c" /locus_tag="SCO0182" /note="SCJ1.31c, doubtful CDS, len: 74 aa. Contains a TTA/leucine codon, possible target for bldA regulation." /product="hypothetical protein" /protein_id="NP_624518.1" /transl_table=11 /translation="MCRAAVGVLEAGARREGVTCGTYGLWDGVTAWREPRSSMPDLTQV LKPIEGSDLVPAASVVAAHAEDRLKGEGH" misc_feature complement(4306..4308) /gene_synonym="SCJ1.31c" /locus_tag="SCO0182" /note="TTA/leucine codon, possible target for bldA regulation." misc_feature complement(4306..4308) /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" gene 4411..5658 /db_xref="GeneID:1095607" /gene_synonym="SCJ1.32" /locus_tag="SCO0183" CDS 4411..5658 /codon_start=1 /db_xref="GeneID:1095607" /gene_synonym="SCJ1.32" /locus_tag="SCO0183" /note="SCJ1.32, unknown,len: 415 aa. Likely to have arisen as a result of a duplication of SCF43A.31/32, followed by a deletion event generating a possible CDS with the 5' coding sequence of SCF43A.31 and the 3' coding sequence of SCF43A.32. Similarity scores are as follows: to Streptomyces coelicolor TR:CAB48918 (EMBL; AL096837) oxidoreductase SCF43A.31 (520 aa), fasta scores opt: 1191 z-score: 1365.3 E(): 0 64.2% identity in 307 aa overlap and to Streptomyces coelicolor TR:CAB48919(EMBL; AL096837) deoxyribodipyrimidine photolyase SCF43A.32 (458 aa), opt: 909 z-score: 1043.2 E(): 0 45.7% identity in 418 aa overlap. Contains a PS00394 DNA photolyases class 1 signature 1 and a PS00691 DNA photolyases class 1 signature 2." /product="deoxiribopirymidine photolyase" /protein_id="NP_624519.1" /transl_table=11 /translation="MRRIVYLGGLTPRGVPERTLSPHLRSRAEVGPILVRDVLHYLAGA ATMPDDIDRAFDVGGPDVPTYREMMRRHATVSGLRRRIIVPAPVLTPGLSSHWVGLVTP VPASIARPLTESLRHEVVCQEHDIARYVPDAPGRPLPFDVALTLALRRVREAQVATRWS SASVPGAPSDPLPTDPDWAGGSLYEDERHLPVDASPEALWKVVEGIGGDNGWYSFPPAW AVRGWLDRFVGGVGLRRGRRDAQRLHPARPVAWRGGRRRGHRRLAGRTGYPVVDAAMRQ LRHQGWMHNRARLLVASFLTKTLYVDWRIGARHFLDLLVDGDVVNNQLNWQWAAGTGTD TRPHRVLNPLVQARRFDPDGVYVRRWVPELRSVEGGKVHEPWRLAAAERGELDYPDPLV ELADGLARFKHARGRD" PFAM_domain 4951..5166 /aSDomain="DUF2867" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF11066.11" /description="Protein of unknown function (DUF2867)" /detection="hmmscan" /domain_id="clusterhmmer_SCO0183_0054" /evalue="3.90E-13" /label="SCO0183" /locus_tag="SCO0183" /protein_end="252" /protein_start="180" /score="50.1" /tool="antismash" /translation="WAGGSLYEDERHLPVDASPEALWKVVEGIGGDNGWYSFPPAWAVR GWLDRFVGGVGLRRGRRDAQRLHPARP" PFAM_domain 5209..5631 /aSDomain="FAD_binding_7" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF03441.17" /description="FAD binding domain of DNA photolyase" /detection="hmmscan" /domain_id="clusterhmmer_SCO0183_0055" /evalue="2.70E-58" /label="SCO0183" /locus_tag="SCO0183" /protein_end="407" /protein_start="266" /score="197.0" /tool="antismash" /translation="AGRTGYPVVDAAMRQLRHQGWMHNRARLLVASFLTKTLYVDWRIG ARHFLDLLVDGDVVNNQLNWQWAAGTGTDTRPHRVLNPLVQARRFDPDGVYVRRWVPEL RSVEGGKVHEPWRLAAAERGELDYPDPLVELADGLAR" misc_feature 5218..5256 /gene_synonym="SCJ1.32" /locus_tag="SCO0183" /note="PS00394 DNA photolyases class 1 signature 1" misc_feature 5278..5337 /gene_synonym="SCJ1.32" /locus_tag="SCO0183" /note="PS00691 DNA photolyases class 1 signature 2" gene 5670..7484 /db_xref="GeneID:1095608" /gene_synonym="SCJ1.33" /locus_tag="SCO0184" CDS 5670..7484 /codon_start=1 /db_xref="GeneID:1095608" /gene_synonym="SCJ1.33" /locus_tag="SCO0184" /note="SCJ1.33 unknown, len: 604 aa. Highly similar to Synechocystis sp. (strain PCC6803) TR:P74080 (EMBL;D90912) hypothetical 58.1 KD protein (504 aa), fasta scores opt: 931 z-score: 996.4 E(): 0 38.8% identity in 479 aa overlap and Methanobacterium thermoautotrophicum TR:O27804 (EMBL;AE000932) conserved protein MTH1776 (491 aa), fasta scores opt: 572 z-score: 613.5 E(): 8.1e-27 31.7% identity in 483 aa overlap. Also shares a low level of similarity with Streptomyces coelicolor TR:CAB48919 (EMBL;AL096837) deoxyribodipyrimidine photolyase SCF43A.32 (458 aa), fasta scores opt: 176 z-score: 191.4 E(): 0.0026 31.1% identity in 219 aa overlap." /product="hypothetical protein" /protein_id="NP_624520.1" /transl_table=11 /translation="MHWLFGDQLGPHFLTPGEEGPGPETPLLMIEARSVFRRRRFHRAK AHLVLSAMRHRAAEPGDRVTYVRADTYRQGLARTARGRPVGVHHPTSHAALRLVRALPQ VTVGPARGFLVPMTGFAAWAEGHGGKRLRQEDFYRWVRRGHGLLMDGEQPAAGRWNLDH DNREPPPREAASLQVGRPYRPREDDIDEEVRHDLDRWERDGDVSFVGRDGPRLFPATRT EGLRALRRFVEHRLATFGPHEDAMLAADPVMSHSLLSSTLNLGPLDPVECVERAERAWR EGRAPLNSVEGFVRQIAGWREYVWQLYWYFGEGYRRSNALGHTAPLPDWWNRLDADAVR ANCLRTVLAQVRDTGWTHHIPRLMVLGSHALQRGWDPAAVTNWFHRCFVDGYDWVMLPN VVGMSQYADGGRMTTKPYTSAGAYVNRMSDLCGPCGYRPGDRTCEHACPYTTGYWAFLD RHRELLAGNQRVARPVRQSDRLADLPDVCAQGTRGVTHRHEPPPLRRRGEVGPHPVPER AEVSASTTGHPAEAVACGQPRVRRGCACLDCRRWWPRRPNRSTTPSPRPMRRTRSTPSS GGYWTNGCATAVPSTPSSPGNWPTVSRR" PFAM_domain 5676..6266 /aSDomain="DPRP" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF04244.16" /description="Deoxyribodipyrimidine photo-lyase-related protein" /detection="hmmscan" /domain_id="clusterhmmer_SCO0184_0056" /evalue="3.50E-31" /label="SCO0184" /locus_tag="SCO0184" /protein_end="199" /protein_start="2" /score="108.9" /tool="antismash" /translation="WLFGDQLGPHFLTPGEEGPGPETPLLMIEARSVFRRRRFHRAKAH LVLSAMRHRAAEPGDRVTYVRADTYRQGLARTARGRPVGVHHPTSHAALRLVRALPQVT VGPARGFLVPMTGFAAWAEGHGGKRLRQEDFYRWVRRGHGLLMDGEQPAAGRWNLDHDN REPPPREAASLQVGRPYRPREDDIDEEVRHDLDR" gene 7268..8446 /db_xref="GeneID:1095609" /gene_synonym="crtB; SCJ1.34" /locus_tag="SCO0185" CDS 7268..8446 /codon_start=1 /db_xref="GeneID:1095609" /gene_functions="biosynthetic-additional (smcogs) SMCOG1182:Polyprenyl synthetase (Score: 223.8; E-value: 4.3e-68)" /gene_kind="biosynthetic-additional" /gene_synonym="crtB; SCJ1.34" /locus_tag="SCO0185" /note="SCJ1.34, crtB, possible geranylgeranyl pyrophosphate synthase, len: 392 aa. Shares a high level of similarity with Streptomyces griseus TR:Q54193 (EMBL:L37405) geranylgeranyl pyrophosphate synthase (425 aa), fasta scores: opt: 964 z-score: 1076.9 E(): 0 48.0% identity in 381 aa overlap and Mycobacterium tuberculosis TR:O53507 (EMBL:AL021957) geranylgeranyl pyrophosphate synthase (352 aa), fasta scores opt: 742 z-score: 831.2 E(): 0 43.0% identity in 328 aa overlap. Contains a PS00723 Polyprenyl synthetases signature 1" /product="geranylgeranyl pyrophosphate synthase" /protein_id="NP_624521.1" /transl_table=11 /translation="MRTTESEKGLRMPGLPPMVAPPAEQVDDPVTATDAANAVDAVLRG VLDERLRHCRAVDPLFARELADRLAALTARGGKRLRTAFAHCGWRAAGGSGDATAVLRT GAALELLQACALVHDDVMDGSVQRRGAPALHVDLARGHWAAGMHGSSESFGTSAAVLTG DLALAWADDLLTETALGTPHGPRLHGEWRAMRTEMVAGQYRDLHAQAARSSGVDEALAI ATLKSALYTVARPLALGAVLAGAADGDALEALRAAGRCAGLAFQLRDDLLGAFGDPALT GKPADDDLRSRKLTYLLAVAVRLADAADDHLAAAALAPDADPKSEKAVRQVRSALVRTG ARDLVETKIGELTDMSLAHFDRCGARPAVRHEFAALIGRATGAVPRGTGEVV" PFAM_domain 7460..8266 /aSDomain="polyprenyl_synt" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00348.20" /db_xref="GO:0008299" /description="Polyprenyl synthetase" /detection="hmmscan" /domain_id="clusterhmmer_SCO0185_0057" /evalue="1.20E-45" /gene_ontologies="GO:0008299: isoprenoid biosynthetic process" /label="SCO0185" /locus_tag="SCO0185" /protein_end="333" /protein_start="64" /score="155.7" /tool="antismash" /translation="LADRLAALTARGGKRLRTAFAHCGWRAAGGSGDATAVLRTGAALE LLQACALVHDDVMDGSVQRRGAPALHVDLARGHWAAGMHGSSESFGTSAAVLTGDLALA WADDLLTETALGTPHGPRLHGEWRAMRTEMVAGQYRDLHAQAARSSGVDEALAIATLKS ALYTVARPLALGAVLAGAADGDALEALRAAGRCAGLAFQLRDDLLGAFGDPALTGKPAD DDLRSRKLTYLLAVAVRLADAADDHLAAAALAPDADPKSEKAVRQVR" misc_feature 7613..7657 /gene_synonym="crtB; SCJ1.34" /locus_tag="SCO0185" /note="PS00723 Polyprenyl synthetases signature 1, [LIVM]{2}.DD.{2,4}D.{4}RR[GH], info count = 26.9" gene 8443..10014 /db_xref="GeneID:1095610" /gene_synonym="crtE; SCJ1.35" /locus_tag="SCO0186" CDS 8443..10014 /codon_start=1 /db_xref="GeneID:1095610" /gene_functions="biosynthetic-additional (rule-based-clusters) DAO" /gene_functions="biosynthetic-additional (smcogs) SMCOG1222:dehydrogenase (Score: 491.4; E-value: 5.8e-149)" /gene_kind="biosynthetic-additional" /gene_synonym="crtE; SCJ1.35" /locus_tag="SCO0186" /note="SCJ1.35, crtE, probable phytoene dehydrogenase (phytoene desaturase) (hypothetical protein), len: 523 aa. High level of similarity to Streptomyces griseus SW:CRTI_STRGR (EMBL; L37405) phytoene dehydrogenase (EC 1.3.-.-) (phytoene desaturase) (507 aa), fasta scores opt: 2459 z-score: 2615.3 E(): 0; 74.5% identity in 501 aa overlap and Streptomyces setonii SW:CRTI_STRSE (EMBL; D55723) phytoene dehydrogenase (EC 1.3.-.-) (phytoene desaturase) (508 aa), fasta scores opt: 2455 z-score: 2611.0 E(): 0; 74.3% identity in 498 aa overlap. Contains a PS00982 Bacterial-type phytoene dehydrogenase signature" /product="phytoene dehydrogenase" /protein_id="NP_624522.1" /sec_met_domain="DAO (E-value: 9.7e-17, bitscore: 60.4, seeds: 521, tool: rule-based-clusters)" /transl_table=11 /translation="MRRVPGPTGHVVVVGAGLSGLACALHLLGAGRRVTVVERDAGPGG RSGRVRLGGYELDTGPTVLTMPHLADEAFAAVGDSLRRRVELTALDPAYRACFADGSAL DVHTDGEAMEAEVRRFAGPAQAAGYRDLRRWLERLYRAQMRRFIDTNFDSPLQLLHPDL ARLAALGGFGRLDGRIGRFLSDERLRRVFSFQALYAGVAPARALAAYAVIAYMDTVAGV WFPKGGMHALPRAMADAAATAGADLRWSAEVKALERSAGRVRAVHLASGERIACDAVVL TCELSTAYGLLGRAPRRPARLRHSPSAVILHAGTDRTWPHLAHHTLSFGAAWERTFEEL TRTGELMSDPSLLITRPTTHDPALAPPGRHLHYVLAPCPNTDVGPDAVAWRDLGPRYRE SLVGVLESRGLEGFADSVQEELLVTPLDWDAQGHAAGSPFSVSHTFAQTGPFRPRNLVR GLDNVVLAGCGTTPGVGVPTVLVSGKLAAARVTGGAGSRPARTRRSPAVSDPCPAPVPA GADDPS" aSDomain 8473..9954 /aSDomain="TIGR02734" /aSTool="tigrfam" /description="crtI_fam: phytoene desaturase" /detection="hmmscan" /domain_id="TIGRFam_SCO0186_0003" /evalue="2.30E-179" /identifier="TIGR02734" /label="SCO0186" /locus_tag="SCO0186" /protein_end="504" /protein_start="10" /score="595.3" /tool="antismash" /translation="VVVVGAGLSGLACALHLLGAGRRVTVVERDAGPGGRSGRVRLGGY ELDTGPTVLTMPHLADEAFAAVGDSLRRRVELTALDPAYRACFADGSALDVHTDGEAME AEVRRFAGPAQAAGYRDLRRWLERLYRAQMRRFIDTNFDSPLQLLHPDLARLAALGGFG RLDGRIGRFLSDERLRRVFSFQALYAGVAPARALAAYAVIAYMDTVAGVWFPKGGMHAL PRAMADAAATAGADLRWSAEVKALERSAGRVRAVHLASGERIACDAVVLTCELSTAYGL LGRAPRRPARLRHSPSAVILHAGTDRTWPHLAHHTLSFGAAWERTFEELTRTGELMSDP SLLITRPTTHDPALAPPGRHLHYVLAPCPNTDVGPDAVAWRDLGPRYRESLVGVLESRG LEGFADSVQEELLVTPLDWDAQGHAAGSPFSVSHTFAQTGPFRPRNLVRGLDNVVLAGC GTTPGVGVPTVLVSGKLAAARVTGGAGSRPARTRRS" PFAM_domain 8494..9912 /aSDomain="Amino_oxidase" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01593.27" /db_xref="GO:0016491" /description="Flavin containing amine oxidoreductase" /detection="hmmscan" /domain_id="clusterhmmer_SCO0186_0058" /evalue="2.50E-58" /gene_ontologies="GO:0016491: oxidoreductase activity" /label="SCO0186" /locus_tag="SCO0186" /protein_end="490" /protein_start="17" /score="198.6" /tool="antismash" /translation="LSGLACALHLLGAGRRVTVVERDAGPGGRSGRVRLGGYELDTGPT VLTMPHLADEAFAAVGDSLRRRVELTALDPAYRACFADGSALDVHTDGEAMEAEVRRFA GPAQAAGYRDLRRWLERLYRAQMRRFIDTNFDSPLQLLHPDLARLAALGGFGRLDGRIG RFLSDERLRRVFSFQALYAGVAPARALAAYAVIAYMDTVAGVWFPKGGMHALPRAMADA AATAGADLRWSAEVKALERSAGRVRAVHLASGERIACDAVVLTCELSTAYGLLGRAPRR PARLRHSPSAVILHAGTDRTWPHLAHHTLSFGAAWERTFEELTRTGELMSDPSLLITRP TTHDPALAPPGRHLHYVLAPCPNTDVGPDAVAWRDLGPRYRESLVGVLESRGLEGFADS VQEELLVTPLDWDAQGHAAGSPFSVSHTFAQTGPFRPRNLVRGLDNVVLAGCGTTPGVG VPTVLVSGKLAAARV" misc_feature 9826..9888 /gene_synonym="crtE; SCJ1.35" /locus_tag="SCO0186" /note="PS00982 Bacterial-type phytoene dehydrogenase signature" gene 10001..10996 /db_xref="GeneID:1095611" /gene_synonym="crtI; SCJ1.36" /locus_tag="SCO0187" CDS 10001..10996 /codon_start=1 /db_xref="GeneID:1095611" /gene_functions="biosynthetic (rule-based-clusters) terpene: phytoene_synt" /gene_kind="biosynthetic" /gene_synonym="crtI; SCJ1.36" /locus_tag="SCO0187" /note="SCJ1.36, crtI, probable phytoene synthase, len: 331 aa. Shares a high level of similarity with Streptomyces griseus SW:CRTB_STRGR (EMBL; L37405) phytoene synthase (342 aa), fasta scores opt: 1388 z-score: 1657.5 E(): 0 67.6% identity in 343 aa overlap and Mycobacterium marinum TR: O05423 (EMBL; U92075) phytoene synthase (319 aa), fasta scores opt: 996 z-score: 1191.5 E():0 52.2% identity in 316 aa overlap. Contains a PS01045 Squalene and phytoene synthases signature 2 and a Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases" /product="phytoene synthase" /protein_id="NP_624523.1" /sec_met_domain="phytoene_synt (E-value: 7.3e-127, bitscore: 421.0, seeds: 8, tool: rule-based-clusters)" /transl_table=11 /translation="MTRRELDAAGITDPLLRAAYTRCRRLNARHGKTYFLATRLLPLER RSAVHALYGFARWADDIVDDLDRHRTAGERDRALRRLESDLADGLRTGTGREPVVRAVA DTADRYDIDHVLFADFLSSMRADLTVTHYPTYADLQAYVHGSAAVIGLQMLPVLGTVTD RKEAAPHAAALGVAFQLTNFLRDVGEDLDRGRVYLPGSLLAAHGVDRPLLEWSRRTGRR DRRIRAALVAAEAMTRRVYRTAEPGIAMLDPRVRPCIRAAFTLYGGILDAIAEQDYTVL HRRAVVSRRRRAATAAEGVLCVAAARWRARTSPRVEAAGGPAAEWQGPVR" PFAM_domain 10085..10873 /aSDomain="SQS_PSY" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00494.22" /db_xref="GO:0009058" /description="Squalene/phytoene synthase" /detection="hmmscan" /domain_id="clusterhmmer_SCO0187_0059" /evalue="5.70E-61" /gene_ontologies="GO:0009058: biosynthetic process" /label="SCO0187" /locus_tag="SCO0187" /protein_end="291" /protein_start="28" /score="206.4" /tool="antismash" /translation="RHGKTYFLATRLLPLERRSAVHALYGFARWADDIVDDLDRHRTAG ERDRALRRLESDLADGLRTGTGREPVVRAVADTADRYDIDHVLFADFLSSMRADLTVTH YPTYADLQAYVHGSAAVIGLQMLPVLGTVTDRKEAAPHAAALGVAFQLTNFLRDVGEDL DRGRVYLPGSLLAAHGVDRPLLEWSRRTGRRDRRIRAALVAAEAMTRRVYRTAEPGIAM LDPRVRPCIRAAFTLYGGILDAIAEQDYTVLHRRAVVSRRR" misc_feature 10145..10915 /gene_synonym="crtI; SCJ1.36" /locus_tag="SCO0187" /note="Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases, score 253.20, E-value 3.5e-72" misc_feature 10520..10597 /gene_synonym="crtI; SCJ1.36" /locus_tag="SCO0187" /note="PS01045 Squalene and phytoene synthases signature 2" gene 10993..12003 /db_xref="GeneID:1095612" /gene_synonym="crtV; SCJ1.37" /locus_tag="SCO0188" CDS 10993..12003 /codon_start=1 /db_xref="GeneID:1095612" /gene_synonym="crtV; SCJ1.37" /locus_tag="SCO0188" /note="SCJ1.37, crtV, probable methylesterase, len: 336 aa. Highly similar to Streptomyces griseus TR:P72448 (EMBL; X95596) methylesterase (338 aa), fasta scores opt: 1315 z-score: 1538.7 E(): 0 60.5% identity in 337 aa overlap" /product="methylesterase" /protein_id="NP_624524.1" /transl_table=11 /translation="MSGRRGGRRWSPPVRRRGAGPDWAAQTPTWRQARPSLIADALERA SARPSGNWFVVGASRQVRAGDRPYGRTVGGVEVVLWRSDDGEPRAGSGICPHLGAPLRD SRVVCGTLVCHWHGLALDGSASAGWRPFPVHDDGVLVWVRLDEVGGEEPTERPVVPTRP ATGRGVDSVFTATGRCEPQDVVANRLDPWHGSWFHPYSFVDLSVVREPQGGEDDAFVVD VSFRVAGRLVVPVRAEFTAPEPRTVVMRITDGEGATSVVETHATPLTGPDHERPRTAVV EAVVAASDRPGFALARAAAPVLRPLMRRTAGRLWRDDLAYAERRWALRSTGRFPG" PFAM_domain 11146..11382 /aSDomain="Rieske" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00355.29" /db_xref="GO:0051537" /description="Rieske [2Fe-2S] domain" /detection="hmmscan" /domain_id="clusterhmmer_SCO0188_0060" /evalue="1.90E-13" /gene_ontologies="GO:0051537: 2 iron, 2 sulfur cluster binding" /label="SCO0188" /locus_tag="SCO0188" /protein_end="130" /protein_start="51" /score="50.3" /tool="antismash" /translation="NWFVVGASRQVRAGDRPYGRTVGGVEVVLWRSDDGEPRAGSGICP HLGAPLRDSRVVCGTLVCHWHGLALDGSASAGWR" PFAM_domain 11434..11991 /aSDomain="DUF5914" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF19299.2" /description="Domain of unknown function (DUF5914)" /detection="hmmscan" /domain_id="clusterhmmer_SCO0188_0061" /evalue="6.80E-96" /label="SCO0188" /locus_tag="SCO0188" /protein_end="333" /protein_start="147" /score="319.4" /tool="antismash" /translation="VGGEEPTERPVVPTRPATGRGVDSVFTATGRCEPQDVVANRLDPW HGSWFHPYSFVDLSVVREPQGGEDDAFVVDVSFRVAGRLVVPVRAEFTAPEPRTVVMRI TDGEGATSVVETHATPLTGPDHERPRTAVVEAVVAASDRPGFALARAAAPVLRPLMRRT AGRLWRDDLAYAERRWALRSTGR" gene complement(12019..13587) /db_xref="GeneID:1095613" /gene_synonym="crtU; SCJ1.38c" /locus_tag="SCO0189" CDS complement(12019..13587) /codon_start=1 /db_xref="GeneID:1095613" /gene_functions="biosynthetic-additional (rule-based-clusters) DAO" /gene_kind="biosynthetic-additional" /gene_synonym="crtU; SCJ1.38c" /locus_tag="SCO0189" /note="SCJ1.38c, crtU, probable dehydrogenase, a partial CDS, len: >336 aa. Highly similar to Streptomyces griseus TR:P72449 (EMBL:X95596) dehydrogenase (517 aa), fasta scores opt: 1277 z-score: 1459.8 E():0 69.0% identity in 281 aa overlap and Synechocystis sp SW:CRTI_SYNY3 (EMBL; X62574) phytoene dehydrogenase (427 aa), fasta scores opt: 133 z-score: 155.8 E():0.25 24.6% identity in 260 aa overlap.; SCJ12.01c, crtU, probable dehydrogenase, partial CDS, len: >278 aa. Highly similar to Streptomyces griseus TR:P72449 (EMBL:X95596) dehydrogenase (517 aa), fasta scores opt: 1311 z-score: 1471.3 E(): 0 74.0% identity in 269 aa overlap and Synechocystis sp. (strain PCC 6803) SW:CRTI_SYNY3 (EMBL:X62574) phytoene dehydrogenase (EC 1.3.-.-) (phytoene desaturase) (427 aa), fasta scores opt: 219 z-score: 250.2 E(): 1.4e-06 27.6% identity in 254 aa overlap." /product="dehydrogenase" /protein_id="NP_733493.1" /sec_met_domain="DAO (E-value: 3.1e-12, bitscore: 45.5, seeds: 521, tool: rule-based-clusters)" /transl_table=11 /translation="MTVRRTAAARRGRDRKAEIVFPAPGADRFGRGDEPSVAVIGGGIA GLAAATLMAERGARVTLYEKEDAVGGRLSGRRTTLADGSAVTMTRGFHAFFRQYYNLRG LLRRTDPGLDRLTPLPDYPLRHSGGLTDGFARVPRTPPLSAIGFVALSPTFGWRDLAAM DPRAALPLLDVRVPQVYERFDGVTATAFLESVRFPEAAHHLAFEVFSRSFFADPRRLSA AELLLMFHIYFLGSSEGLLFDVPVEPFPQALWNPLGDYLRRLGADVRTGTPVHGILPRA DGGADVLTDTGADRHQAVVLALDTAGLRQTVAASPGLGTDTWRDGIAALRTAPPFLVSR LWLDRPVDADRPGFLGTSGYGGLDNVSVLERYEGEAARWAARTGGSVVELHAYAVDPAA EPKEVQDELVDRLHQAYPETREARVVDARHEWRADCPMFEVGSHRRRPTVRTPHPWLTL AGDGIRCDLPVALMERAATTGFLAANALLADRGVRGQVLWTVPRTGRSPVLRAFGAVAG HRSAP" PFAM_domain complement(12127..13458) /aSDomain="Amino_oxidase" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01593.27" /db_xref="GO:0016491" /description="Flavin containing amine oxidoreductase" /detection="hmmscan" /domain_id="clusterhmmer_SCO0189_0062" /evalue="7.90E-33" /gene_ontologies="GO:0016491: oxidoreductase activity" /label="SCO0189" /locus_tag="SCO0189" /protein_end="487" /protein_start="43" /score="114.5" /tool="antismash" /translation="IAGLAAATLMAERGARVTLYEKEDAVGGRLSGRRTTLADGSAVTM TRGFHAFFRQYYNLRGLLRRTDPGLDRLTPLPDYPLRHSGGLTDGFARVPRTPPLSAIG FVALSPTFGWRDLAAMDPRAALPLLDVRVPQVYERFDGVTATAFLESVRFPEAAHHLAF EVFSRSFFADPRRLSAAELLLMFHIYFLGSSEGLLFDVPVEPFPQALWNPLGDYLRRLG ADVRTGTPVHGILPRADGGADVLTDTGADRHQAVVLALDTAGLRQTVAASPGLGTDTWR DGIAALRTAPPFLVSRLWLDRPVDADRPGFLGTSGYGGLDNVSVLERYEGEAARWAART GGSVVELHAYAVDPAAEPKEVQDELVDRLHQAYPETREARVVDARHEWRADCPMFEVGS HRRRPTVRTPHPWLTLAGDGIRCDLPVALMERAATTGFLAANALL" misc_feature 12752..12884 /note="665 (-1) 36793 36925 overlap with cosmid StJ1" misc_feature complement(12752..12884) /gene_synonym="crtU; SCJ1.38c" /locus_tag="SCO0189" /note="overlap with StJ12" gene complement(13584..14324) /db_xref="GeneID:1095614" /gene_synonym="crtT; SCJ12.02c" /locus_tag="SCO0190" CDS complement(13584..14324) /codon_start=1 /db_xref="GeneID:1095614" /gene_functions="biosynthetic-additional (smcogs) SMCOG1089:methyltransferase (Score: 76.7; E-value: 3.1e-23)" /gene_kind="biosynthetic-additional" /gene_synonym="crtT; SCJ12.02c" /locus_tag="SCO0190" /note="SCJ12.02c, crtT, probable methyltransferase, len: 246 aa. Shares a high level of sequence similarity with Streptomyces griseus TR:P72450 (EMBL:X95596) methyltransferase (242 aa), fasta scores opt: 984 z-score: 1164.2 E(): 0 65.0% identity in 234 aa overlap. Contains a Pfam match to entry PF01209 Ubie_methyltran, ubiE/COQ5 methyltransferase family" /product="methyltransferase" /protein_id="NP_624525.1" /transl_table=11 /translation="MTLLRDHDLARAFDHASHTYDGLTALNPGYRTGLLRSARRLALPA DGAGLHLLDLGCGTGASTRALLRAAPRARITAVDASAGMLRRALVKPWPARVRFLHLTA EEFATTREDEGPFDAVFAAYLFRNVTDPDAVLRAVRQLLRPGGRFAAHEYSLSGSPGHR ALWSAVCRGVVIPAGTLTGDRTLYRHLRRSVVAFDTAPEFAARLTRAGLTSVRVAPVAG WQTGIVHTFLARNGGPTTTEERVL" regulatory complement(13596..13601) /gene_synonym="crtT; SCJ12.02c" /locus_tag="SCO0190" /regulatory_class="ribosome_binding_site" misc_feature complement(13623..14324) /gene_synonym="crtT; SCJ12.02c" /locus_tag="SCO0190" /note="Pfam match to entry PF01209 Ubie_methyltran, ubiE/COQ5 methyltransferase family, score -45.20, E-value 1.1e-08" PFAM_domain complement(13668..14309) /aSDomain="Ubie_methyltran" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01209.21" /description="ubiE/COQ5 methyltransferase family" /detection="hmmscan" /domain_id="clusterhmmer_SCO0190_0063" /evalue="1.90E-19" /label="SCO0190" /locus_tag="SCO0190" /protein_end="219" /protein_start="5" /score="70.1" /tool="antismash" /translation="DHDLARAFDHASHTYDGLTALNPGYRTGLLRSARRLALPADGAGL HLLDLGCGTGASTRALLRAAPRARITAVDASAGMLRRALVKPWPARVRFLHLTAEEFAT TREDEGPFDAVFAAYLFRNVTDPDAVLRAVRQLLRPGGRFAAHEYSLSGSPGHRALWSA VCRGVVIPAGTLTGDRTLYRHLRRSVVAFDTAPEFAARLTRAGLTSVRVAP" gene complement(14321..15538) /db_xref="GeneID:1095615" /gene_synonym="crtY; SCJ12.03c" /locus_tag="SCO0191" CDS complement(14321..15538) /codon_start=1 /db_xref="GeneID:1095615" /gene_functions="biosynthetic (rule-based-clusters) terpene: Lycopene_cycl" /gene_kind="biosynthetic" /gene_synonym="crtY; SCJ12.03c" /locus_tag="SCO0191" /note="SCJ12.03c, crtY, probable lycopene cyclase, len: 405 aa. Highly similar to Streptomyces griseus TR:P72451 (EMBL:X95596) lycopene cyclase (418 aa), fasta scores opt: 1426 z-score: 1602.7 E(): 0 56.3% identity in 396 aa overlap" /product="lycopene cyclase" /protein_id="NP_624526.1" /sec_met_domain="Lycopene_cycl (E-value: 3.1e-111, bitscore: 370.9, seeds: 20, tool: rule-based-clusters)" /transl_table=11 /translation="MTPRSAQDSDVLVIGGGAAGLSLAHRLTENGTAPAMTLVEPPDGP LRPAERTWCYWGAAADGLEEAVGASWSVLRLHGADGGSVTVDPAPFTYRMVRSADFERM VHGRLARTDGARLLRGTAESVRAVPAGTEVRCTLPGGRPLTLYARRVFDSRPLPELPPA RTCLLQHFRGWFVHTRTDRFDPAVADLMDFRVPQPAHGLAFGYVLPLAPDRALVEYTEF SRAPLTTEAYESALGHYCRDILGLGELTVERTEQGVIPMTDARFPGRAGPAVYRIGTAG GATRPATGYTFAAVQRHSGAIAAALRDGHDRVPAPHGRRARAMDAVLLRALDTGRIDGP RFFTDLFRRVPAERLLRFLDGTTSLREEWGIGLRTPVRPMLRTAAEVPFLPRRSQPLAR TGGNNR" PFAM_domain complement(14387..15511) /aSDomain="Lycopene_cycl" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF05834.15" /description="Lycopene cyclase protein" /detection="hmmscan" /domain_id="clusterhmmer_SCO0191_0064" /evalue="5.20E-130" /label="SCO0191" /locus_tag="SCO0191" /protein_end="384" /protein_start="9" /score="434.0" /tool="antismash" /translation="DVLVIGGGAAGLSLAHRLTENGTAPAMTLVEPPDGPLRPAERTWC YWGAAADGLEEAVGASWSVLRLHGADGGSVTVDPAPFTYRMVRSADFERMVHGRLARTD GARLLRGTAESVRAVPAGTEVRCTLPGGRPLTLYARRVFDSRPLPELPPARTCLLQHFR GWFVHTRTDRFDPAVADLMDFRVPQPAHGLAFGYVLPLAPDRALVEYTEFSRAPLTTEA YESALGHYCRDILGLGELTVERTEQGVIPMTDARFPGRAGPAVYRIGTAGGATRPATGY TFAAVQRHSGAIAAALRDGHDRVPAPHGRRARAMDAVLLRALDTGRIDGPRFFTDLFRR VPAERLLRFLDGTTSLREEWGIGLRTPVRPMLRTA" gene complement(15809..17059) /db_xref="GeneID:1095616" /gene_synonym="SCJ12.04c" /locus_tag="SCO0192" CDS complement(15809..17059) /codon_start=1 /db_xref="GeneID:1095616" /gene_functions="biosynthetic-additional (rule-based-clusters) DAO" /gene_functions="biosynthetic-additional (smcogs) SMCOG1222:dehydrogenase (Score: 64.3; E-value: 1.9e-19)" /gene_kind="biosynthetic-additional" /gene_synonym="SCJ12.04c" /locus_tag="SCO0192" /note="SCJ12.04c, possible oxidoreductase, len: 416 aa. Similar to many protoporphyrinogen oxidases including: Propionibacterium freudenreichii shermanii SW:PPOX_PROFR (EMBL:D85417) HemY (527 aa), fasta scores opt: 228 z-score: 249.0 E(): 1.6e-06 26.8% identity in 504 aa overlap and Bacillus subtilis SW:PPOX_BACSU (EMBL; M97208) HemY (470 aa), fasta scores opt: 209 z-score: 229.3 E(): 2.1e-05 25.7% identity in 311 aa overlap. Contains a Pfam match to entry PF01593 Amino_oxidase" /product="oxidoreductase" /protein_id="NP_624527.1" /sec_met_domain="DAO (E-value: 4.4e-09, bitscore: 35.2, seeds: 521, tool: rule-based-clusters)" /transl_table=11 /translation="MSDGQHRAADAVVVGAGLAGLACALDLCRAGWRVALLEASDGVGG RMRTDRRDGFLLDRGFQVFNTSYPQVKRRMELKSLRLRPFTAGVVAHTSNGPVRLADPT REPRAAGTLLPGRALPARDLAALAALTARDAVLPVAVTRRRRDRPTSAALSRVGLSDAA IAGILRPFLSGVFLEDRLETSARFFHLVWRSMVRGSLCLPAEGIGAVPAQLADGLPDGV LRLGTPVAEITDAGVLLGDGGEVPARVVVVATDPATAAGLLPDLTVPDTRTVTTYYHAT DSPPTAEPILMVDSTGAILNTCVLSQVAPTYAPPGTGLVSTSVLGTDPPGRAQAVLRRL AELYGTDTSGWEQVAARTVDGALPAMLPPWPLSRTTRIGPGRYVCGDHRATGSVQGALA SGTRAAREVRADREPQR" misc_feature complement(15833..17008) /gene_synonym="SCJ12.04c" /locus_tag="SCO0192" /note="Pfam match to entry PF01593 Amino_oxidase, score -105.60, E-value 0.0012" PFAM_domain complement(15836..17008) /aSDomain="Amino_oxidase" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF01593.27" /db_xref="GO:0016491" /description="Flavin containing amine oxidoreductase" /detection="hmmscan" /domain_id="clusterhmmer_SCO0192_0065" /evalue="2.40E-50" /gene_ontologies="GO:0016491: oxidoreductase activity" /label="SCO0192" /locus_tag="SCO0192" /protein_end="408" /protein_start="17" /score="172.3" /tool="antismash" /translation="LAGLACALDLCRAGWRVALLEASDGVGGRMRTDRRDGFLLDRGFQ VFNTSYPQVKRRMELKSLRLRPFTAGVVAHTSNGPVRLADPTREPRAAGTLLPGRALPA RDLAALAALTARDAVLPVAVTRRRRDRPTSAALSRVGLSDAAIAGILRPFLSGVFLEDR LETSARFFHLVWRSMVRGSLCLPAEGIGAVPAQLADGLPDGVLRLGTPVAEITDAGVLL GDGGEVPARVVVVATDPATAAGLLPDLTVPDTRTVTTYYHATDSPPTAEPILMVDSTGA ILNTCVLSQVAPTYAPPGTGLVSTSVLGTDPPGRAQAVLRRLAELYGTDTSGWEQVAAR TVDGALPAMLPPWPLSRTTRIGPGRYVCGDHRATGSVQGALASGTRAAREV" regulatory complement(17064..17068) /regulatory_class="ribosome_binding_site" gene complement(17293..18297) /db_xref="GeneID:1095617" /gene_synonym="SCJ12.05c" /locus_tag="SCO0193" CDS complement(17293..18297) /codon_start=1 /db_xref="GeneID:1095617" /gene_synonym="SCJ12.05c" /locus_tag="SCO0193" /note="SCJ12.05c, possible DNA-binding regulator, len:334 aa. Some similarity to Myxococcus xanthus TR:Q50900 (EMBL:Z21955) regulatory protein (299 aa), fasta scores opt: 121 z-score: 141.6 E(): 1.6 32.4% identity in 281 aa overlap and Myxococcus xanthus TR:Q50899 (EMBL:Z21955) regulatory protein (288 aa), fasta scores opt: 118 z-score: 138.5 E() 2.4 26.9% identity in 279 aa overlap. Contains a possible helix-turn-helix motif between aa's 23..44." /product="DNA-binding regulator" /protein_id="NP_624528.1" /transl_table=11 /translation="MNAYTGDGDEPVDDGGPRRGGLTTGEVARRLGVAPTTVRTWDRRY GLGPDAHVDGRHRRWTAADLARLERMCALTATGLPPAEAARLARSEERPTAAGPRNTDA ARRAPTGRRSRAGSGLQLGDVRQECRGIARAALRLDASALDELLLAAIAEHGLVAAWTE VIVPTLQAVGRKWETSGEKYVEVEHFLSWHVSGALRRAAPPAVEDRPGSTTVLACVPGE NHTLPLEVLSAALTERGVPVRMFGGALPVESLVAAVRRTGPAAVGLWSQSRTTASRPLA QHVAAMEWGVRGARRRPVVLTLGPGWAGQAVAGLARPSGLAEAVAALEPSVYP" PFAM_domain complement(17698..17910) /aSDomain="B12-binding_2" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF02607.20" /description="B12 binding domain" /detection="hmmscan" /domain_id="clusterhmmer_SCO0193_0067" /evalue="1.10E-07" /label="SCO0193" /locus_tag="SCO0193" /protein_end="200" /protein_start="129" /score="32.4" /tool="antismash" /translation="RGIARAALRLDASALDELLLAAIAEHGLVAAWTEVIVPTLQAVGR KWETSGEKYVEVEHFLSWHVSGALRR" PFAM_domain complement(18028..18231) /aSDomain="MerR_1" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF13411.9" /db_xref="GO:0003677" /db_xref="GO:0006355" /description="MerR HTH family regulatory protein" /detection="hmmscan" /domain_id="clusterhmmer_SCO0193_0066" /evalue="1.90E-12" /gene_ontologies="GO:0003677: DNA binding" /gene_ontologies="GO:0006355: regulation of DNA-templated transcription" /label="SCO0193" /locus_tag="SCO0193" /protein_end="90" /protein_start="22" /score="47.1" /tool="antismash" /translation="TTGEVARRLGVAPTTVRTWDRRYGLGPDAHVDGRHRRWTAADLAR LERMCALTATGLPPAEAARLARS" regulatory 18445..18450 /regulatory_class="ribosome_binding_site" gene 18458..19066 /db_xref="GeneID:1095618" /gene_synonym="SCJ12.06" /locus_tag="SCO0194" CDS 18458..19066 /codon_start=1 /db_xref="GeneID:1095618" /gene_functions="regulatory (smcogs) SMCOG1032:RNA polymerase, sigma-24 subunit, ECF subfamily (Score: 131.9; E-value: 3.1e-40)" /gene_kind="regulatory" /gene_synonym="SCJ12.06" /locus_tag="SCO0194" /note="SCJ12.06, possible sigma factor, len: 202 aa. Similar to many including: Rhodobacter sphaeroide TR:O33546 (EMBL; U11283) RpoE homologue (168 aa), fasta scores opt: 291 z-score: 373.4 E(): 1.9e-13 35.4% identity in 161 aa overlap and Streptomyces coelicolor TR:O54163 (EMBL; AL021411) sigma factor SC7H1.04 (200 aa), fasta scores opt: 255 z-score: 327.4 E(): 7.1e-11 33.7% identity in 184 aa overlap. Contains a PS01063 Sigma-70 factors ECF subfamily signature and a Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains a possible helix-turn-helix motif between aa's 162..183." /product="sigma factor" /protein_id="NP_624529.1" /transl_table=11 /translation="MNTRTRPTTTPVPPVEETRYEEELAHGLVKADEDAFAAIYRRWGS LVHTLATRSLGDAHEAEDVTQQVFVGAWRGRHGFRPERGTLGAWLVGITRRKVVDALAA RTRRLSLVESAGQDITPARLVQPALDEVLDRVLLVEALSRLPQAQRDVLCMAFYEDLTQ AQIAERTGVPLGTVKSHARRGLHRLRTAVGPGAAHDTCV" aSDomain 18557..19030 /aSDomain="TIGR02937" /aSTool="tigrfam" /description="sigma70-ECF: RNA polymerase sigma factor, sigma-70 family" /detection="hmmscan" /domain_id="TIGRFam_SCO0194_0004" /evalue="5.20E-25" /identifier="TIGR02937" /label="SCO0194" /locus_tag="SCO0194" /protein_end="191" /protein_start="33" /score="85.9" /tool="antismash" /translation="DAFAAIYRRWGSLVHTLATRSLGDAHEAEDVTQQVFVGAWRGRHG FRPERGTLGAWLVGITRRKVVDALAARTRRLSLVESAGQDITPARLVQPALDEVLDRVL LVEALSRLPQAQRDVLCMAFYEDLTQAQIAERTGVPLGTVKSHARRGLHRLRTA" PFAM_domain 18572..18778 /aSDomain="Sigma70_r2" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF04542.17" /db_xref="GO:0003700" /db_xref="GO:0006352" /db_xref="GO:0006355" /description="Sigma-70 region 2" /detection="hmmscan" /domain_id="clusterhmmer_SCO0194_0068" /evalue="5.00E-18" /gene_ontologies="GO:0003700: DNA-binding transcription factor activity" /gene_ontologies="GO:0006352: DNA-templated transcription initiation" /gene_ontologies="GO:0006355: regulation of DNA-templated transcription" /label="SCO0194" /locus_tag="SCO0194" /protein_end="107" /protein_start="38" /score="64.8" /tool="antismash" /translation="IYRRWGSLVHTLATRSLGDAHEAEDVTQQVFVGAWRGRHGFRPER GTLGAWLVGITRRKVVDALAARTR" misc_feature 18602..18808 /gene_synonym="SCJ12.06" /locus_tag="SCO0194" /note="Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily), score 47.10, E-value 3.8e-10" misc_feature 18638..18736 /gene_synonym="SCJ12.06" /locus_tag="SCO0194" /note="PS01063 Sigma-70 factors ECF subfamily signature, info count = 32.1" PFAM_domain 18878..19024 /aSDomain="Sigma70_r4" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF04545.19" /db_xref="GO:0003700" /db_xref="GO:0006352" /db_xref="GO:0006355" /description="Sigma-70, region 4" /detection="hmmscan" /domain_id="clusterhmmer_SCO0194_0069" /evalue="4.70E-17" /gene_ontologies="GO:0003700: DNA-binding transcription factor activity" /gene_ontologies="GO:0006352: DNA-templated transcription initiation" /gene_ontologies="GO:0006355: regulation of DNA-templated transcription" /label="SCO0194" /locus_tag="SCO0194" /protein_end="189" /protein_start="140" /score="61.4" /tool="antismash" /translation="ALSRLPQAQRDVLCMAFYEDLTQAQIAERTGVPLGTVKSHARRGL HRLR" regulatory 19160..19164 /regulatory_class="ribosome_binding_site" gene 19175..19861 /db_xref="GeneID:1095619" /gene_synonym="SCJ12.07" /locus_tag="SCO0195" CDS 19175..19861 /codon_start=1 /db_xref="GeneID:1095619" /gene_synonym="SCJ12.07" /locus_tag="SCO0195" /note="SCJ12.07, possible lipoprotein, len: 228 aa. Contains an N-terminal signal sequence and a PS00013 Prokaryotic membrane lipoprotein lipid attachment site." /product="lipoprotein" /protein_id="NP_624530.1" /transl_table=11 /translation="MMSRTTIAVAGSAGACALAPTAPAATAAPEQAQDTGLVSVFHGIP GTTVDVFANGDEPLGDFQPGTVTEGGNTTVAAHLSADGKPRLTTFTDDVSKTDAGRSRL TVRHVAAAPAVDVRAGGHPLFTGLANPDEDTALVEAGIVNADVVLAGTETVVVGPAGLD LKEGTTNVVYAWGSAEDQTLALPGQAFGGMDSTPLAVHPGAGGTAATPNASDRWRARAA TPARSR" misc_feature 19190..19222 /gene_synonym="SCJ12.07" /locus_tag="SCO0195" /note="PS00013 Prokaryotic membrane lipoprotein lipid attachment site." PFAM_domain 19370..19525 /aSDomain="DUF4397" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF14344.9" /description="Domain of unknown function (DUF4397)" /detection="hmmscan" /domain_id="clusterhmmer_SCO0195_0070" /evalue="4.60E-08" /label="SCO0195" /locus_tag="SCO0195" /protein_end="117" /protein_start="65" /score="33.9" /tool="antismash" /translation="TVTEGGNTTVAAHLSADGKPRLTTFTDDVSKTDAGRSRLTVRHVA AAPAVDV" regulatory 19972..19977 /regulatory_class="ribosome_binding_site" gene 19983..20387 /db_xref="GeneID:1095620" /gene_synonym="SCJ12.08" /locus_tag="SCO0196" CDS 19983..20387 /codon_start=1 /db_xref="GeneID:1095620" /gene_synonym="SCJ12.08" /locus_tag="SCO0196" /note="SCJ12.08, unknown, len:134 aa. Shares a low level of similarity with Mycobacterium tuberculosis TR:O53597 (EMBL; AL021426) hypothetical 24.0 KD protein MTV028.10C (224 aa), fasta scores opt: 119 z-score: 159.2 E(): 0.1 32.8% identity in 116 aa overlap." /product="hypothetical protein" /protein_id="NP_624531.1" /transl_table=11 /translation="MGHVHPSHLVELALGHASGEADVGALRHAASCPRCREELLRLTRV VTAARGAEASDLPVPPPERVWQRIALEVLPETDRVPRLRESSAHGSADERVRGSQRRWT DHAGEGLLGLALAIAVLLLRRWRIRAGSGN" gene complement(20519..20959) /db_xref="GeneID:1095621" /gene_synonym="SCJ12.09c" /locus_tag="SCO0197" CDS complement(20519..20959) /codon_start=1 /db_xref="GeneID:1095621" /gene_synonym="SCJ12.09c" /locus_tag="SCO0197" /note="SCJ12.09c, hypothetical protein, len: 146 aa. Some similarity to Mycobacterium tuberculosis TR:O53625 (EMBL; AL021428) hypothetical 16.6 KD protein (152 aa), fasta scores opt: 291 z-score: 377.8 E(): 1.1e-13 42.9% identity in 133 aa overlap. Also similar to TR:Q9RI34 (EMBL:AL109989) S. coelicolor SCJ12.26 (137 aa), fasta scores: opt: 524 z-score: 568.0 E(): 2.2e-26 62.2% identity in 135 aa overlap" /product="hypothetical protein" /protein_id="NP_624532.1" /transl_table=11 /translation="MYRNDGFRELNRQESLQRLANAPVGRIVHTRDALPAVLPVNFVLE KSGAVLLRTSASSELVRAVDGAVVAFEADEVDAVTHSGWSVVVTGLASVVTDPGEHEQL VRTGPRSWVPWPVEVFVRIAPDLVSGRELVGGRTLYGLDPPT" PFAM_domain complement(20567..20926) /aSDomain="Pyridox_ox_2" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF12900.10" /description="Pyridoxamine 5'-phosphate oxidase" /detection="hmmscan" /domain_id="clusterhmmer_SCO0197_0071" /evalue="8.90E-26" /label="SCO0197" /locus_tag="SCO0197" /protein_end="131" /protein_start="11" /score="90.7" /tool="antismash" /translation="RQESLQRLANAPVGRIVHTRDALPAVLPVNFVLEKSGAVLLRTSA SSELVRAVDGAVVAFEADEVDAVTHSGWSVVVTGLASVVTDPGEHEQLVRTGPRSWVPW PVEVFVRIAPDLVSGR" gene complement(21492..22358) /db_xref="GeneID:1095622" /gene_synonym="SCJ12.10c" /locus_tag="SCO0198" CDS complement(21492..22358) /codon_start=1 /db_xref="GeneID:1095622" /gene_synonym="SCJ12.10c" /locus_tag="SCO0198" /note="SCJ12.10c, unknown, len: 288 aa. Similar to several hypothetical proteins including: Mycobacterium tuberculosis SW:YW12_MYCTU (EMBL; Z74025) hypothetical 30.9 KD protein MTCY39.12 (295 aa), fasta scores opt: 363 z-score: 441.0 E(): 3.3e-17 32.3% identity in 288 aa overlap and Mycobacterium tuberculosis TR:O06189 (EMBL; Z95387) hypothetical 31.7 KD protein MTCY1A10.09C (297 aa), fasta scores opt: 336 z-score: 408.6 E(): 2.1e-15 29.3% identity in 294 aa overlap. Also highly similar to S. coelicolor hypothetical proteins (AL109962) SCJ1.29c (283 aa), fasta scores opt: 1161 z-score: 1097.2 E(): 0 63.5% identity in 288 aa overlap and SCJ1.16c (294 aa), fasta scores opt:892 z-score: 844.7 E():0 50.3% identity in 296 aa overlap" /product="hypothetical protein" /protein_id="NP_624533.1" /transl_table=11 /translation="MYLPMVVGVDGSESSLGAVDWAADEAALHEVPLRIVHAYRWDRYE GASLARELGKPSGHVTTDDILAVATRRARRHHPDLAVTTEATAEEPEYVLLREARNASA VILGTRGRGELAGLLLGSVSLTVATMSDCPVVVTRGDHDDRAAGGGRRGRIVVGVADAP TAAVRFACEEARRRGAALDAVRAWRCPTHDTVDHPLLAGTPERLHEERAAKELEAALAD APADVRLRRRTAEGPGSRVLSAASHEADLLVVGRRRPGQFGHRLGRVAHTLLHHSACPV AVVPDTT" PFAM_domain complement(21504..21899) /aSDomain="Usp" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00582.29" /description="Universal stress protein family" /detection="hmmscan" /domain_id="clusterhmmer_SCO0198_0073" /evalue="1.40E-19" /label="SCO0198" /locus_tag="SCO0198" /protein_end="285" /protein_start="153" /score="71.1" /tool="antismash" /translation="RIVVGVADAPTAAVRFACEEARRRGAALDAVRAWRCPTHDTVDHP LLAGTPERLHEERAAKELEAALADAPADVRLRRRTAEGPGSRVLSAASHEADLLVVGRR RPGQFGHRLGRVAHTLLHHSACPVAVVP" PFAM_domain complement(21942..22358) /aSDomain="Usp" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00582.29" /description="Universal stress protein family" /detection="hmmscan" /domain_id="clusterhmmer_SCO0198_0072" /evalue="6.10E-25" /label="SCO0198" /locus_tag="SCO0198" /protein_end="139" /protein_start="0" /score="88.5" /tool="antismash" /translation="MYLPMVVGVDGSESSLGAVDWAADEAALHEVPLRIVHAYRWDRYE GASLARELGKPSGHVTTDDILAVATRRARRHHPDLAVTTEATAEEPEYVLLREARNASA VILGTRGRGELAGLLLGSVSLTVATMSDCPVVVTR" gene complement(22364..23386) /db_xref="GeneID:1095623" /gene_synonym="SCJ12.11c" /locus_tag="SCO0199" CDS complement(22364..23386) /NRPS_PKS="Domain: PKS_ER (15-227). E-value: 3.6e-12. Score: 37.9. Matches aSDomain: nrpspksdomains_SCO0199_PKS_ER.1" /codon_start=1 /db_xref="GeneID:1095623" /gene_functions="biosynthetic-additional (rule-based-clusters) ADH_N" /gene_functions="biosynthetic-additional (rule-based-clusters) ADH_zinc_N" /gene_functions="biosynthetic-additional (smcogs) SMCOG1040:alcohol dehydrogenase (Score: 306.2; E-value: 4.2e-93)" /gene_kind="biosynthetic-additional" /gene_synonym="SCJ12.11c" /locus_tag="SCO0199" /note="SCJ12.11c, probable alcohol dehydrogenase, len: 340 aa. Highly similar to many e.g. Bacillus stearothermophilus SW:ADH3_BACST (EMBL; Z27089) alcohol dehydrogenase (EC 1.1.1.1) (ADH-HT) (339 aa), fasta scores opt: 1281 z-score: 1383.7 E(): 0 55.2% identity in 337 aa overlap. Contains a PS00059 Zinc-containing alcohol dehydrogenases signature and a Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases." /product="alcohol dehydrogenase" /protein_id="NP_624534.1" /sec_met_domain="ADH_N (E-value: 1.9e-31, bitscore: 107.0, seeds: 66, tool: rule-based-clusters)" /sec_met_domain="ADH_zinc_N (E-value: 6.5e-28, bitscore: 96.2, seeds: 86, tool: rule-based-clusters)" /transl_table=11 /translation="MKAAVVREFGKPLVIEDRPDPEPGPGQVLVAVEASGLCHTDIHAA HGDWPVKPTPPFVPGHEGVGLVEKLGDGVTHLAVGQRVAVPWLGKACGRCEHCRSGWET LCEDQVNTGYGCDGGYAEKMLAWADFAQPVPEGVSALDAAPLTCAGVTTYKALKVAEVG PAQLVAVSGVGGLGHLAVQYAKIAGARVVAIDVTDDKLQLARELGADLVIDARTQDVGA ELKRHGGAHAALALAVNPAAFQAVNSGLRRGGKLVMVALPAHGTLQVPIFDTVLNGTSV IGSIVGTRQDLAEVFQLHAEGRTKVIRETRPLAAVNDCIDEVLGGQVKARIVFDLNAGG " regulatory complement(22368..22372) /gene_synonym="SCJ12.11c" /locus_tag="SCO0199" /regulatory_class="ribosome_binding_site" misc_feature complement(22382..23380) /gene_synonym="SCJ12.11c" /locus_tag="SCO0199" /note="Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases, score 359.60, E-value 3.2e-104" PFAM_domain complement(22493..22864) /aSDomain="ADH_zinc_N" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00107.29" /description="Zinc-binding dehydrogenase" /detection="hmmscan" /domain_id="clusterhmmer_SCO0199_0075" /evalue="1.60E-27" /label="SCO0199" /locus_tag="SCO0199" /protein_end="298" /protein_start="174" /score="96.2" /tool="antismash" /translation="GLGHLAVQYAKIAGARVVAIDVTDDKLQLARELGADLVIDARTQD VGAELKRHGGAHAALALAVNPAAFQAVNSGLRRGGKLVMVALPAHGTLQVPIFDTVLNG TSVIGSIVGTRQDLAEVFQL" aSDomain complement(22706..23341) /aSDomain="PKS_ER" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_SCO0199_PKS_ER.1" /evalue="3.60E-12" /label="SCO0199_PKS_ER.1" /locus_tag="SCO0199" /protein_end="227" /protein_start="15" /score="37.9" /tool="antismash" /translation="EDRPDPEPGPGQVLVAVEASGLCHTDIHAAHGDWPVKPTPPFVPG HEGVGLVEKLGDGVTHLAVGQRVAVPWLGKACGRCEHCRSGWETLCEDQVNTGYGCDGG YAEKMLAWADFAQPVPEGVSALDAAPLTCAGVTTYKALKVAEVGPAQLVAVSGVGGLGH LAVQYAKIAGARVVAIDVTDDKLQLARELGADLVIDARTQDVGAELKRH" PFAM_domain complement(23003..23314) /aSDomain="ADH_N" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF08240.15" /description="Alcohol dehydrogenase GroES-like domain" /detection="hmmscan" /domain_id="clusterhmmer_SCO0199_0074" /evalue="4.70E-31" /label="SCO0199" /locus_tag="SCO0199" /protein_end="128" /protein_start="24" /score="107.0" /tool="antismash" /translation="PGQVLVAVEASGLCHTDIHAAHGDWPVKPTPPFVPGHEGVGLVEK LGDGVTHLAVGQRVAVPWLGKACGRCEHCRSGWETLCEDQVNTGYGCDGGYAEKMLAWA " misc_feature complement(23165..23209) /gene_synonym="SCJ12.11c" /locus_tag="SCO0199" /note="PS00059 Zinc-containing alcohol dehydrogenases signature." regulatory complement(23394..23399) /regulatory_class="ribosome_binding_site" gene complement(23425..24330) /db_xref="GeneID:1095624" /gene_synonym="SCJ12.12c" /locus_tag="SCO0200" CDS complement(23425..24330) /codon_start=1 /db_xref="GeneID:1095624" /gene_synonym="SCJ12.12c" /locus_tag="SCO0200" /note="SCJ12.12c, unknown, len: 301 aa. Similar to several hypothetical proteins including: Mycobacterium tuberculosis SW:YW23_MYCTU (EMBL; Z74025) hypothetical 33.9 KD protein MTCY39.23C (317 aa), fasta scores opt: 380 z-score: 447.3 E(): 1.5e-17 33.5% identity in 316 aa overlap and S. coelicolor (EMBL;AL109962) SCJ1.30c (328 aa)fasta scores opt: 1274 z-score: 1163.7 E():0 65.3% identity in 300 aa overlap. Contains 2x Pfam match to entry PF00582 Usp, Universal stress protein family." /product="hypothetical protein" /protein_id="NP_624535.1" /transl_table=11 /translation="MARTITVGLDGSPESRAAAEWAAREGTLRRVPVRLLHVWQPVPEP MAQAPLLGAETHQHWTERIPRDTAEGLRLRHPGVEVTTEQATGNPADALLAGTLDAELL VLGSRALSGLTGFLVGSVGQSVIARTETPVILVRAGEQAADEHLKDPTGIPSAATGFRP VVVGLDTGSPDEAVLSFAFEEARRRRAPLTAVRAWNLPSSYTYSIAAGFDPREELARAQ AEALGEALLPWREKYPDVEVTETCRLGSPAEHLIDAARDASLVVVGRRIRRSPFGVHIG AVAHAVMHHATTPVAVVAHD" misc_feature complement(23437..23754) /gene_synonym="SCJ12.12c" /locus_tag="SCO0200" /note="Pfam match to entry PF00582 Usp, Universal stress protein family, score 47.30, E-value 3.4e-10" PFAM_domain complement(23437..23850) /aSDomain="Usp" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00582.29" /description="Universal stress protein family" /detection="hmmscan" /domain_id="clusterhmmer_SCO0200_0077" /evalue="1.70E-19" /label="SCO0200" /locus_tag="SCO0200" /protein_end="298" /protein_start="160" /score="70.9" /tool="antismash" /translation="FRPVVVGLDTGSPDEAVLSFAFEEARRRRAPLTAVRAWNLPSSYT YSIAAGFDPREELARAQAEALGEALLPWREKYPDVEVTETCRLGSPAEHLIDAARDASL VVVGRRIRRSPFGVHIGAVAHAVMHHATTPVAVV" PFAM_domain complement(23917..24330) /aSDomain="Usp" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF00582.29" /description="Universal stress protein family" /detection="hmmscan" /domain_id="clusterhmmer_SCO0200_0076" /evalue="1.60E-25" /label="SCO0200" /locus_tag="SCO0200" /protein_end="138" /protein_start="0" /score="90.4" /tool="antismash" /translation="MARTITVGLDGSPESRAAAEWAAREGTLRRVPVRLLHVWQPVPEP MAQAPLLGAETHQHWTERIPRDTAEGLRLRHPGVEVTTEQATGNPADALLAGTLDAELL VLGSRALSGLTGFLVGSVGQSVIARTETPVILVR" misc_feature complement(23920..24231) /gene_synonym="SCJ12.12c" /locus_tag="SCO0200" /note="Pfam match to entry PF00582 Usp, Universal stress protein family, score 27.00, E-value 0.00011" misc_feature 24415..24429 /note="TFBS match to OsdR, Development and stress management regulator, confidence: strong, score: 28.31" /tool="antismash" gene complement(24483..25154) /db_xref="GeneID:1095625" /gene_synonym="SCJ12.13c" /locus_tag="SCO0201" CDS complement(24483..25154) /codon_start=1 /db_xref="GeneID:1095625" /gene_synonym="SCJ12.13c" /locus_tag="SCO0201" /note="SCJ12.13c, possible integral membrane protein, len: 223 aa. Contains potential membrane spanning hydrophobic domains." /product="hypothetical protein" /protein_id="NP_624536.1" /transl_table=11 /translation="MSGTNRILSEGVTVMAMHQSTHRGSGFHLPSSRRNGAVSVPGAAD SVEAGALTARAFVFASARVLMGFVFLWAFLDKTFGFGYATASGKGWIDGGSPTEGFLGH VAVGPMESTFHSWAGAAWADWLFMLGLLGVGLALTAGVALRPAAVAGTVMMALMWAAEW PPAKHLSDGSASMSTNPFADYHVLYAVLLIALAAVSAGDALGLGRLWARLPIVRDHAWL R" PFAM_domain complement(24675..24971) /aSDomain="DoxX" /aSTool="clusterhmmer" /database="35.0" /db_xref="PF07681.15" /description="DoxX" /detection="hmmscan" /domain_id="clusterhmmer_SCO0201_0078" /evalue="4.70E-05" /label="SCO0201" /locus_tag="SCO0201" /protein_end="160" /protein_start="61" /score="24.0" /tool="antismash" /translation="ARVLMGFVFLWAFLDKTFGFGYATASGKGWIDGGSPTEGFLGHVA VGPMESTFHSWAGAAWADWLFMLGLLGVGLALTAGVALRPAAVAGTVMMALMWA" ORIGIN 1 gcggcggccg ccggctacta cggcgcgcga gtcgtcctca accggcgtcg tcgcgccgcg 61 tgggagcacg agtggcagga catcggttcc cagtggggac gcgcggccag ttgatccggg 121 acacgtcgta gggcttccac cggcgcgaca tggaacggtt ctcgggtggt gaggaagccc 181 gtgagggggg aggaggagcg atgagcgact tcatggtcgt ggcgcggacg gttccgcgcc 241 gggtctccaa gccgtcgtac gggcggcgcg tgaggcagaa gtccgcaaca tgacgcttcg 301 ggtcgtccac gcgctggccc ggcccgcgcc cgcaccgagg ccccgggtac cgttgtcgcg 361 gggctggtct ttcccggaga accgcttccg atgctggtgg cgcaggctct gtccgccgct 421 gcggtcgtgg tgggtcacag gggtccccat cccttccagg gagctctgat cggatccctc 481 gcgaccgggc tcgccgccca ctccgagtgc cccgtggtgg tcgtaggcga gcccgagaat 541 ccggcgggtc ctgtggcctt gggagtcgac ggatcggccg ccggagcggc tgccgtccgc 601 cttccgggag acttccgtgc agggtgcgga catcaccgcc gtgcacgcct ggacggcctg 661 gaacgcgccg atgccgcctc ccccagacga gagaccgagc cctacgcctg tgaacccggc 721 atgctcgccg cggaggaagg gcggctgctg gccgagacgc tcgcgggcat gtgcgcccgc 781 tatcccgagg tgagggtgga acgcagcacc gtccacggag tgcacggccg acgttgatcg 841 aggaaggggg cacgatcacg acggaagtcg ctcaaggctt tcctgccggc ccagcgtccg 901 gcgacccggc ccggcggact cgacgcccac cgggccggcc gtgtcacaca gcgtttgcgg 961 cgacgacttc gcgcttcggg ccgccgagga ccaccttgag cgctccggtg tcggctgccg 1021 cggagaagac ctcgtacgcc tcctccatgc gctccagcgg gaacgtgtgg gtcaccaact 1081 ggccggtggg gagtcggccg gacgccgcca tgcgcaacag cgtcggcgtg gaacgggtgt 1141 cgaccagacc ggtggtgacg gtgacgttct tgctccacag gtcttccagg tgcagggtcg 1201 ccggcctgcc gtgcacgccg acgttggcga cgtgcccgcc cgggcgcacc acgcgcgtgc 1261 acatctcgaa cgtctcgggg acgcccacgg cctcgatgac cacatcggcg ccgaggcccc 1321 cggtgaggtc ggcgaccagt tgctccgggt cctcgcgggc gtccgccacg gcctcggccc 1381 cgagcttccg ggcggcctcc agccgagcgg tggccagatc cacgacgacg atccgttcgg 1441 gtgcgaacag ccgtgccgtg gcgaccgcgg cgagtcctat ggggccggcg cccaccacga 1501 cgaccgtgtc tccggggctg acgcgtccgt tgagcacgcc cacctcgtag gccgtcggga 1561 agatgtcggc gagcagcacg gcgtcctcgt cggtcaccgc gcccggcagg gagtgcacgg 1621 agaggtccgc gtacgggact cgcacgtact cggcctgagt gccgttgatc aggtggccga 1681 ggatccagcc ccctccgccg aggcactggc cgtacacgcc ctcacggcag taacggcacc 1741 ttccgcaggc ggtgatgcag gacaccagga cgcggtctcc cggccgcacg gtgcgtacgt 1801 ccgtgcccac ctcgacgatc tcgccgaccg cctcgtggcc gaggacggtt ccgggccgca 1861 cctcggggac gtcccccttc aggatgtgca ggtccgtccc gcagatggtg acggcgtcga 1921 cccgcacgat ggcgtcggtg ggctccttga gttccggatc cggtatgtcc tcccacgcgg 1981 accggcccgg accgtggaat acgtagcctt tcatcgtgat gctcactctc cttgtgctcg 2041 ggagcatccg gggccacggt gaccggaccg cgccgggcgg gcccacgacc gtcggtacga 2101 cggggattgc cccacacctc cagactgtcc ccggcagcac gaacccgctt gggccggtcg 2161 gccccccgcc cgccgcctgc cggccccggg tctgttcggt gtgctcacgt ccgctccggc 2221 acgacgacga ccgggcaggc cgagcggtgc aggacggcgt gggcgacccg gccgagccgc 2281 ccttgggtgc ggcggccgat caccagcagg ccggcttccg ccgaagcggc gggcagcacc 2341 gcgcgtgccg ggccctcgac ggtgtaccga cgcacggcga cgtcgggcgg tgcgtcttcc 2401 agggctgctt ccagttccct ggctgcccgc tcctcgtacc gccgggccgg ttctcccgcc 2461 ggcaaggggt gatcgatcgt ctcgtgggcg ggacagcgcc aggcccgaac ggccgcaacg 2521 ggcacctgac gcagacgtgc ttccatgaag gcgagccgta ggaccgacgc cgatacctcg 2581 ccgacaccga cgacgatgcg gccgttccgt cctccgatgg cgcggttgtc gtggttgccg 2641 cgcagcacga cgaccgggca gtcgctcccg gcggccacgg tccggctgac ggaacccagc 2701 agtctgtcgg cgatgccgct gcggcctcgg ctgcccatga cgatcatgga tgcgttgcgc 2761 cccgcgcaga tcagggcgtg ctcggcctcg tcgggcaccg tctcggtggt gacgacgagg 2821 tcgggatgcc gacgcccggc acggatggcg gcggccgcga ggatgtcgtc ggcctgcatg 2881 tcggtggagg gcttccccgg ctcacgggcg agcgcggcgc cctcgtaccg ctcccacagg 2941 tccccgaaga ccacccagag ggggactgcg tgcagggcgg cctcgtcggc cgcccagtcg 3001 acggctcgca ggctgggctc ggagccgtcg accccgacca ctagaggcag atacatgacg 3061 cccctcctct cgaccgggat gcgtcaggga tgggccacga cggcgacggg ggcactgaca 3121 cggtgcagca ccgcgtgggc gaccgcaccg atgtgcacgc cgagcgggct gggccggatg 3181 cgccgtccga cgaccaccag ggacgcctcg tgcgacgctt cggccagaag gtcggcgggg 3241 ctgccggggc gggatgcctc gacgacctcg acatccgggt acgactgccg ccagggcagg 3301 agcagccggg tgaggtcggc ggccttcctg cgggccaccc cttggtccgg tacgccgccg 3361 gcggtcagcg agggatagta cggcggtggc cgccatccgc tgaccacgtg cacggccgtg 3421 ccgcggcgct gtgcctcgtc gaaggcgaac gagagcacgc cgtcgtcggg gctgccgatg 3481 tcgagtccga cgacgaccgg ccggcggcgg ttggccgcgg gcggcacacc gacggaatcc 3541 acgacgtgtt cgccggccgc ctgctcaccg gcacgtacga ggaccacggg agtctcgctg 3601 tgggcgatca cggactgtcc gacggaaccg gccaggaagc cgccgagtcc gctgggcgcg 3661 cgcgagccga ggaccagcag ttccgccccg tcggcgtccc tgaccagggt gtccgccggt 3721 gggccggacc gctggtcact ggtcaccacg acaccggggt ggcgcagccg cagcccttcg 3781 cccaccttct gcgggacacg ctcggtccag tgctggtgtg tcttcgcgcc gaggatcgaa 3841 tcctgggcca ggaccgcggg agccggctcc cacacgtgga gcagacgtac cggcaggtcg 3901 cgcagctcgg cctcgcgggc cgcccactcg gcggcggcgt ggctctcggg cgagccgtcg 3961 attcccaccg tgatcgtgcg ggtcatgtcg cgcacctccc gtgtcggccc ttccgactcc 4021 agcgtgtcgc gcaactgagc cccggggtag ggccactcgt cctcggacac ggccgagggt 4081 cccttcggcg ggcccgtgcg gcgaaccgcg ggtcggcatg ccggaagcac cgtccgccgg 4141 gtgccctgcg ggtgttcagt gcccctcgcc cttcagccgg tcctccgcgt gggcggcgac 4201 gacggaggcg gccggcacga ggtccgagcc ctcgatcggc ttcaggacct gggtgaggtc 4261 cggcatgctc gaccgcggct cccgccacgc ggtcaccccg tcccataagc cgtacgtccc 4321 gcaggtcacg ccctcgcgtc gggcaccggc ttcgaggaca ccgaccgccg cgcggcacac 4381 gtcttcgccc agcaggcgta cgaggcaggc gtgcggagga tcgtctacct gggtggtctg 4441 actccgcggg gcgttcccga gcgcacgctc tcccctcacc tgcgctcccg cgcggaggtc 4501 ggccccatct tggtccgcga cgtgttgcac tacctggccg gggcggccac catgccggac 4561 gacatcgacc gggccttcga cgtcggcggg ccggacgtgc ccacctaccg cgagatgatg 4621 cgccgccacg ccaccgtgag cggactccgg cggcggatca tcgtgcccgc tccggtgctc 4681 acccccgggt tgtccagcca ctgggtcggc ctcgtcacgc cggtcccggc ctccatcgcc 4741 cggccgctga cggagtctct gcgtcatgag gtcgtgtgcc aggagcacga catcgcccgc 4801 tacgtccccg acgctcccgg ccggcccctg ccgttcgacg tggccctgac gctggccctg 4861 cggcgggtcc gggaggccca ggtcgccact cgctggtcgt ccgcctccgt gccgggagcc 4921 cccagcgatc ccctgcccac cgaccccgac tgggccggcg gcagcctcta cgaggacgag 4981 cggcacctgc cggtcgacgc gtccccggag gcgctgtgga aggtggtgga gggcatcggc 5041 ggggacaacg gctggtactc cttcccgccg gcctgggccg tccgcggctg gctggaccgg 5101 ttcgtcggcg gtgtgggtct gcgccgcggc cggcgtgacg cccagcgcct gcacccggca 5161 cgaccggtgg cgtggcgagg aggacgccgc cgaggacatc gccgcctggc gggacggacg 5221 ggctatccgg tcgtcgacgc ggccatgcgc cagttgcgcc accagggttg gatgcacaac 5281 cgggcacggc tgctggtggc gagcttcctg accaagacgc tgtacgtcga ctggcgcatc 5341 ggcgcccggc acttcctgga cctcctcgtg gacggcgacg tcgtcaacaa ccagctcaac 5401 tggcagtggg ccgccggcac cggcaccgac acccgccccc accgcgtcct caacccgctc 5461 gtccaggcca ggcggttcga cccggacggc gtctacgtac ggcgctgggt ccccgagctc 5521 aggagcgtgg agggcgggaa ggtgcacgaa ccctggcgcc tggcggcggc ggaacgcggt 5581 gaactcgact acccggaccc gctcgtcgag ctcgccgacg ggctcgcgcg gttcaagcac 5641 gcccgcggcc gggactgagg ggacgcgtcg tgcattggct cttcggcgac cagctcggcc 5701 cccacttcct cacgccgggc gaagaggggc ccgggccgga aactccgctg ctcatgatcg 5761 aggcgcgctc cgtcttccgg cggcggcgtt tccaccgggc caaggcccac ctggtgctgt 5821 ccgccatgcg ccaccgcgcg gccgaaccgg gcgaccgcgt cacgtacgta cgcgccgaca 5881 cctaccgtca gggactggcc cggaccgcgc gcgggcgccc ggtcggcgtc caccacccca 5941 cctcgcacgc ggctctgcgc ctggtgcgcg ccctgcccca ggtgacagtg gggcccgccc 6001 gcggcttcct cgtgccgatg accggcttcg ccgcctgggc cgagggtcac ggcggcaagc 6061 gcctgcggca ggaggacttc taccgctggg tccgccgcgg gcacggcctg ctcatggacg 6121 gcgagcagcc cgcggcggga cggtggaacc tcgatcacga caaccgggaa cccccgcccc 6181 gcgaggccgc ctccctccag gtcggccgcc cgtaccggcc ccgcgaggac gacatcgacg 6241 aagaggtccg ccacgacctc gaccgctggg aacgcgacgg ggacgtttcc ttcgtcggac 6301 gggacggtcc ccgcctgttc cccgccaccc ggacggaggg gctgcgggca ctgcgacgct 6361 ttgtcgaaca ccggctcgcc accttcggac cgcacgagga cgccatgctc gccgccgacc 6421 ccgtcatgag ccacagcctc ctttcgtcca ccctgaacct cggcccgctc gacccggtcg 6481 agtgcgtcga acgggctgag cgggcttggc gcgagggccg ggcgccgctg aacagcgtgg 6541 agggcttcgt gcggcagatc gccggctggc gcgagtacgt ctggcagctg tactggtact 6601 tcggcgaggg ctaccgacgc tccaacgcgc tcgggcacac cgccccgctg ccggactggt 6661 ggaaccggct ggacgcggac gcggtccggg cgaactgcct gcgcaccgtc ctggcccagg 6721 tccgggacac gggctggacg caccacatcc cccggctgat ggtgctcggc agtcacgcgc 6781 tccagcgggg ctgggacccc gccgccgtca cgaactggtt ccaccgctgc ttcgtggacg 6841 gctacgactg ggtcatgctc cccaacgtcg tcggcatgtc ccagtacgcc gacggcggcc 6901 ggatgaccac caagccctac acctcggcgg gtgcgtacgt gaaccgcatg agcgacctct 6961 gcggcccgtg cggctaccgg cccggcgacc gcacctgcga gcacgcgtgt ccgtacacca 7021 ccgggtactg ggcgttcctc gaccggcacc gggagctgct ggccggcaat cagcgcgtcg 7081 cccggccggt acggcagtcg gaccggctcg ccgacctccc ggacgtgtgc gcacagggca 7141 cgcgcggggt gacgcaccgc catgagcccc cgccgttgcg ccgacggggt gaagtcggac 7201 cgcaccccgt gccggaacgg gcagaagtca gtgcatccac aacagggcac ccggcggaag 7261 cagtggcgtg cggacaaccg agagtgagaa ggggctgcgc atgcctggac tgccgccgat 7321 ggtggccccg ccggccgaac aggtcgacga ccccgtcacc gcgaccgatg cggcgaacgc 7381 ggtcgacgcc gtcctccggg gggtactgga cgaacggctg cgccactgcc gtgccgtcga 7441 ccccctcttc gcccgggaac tggccgaccg tctcgcggcg ctgaccgccc ggggcggcaa 7501 gcggctgcgc accgcgttcg cccactgcgg ctggcgcgcc gcgggcggct cgggagacgc 7561 caccgccgtc ctgcgaacgg gagccgcgct cgaactgctc caggcgtgcg ctctggtcca 7621 cgacgacgtg atggacggct ccgtgcagcg acgaggcgca ccggccctgc acgtcgacct 7681 ggcccgcggg cactgggcag cgggtatgca cggctcgtcg gagtccttcg gcacctcggc 7741 cgccgtcctc accggtgacc tggcgctcgc ctgggcggac gacctgctga ccgagacggc 7801 actcggtacg ccgcacggcc cgcgcctgca cggggagtgg cgggcgatgc gcaccgagat 7861 ggtcgccggc cagtaccgcg acctgcacgc gcaggcggca cggtcctccg gcgtcgacga 7921 ggcgctggcc atcgccacct tgaagagcgc cctgtacacc gtcgcgcggc ccctcgcgct 7981 gggagcggta ctggccggag cggccgacgg ggacgcactg gaggcgctgc gggcggccgg 8041 ccggtgcgcc gggctggcct tccagttgcg tgacgacctc ctgggcgcct tcggcgaccc 8101 cgcgctgacc gggaagccgg ccgacgacga cctgcgctcc cgcaagctca cctacctgct 8161 cgccgtcgcc gtccggctcg ccgatgccgc cgatgatcac ctggcggccg cggcgctggc 8221 tccggacgcg gacccgaagt ccgagaaggc cgtgcggcag gtgcggtccg cgctggtgcg 8281 caccggcgcc cgggacctgg tggagacgaa gatcggggag ctgacggaca tgagcctcgc 8341 gcacttcgac cgctgcggag cgcgcccggc cgtgcggcac gagttcgccg cactgatcgg 8401 gcgcgcgacg ggcgcggtcc cgcgtggcac cggggaggtc gtgtgaggag ggtgccgggg 8461 ccgaccggcc acgtcgtcgt ggtcggggcc gggctgtccg ggctggcctg cgccctgcac 8521 ctgctggggg ccggccgccg ggtcaccgtc gtcgaacggg acgccggtcc gggcggccgg 8581 tccggccggg tacggctggg cggttacgag ctggacaccg gtcccacggt gctgaccatg 8641 ccgcacctgg cggacgaggc gttcgccgcc gtcggggaca gcctccgccg ccgcgtcgaa 8701 ctgaccgcgc tggacccggc ctaccgggcc tgtttcgcgg acggttccgc actcgacgtg 8761 cacaccgacg gcgaggcgat ggaggcggag gtgcgccgct tcgccggacc ggcgcaggcg 8821 gccggatacc gcgatctgcg gcggtggctc gaacggctgt accgggcgca gatgcgccgc 8881 ttcatcgaca cgaacttcga ctcccccctc caactgctgc acccggacct ggcccggctg 8941 gcggcactgg ggggattcgg acggctggac ggccgcatcg gacgcttcct gtccgacgag 9001 cggctgcgcc gcgtcttctc cttccaggcg ctgtacgccg gtgtggcccc ggcccgcgcc 9061 ctcgccgcct acgcggtgat cgcgtacatg gacaccgtgg ccggcgtctg gttccccaag 9121 ggcggcatgc acgcgctccc ccgcgccatg gccgacgcgg cggcaaccgc cggtgccgat 9181 ctgcgctggt cggccgaagt gaaggcgctg gagcggtccg caggacgggt acgcgccgtt 9241 cacctggcct ccggagagcg catcgcctgc gacgccgtgg tgctgacgtg cgagctgtcc 9301 accgcctacg ggctgctggg acgggccccc cggcggccgg cccggctgcg gcactctccg 9361 tccgccgtga tcctgcacgc gggcaccgac cgcacctggc cgcacctcgc ccaccacacc 9421 ctctccttcg gcgccgcgtg ggagcgcacc ttcgaggaac tgacccgtac gggagaactg 9481 atgagtgacc cctccttgct gatcacccgc cctaccacgc acgatcccgc cctggcaccg 9541 ccggggcgcc acctccacta cgtcctcgcg ccctgtccca acacggacgt cggtccggat 9601 gccgtcgcgt ggcgtgacct cggcccgcgc taccgcgaga gcctggtcgg cgtactggag 9661 agccgggggc tggaggggtt cgcggacagt gtccaggagg agctcctggt gacgccgctc 9721 gactgggacg cgcagggcca tgcggcgggc agccccttct cggtctccca caccttcgcc 9781 cagaccggac cgttccgccc gcgcaacctc gtacgggggc tggacaacgt ggtgctcgcg 9841 ggctgcggga ccaccccggg tgtcggcgtt ccgaccgtac tggtcagcgg caaactcgcc 9901 gccgcgcggg tcaccggcgg tgccgggtcc cggcccgccc gcacgcgtcg gtccccggcc 9961 gtttccgacc cgtgccccgc cccggtcccg gcaggtgccg atgacccgtc gtgaactgga 10021 cgccgccggg atcaccgatc ccctgctgcg cgccgcctac acccggtgcc gccgtctcaa 10081 cgcccgccac ggcaagacct acttcctggc cacccgtctg ctgccgctcg aacggcgctc 10141 ggccgtgcac gccctgtacg gcttcgcccg ctgggcggac gacatcgtgg acgacctcga 10201 ccggcaccgc acggccgggg aacgcgaccg tgcgctgcgc cgcctggaga gcgacctggc 10261 cgacgggctg cgcaccggaa cgggccggga accggtggtc cgggccgtcg cggacaccgc 10321 cgaccggtac gacatcgacc acgtgctctt cgccgacttc ctgtcctcga tgcgtgcgga 10381 cctgaccgtc acccattacc ccacctacgc cgatctgcag gcgtacgtac acggttcggc 10441 ggcggtcatc ggcctgcaga tgctgcccgt cctcggcacg gtcacggacc ggaaggaggc 10501 ggcaccgcac gcggcggcgc tgggcgtggc gttccagctc accaacttcc tgcgggacgt 10561 cggcgaggat ctcgaccgcg gccgtgtcta cctgcccggc agcctgctgg ccgcgcacgg 10621 ggtggaccgg cccctgctgg agtggagcag gcgcaccggg cgccgcgacc gccgcatccg 10681 ggccgctctc gtcgcggcgg aggccatgac gcggcgcgtg taccggacgg cggagccggg 10741 catcgccatg ctcgatccac gggtgcgtcc ctgcatccgt gccgcgttca ccctctacgg 10801 cgggattctc gacgcgatcg ccgagcagga ctacaccgtg ctgcatcgtc gcgcggtggt 10861 gtcgcgccgg cgtcgggcgg caacggccgc cgagggtgtg ctgtgcgtgg ccgctgcccg 10921 gtggcgtgcc cgcacctcgc cccgggtgga ggcggcgggt ggtccggcag ccgagtggca 10981 gggaccggtg cggtgagtgg tcgacggggc ggcaggcggt ggtcgccacc cgtgcgccga 11041 cgtggtgcgg gccccgactg ggcggctcag actccgacct ggcggcaggc gcggccctcg 11101 ctcatcgccg acgcgctcga gcgggcctcc gcccggccct ccggcaactg gttcgtggtc 11161 ggcgcctccc ggcaggtgcg cgcgggcgac cggccgtacg gccggacggt cggtggggtg 11221 gaggtcgtgc tgtggcgctc ggacgacggc gagccccgtg ccggctccgg catctgcccg 11281 cacctgggcg ctccgctgcg cgacagccgg gtggtgtgcg gcacgctggt ctgccactgg 11341 cacgggctcg ccctggacgg ttcggcgtcc gccggctggc ggccgttccc ggtgcacgac 11401 gacggtgtcc tcgtctgggt aaggctggac gaggtgggag gcgaggagcc caccgagcgg 11461 cccgtcgtgc ccacgcggcc cgcgaccggc cggggggtcg actccgtgtt cacggcgacg 11521 gggcggtgcg aaccgcagga cgtggtggcc aaccggctcg atccgtggca cggctcgtgg 11581 ttccacccgt actcgttcgt ggacctctcg gtcgtgcggg agccgcaggg gggcgaggac 11641 gacgctttcg tcgtcgacgt ctccttccgg gtggccgggc ggctcgtggt cccggtgcgg 11701 gccgagttca ccgcgccgga gccacgcacg gtcgtcatgc gcatcaccga cggcgagggc 11761 gccacgtccg tggtcgagac gcacgcgacg ccgctgaccg ggccggacca cgagcgtccc 11821 cgcaccgccg tggtcgaggc ggtcgtcgcc gcgtcggacc ggcccggttt cgccctggca 11881 cgggccgccg cccccgtact gcgcccgttg atgcgccgta cggccgggcg gctgtggcgc 11941 gacgacctgg cctacgccga acggcgctgg gcactgcgca gcaccggccg gtttcccggc 12001 tgaggacgcg ggcgccggtc agggagccga gcggtgcccc gcgacggctc cgaacgctcg 12061 gagcacgggt gaacgacccg tccgggggac cgtccacagg acctgaccac gcactccccg 12121 gtcggcgagc agggcgttcg cggccaggaa gccggtggtg gcggctcgtt ccatgagggc 12181 gacgggcagg tcgcagcgga ttccgtcgcc ggccagggtc agccagggat gcggggtacg 12241 cacggtgggg cgccgccggt gggaaccgac ctcgaacatc gggcagtccg cgcgccattc 12301 gtgccgggcg tcgacgacgc gggcctcgcg ggtctccggg tacgcctggt gcagccggtc 12361 gacgagctcg tcctgcacct ccttcggttc ggccgccggg tccacggcgt aggcgtgcag 12421 ttccacgacg gatcccccgg tccgcgcggc ccagcgggcg gcctcgccct cgtaccgctc 12481 caggacgctg acgttgtcca gtccgccgta gccgctggtg ccgaggaacc cgggccggtc 12541 ggcgtcgacc ggccggtcga gccagagccg cgagacgagg aacggcggcg cggtgcgcag 12601 ggcggcgatg ccgtctcgcc aggtgtcggt gcccaggccg ggtgacgcgg cgacggtctg 12661 ccgcagcccc gcggtgtcga gggccagcac caccgcctgg tgacggtcgg caccggtgtc 12721 cgtgagcacg tccgctcccc cgtcggcgcg gggaaggatc ccgtgcaccg gggtgccggt 12781 gcgcacgtcg gctccgaggc gccggaggta gtcgcccagt gggttccaca gtgcctgggg 12841 gaagggttcg accggcacgt cgaagagcag gccctcggac gatccgagga agtagatgtg 12901 gaacatcagc agcagttccg cggcggacag ccggcgcgga tcggcgaaga agctgcggga 12961 gaacacctcg aaggccaggt ggtgcgccgc ttcggggaag cgcacgctct ccaggaacgc 13021 ggtggcggtg acgccgtcga agcgttcgta cacctggggc acgcgcacgt cgaggagcgg 13081 cagggcggcc cgcgggtcca tcgcggcgag gtcgcgccat ccgaaggtgg ggctgagggc 13141 gacgaatccg atcgcgctga ggggcggggt ccgcgggacg cgggcgaagc cgtcggtcag 13201 gccaccgctg tgccgcaagg ggtagtcggg cagcggggtg aggcggtcca ggccggggtc 13261 ggtacggcgg agcagtccgc ggaggttgta gtactggcgg aagaaggcgt ggaacccgcg 13321 ggtcatggtc acggcgctgc cgtcggccag ggtggtgcgc cggccggaga gcctgccgcc 13381 gaccgcgtcc tccttctcgt acagcgtcac gcgggcgccg cgttcggcca tgagggtggc 13441 cgcggccaga ccggcgatcc cgccgccgat caccgcgacg gacggctcgt caccgcgtcc 13501 gaatcggtcc gcaccgggcg cggggaagac gatctcggcc ttgcggtcgc ggccccgtcg 13561 ggcggcggcg gtgcggcgga cggtcacagg acgcgctcct ctgtcgtggt ggggccgccg 13621 ttgcgggcga ggaaggtgtg cacgatgccc gtctgccatc cggcgacggg ggcgacgcgc 13681 accgaggtca ggccggcccg cgtcagccgg gcggcgaatt cgggggcggt gtcgaaggcg 13741 acgacgctgc gccggaggtg gcggtagagg gtgcggtcgc cggtgagggt gcccgcgggg 13801 atgacgactc cgcggcacac cgccgaccac agggcccggt gccccggcga gccgctcagg 13861 ctgtactcgt gggcggcgaa gcgtccgccc ggcctcagga gttgccggac ggcccgcagg 13921 accgcgtccg ggtcggtgac gttgcggaac aggtaggcgg cgaagacggc gtcgaagggg 13981 ccttcgtcct cacgggtcgt ggcgaactcc tcggcggtca ggtggaggaa gcgcacgcgg 14041 gcgggccacg gtttgaccag tgctcggcgc agcatgcccg cggaggcgtc cacggccgtg 14101 atccgggctc gtggcgcggc cctgaggagg gcccgggtgg aggcgccggt accgcacccg 14161 aggtcgagca gatgcagtcc ggctccgtcg gcggggagcg cgagacggcg ggcggaacgc 14221 aggaggcccg tgcggtagcc ggggttcagg gccgtgaggc cgtcgtaggt gtgggaagcg 14281 tggtcgaagg cgcgggccag gtcgtggtcg cgcaggagtg tcatcggttg ttccctccgg 14341 ttcgggcgag gggctgggac cggcgtggca ggaagggcac ttcggccgcg gtgcgcagca 14401 tcggccggac gggagtgcgc aacccgatgc cccactcctc ccggagggag gtcgtgccgt 14461 cgaggaacct cagcaggcgc tcggccggga cccggcggaa caggtcggtg aagaagcgcg 14521 gcccgtcgat gcgaccggtg tccagcgcac gcagcaggac cgcgtccatg gcccgcgccc 14581 gtcgcccgtg cggtgccggg acgcggtcgt ggccgtcccg cagggcggcg gcgatggctc 14641 cgctgtgccg ttgcaccgcg gcgaacgtgt agccggtggc ggggcgagtg gcaccgcccg 14701 cggtcccgat gcggtacacg gccggcccgg cacgtcccgg gaagcgggcg tcggtcatgg 14761 ggatgacgcc ttgttccgtc cgttccacgg tgagttcgcc cagtccgagg atgtcgcggc 14821 agtagtgccc gagtgcggac tcgtacgcct cggtggtcag cggggcgcgg gagaactcgg 14881 tgtactccac gagcgcccgg tccggcgcca gcggcaggac gtagccgaag gcgagtccgt 14941 gggccggctg gggcacgcgg aagtccatca ggtccgcgac cgccgggtcg aaccggtcgg 15001 tgcgggtgtg tacgaaccag ccgcggaagt gctgcagcag acacgtacgc gccggcggca 15061 gctcgggaag cggccgtgag tcgaagaccc gccgggcgta cagcgtcagc ggccggcctc 15121 cgggcagcgt gcaccggacc tccgtgcccg cgggcacggc gcgaaccgat tccgccgtac 15181 cccgcagaag gcgcgcaccg tccgtgcggg ccaggcggcc gtggaccatc cgctcgaagt 15241 cggcggaacg caccatgcgg taggtgaacg gggccggatc gacggtgacc gacccgccgt 15301 cggcgccgtg cagacgcagc acggaccagg acgcgccgac cgcctcttcg aggccgtcgg 15361 cggccgcccc ccagtagcac caggtgcgct ccgcggggcg cagcgggccg tccggcggct 15421 cgaccagggt catggcaggg gccgtgccgt tctccgtcag ccggtgggcg aggctgagtc 15481 cggccgcacc gccaccgatg acgagcacgt cggagtcctg ggcggaacgg ggtgtcacca 15541 cagtcgccgt tcgacgaccg ggcttccgtc gggacccgga tgcggcggct cggcgggcgt 15601 cggacggtcg gcgtccatca gtaccccacc accccgtcac cggccttcgc ggccgcgccg 15661 caggcccggg cggcgcctgc caccgggtca cgcacactct tcggttccac gcttcacccc 15721 tcgtacggac ggcgggtccg tccggtcgcc atggcttcgg gaccgaggcc gtccgtggat 15781 gcggccgggc acgacttcgt catcggcctc acctctgcgg ttcccggtcg gcccgtacct 15841 cccgcgccgc gcgcgtaccc gaggccagcg cgccctgtac ggagccggtc gcccggtggt 15901 ctccgcacac gtaccggccg gggccgatgc gggtggtgcg gctcagcggc caggggggaa 15961 gcatcgccgg cagtgcgccg tcgaccgtgc gggccgcgac ctgctcccag ccgctcgtgt 16021 cggtgccgta cagctcggcc agccgccgga gcaccgcctg tgccctgccg ggcgggtccg 16081 tgcccagtac ggaagtggag accagcccgg tgccgggggg cgcgtacgtg ggagcgacct 16141 ggctgaggac gcacgtgttc aggatggctc cggtgctgtc caccatgagg atcggttcgg 16201 ccgtcggcgg gctgtcggtg gcgtggtagt aggtggtgac ggtgcgggtg tccgggacgg 16261 tcaggtccgg gagcagcccg gcggcggtcg ccgggtccgt cgccaccacg acgacccggg 16321 ccggcacctc gccgccgtcc ccgagcagca ctccggcgtc cgtgatctcc gcgacgggcg 16381 tgcccaggcg caggacgccg tcgggcaggc cgtcggccag ctgggccggt acggcgccga 16441 tgccctccgc cggcaggcac agggatcctc ggaccatgct ccgccagacc aggtggaaga 16501 accgggctga ggtctccagc cggtcctcca ggaagacgcc ggacaggaac ggccgtagga 16561 tgccggcgat cgccgcgtcc gacagtccca cccgggacag ggccgccgaa gtgggacggt 16621 cccggcgccg tcgggtgacg gccacgggca gaacggcgtc ccgtgcggtg agtgccgcca 16681 gcgcggccag atcgcgggcc ggcagagccc gccccggcag cagcgtcccc gccgcgcggg 16741 gctccctggt cggatcggcg aggcggacgg gcccgttcga cgtgtgggcg acgacacccg 16801 ccgtgaacgg cctcagtcgc agactcttca gctccatgcg ccgcttcacc tgcggatagg 16861 aggtgttgaa cacctggaac ccgcggtcca gcaggaatcc gtcccgccgg tccgtgcgca 16921 tccggccgcc gacaccgtcg gaggcctcca gcagtgccac ccgccatccg gcgcggcaca 16981 ggtcgagggc gcacgccagg ccggccagac ccgcgccgac gacgaccgcg tccgctgccc 17041 ggtgttgtcc gtcgctcata tgtctcctca ctcgacgtca cgtccgtgat gcccaggggc 17101 aaaggccggc cggtcggcct ctccgccccg gccggtgccc cggaccggtc ggcacggtcg 17161 gggccggaag ccggtgcgag tgcggggaaa cgcccgccgg ccgacgaccg ggccacgacc 17221 accgggtcag cggaccacgt cccccggccc atgcccaggc gccacgacca aggacggccg 17281 gacgacaaca cctcacgggt acaccgacgg ctccagagcg gcgaccgcct cggcaagccc 17341 cgacggacgc gccagaccgg ccaccgcctg gcccgcccat ccagggccca gggtcaggac 17401 gacgggccgg cgccgggccc cgcgcactcc ccactccatg gcggccacgt gctgggccag 17461 cggccggctg gcggtggtgc gggactgcga ccacagcccc accgcggcgg gcccggtcct 17521 gcgcaccgcc gcgacgagcg actcaacggg cagcgcaccg ccgaacatcc gcaccgggac 17581 gcctcgctcc gtgagtgcag cggacagtac ctccaacggc agagtgtggt tctcccccgg 17641 tacgcaggcg agcaccgtgg tggaaccggg acggtcctcg accgcggggg gcgcggcgcg 17701 gcggagcgcc ccggacacgt gccaggacag gaagtgctcg acctcgacgt acttctcgcc 17761 ggacgtctcc cacttccggc cgactgcctg gagcgtcggc acgatcacct cggtccaggc 17821 cgcgaccagg ccgtgttccg cgatcgcggc gagcagcagt tcgtccaagg cggaggcgtc 17881 cagacgcagg gcggccctcg cgatcccccg gcactcctgt cgtacgtcgc ccagttgcag 17941 gccgctgccc gcccggctcc ggcgcccggt gggagcacgt cgagccgcgt cggtgtttcg 18001 gggcccggcc gccgtcggac gctcttcact gcgcgcgagc cgtgccgcct cggccggtgg 18061 cagcccggtc gccgtcaggg cgcacatccg ttccagcctc gccaggtccg ccgccgtcca 18121 gcgccggtgc cgtccgtcga cgtgcgcgtc cggccccagc ccgtaccggc ggtcccacgt 18181 gcggaccgtg gtgggcgcca cccccagacg ccgggccacc tcgccggtgg tcaatccgcc 18241 acggcgcgga ccgccgtcgt cgaccggctc gtcgccgtct cccgtgtacg cgttcacatg 18301 cccactatac gacgcacaaa cgacgcatgt tgcttgcgtc gtttcctcac ccaacactgg 18361 gaccacgcac acggcagcca cgcagggtag accggcgacg tgccgctcgg ggacggcccc 18421 tcccgtcccc gtacgacgca cggcaggagg aacgggcatg aacacgcgta cacgaccgac 18481 caccaccccg gtcccgcccg tggaggagac gcggtacgag gaggagctgg cgcacggcct 18541 cgtgaaggcc gacgaggacg cgttcgcggc catctaccgg cgctgggggt cgctcgtgca 18601 cactctggcc acccggtccc tcggcgacgc ccacgaggcg gaggacgtga ctcagcaggt 18661 cttcgtcggc gcatggcgcg ggcggcacgg tttccggccc gagcggggca cactcggcgc 18721 ctggctcgtc ggcatcacgc gccggaaggt cgtcgacgcg ctggccgcca ggacacggcg 18781 cctgtcgctg gtcgagtcgg ccgggcagga catcacgccc gcccgtctcg tccagccggc 18841 actggacgag gtactcgacc gcgtactgct cgtggaggcc ctgtcccgat tgccgcaggc 18901 ccagcgggat gtgctgtgca tggccttcta cgaggacctg acgcaggcgc agatcgcgga 18961 acgcacgggg gttcccctgg gcacggtcaa gagccacgcc cgccgcggcc tgcatcggct 19021 gcgcacggcg gtcggcccgg gcgccgcaca tgacacgtgt gtctgaccgg gccggagcag 19081 agacgccccg gggcgcatcc acggcaccgg tcgccggcga aacaccttcg agaccgccca 19141 gcagacggaa actccctacg gaggggtgat tcccatgatg tcccggacca ccatcgccgt 19201 cgccggctcg gccggggcct gtgccctggc cccgaccgca cccgccgcca cggctgctcc 19261 cgagcaggcg caggacacgg gcctggtgtc cgtcttccac ggcatccccg gcacgacggt 19321 cgacgtcttc gccaacggcg acgaaccact cggcgacttc cagcccggca cggtgaccga 19381 aggcggcaac acgaccgtcg ccgcccatct ctccgccgac ggcaagcccc ggctgacgac 19441 gttcaccgac gacgtctcga agacggacgc cggcaggtca cgcctcacgg tacggcacgt 19501 cgcggcagca cccgccgtgg acgtacgggc cggcggacat cctctcttca ccggcctggc 19561 gaacccggac gaggacaccg cgctcgtcga ggccggcatc gtgaacgccg acgtcgtgct 19621 cgccggcacg gagacggtgg tcgtaggacc ggccggactc gacctcaagg agggcacgac 19681 caacgtcgtc tacgcctggg gcagcgccga ggaccagact ctggctctgc ccggccaggc 19741 cttcggcggc atggattcga cgcccctcgc ggtccacccg ggcgccggcg gcacggcagc 19801 caccccgaac gcgtccgacc ggtggcgtgc ccgggccgcg acgccggcac gatcgcggtg 19861 acagccgtcc tcgccgcctc gaaccggccg ccggagccca cgccggaccg cgcgaccgtg 19921 acggcccccg tcctcacaca gtccgcgtgg agaagacgaa gcccgaggca caggagggcg 19981 cagtgggtca cgtgcatccg tcgcacctgg tggagctggc actcggtcac gccagtggcg 20041 aggcggacgt cggcgccctg cggcatgccg cgtcatgccc gcgctgccgc gaggaactgc 20101 tccggttgac ccgcgtggtg accgctgcgc gcggcgcgga agcatcggac ctgccagtgc 20161 ctccgcccga gcgcgtgtgg cagcgcatcg ccctcgaagt actcccggag accgaccggg 20221 tgccccgtct ccgggaatcc tccgctcacg ggtccgccga cgagagggtt cgcggttccc 20281 agcgccggtg gaccgaccac gcgggcgagg gcctcctcgg actggctctg gccatcgccg 20341 tccttctgct ccggcggtgg cggatcaggg ccggctcggg gaactgatca ccgaggtccg 20401 cgtctcccgc gtgcacctgt cgtcccgtcg accgccgtgc atgcagccgt tgccgcggcc 20461 gatgtccgca ccctttccga gtccgcccgc acgtggcggc ctgtcgtgaa cggcgggttc 20521 aagtgggcgg gtccagtccg tacagggtgc ggccgccgac cagctcccgg ccgctgacca 20581 ggtccggcgc gatgcggacg aagacctcca cgggccaggg cacccaggaa cgaggaccgg 20641 tgcgaacgag ttgctcgtgt tccccgggat cggtgaccac cgaggcgagg ccggtgacga 20701 cgacgctcca gccggagtgc gtcacggcgt cgacttcgtc ggcctcgaaa gcgaccacgg 20761 caccgtcgac ggcacggacc agctccgagg aggccgacgt gcgcaacagc acggcaccgc 20821 tcttttccag gacgaagttg accggcagga cggcgggcag ggcgtcgcgg gtgtgcacga 20881 tgcggcccac gggcgcgttg gccagccgct ggaggctctc ctgtcggttc agctcgcgga 20941 atccgtcgtt gcggtacatc agccgggtgt ctctccgtgt gtcgtccggt gcgttgcgcg 21001 tactcccatc ctgctgcccg tcggcgaccg cgacggcgag ttcggcggtg tgcggggcga 21061 cgtgctcggc gtggtactcg acgaggccga cgccctgtcc cgcacgttcg gcgagcaggg 21121 cccggtgccc gcgccgagcc ggcgcgcaca cggtgtccgc ggccgggccg gcggagcggg 21181 agccggccga gaggaagcgc aggcggcggt tgtccggtga catctccgcg tagagcccct 21241 ccagttgctc gtggtccccg gctcgacggc gcggatacgg acggtggtgc cgtccgtgag 21301 cagcgcgtgg actgcggggc ggtgtggcgt gtcgtccttc atggcggttc tccttcgagc 21361 cgctcgggtc ctgtgtcctg ccgagcgtcc gtcacgacgt cggacgcgcc cagggaccga 21421 ccgggggtgc ccgcggggca cgtccggccc ccggtcttcc gccggccgtc ccgggcggcg 21481 gcctcgggcg gtcatgtcgt gtcgggtacg accgcgaccg gacaggcgga gtggtgcaga 21541 agggtgtggg cgacccggcc gaggcggtgc ccgaactgcc cgggacgccg ccggccgacg 21601 accagcaggt ccgcctcgtg ggaggcggcc gacagcactc ggctacccgg tccctcggcc 21661 gtacggcggc gcaggcgcac gtccgccggg gcgtcggcga gcgcggcctc cagctccttg 21721 gccgcccgtt cctcgtgaag acgctcgggc gtgcccgcga gcagcgggtg gtcgaccgtg 21781 tcgtgggtgg ggcatctcca tgcccgtacc gcgtccaggg cggcgccgcg ccgccgggcc 21841 tcctcgcagg cgaagcgcac cgcagcggtg ggcgcgtcgg ccacacccac cacgatgcgg 21901 ccgcgccggc cgccaccggc ggcacggtcg tcgtggtccc cccgggtcac gacgaccgga 21961 cagtccgaca tggtggccac cgtcaggctg acggagccga gcagcaggcc ggcgagttcg 22021 ccccgcccgc gggtgcccag gatcacggcg gacgcgttgc gcgcctcgcg caggaggacg 22081 tactccggtt cctcggccgt cgcttcggtg gtgacggcga ggtccgggtg gtgacgacgg 22141 gcgcgacggg tggcgacggc gaggatgtcg tcggtggtga cgtgaccgga cggcttgccg 22201 agctcccggg cgagggaggc gccctcgtag cggtcccagc ggtaggcgtg gacgatccgc 22261 aagggtactt cgtgcagggc ggcctcgtca gccgcccagt cgactgcccc gaggctcgac 22321 tcggagccgt cgactccgac gaccatgggc aggtacatcg ttctcagcct cccgcgttga 22381 gatcgaacac gatccgggcc ttgacctgtc cgccgaggac ctcgtcgatg cagtcgttga 22441 cggcggcgag cggacgggtc tcccggatga ccttcgtgcg gccctcggcg tggagttgga 22501 agacctcggc gagatcctgc cgggtgccga cgatggagcc gatgaccgag gtgccgttga 22561 ggacggtgtc gaagatcggg acctggaggg tgccgtgcgc cggcagggca accatgacga 22621 gtttcccgcc gcgccgcaga ccggagttga cggcctggaa ggcggccggg ttcaccgcga 22681 gggcgagggc ggcgtgcgcg ccgccgtgtc gcttcagctc ggcgccgacg tcctgggtgc 22741 gggcgtcgat gacgaggtcg gcgccgagtt cccgggcgag ttggagtttg tcgtcggtga 22801 cgtcgatcgc gacgacccgc gctccggcga tcttcgcgta ctgcaccgcg aggtgcccca 22861 gtccgcccac gcccgagacg gcgacgagct gggcgggccc gacttcggcg accttcagtg 22921 ccttgtaggt ggtgacgccc gcgcaggtga gcggggcggc gtcgagggcg ctgacgccct 22981 cgggcaccgg ctgcgcgaag tcggcccagg caagcatctt ctcggcgtac ccgccgtcgc 23041 agccgtaccc ggtgttgacc tggtcctcgc acagggtctc ccagccggac cggcagtgct 23101 cgcaccgccc gcacgccttg ccgagccagg gcacggcgac gcgttgtccg acggcgaggt 23161 gggtcacgcc gtcgcccagc ttctcgacca ggccgacgcc ctcgtgcccg gggacgaacg 23221 gcggggtggg cttgaccggc cagtcgccgt gggcggcgtg gatgtcggtg tggcacaggc 23281 cggatgcctc gacggccacg agcacctgcc ccggaccggg ctccgggtcg ggcctgtcct 23341 cgatgaccag gggcttgccg aactcccgga cgaccgctgc cttcatggtc ctgctccttc 23401 tgtgctcgtc ttcggtgggc cgcgtcagtc gtgcgcgacg acggcgacgg gggtggtggc 23461 gtggtgcatg accgcgtggg cgacggcgcc gatgtgcaca ccgaacgggc tgcggcggat 23521 acggcggccg acgacgacga gggaggcgtc gcgggccgcg tcgatgaggt gctcggcggg 23581 actgccgagc cggcacgtct cggtcacctc gacgtccggg tacttctccc gccagggcag 23641 cagtgcctcg ccgagtgctt cggcctgggc gcgggccagt tcctcgcgcg ggtcgaaccc 23701 ggcggcgatg ctgtaggtgt aggaggacgg caggttccag gccctcacgg cggtcagcgg 23761 ggcccgccgg cgccgcgcct cctcgaaggc gaaggagagg acggcctcgt ccgggctgcc 23821 ggtgtccagt cccacgacca cgggccggaa gcccgtggcg gcggacggga tgccggtggg 23881 gtccttgagg tgttcgtcgg cggcctgttc ccccgcgcgg acgaggatca ccggcgtctc 23941 ggtgcgggcg atcacggact ggccgacgga tccgaccagg aagcccgtga gcccgctgag 24001 ggcgcgcgag ccgagcacca gcagttcggc gtcaagggtg ccggcgagca gggcgtccgc 24061 cggattcccg gtcgcctgct cggtggtcac ctcgaccccc gggtgccgca gcctcaagcc 24121 ctcggccgtg tcccggggga tccgttcggt ccagtgctgg tgggtctcgg cgccgaggag 24181 cggagcctgg gccatgggct ccggtaccgg ctgccagacg tggagcagtc gtaccggcac 24241 ccggcgcagc gtgccctcgc gggccgccca ctccgcggct gcccggctct cgggcgagcc 24301 gtcgagtcct acggtgatcg tgcgggccat tccggccacc tcctgtgtct tctgttctgt 24361 tctcagcgtc tcttcgggcg gtctacgggg gcaggggcct gtggtcccgg gacggggccg 24421 accgtccctg cccgcagggt gatgggacgg gtcctcgggc gggcccgccc caccggtcgt 24481 gttcagcgca gccacgcgtg gtcgcggacg atcgggagcc tggcccacag ccggcccagt 24541 cccagggcgt caccggccga gacagcggcc agcgcgatca gcagcaccgc gtacagcacg 24601 tggtagtcgg cgaacggatt cgtcgacatg ctcgccgacc cgtcggacag gtgcttcgcc 24661 ggcggccact ccgccgccca catcagcgcc atcatcaccg tccccgccac cgcggccggc 24721 cgcagcgcca cccccgccgt caacgccagc ccgacgccga gcaggcccag catgaacagc 24781 cagtcggccc acgccgcccc ggcccacgag tggaacgtcg actccatcgg accgaccgcc 24841 acgtgcccga ggaagccctc ggtcggcgaa ccaccgtcga tccagccctt gccggaggcg 24901 gtggcgtaac cgaacccgaa cgtcttgtcc aggaacgccc acaggaagac gaagcccatc 24961 agcacccggg ccgacgcgaa gacgaaagcc cgggcggtga gcgcgccggc ctccaccgaa 25021 tctgccgccc ccggcacgga tacggcgccg ttacggcgcg aggacggcag gtggaaaccc 25081 gaaccacgat gcgtggactg gtgcatggcc atgacagtga ccccttcgga gaggatgcgg 25141 ttggttcctg acaccactca ctctcccggg ccccgccacc ccgcacccga cgccgaaagt 25201 ccgcaccccg ggggctcaac agccccaatc cgcggggacc ttcggccggc ggtgcccgta 25261 cggcccttac gcgcgcgtcc gcgagggccg aggcggggag gtgttcgccc acctgcccgg 25321 ccggcctcgg acgtgggcgg gaaggaggag taaggaggag ttccgatgag ttcgtcaacc 25381 tcgacgcccc ggtcgcggag cggctggtcg cgacggccgt ggccgcgccg tccctgcgca 25441 ccacccagcc ctggcgcttc cggctcgata ccgacagccg cacggtgcac atccacgccg 25501 ccgcggatcg ggcgcggcgc cacaccgacc aggtgggc //